PL374240A1 - Sposób wytwarzania eseroliny, zwłaszcza oczyszczonej, sposób wytwarzania fenzeriny - Google Patents

Sposób wytwarzania eseroliny, zwłaszcza oczyszczonej, sposób wytwarzania fenzeriny

Info

Publication number
PL374240A1
PL374240A1 PL02374240A PL37424002A PL374240A1 PL 374240 A1 PL374240 A1 PL 374240A1 PL 02374240 A PL02374240 A PL 02374240A PL 37424002 A PL37424002 A PL 37424002A PL 374240 A1 PL374240 A1 PL 374240A1
Authority
PL
Poland
Prior art keywords
phenserine
analog
producing
compounds
isocyanate
Prior art date
Application number
PL02374240A
Other languages
English (en)
Inventor
Joerg Bruening
Original Assignee
Axonyx, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axonyx, Inc. filed Critical Axonyx, Inc.
Publication of PL374240A1 publication Critical patent/PL374240A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL02374240A 2002-01-09 2002-12-11 Sposób wytwarzania eseroliny, zwłaszcza oczyszczonej, sposób wytwarzania fenzeriny PL374240A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/042,586 US6495700B1 (en) 2002-01-09 2002-01-09 Process for producing phenserine and its analog

Publications (1)

Publication Number Publication Date
PL374240A1 true PL374240A1 (pl) 2005-10-03

Family

ID=21922704

Family Applications (1)

Application Number Title Priority Date Filing Date
PL02374240A PL374240A1 (pl) 2002-01-09 2002-12-11 Sposób wytwarzania eseroliny, zwłaszcza oczyszczonej, sposób wytwarzania fenzeriny

Country Status (15)

Country Link
US (1) US6495700B1 (pl)
EP (1) EP1463729B1 (pl)
JP (1) JP2005514459A (pl)
KR (2) KR100712003B1 (pl)
CN (1) CN1301995C (pl)
AT (1) ATE466015T1 (pl)
AU (1) AU2002353102B2 (pl)
BR (1) BRPI0215492A2 (pl)
CA (1) CA2470560C (pl)
DE (1) DE60236207D1 (pl)
HR (1) HRP20040606A2 (pl)
HU (1) HUP0500747A3 (pl)
IL (1) IL162827A0 (pl)
PL (1) PL374240A1 (pl)
WO (1) WO2003059909A1 (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7795307B2 (en) 2003-10-21 2010-09-14 Colucid Pharmaceuticals, Inc. Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents
US20070167509A1 (en) * 2005-06-14 2007-07-19 Joseph Araujo Use of phenserine and analogs to treat behavioral problems and improve trainability
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
AU2007292848A1 (en) * 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
AU2011215870B2 (en) 2010-02-09 2016-01-28 The Johns Hopkins University Methods and compositions for improving cognitive function
US20120225922A1 (en) 2011-03-04 2012-09-06 Qr Pharma Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration
US20130096316A1 (en) * 2011-10-14 2013-04-18 Qr Pharma, Inc. Novel Method for Preparation of Bisnorcymerine and Salts Thereof
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
JP6433482B2 (ja) 2013-03-15 2018-12-05 エージンバイオ， インコーポレイテッド 認知機能を改善するための方法および組成物
WO2016191288A1 (en) 2015-05-22 2016-12-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
WO2017030968A1 (en) 2015-08-14 2017-02-23 Qr Pharma Methods of treatment or prevention of acute brain or nerve injuries
WO2018217892A1 (en) 2017-05-24 2018-11-29 Qr Pharma, Inc. Prevention or treatment of disease states due to metal dis-homeostasis via administration of posiphen to healthy or sick humans
US12582632B2 (en) 2021-05-18 2026-03-24 Annovis Bio, Inc. Inhibition of neurological injuries due to infections via administration of Butanetap and analogs thereof
WO2025255358A1 (en) * 2024-06-06 2025-12-11 Annovis Bio, Inc. Solid forms of posiphen d-tartrate and processes of preparation thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1109003B (it) * 1977-09-20 1985-12-16 Univ Firenze Derivati dell 1 2 3 8 3 a 8 a esai dropirrolo 23 b indolo
US5306825A (en) 1984-03-01 1994-04-26 Consiglio Nazionale Delle Ricerche Physostigmine derivatives with acetylcholinesterase inhibition properties, and the relative production process
IT1199076B (it) * 1984-03-01 1988-12-30 Consiglio Nazionale Ricerche Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
US4791107A (en) 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
IT1225462B (it) 1987-04-03 1990-11-14 Mediolanum Farmaceutici Srl Sali organici di derivati della fisostigmina
US5187165A (en) 1987-05-15 1993-02-16 Hoechst-Roussel Pharmaceuticals Inc. Memory enhancing and analgesic 1,2,3a,8,8a-hexahydro-3a,8(and 1,3a,8)-di(and tri)methylpyrrolo[2,3-b]indoles
US4900748A (en) 1988-03-04 1990-02-13 The United States Of America As Represented By The Department Of Health And Human Services Carbamates related to (-)-physostigmine as cholinergic agents
US5260452A (en) 1989-11-03 1993-11-09 Hoechst-Roussel Pharmaceuticals Inc. 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
US5077289A (en) 1989-11-30 1991-12-31 Hoechst Roussel Pharmaceuticals Inc. Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine
US5177101A (en) 1989-11-30 1993-01-05 Hoechst-Roussel Pharmaceuticals Incorporated Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine
US5705657A (en) 1991-02-14 1998-01-06 Labochim Laboratorio Chimico Internazionale S.P.A. Isocyanate process for the preparation of 1,3A,8-trimethyl-1,2,3,3A, 8, 8A-hexahydro-pyrrole 2,3-B! indol-5 (3AS, 8AR) -hepthylcarbamate
EP0499959A1 (en) 1991-02-18 1992-08-26 Bromine Compounds Ltd. Process for the manufacture of substituted maleimides
ATE242244T1 (de) 1991-09-26 2003-06-15 Us Gov Health & Human Serv Substituierte phenserine und phenylcarbamate von (-)-eserolin, (-)-n1-noreserolin und (-)-n1- benzylnoresorolin als spezifische acetylcholinesterase-inhibitoren
US5206260A (en) 1991-11-07 1993-04-27 Merck & Co., Inc. Hexahydropyrrolo[2,3-b]indole derivatives
PH30885A (en) * 1992-07-21 1997-12-23 Hoechst Roussel Pharma Preparation of physostigmie carbamate derivatives from physostigmine.
US5302721A (en) 1992-07-21 1994-04-12 Hoechst-Roussel Pharmaceuticals Incorporated Method of preparation of physostigmine carbamate derivatives from eseretholes
US5409948A (en) 1992-11-23 1995-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating cognitive disorders with phenserine
US5665880A (en) 1996-10-31 1997-09-09 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseretholes
US5677457A (en) 1996-12-19 1997-10-14 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseroline ethers

Also Published As

Publication number Publication date
CA2470560C (en) 2007-05-15
KR100712003B1 (ko) 2007-05-02
US6495700B1 (en) 2002-12-17
CA2470560A1 (en) 2003-07-24
CN1612880A (zh) 2005-05-04
KR20060097772A (ko) 2006-09-15
HUP0500747A3 (en) 2009-05-28
BRPI0215492A2 (pt) 2016-07-05
KR20040072711A (ko) 2004-08-18
AU2002353102A1 (en) 2003-07-30
EP1463729B1 (en) 2010-04-28
JP2005514459A (ja) 2005-05-19
DE60236207D1 (de) 2010-06-10
IL162827A0 (en) 2005-11-20
HK1075659A1 (en) 2005-12-23
AU2002353102B2 (en) 2007-05-24
HUP0500747A2 (hu) 2005-11-28
HRP20040606A2 (en) 2004-12-31
EP1463729A1 (en) 2004-10-06
ATE466015T1 (de) 2010-05-15
WO2003059909A1 (en) 2003-07-24
CN1301995C (zh) 2007-02-28
EP1463729A4 (en) 2005-06-29

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Legal Events

Date Code Title Description
DISC Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications)