PL373400A1 - Pochodne tetrahydrokarbazolu jako ligandy receptorów sprzężonych z białkiem G (GPCR) - Google Patents

Pochodne tetrahydrokarbazolu jako ligandy receptorów sprzężonych z białkiem G (GPCR)

Info

Publication number
PL373400A1
PL373400A1 PL02373400A PL37340002A PL373400A1 PL 373400 A1 PL373400 A1 PL 373400A1 PL 02373400 A PL02373400 A PL 02373400A PL 37340002 A PL37340002 A PL 37340002A PL 373400 A1 PL373400 A1 PL 373400A1
Authority
PL
Poland
Prior art keywords
gpcr
ligands
protein coupled
coupled receptors
tetrahydrocarbozole
Prior art date
Application number
PL02373400A
Other languages
English (en)
Inventor
Marcus Koppitz
Hans Peter Muhn
Ken Shaw
Holger Hess-Stumpp
Klaus Paulini
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10164564A external-priority patent/DE10164564B4/de
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of PL373400A1 publication Critical patent/PL373400A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL02373400A 2001-12-14 2002-12-16 Pochodne tetrahydrokarbazolu jako ligandy receptorów sprzężonych z białkiem G (GPCR) PL373400A1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10164564A DE10164564B4 (de) 2001-12-14 2001-12-14 Tetrahydrocarbazolderivate als Liganden für G-Protein gekoppelte Rezeptoren (GPCR)
US34187801P 2001-12-21 2001-12-21

Publications (1)

Publication Number Publication Date
PL373400A1 true PL373400A1 (pl) 2005-08-22

Family

ID=26010882

Family Applications (1)

Application Number Title Priority Date Filing Date
PL02373400A PL373400A1 (pl) 2001-12-14 2002-12-16 Pochodne tetrahydrokarbazolu jako ligandy receptorów sprzężonych z białkiem G (GPCR)

Country Status (17)

Country Link
EP (1) EP1453803A2 (pl)
JP (1) JP2005518375A (pl)
CN (1) CN100500654C (pl)
AR (1) AR037863A1 (pl)
AU (1) AU2002361430B2 (pl)
BR (1) BR0214958A (pl)
CA (1) CA2468880A1 (pl)
HR (1) HRP20040609A2 (pl)
HU (1) HUP0500014A3 (pl)
IL (2) IL161626A0 (pl)
MX (1) MXPA04005768A (pl)
NO (1) NO326692B1 (pl)
NZ (1) NZ533430A (pl)
PL (1) PL373400A1 (pl)
RU (1) RU2319692C2 (pl)
TW (1) TWI246423B (pl)
WO (1) WO2003051837A2 (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05012459A (es) * 2003-05-19 2006-02-22 Irm Llc Compuestos y composiciones inmunosupresoras.
ES2314446T3 (es) * 2003-06-10 2009-03-16 Smithkline Beecham Corporation Derivados de tetrahidrocarbazol y su uso farmaceutico.
EP1677794B1 (en) * 2003-09-12 2014-12-03 Elixir Pharmaceuticals, Inc. Methods of treating disorder
US20060074124A1 (en) 2003-09-12 2006-04-06 Andrew Napper Methods of treating a disorder
ES2314633T3 (es) * 2004-03-26 2009-03-16 F. Hoffmann-La Roche Ag Tetrahidrocarbazoles y derivados.
DE102004033902A1 (de) * 2004-07-14 2006-02-16 Zentaris Gmbh Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)
RU2430088C2 (ru) * 2004-07-14 2011-09-27 Центарис Гмбх Производные тетрагидрокарбазола и фармацевтическая композиция на их основе
CA2594280C (en) * 2004-12-27 2013-04-23 Anja Fecher 2,3,4,9-tetrahydro-1h-carbazole derivatives as crth2 receptor antagonists
CA2612723A1 (en) * 2005-06-24 2007-01-04 Eli Lilly And Company Tetrahydrocarbazole derivatives useful as androgen receptor modulators
ATE530523T1 (de) * 2006-08-07 2011-11-15 Actelion Pharmaceuticals Ltd (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)- essigsäurederivate
EP1967202A1 (en) * 2007-03-05 2008-09-10 AEterna Zentaris GmbH Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity
EP1988098A1 (en) * 2007-04-27 2008-11-05 AEterna Zentaris GmbH Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors
EP2095818A1 (en) * 2008-02-29 2009-09-02 AEterna Zentaris GmbH Use of LHRH antagonists at non-castrating doses
AR080703A1 (es) 2010-03-22 2012-05-02 Actelion Pharmaceuticals Ltd Derivados de 3-(heteroaril-amino)-1,2,3,4-tetrahidro-9h-carbazol, moduladores de receptores de prostaglandina d2, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de trastornos alergicos o inmunitarios tales como asma.
DK2697223T3 (en) 2011-04-14 2016-09-05 Actelion Pharmaceuticals Ltd 7- (heteroaryl-amino) -6,7,8,9-tetrahydro-pyrido [1,2-a] indole-acetic acid derivatives and their use as prostaglandin D2 receptor
PE20161177A1 (es) 2014-03-17 2016-11-18 Actelion Pharmaceuticals Ltd Derivados del acido acetico azaindol y su uso como moduladores del receptor de prostaglandina d2
WO2015140701A1 (en) 2014-03-18 2015-09-24 Actelion Pharmaceuticals Ltd Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
KR20180053345A (ko) 2015-09-15 2018-05-21 이도르시아 파마슈티컬스 리미티드 결정질 형태

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1418703A (en) * 1973-06-02 1975-12-24 Pfizer Ltd 3-alkyl-9-substituted-1,2,3,4-tetrahydrocarbazoles
BG25793A3 (bg) * 1973-07-18 1978-12-12 Schering Aktiengesellschaft Метод за получаване на карбазолови деривати
ATE90076T1 (de) * 1986-03-27 1993-06-15 Merck Frosst Canada Inc Tetrahydrocarbazole ester.
US5607939A (en) * 1994-04-28 1997-03-04 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
EP0986385A4 (en) * 1997-06-05 2001-05-16 Merck & Co Inc GONADORELIN ANTAGONISTS

Also Published As

Publication number Publication date
IL161626A0 (en) 2004-09-27
BR0214958A (pt) 2004-12-28
WO2003051837A8 (de) 2004-05-06
JP2005518375A (ja) 2005-06-23
AR037863A1 (es) 2004-12-09
AU2002361430B2 (en) 2007-09-13
WO2003051837A2 (de) 2003-06-26
MXPA04005768A (es) 2004-09-10
CA2468880A1 (en) 2003-06-26
RU2004121776A (ru) 2005-05-10
TWI246423B (en) 2006-01-01
NZ533430A (en) 2005-12-23
HRP20040609A2 (en) 2005-06-30
IL192991A0 (en) 2011-08-01
EP1453803A2 (de) 2004-09-08
AU2002361430A1 (en) 2003-06-30
RU2319692C2 (ru) 2008-03-20
NO20042198L (no) 2004-07-09
HUP0500014A3 (en) 2010-06-28
NO326692B1 (no) 2009-02-02
WO2003051837A3 (de) 2004-02-26
CN100500654C (zh) 2009-06-17
TW200305405A (en) 2003-11-01
HUP0500014A2 (hu) 2005-04-28
CN1599720A (zh) 2005-03-23

Similar Documents

Publication Publication Date Title
IL161626A0 (en) Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr)
AU2001268471A1 (en) G-protein coupled receptors
AU2003227909A1 (en) Imidazo-triazine derivatives as ligands for gaba receptors
PL373953A1 (pl) Pochodne 7-aminobenzotiazolu jako ligandy receptora adenozynowego
AU2001280785A1 (en) G-protein coupled receptors
AU4439801A (en) Pyrazolo-triazine derivatives as ligands for gaba receptors
DE10164564B4 (de) Tetrahydrocarbazolderivate als Liganden für G-Protein gekoppelte Rezeptoren (GPCR)
AU2001238178A1 (en) Seven-transmembrane proteins/g-protein coupled receptors
IL162444A0 (en) Triazolo-quinolin derivatives useful as adenosine receptor ligands
AU2001251175A1 (en) G-protein coupled receptors
AU2001270822A1 (en) Imidazolophthalazine derivatives as ligands for gabaa receptors
GB0226227D0 (en) Receptors
AU2001296444A1 (en) G-protein coupled receptors
AU2001261814A1 (en) G-protein coupled receptors
AU2001240019A1 (en) G-protein coupled receptors
AU2002235543A1 (en) Imidazolophthalazine derivatives as ligands for gabaa receptors
AU2003229884A1 (en) Imidazo-pyridine derivatives as ligands for gaba receptors
AU2002254466A1 (en) G-protein coupled receptors
AU2002316366A1 (en) G-protein coupled receptors
AU2002327615A1 (en) G-protein coupled receptors
AU2002308498A8 (en) G-protein coupled receptors
AU2003219312A1 (en) Imidazo-pyridine derivatives as ligands for gaba receptors
AU2003259974A8 (en) G-protein coupled receptors
AU2002307903A1 (en) G-protein coupled receptor
EP1463941A4 (en) NEW G-PROTEIN-COUPLED RECIPES

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)