PL375113A1 - Casein derived peptides and uses thereof in therapy - Google Patents
Casein derived peptides and uses thereof in therapyInfo
- Publication number
- PL375113A1 PL375113A1 PL02375113A PL37511302A PL375113A1 PL 375113 A1 PL375113 A1 PL 375113A1 PL 02375113 A PL02375113 A PL 02375113A PL 37511302 A PL37511302 A PL 37511302A PL 375113 A1 PL375113 A1 PL 375113A1
- Authority
- PL
- Poland
- Prior art keywords
- peptides
- therapy
- casein
- derived peptides
- derived
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 239000005018 casein Substances 0.000 title abstract 3
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 title abstract 3
- 235000021240 caseins Nutrition 0.000 title abstract 3
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 230000004936 stimulating effect Effects 0.000 abstract 2
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 208000014951 hematologic disease Diseases 0.000 abstract 1
- 230000011132 hemopoiesis Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- AIDS & HIV (AREA)
- Marine Sciences & Fisheries (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Biologically active peptides that are derived from or are similar to sequences identical with the N-terminus of the S1 fraction of milk casein. These peptides are capable of stimulating and enhancing immune response, protecting against viral infection, normalizing serum cholesterol levels, and stimulating hematopoiesis. The casein-derived peptides are non-toxic and can be used to treat and prevent immune pathologies, hypercholesterolemia, hematological disorders and viral-related diseases.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/942,121 US20020147144A1 (en) | 2000-03-01 | 2001-08-30 | Casein derived peptides and uses thereof in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL375113A1 true PL375113A1 (en) | 2005-11-28 |
Family
ID=25477603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL02375113A PL375113A1 (en) | 2001-08-30 | 2002-08-29 | Casein derived peptides and uses thereof in therapy |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1556074A4 (en) |
| JP (1) | JP2005511499A (en) |
| KR (1) | KR20040078639A (en) |
| CN (1) | CN1694719A (en) |
| AU (1) | AU2002324323A2 (en) |
| BR (1) | BR0212625A (en) |
| CA (1) | CA2458924A1 (en) |
| CZ (1) | CZ2004335A3 (en) |
| HU (1) | HUP0500995A3 (en) |
| IL (1) | IL160548A0 (en) |
| MX (1) | MXPA04001890A (en) |
| NO (1) | NO20040880L (en) |
| PL (1) | PL375113A1 (en) |
| WO (1) | WO2003018606A2 (en) |
| ZA (1) | ZA200401574B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0313892D0 (en) * | 2003-06-16 | 2003-07-23 | Hannah Res Inst | Control of lactation |
| AU2005209845A1 (en) * | 2004-01-30 | 2005-08-18 | Chemgenex Pharmaceuticals, Inc. | Naphthalimide dosing by N-acetyl transferase genotyping |
| WO2005081628A2 (en) * | 2004-03-01 | 2005-09-09 | Peptera Pharmaceutical Ltd. | Casein derived peptides and therapeutic uses thereof |
| GB0423352D0 (en) * | 2004-10-21 | 2004-11-24 | Hannah Res Inst | "Control of mammary cell number" |
| ES2319475B1 (en) * | 2005-06-08 | 2010-02-16 | Consejo Superior Investig. Cientificas | BIOACTIVE PEPTIDES IDENTIFIED IN ENZYMATIC HYDROLYZES OF LACTEE CASEINS AND PROCEDURE OF OBTAINING. |
| CN101410131B (en) | 2006-06-09 | 2012-09-12 | 森永乳业株式会社 | Lipid-metabolism-improving agent |
| JP2011026213A (en) * | 2009-07-22 | 2011-02-10 | Snow Brand Milk Prod Co Ltd | Type 1 diabetes-inhibiting peptide |
| CA2870537A1 (en) * | 2012-04-16 | 2013-10-24 | The Cleveland Clinic Foundation | Multivalent breast cancer vaccine |
| CN110381964A (en) * | 2017-03-03 | 2019-10-25 | 森永乳业株式会社 | GLP-1 secretion enhancers and compositions |
| CN107814835B (en) * | 2017-12-01 | 2020-04-28 | 熊猫乳品集团股份有限公司 | Bioactive polypeptide AVPITPTLNREQ, and preparation method and application thereof |
| CN108017709B (en) * | 2017-12-12 | 2020-04-10 | 浙江辉肽生命健康科技有限公司 | Bioactive polypeptide KEPMIGVNQELA, and preparation method and application thereof |
| CN113952446B (en) * | 2021-09-03 | 2023-12-05 | 河南省医药科学研究院 | Application of bioactive peptide in inhibiting bone marrow toxicity |
| CN120815163B (en) * | 2025-09-16 | 2025-12-12 | 华中科技大学同济医学院附属同济医院 | Antitumor drug capable of inhibiting CCNB2 expression and application thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3778426A (en) * | 1970-12-16 | 1973-12-11 | Research Corp | Therapeutically useful polypeptides |
| JP4191261B2 (en) * | 1997-03-21 | 2008-12-03 | 雪印乳業株式会社 | Iron casein complex and its production method |
| IL134830A0 (en) * | 2000-03-01 | 2001-05-20 | Chay 13 Medical Res Group N V | Peptides and immunostimulatory and anti-bacterial pharmaceutical compositions containing them |
-
2002
- 2002-08-29 WO PCT/IL2002/000720 patent/WO2003018606A2/en not_active Ceased
- 2002-08-29 MX MXPA04001890A patent/MXPA04001890A/en not_active Application Discontinuation
- 2002-08-29 PL PL02375113A patent/PL375113A1/en not_active Application Discontinuation
- 2002-08-29 CA CA002458924A patent/CA2458924A1/en not_active Abandoned
- 2002-08-29 JP JP2003523265A patent/JP2005511499A/en active Pending
- 2002-08-29 IL IL16054802A patent/IL160548A0/en unknown
- 2002-08-29 HU HU0500995A patent/HUP0500995A3/en unknown
- 2002-08-29 EP EP02758768A patent/EP1556074A4/en not_active Withdrawn
- 2002-08-29 BR BRPI0212625-7A patent/BR0212625A/en not_active IP Right Cessation
- 2002-08-29 CZ CZ2004335A patent/CZ2004335A3/en unknown
- 2002-08-29 CN CNA028216741A patent/CN1694719A/en active Pending
- 2002-08-29 AU AU2002324323A patent/AU2002324323A2/en not_active Abandoned
- 2002-08-29 KR KR10-2004-7002884A patent/KR20040078639A/en not_active Withdrawn
-
2004
- 2004-02-26 ZA ZA200401574A patent/ZA200401574B/en unknown
- 2004-02-27 NO NO20040880A patent/NO20040880L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002324323A2 (en) | 2003-03-10 |
| CZ2004335A3 (en) | 2004-07-14 |
| WO2003018606A3 (en) | 2005-05-06 |
| IL160548A0 (en) | 2004-07-25 |
| BR0212625A (en) | 2007-06-19 |
| JP2005511499A (en) | 2005-04-28 |
| WO2003018606A9 (en) | 2004-04-08 |
| HUP0500995A3 (en) | 2008-09-29 |
| ZA200401574B (en) | 2007-02-28 |
| HUP0500995A2 (en) | 2007-05-02 |
| CA2458924A1 (en) | 2003-03-06 |
| MXPA04001890A (en) | 2004-06-18 |
| EP1556074A4 (en) | 2008-05-07 |
| CN1694719A (en) | 2005-11-09 |
| NO20040880L (en) | 2004-04-20 |
| WO2003018606A2 (en) | 2003-03-06 |
| EP1556074A2 (en) | 2005-07-27 |
| KR20040078639A (en) | 2004-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |