PL373644A1 - Novel derivatives of cycloalcanodiones, method for the production thereof and their pharmacological applications - Google Patents

Novel derivatives of cycloalcanodiones, method for the production thereof and their pharmacological applications

Info

Publication number
PL373644A1
PL373644A1 PL03373644A PL37364403A PL373644A1 PL 373644 A1 PL373644 A1 PL 373644A1 PL 03373644 A PL03373644 A PL 03373644A PL 37364403 A PL37364403 A PL 37364403A PL 373644 A1 PL373644 A1 PL 373644A1
Authority
PL
Poland
Prior art keywords
cycloalcanodiones
production
novel derivatives
treatment
pharmacological applications
Prior art date
Application number
PL03373644A
Other languages
Polish (pl)
Inventor
Rio Zambrana Joaquin Del
Manso Diana Frechilla
Rodriguez Luz M. Lopez
Salama Bellinda Benhamu
Cubero Jose Angel Fuentes
Wallace Mercedes Delgado
Original Assignee
Cepa Schwarz Pharma S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cepa Schwarz Pharma S.L. filed Critical Cepa Schwarz Pharma S.L.
Publication of PL373644A1 publication Critical patent/PL373644A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

New cycloalkanedione derivatives that are serotonin (5-hydroxytriptamine, 5-HT) 5-HT1A receptor subtype agonists and, consequently, they are useful in the treatment of pathological states for which an agonist of these receptors is indicated. <??>They are particularly useful as neuroprotective agents, of special interest in the treatment and prophylaxis of cerebral damage produced by traumatic or ischemic stroke. <??>In general terms, said cycloalkanedione derivatives correspond to formula I: <CHEM>
PL03373644A 2002-07-31 2003-07-29 Novel derivatives of cycloalcanodiones, method for the production thereof and their pharmacological applications PL373644A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200201811A ES2199086B1 (en) 2002-07-31 2002-07-31 NEW DERIVATIVES OF CYCLLOCANODIONAS, PROCEDURE FOR ITS PREPARATION AND ITS PHARMACOLOGICAL APPLICATIONS.

Publications (1)

Publication Number Publication Date
PL373644A1 true PL373644A1 (en) 2005-09-05

Family

ID=31198114

Family Applications (1)

Application Number Title Priority Date Filing Date
PL03373644A PL373644A1 (en) 2002-07-31 2003-07-29 Novel derivatives of cycloalcanodiones, method for the production thereof and their pharmacological applications

Country Status (23)

Country Link
US (1) US7351732B2 (en)
EP (1) EP1544201B1 (en)
JP (1) JP2005539017A (en)
KR (1) KR20050042471A (en)
CN (2) CN100422185C (en)
AT (1) ATE331717T1 (en)
AU (1) AU2003254512A1 (en)
BR (1) BR0313375A (en)
CA (1) CA2492837A1 (en)
CY (1) CY1106170T1 (en)
DE (1) DE60306534T2 (en)
DK (1) DK1544201T3 (en)
ES (2) ES2199086B1 (en)
IL (1) IL166469A0 (en)
MX (1) MXPA05001245A (en)
NO (1) NO20051068L (en)
NZ (1) NZ538489A (en)
PL (1) PL373644A1 (en)
PT (1) PT1544201E (en)
RU (1) RU2322445C2 (en)
UA (1) UA79801C2 (en)
WO (1) WO2004014915A1 (en)
ZA (1) ZA200500784B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2199086B1 (en) 2002-07-31 2005-06-01 Cepa Schwarz Pharma Sl NEW DERIVATIVES OF CYCLLOCANODIONAS, PROCEDURE FOR ITS PREPARATION AND ITS PHARMACOLOGICAL APPLICATIONS.
ES2238015B1 (en) * 2004-01-30 2006-11-01 Cepa Schwarz Pharma, S.L. CICLOALCANODIONAS DERIVATIVES WITH NEUROPROTECTING ACTIVITY.
WO2008015538A2 (en) * 2006-07-31 2008-02-07 Schwarz Pharma S.L. Use of diaza- and thiaza-cycloalkanediones for preventing and/or treating pain and /or migraine
EP2338873A1 (en) 2009-12-22 2011-06-29 Gmeiner, Peter New aminotetraline derivatives

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4055410A (en) * 1976-03-15 1977-10-25 E. I. Du Pont De Nemours And Company Substituted bromo- or chloroacetamide herbicides
EP0002978B1 (en) * 1977-12-29 1982-10-06 Synthelabo Thiazolidinedione-2,4 derivatives, their preparation and pharmaceutical applications
DE3901814A1 (en) * 1988-07-28 1990-02-01 Bayer Ag SUBSTITUTED AMINOMETHYLZETRALINE AND ITS HETEROCYCLIC ANALOG
EP0510691B1 (en) * 1991-04-26 2004-11-03 Osaka Bioscience Institute DNA coding for human cell surface antigen
TW288010B (en) * 1992-03-05 1996-10-11 Pfizer
AP486A (en) * 1993-04-27 1996-04-16 Pfizer Indole derivatives.
AU3079295A (en) 1994-09-01 1996-03-22 Universidad Complutense De Madrid New arylpiperazine derivatives
ES2082727B1 (en) 1994-09-01 1996-10-16 Univ Madrid Complutense NEW ARILPIPERAZIN DERIVATIVES.
ES2094690B1 (en) 1994-11-22 1997-08-01 Univ Madrid Complutense NEW DERIVATIVES OF IMIDA-PIPERAZINES.
ES2109190B1 (en) 1996-03-22 1998-07-01 Univ Madrid Complutense NEW BENCIMIDAZOLE DERIVATIVES AFFINATED BY 5-HT / 5-HT SEROTONINERGIC RECEPTORS
ES2129370B1 (en) 1997-09-23 2000-03-01 Univ Madrid Complutense PROCEDURE FOR OBTAINING 2- (4- (4- (M-ETILSULFONAMIDOFENIL) P IPERAZIN-1-IL (BUTIL) -1,3-DIOXOPERHIDROPIRROLO) 1,2-C (IMIDAZOLE
US6133277A (en) 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
ES2154605B1 (en) 1999-09-14 2001-11-16 Univ Madrid Complutense NEW MIXED DERIVATIVES OF BENCIMIDAZOL-ARILPIPERAZINA AFFINED BY SEROTONINERGIC RECEPTORS 5-HT1A AND 5-HT3
DE10148425A1 (en) 2001-10-01 2003-04-17 Bayer Ag chromans
ES2199086B1 (en) 2002-07-31 2005-06-01 Cepa Schwarz Pharma Sl NEW DERIVATIVES OF CYCLLOCANODIONAS, PROCEDURE FOR ITS PREPARATION AND ITS PHARMACOLOGICAL APPLICATIONS.
ES2238015B1 (en) 2004-01-30 2006-11-01 Cepa Schwarz Pharma, S.L. CICLOALCANODIONAS DERIVATIVES WITH NEUROPROTECTING ACTIVITY.
EP1674103A1 (en) 2004-12-27 2006-06-28 Cepa Schwarz Pharma s.l. Arylpiperazine derivatives and use thereof as 5-HT1A receptor ligands

Also Published As

Publication number Publication date
NZ538489A (en) 2006-09-29
CN101172977A (en) 2008-05-07
CA2492837A1 (en) 2004-02-19
PT1544201E (en) 2006-11-30
WO2004014915A1 (en) 2004-02-19
ES2199086A1 (en) 2004-02-01
CN100422185C (en) 2008-10-01
UA79801C2 (en) 2007-07-25
ES2271673T3 (en) 2007-04-16
IL166469A0 (en) 2006-01-15
AU2003254512A1 (en) 2004-02-25
US20050250777A1 (en) 2005-11-10
EP1544201B1 (en) 2006-06-28
US7351732B2 (en) 2008-04-01
ES2199086B1 (en) 2005-06-01
CY1106170T1 (en) 2011-06-08
KR20050042471A (en) 2005-05-09
JP2005539017A (en) 2005-12-22
ZA200500784B (en) 2006-08-30
RU2005102821A (en) 2005-10-10
RU2322445C2 (en) 2008-04-20
ATE331717T1 (en) 2006-07-15
NO20051068L (en) 2005-02-25
DE60306534T2 (en) 2007-04-19
CN1671708A (en) 2005-09-21
EP1544201A1 (en) 2005-06-22
DK1544201T3 (en) 2006-10-30
BR0313375A (en) 2005-06-21
MXPA05001245A (en) 2005-09-12
DE60306534D1 (en) 2006-08-10

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