PL375443A1 - Sposób obniżenia poziomu agregatów w polietylenoglikolowanym białku - Google Patents

Sposób obniżenia poziomu agregatów w polietylenoglikolowanym białku

Info

Publication number
PL375443A1
PL375443A1 PL03375443A PL37544303A PL375443A1 PL 375443 A1 PL375443 A1 PL 375443A1 PL 03375443 A PL03375443 A PL 03375443A PL 37544303 A PL37544303 A PL 37544303A PL 375443 A1 PL375443 A1 PL 375443A1
Authority
PL
Poland
Prior art keywords
pegylated protein
aggregate levels
decreasing aggregate
decreasing
desired pegylated
Prior art date
Application number
PL03375443A
Other languages
English (en)
Other versions
PL212726B1 (pl
Inventor
Denis M. Boyle
John J. Buckley
Gary V. Johnson
David E. Steinmeyer
Michele Toal
Serdar Aykent
Anurag S. Rathore
Original Assignee
Pharmacia Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/646,798 external-priority patent/US20040048315A1/en
Application filed by Pharmacia Corporation filed Critical Pharmacia Corporation
Publication of PL375443A1 publication Critical patent/PL375443A1/pl
Publication of PL212726B1 publication Critical patent/PL212726B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/32—Extraction; Separation; Purification by precipitation as complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
PL375443A 2002-09-20 2003-09-22 Sposób obnizenia poziomu agregatu polietylenoglikolowanego antagonisty hormonu wzrostu B-2036 i jego izoform PL212726B1 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41222702P 2002-09-20 2002-09-20
US10/646,798 US20040048315A1 (en) 2002-08-28 2003-08-25 Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
US66288403A 2003-09-16 2003-09-16

Publications (2)

Publication Number Publication Date
PL375443A1 true PL375443A1 (pl) 2005-11-28
PL212726B1 PL212726B1 (pl) 2012-11-30

Family

ID=32034217

Family Applications (1)

Application Number Title Priority Date Filing Date
PL375443A PL212726B1 (pl) 2002-09-20 2003-09-22 Sposób obnizenia poziomu agregatu polietylenoglikolowanego antagonisty hormonu wzrostu B-2036 i jego izoform

Country Status (17)

Country Link
EP (1) EP1545428B1 (pl)
JP (1) JP4633463B2 (pl)
KR (1) KR101120130B1 (pl)
AT (1) ATE453662T1 (pl)
AU (1) AU2003272585B2 (pl)
BR (1) BRPI0314120B8 (pl)
CA (1) CA2498886C (pl)
DE (1) DE60330787D1 (pl)
DK (1) DK1545428T3 (pl)
ES (1) ES2337041T3 (pl)
HK (1) HK1079798B (pl)
IL (1) IL167538A (pl)
MX (1) MXPA05003121A (pl)
PL (1) PL212726B1 (pl)
PT (1) PT1545428E (pl)
SI (1) SI1545428T1 (pl)
WO (1) WO2004026251A2 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1715895A2 (en) * 2004-02-09 2006-11-02 Pharmacia Corporation Chemically-modified human growth hormone receptor antagonist conjugates
US8080391B2 (en) * 2004-12-22 2011-12-20 Ambrx, Inc. Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer
WO2011018515A1 (en) * 2009-08-14 2011-02-17 Novo Nordisk Health Care Ag Method of purifying pegylated proteins
DK2707383T3 (en) * 2011-05-13 2018-07-23 Biogen Ma Inc PROCEDURES FOR PREVENTION AND REMOVAL OF TRISULPHIDE BINDINGS
RU2014108241A (ru) 2011-08-25 2015-09-27 Ф.Хоффманн-Ля Рош Аг Способ катион- и анионобменной хроматографии
HRP20220041T1 (hr) * 2017-12-29 2022-04-15 F. Hoffmann - La Roche Ag Postupak za dobivanje pegiliranog proteinskog pripravka
CN112107880B (zh) * 2020-09-16 2022-08-09 珠海中科先进技术研究院有限公司 一种低共熔混合物及利用其萃取鲟鱼鱼籽蛋白质的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3641115A1 (de) * 1986-12-02 1988-06-16 Lentia Gmbh Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins
US5153265A (en) * 1988-01-20 1992-10-06 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
US5969109A (en) * 1990-02-28 1999-10-19 Bona; Constantin Chimeric antibodies comprising antigen binding sites and B and T cell epitopes
DK44593D0 (da) * 1993-04-20 1993-04-20 Novo Nordisk As Fremgangsmaade til fremstilling af et polypeptid
ZA955789B (en) * 1994-07-15 1996-03-11 Novo Nordisk As A method of converting a hydrophobic derivative of a polypeptide into the native form
WO1996040731A1 (en) * 1995-06-07 1996-12-19 Mount Sinai School Of Medicine Of The City University Of New York Pegylated modified proteins
JP3628333B2 (ja) * 1995-09-21 2005-03-09 ジェネンテック インコーポレーテッド ヒト成長ホルモン変異体
SE9802454D0 (sv) * 1998-07-08 1998-07-08 Pharmacia & Upjohn Ab Production of peptides
SE9904502D0 (sv) * 1999-12-09 1999-12-09 Pharmacia & Upjohn Ab Production of peptides

Also Published As

Publication number Publication date
CA2498886A1 (en) 2004-04-01
PT1545428E (pt) 2010-02-25
AU2003272585B2 (en) 2009-12-10
WO2004026251A2 (en) 2004-04-01
HK1079798B (zh) 2010-11-19
EP1545428B1 (en) 2009-12-30
SI1545428T1 (sl) 2010-03-31
CA2498886C (en) 2013-06-25
KR101120130B1 (ko) 2012-04-18
DK1545428T3 (da) 2010-05-03
PL212726B1 (pl) 2012-11-30
JP2006516021A (ja) 2006-06-15
HK1079798A1 (zh) 2006-04-13
IL167538A (en) 2015-10-29
BR0314120A (pt) 2005-07-12
BRPI0314120B8 (pt) 2021-05-25
ES2337041T3 (es) 2010-04-20
DE60330787D1 (de) 2010-02-11
EP1545428A2 (en) 2005-06-29
ATE453662T1 (de) 2010-01-15
WO2004026251A3 (en) 2004-09-02
KR20050046011A (ko) 2005-05-17
EP1545428A4 (en) 2006-03-01
MXPA05003121A (es) 2005-06-22
JP4633463B2 (ja) 2011-02-16
BRPI0314120B1 (pt) 2020-12-29
AU2003272585A1 (en) 2004-04-08

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