PL373553A1 - Sól 6-glukuronidu morfiny - Google Patents

Sól 6-glukuronidu morfiny

Info

Publication number: PL373553A1
Authority: PL; Poland
Prior art keywords: hbr; glucuronide; morphine; salt; medicament
Prior art date: 2002-08-14

Application number

PL03373553A

Other languages

English (en)

Other versions

PL211031B1 (pl

Inventor

John Aitken Graham

Rudolf Franzmair

Andreas Koch

Herwig Schneider

Original Assignee

Cenes Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-14

Filing date

2003-08-14

Publication date

2005-09-05

2003-08-14 Application filed by Cenes Limited filed Critical Cenes Limited

2005-09-05 Publication of PL373553A1 publication Critical patent/PL373553A1/pl

2012-04-30 Publication of PL211031B1 publication Critical patent/PL211031B1/pl

Links

GNJCUHZOSOYIEC-GAROZEBRSA-N Morphine-6-glucuronide Chemical compound O([C@H]1C=C[C@H]2[C@H]3CC=4C5=C(C(=CC=4)O)O[C@@H]1[C@]52CCN3C)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O GNJCUHZOSOYIEC-GAROZEBRSA-N 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title 1
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 7
239000003814 drug Substances 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
230000000202 analgesic effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL373553A 2002-08-14 2003-08-14 Sól bromowodorkowa 6-β-D-glukuronidu morfiny, kompozycja farmaceutyczna zawierająca tę sól, zastosowanie soli oraz sposób jej wytwarzania PL211031B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0218811.8A GB0218811D0 (en)	2002-08-14	2002-08-14	Salts of morphine-6-glucuronide

Publications (2)

Publication Number	Publication Date
PL373553A1 true PL373553A1 (pl)	2005-09-05
PL211031B1 PL211031B1 (pl)	2012-04-30

Family

ID=9942230

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL373553A PL211031B1 (pl)	2002-08-14	2003-08-14	Sól bromowodorkowa 6-β-D-glukuronidu morfiny, kompozycja farmaceutyczna zawierająca tę sól, zastosowanie soli oraz sposób jej wytwarzania

Country Status (17)

Country	Link
US (1)	US20060166900A1 (pl)
EP (1)	EP1537132B1 (pl)
JP (1)	JP4727990B2 (pl)
KR (1)	KR101077501B1 (pl)
AT (1)	ATE315041T1 (pl)
AU (1)	AU2003255790B2 (pl)
CA (1)	CA2494812C (pl)
DE (1)	DE60303149T2 (pl)
DK (1)	DK1537132T3 (pl)
EA (1)	EA008212B1 (pl)
ES (1)	ES2256790T3 (pl)
GB (1)	GB0218811D0 (pl)
IL (1)	IL166596A0 (pl)
NO (1)	NO20051261L (pl)
PL (1)	PL211031B1 (pl)
WO (1)	WO2004016633A1 (pl)
ZA (1)	ZA200501053B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA200711123B (en)	2005-06-27	2009-08-26	Biovail Lab Int Srl	Modified-release formulations of a bupropion salt
FR2939437B1 (fr) *	2008-12-10	2010-12-17	Sanofi Aventis	Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique
FR2939796B1 (fr) *	2008-12-11	2010-12-17	Sanofi Aventis	Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique
CN107028968B (zh) *	2016-02-03	2020-12-04	江苏恒瑞医药股份有限公司	一种含有葡萄糖醛酸吗啡或其可药用盐的药物组合物
EP3528873A2 (en)	2016-10-21	2019-08-28	Somniferum Labs LLC	Apparatus for controlled delivery of opioid and other medications
CN110054656B (zh) *	2019-05-28	2021-02-02	宜昌人福药业有限责任公司	一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
CN113831373B (zh) *	2020-06-23	2023-05-16	宜昌人福药业有限责任公司	一种吗啡-6-葡萄糖苷酸脱水物杂质的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4908389A (en) *	1986-08-27	1990-03-13	Warner-Lambert Company	Penetration enhancement system
FR2680786B1 (fr) *	1991-09-04	1995-03-10	Irepa	Procede de synthese de glucuronides d'epoxy-4,5 morphinanes.
DE4403709A1 (de) *	1994-02-07	1995-08-10	Lohmann Therapie Syst Lts	Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid
US5460826A (en) *	1994-06-27	1995-10-24	Alza Corporation	Morphine therapy
EP0816375A1 (en) *	1995-11-29	1998-01-07	Rolabo Sl	Glycoconjugates of opiated substances
SK4322000A3 (en) *	1997-09-25	2000-10-09	Lohmann Therapie Syst Lts	Transdermal or transmucosal composition for administering morphine alkaloids, the application thereof, appropriate compounds and method for their producing
US6740641B2 (en) *	2001-07-27	2004-05-25	Euro-Celtique, S.A.	Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain

2002
- 2002-08-14 GB GBGB0218811.8A patent/GB0218811D0/en not_active Ceased
2003
- 2003-08-14 KR KR1020057002442A patent/KR101077501B1/ko not_active Expired - Fee Related
- 2003-08-14 PL PL373553A patent/PL211031B1/pl unknown
- 2003-08-14 US US10/524,149 patent/US20060166900A1/en not_active Abandoned
- 2003-08-14 CA CA2494812A patent/CA2494812C/en not_active Expired - Fee Related
- 2003-08-14 WO PCT/GB2003/003562 patent/WO2004016633A1/en not_active Ceased
- 2003-08-14 JP JP2004528672A patent/JP4727990B2/ja not_active Expired - Fee Related
- 2003-08-14 ES ES03787894T patent/ES2256790T3/es not_active Expired - Lifetime
- 2003-08-14 EA EA200500175A patent/EA008212B1/ru not_active IP Right Cessation
- 2003-08-14 DK DK03787894T patent/DK1537132T3/da active
- 2003-08-14 AU AU2003255790A patent/AU2003255790B2/en not_active Ceased
- 2003-08-14 EP EP03787894A patent/EP1537132B1/en not_active Expired - Lifetime
- 2003-08-14 DE DE60303149T patent/DE60303149T2/de not_active Expired - Lifetime
- 2003-08-14 AT AT03787894T patent/ATE315041T1/de active
2005
- 2005-01-31 IL IL16659605A patent/IL166596A0/xx not_active IP Right Cessation
- 2005-02-04 ZA ZA2005/01053A patent/ZA200501053B/en unknown
- 2005-03-11 NO NO20051261A patent/NO20051261L/no unknown

Also Published As

Publication number	Publication date
AU2003255790B2 (en)	2010-05-27
AU2003255790A1 (en)	2004-03-03
IL166596A0 (en)	2006-01-15
CA2494812A1 (en)	2004-02-26
DE60303149T2 (de)	2006-09-28
DK1537132T3 (da)	2006-05-08
US20060166900A1 (en)	2006-07-27
JP2006500360A (ja)	2006-01-05
EP1537132A1 (en)	2005-06-08
KR101077501B1 (ko)	2011-10-28
EP1537132B1 (en)	2006-01-04
PL211031B1 (pl)	2012-04-30
ZA200501053B (en)	2005-10-26
ES2256790T3 (es)	2006-07-16
JP4727990B2 (ja)	2011-07-20
GB0218811D0 (en)	2002-09-18
ATE315041T1 (de)	2006-02-15
EA008212B1 (ru)	2007-04-27
DE60303149D1 (de)	2006-03-30
CA2494812C (en)	2011-03-08
KR20050055710A (ko)	2005-06-13
NO20051261L (no)	2005-03-11
WO2004016633A1 (en)	2004-02-26
EA200500175A1 (ru)	2005-08-25

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