PL373962A1 - Sposoby i kompozycje do analizowania białek - Google Patents

Sposoby i kompozycje do analizowania białek

Info

Publication number
PL373962A1
PL373962A1 PL02373962A PL37396202A PL373962A1 PL 373962 A1 PL373962 A1 PL 373962A1 PL 02373962 A PL02373962 A PL 02373962A PL 37396202 A PL37396202 A PL 37396202A PL 373962 A1 PL373962 A1 PL 373962A1
Authority
PL
Poland
Prior art keywords
compositions
methods
analyzing proteins
proteins
analyzing
Prior art date
Application number
PL02373962A
Other languages
English (en)
Inventor
Sharat Singh
Hossein Salimi-Moosavi
Syed Hasan Tahir
Gerald J. Wallweber
Hrair Kirakossian
Tracy J. Matray
Vincent S. Hernandez
Original Assignee
Aclara Biosciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aclara Biosciences, Inc. filed Critical Aclara Biosciences, Inc.
Publication of PL373962A1 publication Critical patent/PL373962A1/pl

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G01N33/561Immunoelectrophoresis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
PL02373962A 2001-05-21 2002-05-21 Sposoby i kompozycje do analizowania białek PL373962A1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29254801P 2001-05-21 2001-05-21
US33490101P 2001-10-24 2001-10-24

Publications (1)

Publication Number Publication Date
PL373962A1 true PL373962A1 (pl) 2005-09-19

Family

ID=26967405

Family Applications (1)

Application Number Title Priority Date Filing Date
PL02373962A PL373962A1 (pl) 2001-05-21 2002-05-21 Sposoby i kompozycje do analizowania białek

Country Status (11)

Country Link
US (4) US7255999B2 (pl)
EP (1) EP1506399A2 (pl)
JP (1) JP2005505749A (pl)
KR (1) KR20040082273A (pl)
CN (1) CN1559006A (pl)
AU (1) AU2002310012A1 (pl)
CA (1) CA2445053A1 (pl)
CZ (1) CZ20033143A3 (pl)
NO (1) NO20035010L (pl)
PL (1) PL373962A1 (pl)
WO (1) WO2002095356A2 (pl)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2445053A1 (en) 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
JP2005509859A (ja) * 2001-11-09 2005-04-14 アクララ バイオサイエンシーズ, インコーポレイテッド タグ標識された微粒子組成物および方法
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US20060166282A1 (en) * 2002-07-26 2006-07-27 Sharat Singh Methods and compositions for screening cell binding molecules
US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
EP1599492A4 (en) * 2003-01-17 2008-09-24 Virologic Inc RECIPIENTS DORPHANIZATION BY USING MARKED MOLECULAR LIBRARIES
US7029855B1 (en) * 2003-01-28 2006-04-18 Proteomyx Inc. Radioactive multiplexing analytical methods for biomarkers discovery
EP1613205B1 (en) 2003-04-01 2013-04-24 Monogram BioSciences, Inc. Erbb surface receptor complexes as biomarkers
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
EP1673399B1 (en) * 2003-08-11 2017-04-05 Monogram BioSciences, Inc. Detecting and profiling molecular complexes
EP1689882B1 (en) * 2003-10-07 2014-11-26 TRAN, Nathaniel Tue Radioactive multiplexing analytical methods
US7402399B2 (en) * 2003-10-14 2008-07-22 Monogram Biosciences, Inc. Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy
IL160869A0 (en) * 2004-03-15 2004-08-31 Dnr Imaging System Ltd Integrated system for real time gel electrophoresis running and documenting
JP4311319B2 (ja) * 2004-09-22 2009-08-12 ウシオ電機株式会社 ショートアーク型放電ランプ
CN101035572B (zh) 2004-10-07 2010-12-08 纳幕尔杜邦公司 用于医疗用途的多糖基聚合物组织粘合剂
US20060100787A1 (en) * 2004-11-09 2006-05-11 Intel Corporation Synthesis of nanocodes, and imaging using scanning probe microscopy
US20060204999A1 (en) * 2005-03-14 2006-09-14 Stephen Macevicz Detecting molecular complexes
WO2006099604A2 (en) * 2005-03-16 2006-09-21 Compass Genetics, Llc Methods and compositions for assay readouts on multiple analytical platforms
US20060281104A1 (en) * 2005-06-13 2006-12-14 Macevicz Stephen C Leuco dye particles and uses thereof
JP4724816B2 (ja) * 2005-09-06 2011-07-13 シャープ株式会社 タンパク質の測定方法
US8357277B2 (en) 2007-11-27 2013-01-22 Laboratory Corp. of America Holdings Enhanced method for detecting and/or quantifying an analyte in a sample
US8530182B2 (en) * 2007-12-05 2013-09-10 Centers For Disease Control And Prevention Viral protein quantification process and vaccine quality control therewith
EP2235536A4 (en) * 2007-12-20 2011-05-04 Lab Corp America Holdings HER-2-DIAGNOSTIC PROCEDURE
US20100015231A1 (en) * 2008-07-17 2010-01-21 E.I. Du Pont De Nemours And Company Low swell, long-lived hydrogel sealant
EP2349357B1 (en) * 2008-11-19 2012-10-03 Actamax Surgical Materials LLC Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether
ES2637411T3 (es) 2008-12-01 2017-10-13 Laboratory Corporation Of America Holdings Métodos y ensayos para medir p95 Y/O p95 en una muestra y anticuerpos específicos para p95
US20100160960A1 (en) * 2008-12-19 2010-06-24 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive having increased degradation time
EP2387711B1 (en) 2009-01-15 2015-04-22 Laboratory Corporation of America Holdings Methods of determining patient response by measurement of her-3
JP2012515353A (ja) * 2009-01-15 2012-07-05 ラボラトリー コーポレイション オブ アメリカ ホールディングス Her−2発現の測定による患者の反応を判定する方法
WO2010118284A1 (en) 2009-04-09 2010-10-14 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive having reduced degradation time
US20120094955A1 (en) * 2009-04-09 2012-04-19 Actamax Surgical Materials Llc Method of dissolving an oxidized polysaccharide in an aqueous solution
US8796242B2 (en) 2009-07-02 2014-08-05 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
WO2011002888A2 (en) 2009-07-02 2011-01-06 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive for medical use
EP2606072A4 (en) * 2010-08-19 2016-04-20 Peg Biosciences Inc SYNERGISTIC BIOMOLECULAR POLYMER CONJUGATES
TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
WO2012168803A2 (en) 2011-06-07 2012-12-13 Koninklijke Philips Electronics N.V. Providing nucleotide sequence data
DE102011109063B3 (de) 2011-07-28 2012-12-20 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Verfahren zum Nachweis von Biomolekülen
US10370409B2 (en) 2011-10-25 2019-08-06 The Scripps Research Institute Synthesis of libraries of peptide tertiary amides
JP5468056B2 (ja) * 2011-12-15 2014-04-09 富士フイルム株式会社 電気泳動組成物、マイクロカプセル、及び、電気泳動表示素子
US8921277B2 (en) 2012-09-26 2014-12-30 Palo Alto Research Center Incorporated Multiplexed flow assay based on absorption-encoded micro beads
WO2014053479A1 (en) 2012-10-02 2014-04-10 Roche Diagnostics Gmbh Methods of specifically releasing a sub-group of objects
US20160041171A1 (en) 2013-04-05 2016-02-11 Laboratory Corporation Of America Holdings Systems and methods for facilitating diagnosis, prognosis and treatment of cancer based on detection of her3 activation
US20160184474A1 (en) 2013-07-29 2016-06-30 Actamax Surgical Materials, Llc Low swell tissue adhesive and sealant formulations
CN107406410B (zh) * 2014-08-20 2021-10-29 多伦多大学理事会 有机碲化合物、组合物及其使用方法
EP3050886A1 (en) * 2015-02-02 2016-08-03 Bürkert Werke GmbH Fluorescent dyes and dye precursors
WO2017015097A1 (en) 2015-07-17 2017-01-26 Nanostring Technologies, Inc. Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
SG10202107053QA (en) 2015-07-17 2021-08-30 Nanostring Technologies Inc Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
WO2017161030A1 (en) * 2016-03-15 2017-09-21 Laboratory Corporation Of America Holdings Methods of assessing protein interactions between cells
US9994713B2 (en) * 2016-03-28 2018-06-12 King Fahd University Of Petroleum And Minerals Fluorescent schiff base conjugate Cu(II) chemosensors and methods thereof
CN107462618B (zh) * 2016-06-03 2019-05-21 中国科学院生态环境研究中心 一种蛋白质O-GlcNAc糖基转移酶活性电化学传感检测方法
KR102406008B1 (ko) 2016-10-14 2022-06-07 창원대학교 산학협력단 전자전달해리(etd) 질량분석을 이용한 단백질의 정량분석법
EP4556575A3 (en) 2016-11-21 2025-10-08 Bruker Spatial Biology, Inc. A method for sequencing nucleic acids
CN116148467A (zh) * 2017-12-12 2023-05-23 清华大学 检测翻译后修饰蛋白质与其配体间相互作用的成套试剂
CN108387435B (zh) * 2018-01-30 2020-09-15 中国计量大学 一种痕量丝素蛋白富集方法
US20190249248A1 (en) 2018-02-12 2019-08-15 Nanostring Technologies, Inc. Biomolecular probes and methods of detecting gene and protein expression
HUE065344T2 (hu) * 2018-03-19 2024-05-28 Regeneron Pharma Mikrochip kapilláris elektroforézis assay-k és reagensek
EP3794146B1 (en) 2018-05-14 2025-12-10 Bruker Spatial Biology, Inc. Method for identifying a predetermined nucleotide sequence
CN117233380A (zh) 2020-09-28 2023-12-15 美勒斯公司 用于检测细胞表面部分的表达或聚集的方法
CN113567520B (zh) * 2021-07-08 2024-06-07 西北农林科技大学 一种用于痕量蛋白分子精准检测的电化学传感方法
CN115144348B (zh) * 2022-07-06 2025-02-14 浙江伊利康生物技术有限公司 糖化白蛋白检测试剂盒、制备方法及其应用方法

Family Cites Families (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2153059A (en) * 1936-02-26 1939-04-04 Gen Aniline Works Inc Chromable dyestuffs of the triarylmethane series and process of preparing them
US2242572A (en) * 1939-06-21 1941-05-20 Gen Aniline & Film Corp Chromable dyestuffs of the triarylmethane series and a process of preparing them
US3932415A (en) * 1972-04-17 1976-01-13 Eastman Kodak Company Pyrylium dyes having a fused rigidized nitrogen-containing ring
US4331590A (en) * 1978-03-13 1982-05-25 Miles Laboratories, Inc. β-Galactosyl-umbelliferone-labeled protein and polypeptide conjugates
FR2431581A1 (fr) * 1978-07-18 1980-02-15 Soum Rene Systeme d'assemblage de planchers
US4230558A (en) 1978-10-02 1980-10-28 Coulter Electronics, Inc. Single drop separator
US4318846A (en) * 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
US4973679A (en) * 1981-03-27 1990-11-27 University Patents, Inc. Process for oligonucleo tide synthesis using phosphormidite intermediates
US5650270A (en) * 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5516931A (en) * 1982-02-01 1996-05-14 Northeastern University Release tag compounds producing ketone signal groups
US4709016A (en) * 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US4650750A (en) * 1982-02-01 1987-03-17 Giese Roger W Method of chemical analysis employing molecular release tag compounds
DE3329892A1 (de) * 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
US4562248A (en) 1983-11-25 1985-12-31 Eastman Kodak Company Azo dyes from unsubstituted or substituted 3-amino-pyridine and aryl or heterocyclic couplers
GB8407736D0 (en) * 1984-03-26 1984-05-02 Univ London Detecting specific polynucleotide sequences
US4675300A (en) * 1985-09-18 1987-06-23 The Board Of Trustees Of The Leland Stanford Junior University Laser-excitation fluorescence detection electrokinetic separation
US4780421A (en) * 1986-04-03 1988-10-25 Sclavo Inc. Cleavable labels for use in binding assays
FR2596761B1 (fr) 1986-04-08 1988-05-20 Commissariat Energie Atomique Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides
US4811218A (en) * 1986-06-02 1989-03-07 Applied Biosystems, Inc. Real time scanning electrophoresis apparatus for DNA sequencing
US5494793A (en) * 1986-12-15 1996-02-27 British Technology Group Usa Inc. Monomeric phthalocyanine reagents
JPS641949A (en) * 1987-06-24 1989-01-06 Hitachi Ltd Regeneration of electrophoretic gel
US4894348A (en) * 1987-07-01 1990-01-16 Ronald Robert C Fluorescein-conjugated proteins with enhanced fluorescence
US5057301A (en) * 1988-04-06 1991-10-15 Neorx Corporation Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents
WO1989012232A1 (en) * 1988-06-08 1989-12-14 London Diagnostics, Inc. Assays utilizing sensitizer-induced production of detectable signals
NL8801826A (nl) * 1988-07-19 1990-02-16 Tno Werkwijze voor het detecteren van mutaties in markergenen.
US4997928A (en) * 1988-09-15 1991-03-05 E. I. Du Pont De Nemours And Company Fluorescent reagents for the preparation of 5'-tagged oligonucleotides
US5064104A (en) * 1988-10-28 1991-11-12 Milancolimited, Inc. Apparatus for vending a product
US5571666A (en) * 1988-10-28 1996-11-05 Oklahoma Medical Research Foundation Thiazine dyes used to inactivate HIV in biological fluids
US5254469A (en) * 1989-09-12 1993-10-19 Eastman Kodak Company Oligonucleotide-enzyme conjugate that can be used as a probe in hybridization assays and polymerase chain reaction procedures
US5654442A (en) * 1989-11-14 1997-08-05 The Perkin-Elmer Corporation 4,7-dichlorofluorescein dyes as molecular probes
US5274240A (en) 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
WO1991011521A1 (en) * 1990-01-26 1991-08-08 La Jolla Cancer Research Foundation Polypeptides encoding transcriptional activators and uses thereof
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
ES2094795T3 (es) 1990-11-02 1997-02-01 Ici Plc Ftalocianinas polisustituidas.
US5578498A (en) * 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US6251581B1 (en) * 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5846717A (en) * 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5770358A (en) 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries
US5254468A (en) * 1991-10-31 1993-10-19 The University Of Toledo Bilayer pellet containing immobilized xylose isomerase and urease for the simultaneous isomerization and fermentation of xylose to ethanol
US5843680A (en) * 1992-01-31 1998-12-01 Biometric Imaging, Inc. Differential separation assay methods and test kits
US5137609A (en) * 1992-01-31 1992-08-11 Biometric Imaging Inc. Differential separation assay
JP3130629B2 (ja) 1992-03-13 2001-01-31 オリンパス光学工業株式会社 電気泳動における分画処理方法
DE69207580T2 (de) * 1992-03-23 1996-08-08 Hoffmann La Roche Verfahren zum DNS-Nachweis
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
EP0636186B1 (en) * 1992-04-03 1998-11-25 The Perkin-Elmer Corporation Probe composition and method
US5470705A (en) * 1992-04-03 1995-11-28 Applied Biosystems, Inc. Probe composition containing a binding domain and polymer chain and methods of use
CA2141451C (en) * 1992-07-31 2003-10-07 John S. Pease Photoactivatable chemiluminescent matrices
JP3207933B2 (ja) * 1992-09-09 2001-09-10 株式会社ヤトロン アクリジニウム誘導体の発光方法及びそれを用いた検査対象物質の検出方法
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5958202A (en) * 1992-09-14 1999-09-28 Perseptive Biosystems, Inc. Capillary electrophoresis enzyme immunoassay
US5721099A (en) * 1992-10-01 1998-02-24 Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5719028A (en) * 1992-12-07 1998-02-17 Third Wave Technologies Inc. Cleavase fragment length polymorphism
US5374527A (en) 1993-01-21 1994-12-20 Applied Biosystems, Inc. High resolution DNA sequencing method using low viscosity medium
US5324401A (en) * 1993-02-05 1994-06-28 Iowa State University Research Foundation, Inc. Multiplexed fluorescence detector system for capillary electrophoresis
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US5635602A (en) * 1993-08-13 1997-06-03 The Regents Of The University Of California Design and synthesis of bispecific DNA-antibody conjugates
WO1995006877A1 (en) * 1993-09-03 1995-03-09 Behringwerke Ag Fluorescent oxygen channeling immunoassays
CN1154640C (zh) * 1993-10-01 2004-06-23 纽约市哥伦比亚大学理事 用标示物编码的多元组合化学库
US5503994A (en) * 1993-10-08 1996-04-02 The Board Of Trustees Of The Leland Stanford Junior University System for sample detection with compensation for difference in sensitivity to detection of components moving at different velocities
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
WO1995016910A1 (en) * 1993-12-17 1995-06-22 Perkin-Elmer Corporation Uncharged polymers for separation of biomolecules by capillary electrophoresis
US5571680A (en) * 1994-01-21 1996-11-05 Beckman Instruments, Inc. Homogeneous immunoassays and enzyme based assays of analytes using capillary electrophoresis
US5623055A (en) * 1994-01-28 1997-04-22 Prolinx, Inc. Phenylboronic acid complexes derived from aminosalicylic acid for bioconjugate preparation
US5543026A (en) * 1994-02-07 1996-08-06 The Perkin-Elmer Corporation Real-time scanning fluorescence electrophoresis apparatus for the analysis of polynucleotide fragments
US5851770A (en) * 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
US5986076A (en) * 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
US6045995A (en) * 1994-08-24 2000-04-04 Isis Pharmaceuticals, Inc. Capillary electrophoretic detection of nucleic acids
US5843666A (en) * 1994-09-02 1998-12-01 Lumigen, Inc. Chemiluminescent detection methods using dual enzyer-labeled binding partners
US5691151A (en) * 1994-10-07 1997-11-25 Regents Of University Of California Methods of screening for ulcerative colitis and crohn's disease by detecting VH3-15 autoantibody and panca
US5560811A (en) * 1995-03-21 1996-10-01 Seurat Analytical Systems Incorporated Capillary electrophoresis apparatus and method
WO1996031263A1 (en) * 1995-04-06 1996-10-10 Arqule, Inc. Method for rapid purification, analysis and characterization of collections of chemical compounds
US5591422A (en) * 1995-06-02 1997-01-07 Pharmacyclics, Inc. Texaphyrin complexes having improved functionalization
US5843655A (en) * 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
SE9503991D0 (sv) 1995-11-10 1995-11-10 Pharmacia Biotech Ab Method and apparatus for determining the existence of a mutation
US5846839A (en) * 1995-12-22 1998-12-08 Glaxo Group Limited Methods for hard-tagging an encoded synthetic library
DE69700902T2 (de) 1996-01-23 2000-07-20 Rapigene, Inc. Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit
US6312893B1 (en) * 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
DK0840804T3 (da) 1996-01-23 2000-07-17 Rapigene Inc Fremgangsmåder og sammensætninger til analyse af nukleinsyremolekyler ved anvendelse af størrelsesseparationsteknikker
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US5804400A (en) 1996-02-05 1998-09-08 Igen International, Inc. Electrochemiluminescent assay
US6090947A (en) * 1996-02-26 2000-07-18 California Institute Of Technology Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
US5863727A (en) 1996-05-03 1999-01-26 The Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US5800996A (en) * 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
US5945526A (en) * 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US5811239A (en) * 1996-05-13 1998-09-22 Frayne Consultants Method for single base-pair DNA sequence variation detection
WO1998001533A1 (en) * 1996-07-08 1998-01-15 Burstein Laboratories, Inc. Cleavable signal element device and method
US6780982B2 (en) * 1996-07-12 2004-08-24 Third Wave Technologies, Inc. Charge tags and the separation of nucleic acid molecules
US5998140A (en) * 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
US5831046A (en) * 1996-08-05 1998-11-03 Prolinx, Incorporated Boronic acid-contaning nucleic acid monomers
US6045676A (en) * 1996-08-26 2000-04-04 The Board Of Regents Of The University Of California Electrochemical detector integrated on microfabricated capilliary electrophoresis chips
US5763602A (en) * 1996-10-01 1998-06-09 Li; Ying-Syi Methods of syntheses of phthalocyanine compounds
FI963989L (fi) 1996-10-04 1998-04-05 Wallac Oy Homogeenisiä määritysmenetelmiä, jotka perustuvat luminesenssienergiasiirtoon
US5894878A (en) 1996-10-04 1999-04-20 Morgan; Spencer T. Protective and decorative computer cover
US6245937B1 (en) * 1996-11-29 2001-06-12 Dupont Pharmaceuticals Research Laboratories, Inc. Liquid phase parallel synthesis of chemical libraries
US5856107A (en) 1997-02-04 1999-01-05 Trega Biosciences, Inc. Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein
CA2297158C (en) 1997-07-22 2009-12-22 Rapigene Inc. Methods and compounds for analyzing nucleic acids by mass spectrometry
WO1999013108A1 (en) 1997-09-10 1999-03-18 University Of Maryland, Baltimore Method of amplifying dna and rna mismatch cleavage products
US6008379A (en) 1997-10-01 1999-12-28 The Perkin-Elmer Corporation Aromatic-substituted xanthene dyes
US5952654A (en) * 1997-10-29 1999-09-14 Northeastern University Field-release mass spectrometry
US6562567B2 (en) * 1998-01-27 2003-05-13 California Institute Of Technology Method of detecting a nucleic acid
JP2002504689A (ja) 1998-02-18 2002-02-12 デイド・ベーリング・インコーポレイテッド 複数の検体の検出において使用するための化学ルミネセンス組成物
US6335201B1 (en) * 1998-03-06 2002-01-01 The Regents Of The University Of California Method and apparatus for detecting enzymatic activity using molecules that change electrophoretic mobility
US6740497B2 (en) * 1998-03-06 2004-05-25 The Regents Of The University Of California Method and apparatus for detecting cancerous cells using molecules that change electrophoretic mobility
AU3067099A (en) * 1998-03-11 1999-09-27 Wistar Institute, The Antibodies for assessing protein post-translational modification status and methods of making and using the same
AU3601599A (en) * 1998-03-25 1999-10-18 Ulf Landegren Rolling circle replication of padlock probes
GB9812596D0 (en) 1998-06-11 1998-08-12 Amersham Pharm Biotech Uk Ltd Energy transfer assay method
US6017769A (en) * 1998-06-17 2000-01-25 Lumigen, Inc. Non-enzymatic methods of generating chemiluminescence from acridan alkenes
US6821402B1 (en) 1998-09-16 2004-11-23 Applera Corporation Spectral calibration of fluorescent polynucleotide separation apparatus
AU3519900A (en) 1999-03-19 2000-10-09 Aclara Biosciences, Inc. Methods for single nucleotide polymorphism detection
US6013783A (en) * 1999-03-19 2000-01-11 Prolinx Incorporated Boronic acid containing oligonucleotides and polynucleotides
US6627400B1 (en) * 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US6322980B1 (en) * 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US6673550B2 (en) * 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US20020142329A1 (en) * 1999-04-30 2002-10-03 Aclara Biosciences, Inc. Compositions and methods employing cleavable electrophoretic tag reagents
US6649351B2 (en) * 1999-04-30 2003-11-18 Aclara Biosciences, Inc. Methods for detecting a plurality of analytes by mass spectrometry
US6142162A (en) 1999-06-18 2000-11-07 Odoreyes Technology, Inc. System and method for odorizing natural gas
US6331530B1 (en) * 1999-07-13 2001-12-18 The Trustees Of Columbia University In The City Of New York Hydrophilic carrier for photosensitizers that cleaves when they catalyze the formation of singlet oxygen
US6191278B1 (en) * 1999-11-03 2001-02-20 Pe Corporation Water-soluble rhodamine dyes and conjugates thereof
US6372907B1 (en) * 1999-11-03 2002-04-16 Apptera Corporation Water-soluble rhodamine dye peptide conjugates
US7306904B2 (en) * 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
DE60137722D1 (de) * 2000-06-13 2009-04-02 Univ Boston Verwendung von mass-matched nukleotide in der analyse von oligonukleotidmischungen sowie in der hoch-multiplexen nukleinsäuresequenzierung
WO2002029109A2 (en) 2000-10-05 2002-04-11 Aclara Biosciences, Inc. Multiplexed differential displacement for nucleic acid determinations
EP1317464B1 (en) 2000-10-11 2009-05-13 Applera Corporation Fluorescent nucleobase conjugates having anionic linkers
US6468338B1 (en) * 2000-10-12 2002-10-22 Eastman Kodak Company Dye for ink jet ink
US6743905B2 (en) 2001-04-16 2004-06-01 Applera Corporation Mobility-modified nucleobase polymers and methods of using same
US7041459B2 (en) * 2001-05-21 2006-05-09 Monogram Biosciences, Inc. Analyzing phosphorylated proteins
CA2445053A1 (en) 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
WO2002097112A2 (en) 2001-05-26 2002-12-05 Aclara Biosciences, Inc. Catalytic amplification of multiplexed assay signals
JP2006509183A (ja) 2002-03-05 2006-03-16 アクララ バイオサイエンシーズ, インコーポレイテッド 膜結合増感剤を用いる多重分析
US20040229380A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
JP4443407B2 (ja) 2002-07-25 2010-03-31 アクララ バイオサイエンシーズ, インコーポレイテッド レセプターオリゴマー形成の検出
CA2493671A1 (en) * 2002-07-26 2004-02-05 Aclara Biosciences, Inc. Lipophilic electrophoretic probes

Also Published As

Publication number Publication date
EP1506399A2 (en) 2005-02-16
US9110075B2 (en) 2015-08-18
US9939447B2 (en) 2018-04-10
CA2445053A1 (en) 2002-11-28
WO2002095356A3 (en) 2004-12-23
CZ20033143A3 (en) 2004-04-14
KR20040082273A (ko) 2004-09-24
CN1559006A (zh) 2004-12-29
US20160069893A1 (en) 2016-03-10
US20120088307A1 (en) 2012-04-12
US7255999B2 (en) 2007-08-14
NO20035010D0 (no) 2003-11-11
AU2002310012A1 (en) 2002-12-03
US20080311674A1 (en) 2008-12-18
US20030013126A1 (en) 2003-01-16
WO2002095356A2 (en) 2002-11-28
NO20035010L (no) 2003-11-11
JP2005505749A (ja) 2005-02-24

Similar Documents

Publication Publication Date Title
PL373962A1 (pl) Sposoby i kompozycje do analizowania białek
HUP0501021A3 (en) Methods and compositions for analyzing proteins
IL152918A0 (en) Stabilized tetrazolium-phenazine reagent compositions and methods for using the same
AU2002357119A8 (en) Mitocidal compositions and methods
GB2401433B (en) Codon-based sequence analysis
GB0130557D0 (en) Proteins
AU2002357748A8 (en) Osteopontin-related compositions and methods
AU2002358219A8 (en) Protein analysis using mass spectrometry
AU2002364749A8 (en) Method for protein expression analysis
EP1436233A4 (en) BINDING PROTEINS WITH METALS AND RELATED METHODS
AU2002365269A8 (en) Mut-il-18 or mut-il-18r proteins, antibodies, compositions, methods and uses
AU2002311759A8 (en) Methods and compositions for analyzing nucleic acids
AU2002341828A1 (en) Enhanced proteins and methods for their use
AU2002359869A8 (en) Pak5-related compositions and methods
GB0202334D0 (en) Protein analysis
GB0107033D0 (en) Method and composition
GB0123858D0 (en) Method for analysing protein/peptide expression
GB0131025D0 (en) Protein analysis
GB0130560D0 (en) Proteins
AU2002309588A1 (en) Methods and compositions for mutation analysis
AU2002312047A8 (en) Compositions and methods for adipose abundant protein
EP1578343A4 (en) COMPOSITIONS AND METHODS FOR ABUNDANT ADIPOSIS PROTEIN
GB0109930D0 (en) Methods for spectral analysis and their applications
GB0117428D0 (en) Methods for spectral analysis and their applications
AU2002249920A1 (en) Method for analyzing proteins

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)