PL376154A1 - Pochodne triazaspiro[5.5]undekanu i leki zawierające te pochodne jako składnik aktywny - Google Patents
Pochodne triazaspiro[5.5]undekanu i leki zawierające te pochodne jako składnik aktywnyInfo
- Publication number
- PL376154A1 PL376154A1 PL03376154A PL37615403A PL376154A1 PL 376154 A1 PL376154 A1 PL 376154A1 PL 03376154 A PL03376154 A PL 03376154A PL 37615403 A PL37615403 A PL 37615403A PL 376154 A1 PL376154 A1 PL 376154A1
- Authority
- PL
- Poland
- Prior art keywords
- triazaspiro
- drugs
- same
- active ingredient
- undecane derivatives
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- RSJKGSCJYJTIGS-BJUDXGSMSA-N undecane Chemical class CCCCCCCCCC[11CH3] RSJKGSCJYJTIGS-BJUDXGSMSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- AIDS & HIV (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002270849 | 2002-09-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL376154A1 true PL376154A1 (pl) | 2005-12-27 |
Family
ID=32024865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL03376154A PL376154A1 (pl) | 2002-09-18 | 2003-09-17 | Pochodne triazaspiro[5.5]undekanu i leki zawierające te pochodne jako składnik aktywny |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20050267114A1 (pl) |
| EP (1) | EP1541574A4 (pl) |
| JP (1) | JPWO2004026873A1 (pl) |
| KR (1) | KR20050057408A (pl) |
| CN (1) | CN1688577A (pl) |
| AU (1) | AU2003272879A1 (pl) |
| BR (1) | BR0314304A (pl) |
| CA (1) | CA2497903A1 (pl) |
| MX (1) | MXPA05002771A (pl) |
| NO (1) | NO20051379L (pl) |
| PL (1) | PL376154A1 (pl) |
| RU (1) | RU2005111225A (pl) |
| TW (1) | TW200413372A (pl) |
| WO (1) | WO2004026873A1 (pl) |
| ZA (1) | ZA200502222B (pl) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003271057A1 (en) * | 2002-09-18 | 2004-04-08 | Ono Pharmaceutical Co., Ltd. | Novel crystals of triazaspiro(5.5)undecane derivative |
| WO2004080966A1 (ja) * | 2003-03-14 | 2004-09-23 | Ono Pharmaceutical Co., Ltd. | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
| JPWO2004094424A1 (ja) * | 2003-04-21 | 2006-07-13 | 小野薬品工業株式会社 | 含窒素複素環化合物およびその用途 |
| US7498346B2 (en) * | 2003-12-11 | 2009-03-03 | Genzyme Corporation | Chemokine receptor binding compounds |
| NZ553696A (en) | 2004-09-13 | 2010-02-26 | Ono Pharmaceutical Co | Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient |
| GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
| GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
| GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| CN101163690A (zh) | 2005-04-20 | 2008-04-16 | 默克公司 | 苯并噻吩异羟肟酸衍生物 |
| EP1874295A4 (en) | 2005-04-20 | 2009-08-12 | Merck & Co Inc | benzothiophene |
| EP1874294A4 (en) | 2005-04-20 | 2010-12-01 | Merck Sharp & Dohme | BENZOTHIOPHENO HYDROXAMIDIC DERIVATIVES WITH CARBAMATE, UREA, AMID AND SULPHONAMIDE SUBSTITUTIONS |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| US20110052612A1 (en) * | 2005-05-31 | 2011-03-03 | Ono Pharmaceutical Co., Ltd. | Spiropiperidine compound and medicinal use thereof |
| JP2008546793A (ja) | 2005-06-24 | 2008-12-25 | メルク エンド カムパニー インコーポレーテッド | 修飾マロン酸誘導体 |
| US7910708B2 (en) | 2005-10-21 | 2011-03-22 | Novartis Ag | Anti-IL13 human antibodies |
| AR057579A1 (es) | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| GB0526244D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| CA2642813A1 (en) | 2006-02-28 | 2007-09-07 | Merck & Co., Inc. | Inhibitors of histone deacetylase |
| WO2007105637A1 (ja) * | 2006-03-10 | 2007-09-20 | Ono Pharmaceutical Co., Ltd. | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
| ATE549337T1 (de) | 2006-04-21 | 2012-03-15 | Novartis Ag | Purinderivate zur verwendung als adenosin-a2a- rezeptoragonisten |
| CA2649861A1 (en) | 2006-04-26 | 2007-11-08 | Merck & Co., Inc. | Disubstituted aniline compounds |
| JP2009537529A (ja) | 2006-05-18 | 2009-10-29 | メルク エンド カムパニー インコーポレーテッド | アリール縮合スピロ環化合物 |
| JP2009544611A (ja) | 2006-07-20 | 2009-12-17 | メルク エンド カムパニー インコーポレーテッド | ヒストン脱アセチル化酵素阻害剤としてのリン誘導体 |
| CA2662766C (en) * | 2006-09-08 | 2011-08-09 | Pfizer Products Inc. | Diaryl ether derivatives and uses thereof |
| KR20090073121A (ko) | 2006-09-29 | 2009-07-02 | 노파르티스 아게 | Pi3k 지질 키나제 억제제로서의 피라졸로피리미딘 |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| RS51644B (sr) | 2007-01-10 | 2011-10-31 | Irm Llc. | Jedinjenja i preparati kao inhibitori kanal aktivirajuće proteaze |
| EP2128163A1 (en) * | 2007-01-25 | 2009-12-02 | Takeda Pharmaceutical Company Limited | Spiro-ring compound |
| RU2320660C1 (ru) * | 2007-01-31 | 2008-03-27 | Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" | 1-АРОИЛОКСИ-4-ГИДРОКСИ-3-ОКСО-1,2,3,4,4а,5,6,7,8,8а-ДЕКАГИДРОХИНОКСАЛИН-2-СПИРО(1-о-ГИДРОКСИФЕНИЛ-4,5-ДИОКСО-2,3,4,5-ТЕТРАГИДРОПИРРОЛЫ) И СПОСОБ ИХ ПОЛУЧЕНИЯ |
| KR20100005730A (ko) | 2007-05-07 | 2010-01-15 | 노파르티스 아게 | 유기 화합물 |
| US8461189B2 (en) | 2007-06-27 | 2013-06-11 | Merck Sharp & Dohme Corp. | Pyridyl derivatives as histone deacetylase inhibitors |
| AU2008269154B2 (en) | 2007-06-27 | 2014-06-12 | Merck Sharp & Dohme Llc | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
| EA017919B1 (ru) | 2007-12-10 | 2013-04-30 | Новартис Аг | Производные пиразин-2-карбоксамида для лечения заболеваний, которые поддаются лечению путем блокирования эпителиальных натриевых каналов |
| KR20110040818A (ko) | 2008-06-10 | 2011-04-20 | 노파르티스 아게 | 상피 나트륨 채널 차단제로서의 피라진 유도체 |
| WO2010009196A1 (en) * | 2008-07-15 | 2010-01-21 | Temple University Of The Commonwealth System Of Higher Education | Synthesis of bis-peptides oligomers comprising at least one n-substituted diketopiperazine as structural moiety |
| PL2391366T3 (pl) | 2009-01-29 | 2013-04-30 | Novartis Ag | Podstawione benzimidazole do leczenia gwiaździaków |
| TW201035088A (en) | 2009-02-27 | 2010-10-01 | Supergen Inc | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors |
| SG176628A1 (en) | 2009-06-05 | 2012-01-30 | Link Medicine Corp | Aminopyrrolidinone derivatives and uses thereof |
| US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
| EA201200260A1 (ru) | 2009-08-12 | 2012-09-28 | Новартис Аг | Гетероциклические гидразоны и их применение для лечения рака и воспаления |
| MY162604A (en) | 2009-08-17 | 2017-06-30 | Intellikine Llc | Heterocyclic compounds and uses thereof |
| MX2012002179A (es) | 2009-08-20 | 2012-03-16 | Novartis Ag | Compuestos heterociclicos de oxima. |
| EP2813227A1 (en) | 2009-10-22 | 2014-12-17 | Vertex Pharmaceuticals Incorporated | Compositions for treatment of cystic fibrosis and other chronic diseases |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| CN105130948A (zh) | 2010-04-22 | 2015-12-09 | 弗特克斯药品有限公司 | 制备环烷基甲酰胺基-吲哚化合物的方法 |
| WO2011143444A2 (en) * | 2010-05-14 | 2011-11-17 | President And Fellows Of Harvard College | Diphenylbutypiperidine autophagy inducers |
| RS55856B1 (sr) | 2010-07-14 | 2017-08-31 | Novartis Ag | Heterociklična jedinjenja agonisti ip receptora |
| US8372845B2 (en) | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
| JP2014505088A (ja) | 2011-02-10 | 2014-02-27 | ノバルティス アーゲー | C−METチロシンキナーゼ阻害剤としての[1,2,4]トリアゾロ[4,3−b]ピリダジン化合物 |
| EP2678016B1 (en) | 2011-02-23 | 2016-08-10 | Intellikine, LLC | Heterocyclic compounds and uses thereof |
| US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
| UY34329A (es) | 2011-09-15 | 2013-04-30 | Novartis Ag | Compuestos de triazolopiridina |
| WO2013038373A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
| WO2013038378A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
| WO2013038381A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine/pyrazine amide derivatives |
| WO2013038386A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Heterocyclic compounds for the treatment of cystic fibrosis |
| ES2882807T3 (es) | 2011-09-16 | 2021-12-02 | Novartis Ag | Heterociclil carboxamidas N-sustituidas |
| US20130209543A1 (en) | 2011-11-23 | 2013-08-15 | Intellikine Llc | Enhanced treatment regimens using mtor inhibitors |
| WO2013105063A1 (en) | 2012-01-13 | 2013-07-18 | Novartis Ag | Fused piperidines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders |
| EP2802585A1 (en) | 2012-01-13 | 2014-11-19 | Novartis AG | Fused piperidines as ip receptor agonists for the treatment of pah and related disorders |
| CN104053659B (zh) | 2012-01-13 | 2016-11-09 | 诺华股份有限公司 | 用于治疗肺动脉高压(pah)及相关病症的作为ip 受体激动剂的稠合的吡咯类 |
| US20140357641A1 (en) | 2012-01-13 | 2014-12-04 | Novartis Ag | IP receptor agonist heterocyclic compounds |
| EP2802581A1 (en) | 2012-01-13 | 2014-11-19 | Novartis AG | 7,8- dihydropyrido [3, 4 - b]pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders |
| ES2561353T3 (es) | 2012-01-13 | 2016-02-25 | Novartis Ag | Sales de un agonista del receptor IP |
| RU2502738C2 (ru) * | 2012-02-07 | 2013-12-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" | 1,6'-ДИАРИЛ-3-АРОИЛ-4-ГИДРОКСИ-1',3'-ДИМЕТИЛСПИРО[ПИРРОЛ-2,5'-ПИРРОЛО[2,3-d]ПИРИМИДИН]-2',4',5(1Н,1'Н,3'Н)-ТРИОНЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
| US8809340B2 (en) | 2012-03-19 | 2014-08-19 | Novartis Ag | Crystalline form |
| CN110507654A (zh) | 2012-04-03 | 2019-11-29 | 诺华有限公司 | 有酪氨酸激酶抑制剂的组合产品和其应用 |
| EP2956455B1 (en) | 2013-02-13 | 2017-05-17 | Novartis AG | Ip receptor agonist heterocyclic compounds |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| EP2968340A4 (en) | 2013-03-15 | 2016-08-10 | Intellikine Llc | COMBINING KINASE INHIBITORS AND USES THEREOF |
| WO2015084804A1 (en) | 2013-12-03 | 2015-06-11 | Novartis Ag | Combination of mdm2 inhibitor and braf inhibitor and their use |
| JP6543268B2 (ja) | 2014-04-15 | 2019-07-10 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | 嚢胞性線維症膜コンダクタンス調節因子が媒介する疾患を処置するための医薬組成物 |
| US10112926B2 (en) | 2014-04-24 | 2018-10-30 | Novartis Ag | Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors |
| PL3134395T3 (pl) | 2014-04-24 | 2018-07-31 | Novartis Ag | Pochodne pirazyny jako inhibitory 3-kinazy fosfatydyloinozytolu |
| EP3134397A1 (en) | 2014-04-24 | 2017-03-01 | Novartis AG | Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
| WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
| KR20170036037A (ko) | 2014-07-31 | 2017-03-31 | 노파르티스 아게 | 조합 요법 |
| WO2016140501A1 (en) * | 2015-03-04 | 2016-09-09 | Kainos Medicine, Inc. | Pyridine n-oxide for enhancer of zeste homolog 2 inhibitors |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| KR102526964B1 (ko) | 2018-02-26 | 2023-04-28 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 복제 억제제로서의 치환된 피롤리진 화합물 |
| TW202110844A (zh) * | 2019-06-04 | 2021-03-16 | 日商第一三共股份有限公司 | 具有二螺二酮哌構造之化合物 |
| EP3980121A1 (en) | 2019-06-10 | 2022-04-13 | Novartis AG | Pyridine and pyrazine derivative for the treatment of cf, copd, and bronchiectasis |
| PH12022550468A1 (en) | 2019-08-28 | 2023-03-06 | Novartis Ag | Substituted 1,3-phenyl heteroaryl derivatives and their use in the treatment of disease |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001508798A (ja) * | 1997-01-21 | 2001-07-03 | メルク エンド カンパニー インコーポレーテッド | ケモカインレセプター活性のモジュレーターとしての3,3−二置換ピペリジン類 |
| US6288083B1 (en) * | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| PT1236726E (pt) * | 1999-12-03 | 2005-04-29 | Ono Pharmaceutical Co | Derivados de triazaespiro[5.5]undecano e farmacos que os contem como ingrediente activo |
| IL157940A0 (en) * | 2001-03-19 | 2004-03-28 | Ono Pharmaceutical Co | Drugs containing triazaspiro [5.5] undecane derivatives as the active ingredient |
| RU2269528C2 (ru) * | 2001-03-19 | 2006-02-10 | Оно Фармасьютикал Ко., Лтд. | Производные триазаспиро [5.5] ундекана и фармацевтическая композиция, включающая его в качестве активного ингредиента |
| JP2002348288A (ja) * | 2001-05-28 | 2002-12-04 | Ono Pharmaceut Co Ltd | スピロ複素環誘導体およびそれらを有効成分とする薬剤 |
| BR0213372A (pt) * | 2001-10-23 | 2005-02-01 | Ono Pharmaceutical Co | Medicamento compreendendo combinação de derivado de traizaespiro[5,5]undecano com inibidor de citocromo p450 isozima 3a4 e/ou inibidor de glocoproteìna-p |
| AU2003240742A1 (en) * | 2002-06-07 | 2003-12-22 | Altana Pharma Ag | 4,5-dihydro-imidazo (4,5,1-ij) quinolin-6-ones derivatives and their use as poly (adp-ribosyl) transferase (parp) inhibitors |
| WO2004024683A2 (en) * | 2002-09-13 | 2004-03-25 | University Of Maryland Biotechnology | COMPOSITIONS FOR INDUCING INCREASED LEVELS OF β-CHEMOKINES AND METHODS OF USE THEREFOR |
| AU2003271057A1 (en) * | 2002-09-18 | 2004-04-08 | Ono Pharmaceutical Co., Ltd. | Novel crystals of triazaspiro(5.5)undecane derivative |
| US7556806B2 (en) * | 2002-10-11 | 2009-07-07 | University Of Maryland Biotechnology Institute | Carbohydrate-based synthetic vaccines for HIV |
| EP1553098A1 (en) * | 2002-10-18 | 2005-07-13 | Ono Pharmaceutical Co., Ltd. | Spiroheterocyclic derivative compounds and drugs comprising the compounds as the active ingredient |
| JP4710606B2 (ja) * | 2003-04-18 | 2011-06-29 | 小野薬品工業株式会社 | スピロピペリジン化合物およびその医薬用途 |
| JPWO2004098638A1 (ja) * | 2003-05-06 | 2006-07-13 | 小野薬品工業株式会社 | エフェクター細胞機能阻害剤 |
| BRPI0410360A (pt) * | 2003-05-16 | 2006-08-01 | Univ Maryland Biotech Inst | composições para a sub-regulação da expressão de ccr5 e métodos para seu uso |
| CA2573951A1 (en) * | 2003-07-18 | 2005-01-27 | Virochem Pharma Inc. | Spiro compounds and methods for the modulation of chemokine receptor activity |
| IL157398A0 (en) * | 2003-08-14 | 2004-02-19 | Hadasit Med Res Service | Pharmaceutical compositions comprising ccr5 antagonists |
-
2003
- 2003-09-17 KR KR1020057004600A patent/KR20050057408A/ko not_active Withdrawn
- 2003-09-17 WO PCT/JP2003/011834 patent/WO2004026873A1/ja not_active Ceased
- 2003-09-17 PL PL03376154A patent/PL376154A1/pl not_active Application Discontinuation
- 2003-09-17 EP EP03753933A patent/EP1541574A4/en not_active Withdrawn
- 2003-09-17 TW TW092125573A patent/TW200413372A/zh unknown
- 2003-09-17 JP JP2004537582A patent/JPWO2004026873A1/ja not_active Withdrawn
- 2003-09-17 CA CA002497903A patent/CA2497903A1/en not_active Abandoned
- 2003-09-17 RU RU2005111225/04A patent/RU2005111225A/ru not_active Application Discontinuation
- 2003-09-17 AU AU2003272879A patent/AU2003272879A1/en not_active Abandoned
- 2003-09-17 MX MXPA05002771A patent/MXPA05002771A/es unknown
- 2003-09-17 US US10/527,435 patent/US20050267114A1/en not_active Abandoned
- 2003-09-17 BR BR0314304-0A patent/BR0314304A/pt not_active IP Right Cessation
- 2003-09-17 CN CNA038243865A patent/CN1688577A/zh active Pending
-
2005
- 2005-03-16 ZA ZA200502222A patent/ZA200502222B/en unknown
- 2005-03-16 NO NO20051379A patent/NO20051379L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004026873A1 (ja) | 2004-04-01 |
| NO20051379L (no) | 2005-06-17 |
| EP1541574A1 (en) | 2005-06-15 |
| JPWO2004026873A1 (ja) | 2006-01-19 |
| RU2005111225A (ru) | 2005-08-27 |
| AU2003272879A1 (en) | 2004-04-08 |
| CA2497903A1 (en) | 2004-04-01 |
| ZA200502222B (en) | 2005-12-28 |
| KR20050057408A (ko) | 2005-06-16 |
| US20050267114A1 (en) | 2005-12-01 |
| BR0314304A (pt) | 2005-07-26 |
| MXPA05002771A (es) | 2005-06-06 |
| TW200413372A (en) | 2004-08-01 |
| CN1688577A (zh) | 2005-10-26 |
| EP1541574A4 (en) | 2007-06-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2002238947A1 (en) | Triazaspiro[5.5]undecane derivatives and drugs containing the same as the active ingredient | |
| IL157940A0 (en) | Drugs containing triazaspiro [5.5] undecane derivatives as the active ingredient | |
| AU3076700A (en) | 2h-phthalazin-1-one derivatives and drugs comprising these derivatives as the active ingredient | |
| IL191960A (en) | History of imidazo [5,1– a] pyridine and pharmaceutical preparations containing them | |
| IL163866A0 (en) | 8-Azaprostaglandin derivative compounds and drugs containing the compounds s active ingredient | |
| IL164699A0 (en) | Diketohydrazine derivative compounds and drugs containing the compounds as the active ingredient | |
| AU2002354054A1 (en) | Spiroheterocyclic derivative compounds and drugs comprising the compounds as the active ingredient | |
| IL202190A0 (en) | Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient | |
| AU7962200A (en) | Novel indole derivatives and drugs containing the same as the active ingredient | |
| HUP0204170A3 (en) | 5-thia-omega-substituted phenyl-prostaglandin e derivatives, process for producing the same and drugs containing the same as the active ingredient | |
| AU2002226674A1 (en) | Tricyclic and heterocyclic derivative compounds and drugs containing these compounds as the active ingredient | |
| PL373223A1 (pl) | Pochodne 7,8,9,10-tetrahydro-6H-azepino-6,7,8,9-tetrahydropirydo-i 2,3-dihydro-2H-pirolo [2,1-b]-chinazolinonu | |
| EP1557415A4 (en) | Heterocyclic compounds and antitumor agents containing them as an active ingredient | |
| ZA200410211B (en) | Quinuclidine derivatives and pharmaceutical compositions containing the same. | |
| IL156536A0 (en) | Pyrazolo [3,4-d] pyrimidin-4-one derivatives and pharmaceutical compositions containing the same | |
| ZA200007415B (en) | Amino acid derivatives and drugs containing the same as the active ingredient. | |
| AU6309698A (en) | Drugs containing aminopyridine derivatives as the active ingredient | |
| AU2001277738A1 (en) | Piperidine derivatives and drugs containing these derivatives as the active ingredient | |
| AU1650401A (en) | Oxadiazole derivatives and drugs containing these derivatives as the active ingredient | |
| AU2001228810A1 (en) | Benzene-fused heterocycle derivatives and drugs containing the same as the active ingredient | |
| TWI320413B (en) | 1,4-diazabicyclo [ 3.2.2 ] nonanecarboxamide derivatives, preparation thereof and therapeutic use thereof | |
| AU1650501A (en) | 1,3,4-oxadiazoline derivatives and drugs containing these derivatives as the active ingredient | |
| AU2023801A (en) | Dihalopropenyloxybenzene derivatives and pesticides containing the same as the active ingredient | |
| HUP0104238A3 (en) | Benzoxazole derivatives and drugs containing the same as the active ingredient and their use | |
| AU1556601A (en) | 1,3,4-oxadiazolin-2-one derivatives and drugs containing these derivatives as the active ingredient |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |