PL3723815T3 - Psma ligands for imaging and endoradiotherapy - Google Patents

Psma ligands for imaging and endoradiotherapy

Info

Publication number: PL3723815T3
Authority: PL; Poland
Prior art keywords: endoradiotherapy; imaging; psma ligands; psma; ligands
Prior art date: 2017-12-11

Application number

PL18812215.4T

Other languages

Polish (pl)

Inventor

Hans-Jürgen Wester

Alexander Schmidt

Mara PARZINGER

Original Assignee

Technische Universität München

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-12-11

Filing date

2018-12-11

Publication date

2022-07-18

2018-12-11 Application filed by Technische Universität München filed Critical Technische Universität München

2022-07-18 Publication of PL3723815T3 publication Critical patent/PL3723815T3/en

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Optics & Photonics (AREA)
Epidemiology (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nuclear Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL18812215.4T 2017-12-11 2018-12-11 Psma ligands for imaging and endoradiotherapy PL3723815T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP17206510		2017-12-11
PCT/EP2018/084399 WO2019115547A1 (en)	2017-12-11	2018-12-11	Psma ligands for imaging and endoradiotherapy

Publications (1)

Publication Number	Publication Date
PL3723815T3 true PL3723815T3 (en)	2022-07-18

Family

ID=60654872

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL18812215.4T PL3723815T3 (en)	2017-12-11	2018-12-11	Psma ligands for imaging and endoradiotherapy

Country Status (33)

Country	Link
US (2)	US11497819B2 (en)
EP (3)	EP3723815B1 (en)
JP (3)	JP7317375B2 (en)
KR (1)	KR102815791B1 (en)
CN (2)	CN111182927B (en)
AU (2)	AU2018382479B2 (en)
BR (1)	BR112020011727A2 (en)
CA (1)	CA3078104A1 (en)
CL (1)	CL2020001542A1 (en)
CR (1)	CR20200241A (en)
CU (1)	CU24677B1 (en)
CY (1)	CY1125376T1 (en)
DK (2)	DK3723815T3 (en)
EC (1)	ECSP20029142A (en)
ES (2)	ES2914832T3 (en)
FI (1)	FI4008359T3 (en)
HR (2)	HRP20220764T1 (en)
HU (2)	HUE069034T2 (en)
IL (3)	IL319022A (en)
JO (1)	JOP20200135A1 (en)
LT (2)	LT3723815T (en)
MX (2)	MX2020005430A (en)
PE (1)	PE20210456A1 (en)
PL (1)	PL3723815T3 (en)
PT (2)	PT3723815T (en)
RS (2)	RS63279B1 (en)
SG (1)	SG11202002965WA (en)
SI (2)	SI4008359T1 (en)
SM (1)	SMT202400439T1 (en)
TN (1)	TN2020000072A1 (en)
UA (1)	UA126413C2 (en)
WO (1)	WO2019115547A1 (en)
ZA (1)	ZA202003472B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUE070098T2 (en) *	2017-07-28	2025-05-28	Univ Muenchen Tech	Dual mode radiotracer and -therapeutics
BR112020011727A2 (en)	2017-12-11	2020-11-17	Technische Universität München	psma binders for imaging and endoradiotherapy
CA3128406A1 (en) *	2019-01-30	2020-08-06	Technische Universitat Munchen	Cancer diagnostic imaging agents
EA202191691A1 (en) *	2019-01-30	2021-11-01	Технише Универзитет Мюнхен	RADIOACTIVE LABEL BINDING PSMA IN TWO WAYS AND THERAPEUTIC AGENT
AU2020257786B2 (en)	2019-04-17	2025-10-23	Provincial Health Services Authority	Novel radiolabelled compounds for diagnosis or treatment of prostate-specific membrane antigen-expressing cancer
BR112021025810A2 (en)	2019-06-21	2022-05-10	Provincial Health Services Authority	Radiolabeled compounds targeting prostate-specific membrane antigen
CN112321673B (en) *	2020-11-04	2022-09-20	北京市肿瘤防治研究所	Prostate specific membrane antigen targeted inhibitor, application and probe
US20220211883A1 (en) *	2020-12-17	2022-07-07	Trustees Of Tufts College	Fap-activated radiotheranostics and uses related thereto
EP4023250A1 (en) *	2021-01-04	2022-07-06	Technische Universität München	Dual mode radiotracer and -therapeutics
CN113354707A (en) *	2021-06-07	2021-09-07	苏州思萃同位素技术研究所有限公司	Synthetic method of three-function diagnosis and treatment integrated prodrug for prostate cancer and product thereof
WO2023173074A2 (en) *	2022-03-10	2023-09-14	The Research Foundation For The State University Of New York	Immunostimulant-cytotoxic conjugate composition and methods for cancer treatment
CN115010629B (en) *	2022-06-07	2024-02-23	西南医科大学附属医院	Prostate specific membrane antigen inhibitor, nuclide marker, preparation method and application
KR20250073273A (en)	2022-09-23	2025-05-27	누클리디움 아게	High purity copper radioactive pharmaceutical composition and its diagnostic and therapeutic uses
TW202426433A (en)	2022-09-23	2024-07-01	瑞士商紐利迪姆股份公司	Fibroblast activation protein (fap) inhibitors, fap conjugates, and diagnostic and therapeutic uses thereof
CN121604981A (en)	2023-07-21	2026-03-03	诺华公司	Therapeutic regimens of radioligands targeting PSMA
WO2025029946A1 (en)	2023-07-31	2025-02-06	Curium Us Llc	[177lu] lutetium-psma i&t composition and dosimetry, kit, method of making, and method of using thereof
WO2025147677A1 (en) *	2024-01-05	2025-07-10	Point Biopharma, Inc.	Preparation of psma-targeted radiopharmaceutical
CN119101006B (en) *	2024-09-05	2025-11-07	西南医科大学附属医院	Prostate specific membrane antigen inhibitor, radioactive marker thereof, preparation method and application thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR057023A1 (en)	2005-05-16	2007-11-14	Gilead Sciences Inc	HETEROCICLICAL COMPOUNDS WITH HIV-INTEGRASA INHIBITING PROPERTIES
JP2010523979A (en) *	2007-04-05	2010-07-15	オーレオンラボラトリーズ，インコーポレイテッド	System and method for treatment, diagnosis and prediction of medical conditions
PT2318366T (en) *	2008-08-01	2017-08-02	Univ Johns Hopkins	Psma-binding agents and uses thereof
CN102308212A (en) *	2008-12-04	2012-01-04	加利福尼亚大学董事会	Materials and methods for determining diagnosis and prognosis of prostate cancer
WO2010135431A2 (en) *	2009-05-19	2010-11-25	The Regents Of The University Of California	Compositions, devices, and methods related to prostate-specific membrane antigen
EP3456700A1 (en) *	2013-10-18	2019-03-20	Deutsches Krebsforschungszentrum	Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
CN106660943B (en) *	2014-05-06	2020-03-17	约翰霍普金斯大学	Metal/radiometal labeled PSMA inhibitors for PSMA-targeted imaging and radiotherapy
US10688200B2 (en)	2015-12-31	2020-06-23	Five Eleven Pharma Inc.	Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy
RS65188B1 (en) *	2016-03-22	2024-03-29	Univ Johns Hopkins	Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
BR112020011727A2 (en)	2017-12-11	2020-11-17	Technische Universität München	psma binders for imaging and endoradiotherapy
TW201930265A (en)	2017-12-11	2019-08-01	西班牙商阿爾米雷爾有限公司	Pyrrole derivatives as ACC inhibitors
US11299472B2 (en)	2017-12-11	2022-04-12	Helsinn Healthcare Sa	Fumarate salt of (R)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2- trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl) urea, methods of preparation, and uses thereof

2018
- 2018-12-11 BR BR112020011727-7A patent/BR112020011727A2/en unknown
- 2018-12-11 PL PL18812215.4T patent/PL3723815T3/en unknown
- 2018-12-11 KR KR1020207014036A patent/KR102815791B1/en active Active
- 2018-12-11 US US16/765,729 patent/US11497819B2/en active Active
- 2018-12-11 ES ES18812215T patent/ES2914832T3/en active Active
- 2018-12-11 PT PT188122154T patent/PT3723815T/en unknown
- 2018-12-11 HR HRP20220764TT patent/HRP20220764T1/en unknown
- 2018-12-11 EP EP18812215.4A patent/EP3723815B1/en active Active
- 2018-12-11 EP EP24198677.7A patent/EP4464341A3/en active Pending
- 2018-12-11 SM SM20240439T patent/SMT202400439T1/en unknown
- 2018-12-11 AU AU2018382479A patent/AU2018382479B2/en active Active
- 2018-12-11 JP JP2020526146A patent/JP7317375B2/en active Active
- 2018-12-11 HR HRP20241453TT patent/HRP20241453T1/en unknown
- 2018-12-11 PT PT212181804T patent/PT4008359T/en unknown
- 2018-12-11 RS RS20220527A patent/RS63279B1/en unknown
- 2018-12-11 IL IL319022A patent/IL319022A/en unknown
- 2018-12-11 CA CA3078104A patent/CA3078104A1/en active Pending
- 2018-12-11 CN CN201880056196.2A patent/CN111182927B/en active Active
- 2018-12-11 FI FIEP21218180.4T patent/FI4008359T3/en active
- 2018-12-11 SI SI201831155T patent/SI4008359T1/en unknown
- 2018-12-11 WO PCT/EP2018/084399 patent/WO2019115547A1/en not_active Ceased
- 2018-12-11 DK DK18812215.4T patent/DK3723815T3/en active
- 2018-12-11 EP EP21218180.4A patent/EP4008359B1/en active Active
- 2018-12-11 UA UAA202003533A patent/UA126413C2/en unknown
- 2018-12-11 SG SG11202002965WA patent/SG11202002965WA/en unknown
- 2018-12-11 MX MX2020005430A patent/MX2020005430A/en unknown
- 2018-12-11 LT LTEPPCT/EP2018/084399T patent/LT3723815T/en unknown
- 2018-12-11 RS RS20241176A patent/RS66086B1/en unknown
- 2018-12-11 PE PE2020000552A patent/PE20210456A1/en unknown
- 2018-12-11 CU CU2020000052A patent/CU24677B1/en unknown
- 2018-12-11 DK DK21218180.4T patent/DK4008359T3/en active
- 2018-12-11 ES ES21218180T patent/ES2997266T3/en active Active
- 2018-12-11 HU HUE21218180A patent/HUE069034T2/en unknown
- 2018-12-11 IL IL313103A patent/IL313103B2/en unknown
- 2018-12-11 TN TNP/2020/000072A patent/TN2020000072A1/en unknown
- 2018-12-11 LT LTEP21218180.4T patent/LT4008359T/en unknown
- 2018-12-11 CN CN202310801735.3A patent/CN116617421B/en active Active
- 2018-12-11 IL IL274072A patent/IL274072B2/en unknown
- 2018-12-11 JO JOP/2020/0135A patent/JOP20200135A1/en unknown
- 2018-12-11 HU HUE18812215A patent/HUE059083T2/en unknown
- 2018-12-11 CR CR20200241A patent/CR20200241A/en unknown
- 2018-12-11 SI SI201830691T patent/SI3723815T1/en unknown
2020
- 2020-06-03 EC ECSENADI202029142A patent/ECSP20029142A/en unknown
- 2020-06-10 CL CL2020001542A patent/CL2020001542A1/en unknown
- 2020-06-10 ZA ZA2020/03472A patent/ZA202003472B/en unknown
- 2020-07-13 MX MX2023005053A patent/MX2023005053A/en unknown
2022
- 2022-07-15 US US17/866,034 patent/US20230122957A1/en active Pending
- 2022-07-20 CY CY20221100496T patent/CY1125376T1/en unknown
2023
- 2023-07-11 JP JP2023113523A patent/JP7572080B2/en active Active
2024
- 2024-10-03 JP JP2024173980A patent/JP2025011169A/en active Pending
2025
- 2025-02-07 AU AU2025200837A patent/AU2025200837A1/en active Pending

Also Published As

Publication number	Publication date
LT3723815T (en)	2022-07-25
NZ763033A (en)	2025-02-28
ZA202003472B (en)	2022-06-29
JP2021505532A (en)	2021-02-18
RU2020116158A (en)	2022-01-13
CL2020001542A1 (en)	2020-10-02
SMT202400439T1 (en)	2024-11-15
JP7572080B2 (en)	2024-10-23
HRP20241453T1 (en)	2024-12-20
TN2020000072A1 (en)	2022-01-06
US20200297876A1 (en)	2020-09-24
AU2018382479A1 (en)	2020-04-16
PE20210456A1 (en)	2021-03-08
DK3723815T3 (en)	2022-07-11
SG11202002965WA (en)	2020-04-29
RS66086B1 (en)	2024-11-29
JP7317375B2 (en)	2023-07-31
JP2023139063A (en)	2023-10-03
AU2025200837A1 (en)	2025-02-27
MX2023005053A (en)	2023-05-17
RS63279B1 (en)	2022-06-30
PT3723815T (en)	2022-05-30
EP4464341A3 (en)	2025-01-22
CU20200052A7 (en)	2021-03-11
HUE069034T2 (en)	2025-02-28
IL313103A (en)	2024-07-01
DK4008359T3 (en)	2024-10-14
IL274072B2 (en)	2024-11-01
CR20200241A (en)	2020-09-21
CU24677B1 (en)	2023-09-07
ES2997266T3 (en)	2025-02-14
HRP20220764T1 (en)	2022-09-16
IL313103B2 (en)	2025-07-01
SI4008359T1 (en)	2025-03-31
EP4464341A2 (en)	2024-11-20
EP4008359B1 (en)	2024-09-11
CN116617421B (en)	2026-04-07
IL274072B1 (en)	2024-07-01
FI4008359T3 (en)	2024-11-11
KR20200097690A (en)	2020-08-19
CN111182927A (en)	2020-05-19
IL319022A (en)	2025-04-01
ES2914832T3 (en)	2022-06-16
HUE059083T2 (en)	2022-10-28
EP3723815A1 (en)	2020-10-21
US11497819B2 (en)	2022-11-15
LT4008359T (en)	2024-12-27
EP3723815B1 (en)	2022-04-20
KR102815791B1 (en)	2025-05-30
IL313103B1 (en)	2025-03-01
BR112020011727A2 (en)	2020-11-17
JP2025011169A (en)	2025-01-23
WO2019115547A1 (en)	2019-06-20
CN111182927B (en)	2023-07-21
CA3078104A1 (en)	2019-06-20
AU2018382479B2 (en)	2024-11-07
ECSP20029142A (en)	2020-09-30
MX2020005430A (en)	2020-08-27
US20230122957A1 (en)	2023-04-20
IL274072A (en)	2020-06-30
UA126413C2 (en)	2022-09-28
CY1125376T1 (en)	2025-05-09
EP4008359A1 (en)	2022-06-08
CN116617421A (en)	2023-08-22
PT4008359T (en)	2024-10-25
JOP20200135A1 (en)	2020-06-02
SI3723815T1 (en)	2022-07-29

Publication	Publication Date	Title
ZA202003472B (en)	2022-06-29	Psma ligands for imaging and endoradiotherapy
AU201614482S (en)	2016-09-05	Shakers
GB201701593D0 (en)	2017-03-15	Imaging apparatus
IL255928A (en)	2018-01-31	Imaging device
GB201712357D0 (en)	2017-09-13	Spetral imaging
SG11202002262WA (en)	2020-04-29	Filtration device
PL3420150T3 (en)	2020-07-13	Screening device
GB2561441B (en)	2020-07-01	Connection apparatus
GB201609747D0 (en)	2016-07-20	Data directed desi-ms imaging
PL3718435T3 (en)	2024-03-18	Slide unit
PL3634913T3 (en)	2022-03-28	Percolation-type filtration device
GB201711617D0 (en)	2017-08-30	Cover apparatus
GB201710522D0 (en)	2017-08-16	Spatial filter
GB201607456D0 (en)	2016-06-15	Imaging unit
GB201819514D0 (en)	2019-01-16	Connection apparatus
GB201816607D0 (en)	2018-11-28	Light-sheet imaging
PL3593208T3 (en)	2022-02-28	Device for photographing objects
HK40031508A (en)	2021-03-12	Psma ligands for imaging and endoradiotherapy
GB201705679D0 (en)	2017-05-24	Imaging agent
GB201517277D0 (en)	2015-11-11	Imaging device
GB201705653D0 (en)	2017-05-24	Methods and means for imaging
GB201714175D0 (en)	2017-10-18	An imaging device
GB201722155D0 (en)	2018-02-14	Grills
GB201719957D0 (en)	2018-01-17	Instamatic cameras
GB201718522D0 (en)	2017-12-27	T