PL373361A1 - Erytropoetyna zmniejsza in vivo toksyczność wywołaną chemioterapią - Google Patents

Erytropoetyna zmniejsza in vivo toksyczność wywołaną chemioterapią

Info

Publication number: PL373361A1
Authority: PL; Poland
Prior art keywords: erythropoietin; ameliorates; chemotherapy; vivo; induced toxicity
Prior art date: 2001-04-09

Application number

PL02373361A

Other languages

English (en)

Inventor

George Sigounas

Paul Mehlhop

Original Assignee

East Carolina University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-09

Filing date

2002-04-08

Publication date

2005-08-22

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23082337&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL373361(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-04-08 Application filed by East Carolina University filed Critical East Carolina University

2005-08-22 Publication of PL373361A1 publication Critical patent/PL373361A1/pl

Links

102000003951 Erythropoietin Human genes 0.000 title abstract 4
108090000394 Erythropoietin Proteins 0.000 title abstract 4
229940105423 erythropoietin Drugs 0.000 title abstract 4
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title abstract 4
238000002512 chemotherapy Methods 0.000 title 1
238000001727 in vivo Methods 0.000 title 1
230000001988 toxicity Effects 0.000 title 1
231100000419 toxicity Toxicity 0.000 title 1
229940127089 cytotoxic agent Drugs 0.000 abstract 3
239000002254 cytotoxic agent Substances 0.000 abstract 3
231100000599 cytotoxic agent Toxicity 0.000 abstract 3
206010061924 Pulmonary toxicity Diseases 0.000 abstract 1
231100000374 pneumotoxicity Toxicity 0.000 abstract 1
230000007047 pulmonary toxicity Effects 0.000 abstract 1
230000007675 toxicity by organ Effects 0.000 abstract 1
231100000155 toxicity by organ Toxicity 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Zoology (AREA)
Toxicology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)

PL02373361A 2001-04-09 2002-04-08 Erytropoetyna zmniejsza in vivo toksyczność wywołaną chemioterapią PL373361A1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US28262101P	2001-04-09	2001-04-09

Publications (1)

Publication Number	Publication Date
PL373361A1 true PL373361A1 (pl)	2005-08-22

Family

ID=23082337

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL02373361A PL373361A1 (pl)	2001-04-09	2002-04-08	Erytropoetyna zmniejsza in vivo toksyczność wywołaną chemioterapią

Country Status (22)

Country	Link
US (2)	US20020169128A1 (pl)
EP (1)	EP1377164B1 (pl)
JP (1)	JP4428924B2 (pl)
KR (1)	KR100885525B1 (pl)
CN (2)	CN101152565A (pl)
AT (1)	ATE399020T1 (pl)
AU (1)	AU2002256133B2 (pl)
BR (1)	BR0208727A (pl)
CA (1)	CA2443025A1 (pl)
DE (1)	DE60227244D1 (pl)
DK (1)	DK1377164T3 (pl)
ES (1)	ES2309166T3 (pl)
HU (1)	HUP0303838A3 (pl)
IL (3)	IL158155A0 (pl)
MX (1)	MXPA03009182A (pl)
NO (1)	NO20034504L (pl)
NZ (1)	NZ528675A (pl)
PL (1)	PL373361A1 (pl)
PT (1)	PT1377164E (pl)
RU (1)	RU2296563C2 (pl)
WO (1)	WO2002080676A1 (pl)
ZA (1)	ZA200307803B (pl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US6926898B2 (en)	2000-04-12	2005-08-09	Human Genome Sciences, Inc.	Albumin fusion proteins
WO2005003296A2 (en)	2003-01-22	2005-01-13	Human Genome Sciences, Inc.	Albumin fusion proteins
CA2841097A1 (en)	2001-12-21	2003-07-24	Human Genome Sciences, Inc.	Albumin and g-csf fusion proteins
KR101163683B1 (ko)	2003-05-12	2012-07-10	아피맥스, 인크.	에리스로포이에틴 수용체에 결합하는 신규의 펩티드
CN1849141A (zh) *	2003-05-12	2006-10-18	阿费麦克斯公司	用于聚(乙二醇)修饰的肽的间隔臂部分
JP2007530440A (ja) *	2003-05-12	2007-11-01	アフィーマックス・インコーポレイテッド	新規ポリ（エチレングリコール）修飾化合物およびその用途
PL1625156T3 (pl) *	2003-05-12	2013-03-29	Affymax Inc	Peptydy wiążące się do receptora erytropoetyny
US20080312201A1 (en) *	2004-09-10	2008-12-18	Patrick Fogarty	Reduced Toxicity Methotrexate Formulations and Methods for Using the Same
WO2006062685A2 (en) *	2004-11-11	2006-06-15	Affymax, Inc.	Novel peptides that bind to the erythropoietin receptor
EP1814910A4 (en) *	2004-11-11	2009-04-29	Affymax Inc	NEW AT ERYTHROPOIETIN RECEPTOR BINDING PEPTIDES
US8324159B2 (en) *	2005-06-03	2012-12-04	Affymax, Inc.	Erythropoietin receptor peptide formulations and uses
US7919461B2 (en)	2005-06-03	2011-04-05	Affymax, Inc.	Erythropoietin receptor peptide formulations and uses
US7550433B2 (en) *	2005-06-03	2009-06-23	Affymax, Inc.	Erythropoietin receptor peptide formulations and uses
EP2057997A4 (en) *	2006-08-22	2012-11-07	Chugai Pharmaceutical Co Ltd	MEANS FOR THE PREVENTION AND / OR TREATMENT OF PERIPHERAL NEUROPATHY
WO2008050836A1 (en) *	2006-10-25	2008-05-02	Ajinomoto Co., Inc.	Agent for ameliorating adverse side-effect of chemotherapeutic agent
EP1992355A1 (en) *	2007-05-16	2008-11-19	Eberhardt Spanuth	Pharmaceutical combination medication comprising NSAIDs or cytoxic drugs
RU2410095C2 (ru) *	2009-04-20	2011-01-27	Государственное образовательное учреждение высшего профессионального образования "Мордовский государственный университет им. Н.П. Огарева"	Средство для повышения эффективности и снижения токсичности противоопухолевых препаратов
ES3063334T3 (en) *	2015-06-18	2026-04-16	Yeda Res & Dev	Conditioning protocols and use of same for tissue regeneration
US10695402B2 (en)	2017-03-16	2020-06-30	University Of Rochester	Erythropoietin for gastrointestinal dysfunction
WO2022159414A1 (en)	2021-01-22	2022-07-28	University Of Rochester	Erythropoietin for gastroinfestinal dysfunction

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4859765A (en) *	1983-10-17	1989-08-22	Syntex (U.S.A.) Inc.	Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture
US4863857A (en) *	1985-03-01	1989-09-05	Board Of Regents, The University Of Texas System	Polypeptide complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known
NZ215865A (en) *	1985-04-22	1988-10-28	Commw Serum Lab Commission	Method of determining the active site of a receptor-binding analogue
IT210425Z2 (it) *	1987-01-22	1988-12-30	Erga Srl	Portachiavi con mezzo di scrittura telescopico incorporato
US4853871A (en) *	1987-04-06	1989-08-01	Genex Corporation	Computer-based method for designing stablized proteins
US4856871A (en) *	1987-08-31	1989-08-15	General Electric Company	Replaceable laser and lens assembly
JP2632014B2 (ja) *	1988-03-03	1997-07-16	中外製薬株式会社	骨髄機能障害性貧血治療剤
GB9613070D0 (en) *	1996-06-21	1996-08-28	Rowett Research Services Limit	Dietary lectins
US20020052309A1 (en) *	1996-09-11	2002-05-02	Athanasius A. Anagnostou	Method of treating endothelial injury
US6719977B1 (en) *	1998-02-12	2004-04-13	The General Hospital Corporation	Methods to potentiate cancer therapies
WO2000067776A1 (en) *	1999-05-11	2000-11-16	Ortho-Mcneil Pharmaceuticals, Inc.	Pharmacokinetic and pharmacodynamic modeling of erythropoietin administration
US6531121B2 (en) *	2000-12-29	2003-03-11	The Kenneth S. Warren Institute, Inc.	Protection and enhancement of erythropoietin-responsive cells, tissues and organs

2002
- 2002-04-05 US US10/117,011 patent/US20020169128A1/en not_active Abandoned
- 2002-04-08 PL PL02373361A patent/PL373361A1/pl not_active Application Discontinuation
- 2002-04-08 RU RU2003132584/14A patent/RU2296563C2/ru not_active IP Right Cessation
- 2002-04-08 HU HU0303838A patent/HUP0303838A3/hu unknown
- 2002-04-08 PT PT02725577T patent/PT1377164E/pt unknown
- 2002-04-08 CN CNA2007101533855A patent/CN101152565A/zh active Pending
- 2002-04-08 MX MXPA03009182A patent/MXPA03009182A/es active IP Right Grant
- 2002-04-08 DE DE60227244T patent/DE60227244D1/de not_active Expired - Lifetime
- 2002-04-08 IL IL15815502A patent/IL158155A0/xx unknown
- 2002-04-08 KR KR1020037013132A patent/KR100885525B1/ko not_active Expired - Fee Related
- 2002-04-08 AT AT02725577T patent/ATE399020T1/de not_active IP Right Cessation
- 2002-04-08 AU AU2002256133A patent/AU2002256133B2/en not_active Ceased
- 2002-04-08 DK DK02725577T patent/DK1377164T3/da active
- 2002-04-08 WO PCT/US2002/011081 patent/WO2002080676A1/en not_active Ceased
- 2002-04-08 CA CA002443025A patent/CA2443025A1/en not_active Abandoned
- 2002-04-08 ES ES02725577T patent/ES2309166T3/es not_active Expired - Lifetime
- 2002-04-08 JP JP2002578724A patent/JP4428924B2/ja not_active Expired - Fee Related
- 2002-04-08 BR BR0208727-8A patent/BR0208727A/pt not_active IP Right Cessation
- 2002-04-08 NZ NZ528675A patent/NZ528675A/en unknown
- 2002-04-08 EP EP02725577A patent/EP1377164B1/en not_active Revoked
- 2002-04-08 CN CNB028078136A patent/CN100379446C/zh not_active Expired - Fee Related
2003
- 2003-09-29 IL IL158155A patent/IL158155A/en not_active IP Right Cessation
- 2003-10-06 ZA ZA200307803A patent/ZA200307803B/en unknown
- 2003-10-08 NO NO20034504A patent/NO20034504L/no not_active Application Discontinuation
2009
- 2009-05-17 IL IL198783A patent/IL198783A0/en unknown
2011
- 2011-03-31 US US13/077,335 patent/US20110195046A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ATE399020T1 (de)	2008-07-15
WO2002080676A1 (en)	2002-10-17
CN1499927A (zh)	2004-05-26
NO20034504L (no)	2003-12-09
MXPA03009182A (es)	2004-02-17
JP2004532840A (ja)	2004-10-28
RU2296563C2 (ru)	2007-04-10
KR100885525B1 (ko)	2009-02-26
IL158155A0 (en)	2004-03-28
ZA200307803B (en)	2005-02-09
US20020169128A1 (en)	2002-11-14
EP1377164A1 (en)	2004-01-07
DE60227244D1 (de)	2008-08-07
US20110195046A1 (en)	2011-08-11
CN100379446C (zh)	2008-04-09
NZ528675A (en)	2006-10-27
DK1377164T3 (da)	2008-10-13
KR20030087064A (ko)	2003-11-12
BR0208727A (pt)	2005-05-10
JP4428924B2 (ja)	2010-03-10
IL158155A (en)	2009-12-24
HUP0303838A2 (hu)	2004-03-01
NO20034504D0 (no)	2003-10-08
CA2443025A1 (en)	2002-10-17
ES2309166T3 (es)	2008-12-16
AU2002256133B2 (en)	2007-05-31
EP1377164A4 (en)	2005-05-04
RU2003132584A (ru)	2005-04-10
IL198783A0 (en)	2010-02-17
HUP0303838A3 (en)	2010-03-29
EP1377164B1 (en)	2008-06-25
CN101152565A (zh)	2008-04-02
PT1377164E (pt)	2008-09-30

Legal Events

Date	Code	Title	Description
2013-09-30	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
IL198783A0 (en)	2010-02-17	Erythropoietin ameliorates chemotherapy-induced toxicity in vivo
SG158731A1 (en)	2010-02-26	Novel medicament compositions, based on anticholinergically effective compounds and beta-mimetics
SE0001899D0 (sv)	2000-05-22	New compounds
MXPA02012763A (es)	2003-04-25	Combinaciones de inhibidores de dipeptidil peptidasa iv y otros agentes antidiabeticos para el tratamiento de diabetes mellitus.
MXPA04004837A (es)	2004-08-02	Inhibidores de 11-??-hidroxiesteroide deshidrogenasa de tipo 1.
MY145590A (en)	2012-02-29	Phenylacetamides and their use as glucokinase modulators
NO20015584D0 (no)	2001-11-15	Lantidsvarende insulintrofiske peptider
MY144992A (en)	2011-12-15	Substituted 1,2,3,4-tetrahydroisoquinoline derivatives.
EP1676488A3 (en)	2013-02-20	Compositions and methods for body weight management
AU2001296865A1 (en)	2002-03-22	(5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid and salts thereof and compositions containing the same for delivering active agents
DE60125417D1 (de)	2007-02-01	Verminderung der nebenwirkungen der chemotherapie in krebspatienten
GEP20043162B (en)	2004-01-26	Derivatives of Isosorbid Mononitrate, Utilization as Vasodilator Agents with Reduced Tolerance
NZ516290A (en)	2004-03-26	Substituted phenoxyacetic acids
DE60121804D1 (de)	2006-09-07	Pharmazeutische zusammensetzung eines biguanin (metformin) und arginin
PL360492A1 (pl)	2004-09-06	Zastosowanie kwasu pamowego lub jednej z jego pochodnych lub jednego z jego analogów do wytwarzanialeku do leczenia chorób charakteryzujących się odkładaniem amyloidowych agregatów
EE05241B1 (et)	2009-12-15	Distamtsiini a-halogenoakrlolderivaadi kasutamine
EP1023901A4 (en)	2004-10-27	MEDICINES FOR HEPATITIS C AND THE USE THEREOF
NZ523606A (en)	2004-12-24	Pharmaceutical compositions and methods for use
MXPA01007210A (es)	2004-10-29	Agente para el tratamiento de enfermedad de parkinson que comprende un agente que mejora la funcion del astrocito como ingrediente activo.
SE0000303D0 (sv)	2000-01-31	Novel compounds
EP1930023A3 (en)	2008-08-06	Erythropoietin ameliorates chemotherapy-induced toxicity in vivo
PL367630A1 (pl)	2005-03-07	Zastosowanie acetylo-L-karnityny w połączeniu z biotyną do leczenia pacjentów cierpiących na cukrzycę insulino-niezależną typu 2
MXPA04006269A (es)	2004-09-27	Composicion farmaceutica que comprende un inhibidor de alfa-glucosidasa y acido 4-oxobutanoico y uso de la misma para tratamiento de diabetes.
MXPA02011535A (es)	2003-06-06	Medicamento para combatir la depresion respiratoria.
GB0128071D0 (en)	2002-01-16	Medicament