PL372268A1 - Inhibitory metaloproteinazy - Google Patents

Inhibitory metaloproteinazy

Info

Publication number: PL372268A1
Authority: PL; Poland
Prior art keywords: thiadiazoles; oxa; metalloproteinase inhibitors; inhibitors; oproteinases
Prior art date: 2002-02-22

Application number

PL03372268A

Other languages

English (en)

Other versions

PL210773B1 (pl

Inventor

Andrew Paul Ayscough

Stephen John Davies

Gilles Pain

Jean-Yves Gillon

Original Assignee

Vernalis (Oxford) Ltd.

Laboratoires Serono S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-22

Filing date

2003-02-20

Publication date

2005-07-11

2003-02-20 Application filed by Vernalis (Oxford) Ltd., Laboratoires Serono S.A. filed Critical Vernalis (Oxford) Ltd.

2005-07-11 Publication of PL372268A1 publication Critical patent/PL372268A1/pl

2012-02-29 Publication of PL210773B1 publication Critical patent/PL210773B1/pl

Links

239000003475 metalloproteinase inhibitor Substances 0.000 title 1
150000004866 oxadiazoles Chemical class 0.000 title 1
150000004867 thiadiazoles Chemical class 0.000 title 1
101000577881 Homo sapiens Macrophage metalloelastase Proteins 0.000 abstract 1
101000990902 Homo sapiens Matrix metalloproteinase-9 Proteins 0.000 abstract 1
102100027998 Macrophage metalloelastase Human genes 0.000 abstract 1
102100030412 Matrix metalloproteinase-9 Human genes 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000011159 matrix material Substances 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Virology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Communicable Diseases (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Vascular Medicine (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Transplantation (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PL372268A 2002-02-22 2003-02-20 Inhibitory metaloproteinaz macierzy, zawierające je kompozycje farmaceutyczne i weterynaryjne i ich zastosowanie PL210773B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0204159.8A GB0204159D0 (en)	2002-02-22	2002-02-22	Metalloproteinase inhibitors

Publications (2)

Publication Number	Publication Date
PL372268A1 true PL372268A1 (pl)	2005-07-11
PL210773B1 PL210773B1 (pl)	2012-02-29

Family

ID=9931543

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL372268A PL210773B1 (pl)	2002-02-22	2003-02-20	Inhibitory metaloproteinaz macierzy, zawierające je kompozycje farmaceutyczne i weterynaryjne i ich zastosowanie

Country Status (26)

Country	Link
US (4)	US7358265B2 (pl)
EP (1)	EP1476438B1 (pl)
JP (1)	JP4615864B2 (pl)
KR (1)	KR101098614B1 (pl)
CN (1)	CN100351245C (pl)
AT (1)	ATE360007T1 (pl)
AU (1)	AU2003205910B2 (pl)
BR (1)	BR0307899A (pl)
CA (1)	CA2475867C (pl)
CY (1)	CY1106730T1 (pl)
DE (1)	DE60313292T2 (pl)
DK (1)	DK1476438T3 (pl)
EA (1)	EA007609B1 (pl)
ES (1)	ES2286404T3 (pl)
GB (1)	GB0204159D0 (pl)
HR (1)	HRP20040725A2 (pl)
IL (1)	IL163413A (pl)
MX (1)	MXPA04008132A (pl)
NO (1)	NO330772B1 (pl)
PL (1)	PL210773B1 (pl)
PT (1)	PT1476438E (pl)
RS (1)	RS51354B (pl)
SI (1)	SI1476438T1 (pl)
UA (1)	UA78275C2 (pl)
WO (1)	WO2003070711A1 (pl)
ZA (1)	ZA200406755B (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003227952A1 (en) *	2003-05-17	2004-12-03	British Biotech Pharmaceuticals Ltd	Metalloproteinase inhibitors
US7786121B2 (en) *	2003-08-23	2010-08-31	Vernalis (Oxford) Limited	Derivatives of hydroxamic acid as metalloproteinase inhibitors
US7838522B2 (en)	2004-11-17	2010-11-23	Ares Trading S.A.	Benzothiazole formulations and use thereof
PT1828160E (pt)	2004-12-21	2012-01-05	Merck Serono Sa	Derivados cíclicos de sulfonilamino e sua utilização
RS51957B (sr)	2005-01-31	2012-02-29	Merck Serono Sa.	Derivati n-hidroksiamida i njihova upotreba
KR20080044836A (ko)	2005-07-15	2008-05-21	라보라뚜와르 세로노 에스. 에이.	자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt)	2005-07-15	2010-12-14	Serono Lab	inibidores de jnk para o tratamento de endometriose
EA013816B1 (ru)	2005-09-01	2010-08-30	Арес Трейдинг С.А.	Лечение неврита зрительного нерва
US8153166B2 (en) *	2006-06-08	2012-04-10	Chih-Hsiung Lin	Composition for prophylaxis or treatment of urinary system infection and method thereof
HUE038169T2 (hu)	2013-09-06	2018-09-28	Aurigene Discovery Tech Ltd	1,2,4-Oxadiazol származékok mint immunomodulátorok
BR112017019304A2 (pt) *	2015-03-10	2018-05-08	Aurigene Discovery Technologies Limited	compostos de 1,2,4-oxadiazol 3-substituído e tiadiazol como imunomoduladores
KR102894264B1 (ko)	2015-03-10	2025-12-02	오리진 온콜로지 리미티드	면역조절제로서의 1,2,4-옥사다이아졸 및 티아다이아졸 화합물
CN105384736B (zh) *	2015-10-28	2018-11-02	南昌大学	一种ⅳ型胶原酶抑制剂及合成方法
WO2019061324A1 (en)	2017-09-29	2019-04-04	Curis Inc.	CRYSTALLINE FORMS OF IMMUNOMODULATORS
EP3694841A1 (en)	2017-10-11	2020-08-19	Aurigene Discovery Technologies Limited	Crystalline forms of 3-substituted 1,2,4-oxadiazole
MY206121A (en)	2017-11-03	2024-11-29	Aurigene Discovery Tech Ltd	Dual inhibitors of tim-3 and pd-1 pathways
AU2018360389B2 (en)	2017-11-06	2024-09-19	Aurigene Oncology Limited	Conjoint therapies for immunomodulation
CN108530378B (zh) *	2018-05-29	2021-09-14	济南大学	一类含有噁二唑结构的氮原子双取代异羟肟酸类化合物、用途及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5665753A (en) *	1994-03-03	1997-09-09	Smithkline Beecham Corporation	Cytokine inhibiting imidazole substituted hydroxamic acid derivatives
GB9404046D0 (en) *	1994-03-03	1994-04-20	Smithkline Beecham Corp	Novel compounds
US5703092A (en)	1995-04-18	1997-12-30	The Dupont Merck Pharmaceutical Company	Hydroxamic acid compounds as metalloprotease and TNF inhibitors
ES2212142T3 (es) *	1996-12-17	2004-07-16	Warner-Lambert Company Llc	Uso de inhibidores de metaloproteinasas de la matriz para promover la curacion de heridas.
JP2002506873A (ja) *	1998-03-18	2002-03-05	アリアド・ファーマシューティカルズ・インコーポレイテッド	複素環式シグナル伝達阻害剤、それを含む組成物
JP2001031637A (ja) *	1999-05-17	2001-02-06	Fuji Chemical Industries Ltd	新規なヒドロキサム酸誘導体
GB9930570D0 (en) *	1999-12-23	2000-02-16	Pfizer Ltd	Therapy
US6448278B2 (en)	1999-12-23	2002-09-10	Pfizer Inc.	Procollagen C-proteinase inhibitors

2002
- 2002-02-22 GB GBGB0204159.8A patent/GB0204159D0/en not_active Ceased
2003
- 2003-02-20 UA UA20040806941A patent/UA78275C2/uk unknown
- 2003-02-20 DK DK03702791T patent/DK1476438T3/da active
- 2003-02-20 RS YUP-716/04A patent/RS51354B/sr unknown
- 2003-02-20 US US10/504,317 patent/US7358265B2/en not_active Expired - Fee Related
- 2003-02-20 MX MXPA04008132A patent/MXPA04008132A/es active IP Right Grant
- 2003-02-20 KR KR1020047012821A patent/KR101098614B1/ko not_active Expired - Fee Related
- 2003-02-20 DE DE60313292T patent/DE60313292T2/de not_active Expired - Lifetime
- 2003-02-20 AU AU2003205910A patent/AU2003205910B2/en not_active Ceased
- 2003-02-20 JP JP2003569618A patent/JP4615864B2/ja not_active Expired - Fee Related
- 2003-02-20 CA CA2475867A patent/CA2475867C/en not_active Expired - Fee Related
- 2003-02-20 PL PL372268A patent/PL210773B1/pl unknown
- 2003-02-20 ES ES03702791T patent/ES2286404T3/es not_active Expired - Lifetime
- 2003-02-20 EP EP03702791A patent/EP1476438B1/en not_active Expired - Lifetime
- 2003-02-20 BR BR0307899-0A patent/BR0307899A/pt not_active IP Right Cessation
- 2003-02-20 AT AT03702791T patent/ATE360007T1/de active
- 2003-02-20 EA EA200401095A patent/EA007609B1/ru not_active IP Right Cessation
- 2003-02-20 SI SI200330870T patent/SI1476438T1/sl unknown
- 2003-02-20 CN CNB038089122A patent/CN100351245C/zh not_active Expired - Fee Related
- 2003-02-20 PT PT03702791T patent/PT1476438E/pt unknown
- 2003-02-20 WO PCT/GB2003/000741 patent/WO2003070711A1/en not_active Ceased
- 2003-02-20 HR HR20040725A patent/HRP20040725A2/hr not_active Application Discontinuation
2004
- 2004-08-09 IL IL163413A patent/IL163413A/en not_active IP Right Cessation
- 2004-08-25 ZA ZA200406755A patent/ZA200406755B/en unknown
- 2004-09-14 NO NO20043846A patent/NO330772B1/no not_active IP Right Cessation
2007
- 2007-07-13 CY CY20071100937T patent/CY1106730T1/el unknown
2008
- 2008-02-08 US US12/028,275 patent/US20080227833A1/en not_active Abandoned
2009
- 2009-10-14 US US12/588,372 patent/US20100035943A1/en not_active Abandoned
2010
- 2010-10-07 US US12/900,262 patent/US20110086893A1/en not_active Abandoned

Also Published As

Publication number	Publication date
KR101098614B1 (ko)	2011-12-23
EA200401095A1 (ru)	2005-02-24
PT1476438E (pt)	2007-07-25
PL210773B1 (pl)	2012-02-29
BR0307899A (pt)	2004-12-07
CA2475867C (en)	2011-07-05
CN1646505A (zh)	2005-07-27
DE60313292T2 (de)	2007-12-27
DE60313292D1 (de)	2007-05-31
WO2003070711A1 (en)	2003-08-28
AU2003205910B2 (en)	2008-12-04
CY1106730T1 (el)	2012-10-24
CN100351245C (zh)	2007-11-28
US20050222189A1 (en)	2005-10-06
NO330772B1 (no)	2011-07-11
EA007609B1 (ru)	2006-12-29
ATE360007T1 (de)	2007-05-15
US20110086893A1 (en)	2011-04-14
IL163413A (en)	2010-11-30
KR20040101232A (ko)	2004-12-02
MXPA04008132A (es)	2005-06-17
NO20043846L (no)	2004-09-14
US7358265B2 (en)	2008-04-15
SI1476438T1 (sl)	2007-10-31
DK1476438T3 (da)	2007-08-20
GB0204159D0 (en)	2002-04-10
HRP20040725A2 (en)	2005-04-30
EP1476438A1 (en)	2004-11-17
YU71604A (sh)	2006-08-17
US20080227833A1 (en)	2008-09-18
JP4615864B2 (ja)	2011-01-19
JP2005522455A (ja)	2005-07-28
UA78275C2 (en)	2007-03-15
HK1078583A1 (zh)	2006-03-17
EP1476438B1 (en)	2007-04-18
ZA200406755B (en)	2006-07-26
ES2286404T3 (es)	2007-12-01
RS51354B (sr)	2011-02-28
CA2475867A1 (en)	2003-08-28
AU2003205910A1 (en)	2003-09-09
US20100035943A1 (en)	2010-02-11

Legal Events

Date	Code	Title	Description
2013-01-31	RECP	Rectifications of patent specification

Publication	Publication Date	Title
PL372268A1 (pl)	2005-07-11	Inhibitory metaloproteinazy
MX2007005408A (es)	2007-05-16	Compuestos de aminoquinazolinas.
DE60310576D1 (en)	2007-02-01	2-hydroxy-6-phenylphenanthridine als pde-4-hemmer
ATE433981T1 (de)	2009-07-15	Heterocyclische verbindungen
TW200510405A (en)	2005-03-16	Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors
IL185275A0 (en)	2008-02-09	N-sulphonylpyrrole derivatives and pharmaceutical compositions containing the same
DE50005437D1 (en)	2004-04-01	Substituierte thien-3-yl-sulfonylamino(thio)carbonyl-triazolin(thi)one
IL156774A0 (en)	2004-02-08	Inhibitors of cruzipain and other cysteine proteases
AU2003250471A8 (en)	2004-02-25	Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors
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NO20062629L (no)	2006-09-06	Oksazolderivater av tetrackliner
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NO20015892D0 (no)	2001-12-03	Inhibitorer av metallproteinaser
SG151306A1 (en)	2009-04-30	Novel benzothiazoles and the use thereof as medicaments
AP2006003489A0 (en)	2006-02-28	Novel composition comprising rosiglitazone and another antidiabetic agent.
WO2005097047A8 (de)	2006-08-17	Verwendung von mitteln zur kosmetischen behandlung von keratin enthaltenden material
GB2416123A (en)	2006-01-18	Stable carprofen composition
ATE403655T1 (de)	2008-08-15	Imidazopyridinderivate als induzierbare no- synthaseinhibitoren
EA200600608A1 (ru)	2006-10-27	Производные имидазопиридина как ингибиторы индуцируемой no-синтазы
UA84302C2 (ru)	2008-10-10	Изопентилкарбоксанилиды и способ борьбы с нежелательными микроорганизмами
ATE398617T1 (de)	2008-07-15	Imidazoä4,5-büpyridinderivate als inhibitoren der induzierbaren no-synthase
WO2002057248A3 (en)	2002-10-03	Inhibitors of cruzipain and other cysteine proteases
AU2003266093A1 (en)	2004-05-04	Cyclooct-(en-)yl derivatives for use as fragrances
WO2004050608A3 (de)	2004-10-07	2-oxyamino-1-cyclopenten-1-nitrile als materialschutzmittel
BR0316369B1 (pt)	2012-09-18	vestimenta para proteção parcial do corpo contra agentes biológicos.