PL377467A1 - Aromatyczne związki jako środki przeciwzapalne, immunomodulujące i antyproliferacyjne - Google Patents

Aromatyczne związki jako środki przeciwzapalne, immunomodulujące i antyproliferacyjne

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Publication number
PL377467A1
PL377467A1 PL377467A PL37746703A PL377467A1 PL 377467 A1 PL377467 A1 PL 377467A1 PL 377467 A PL377467 A PL 377467A PL 37746703 A PL37746703 A PL 37746703A PL 377467 A1 PL377467 A1 PL 377467A1
Authority
PL
Poland
Prior art keywords
immunomodulatory
inflammatory
aromatic compounds
proliferatory
agents
Prior art date
Application number
PL377467A
Other languages
English (en)
Other versions
PL209303B1 (pl
Inventor
Johann Leban
Stefan Tasler
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Publication of PL377467A1 publication Critical patent/PL377467A1/pl
Publication of PL209303B1 publication Critical patent/PL209303B1/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
PL377467A 2002-12-23 2003-12-17 Związek aromatyczny, kompozycja farmaceutyczna zawierająca związek aromatyczny i zastosowanie związku aromatycznego jako środka przeciwzapalnego, immunomodulującego i antyproliferacyjnego PL209303B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10260800 2002-12-23

Publications (2)

Publication Number Publication Date
PL377467A1 true PL377467A1 (pl) 2006-02-06
PL209303B1 PL209303B1 (pl) 2011-08-31

Family

ID=32667540

Family Applications (2)

Application Number Title Priority Date Filing Date
PL377467A PL209303B1 (pl) 2002-12-23 2003-12-17 Związek aromatyczny, kompozycja farmaceutyczna zawierająca związek aromatyczny i zastosowanie związku aromatycznego jako środka przeciwzapalnego, immunomodulującego i antyproliferacyjnego
PL377478A PL377478A1 (pl) 2002-12-23 2003-12-17 Cykloalkenowe kwasy dikarboksylowe jako środki przeciwzapalne, immunomodulujące oraz antyproliferacyjne

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL377478A PL377478A1 (pl) 2002-12-23 2003-12-17 Cykloalkenowe kwasy dikarboksylowe jako środki przeciwzapalne, immunomodulujące oraz antyproliferacyjne

Country Status (22)

Country Link
EP (3) EP2283898A1 (pl)
JP (3) JP2006514023A (pl)
KR (1) KR101107456B1 (pl)
CN (3) CN1732147A (pl)
AT (2) ATE450498T1 (pl)
AU (2) AU2003293914B2 (pl)
BR (2) BR0317731A (pl)
CA (2) CA2509138A1 (pl)
CY (1) CY1111851T1 (pl)
DE (1) DE60330391D1 (pl)
DK (1) DK1578741T3 (pl)
ES (1) ES2368735T3 (pl)
IL (2) IL169184A (pl)
MX (2) MXPA05006890A (pl)
NO (2) NO20052907L (pl)
NZ (1) NZ541382A (pl)
PL (2) PL209303B1 (pl)
PT (1) PT1578741E (pl)
RU (2) RU2367650C2 (pl)
SI (1) SI1578741T1 (pl)
WO (1) WO2004056797A1 (pl)
ZA (1) ZA200504387B (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2362771A1 (en) * 2008-11-07 2011-09-07 4Sc Ag Combinational therapy comprising dhodh inhibitor and methotrexate for treating autoimmune disease
RU2389724C1 (ru) * 2008-12-25 2010-05-20 Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" 4-(4-метилфенил)-4-оксо-2-[3-этоксикарбонил-4,5-r2,r1-тиофен-2-иламино]бут-2-еновые кислоты, обладающие противовоспалительной и анальгетической активностью
TWI530286B (zh) * 2009-05-04 2016-04-21 帕納特斯製藥格斯有限公司 作為抑制病毒化合物之抗發炎劑
US8686048B2 (en) 2010-05-06 2014-04-01 Rhizen Pharmaceuticals Sa Immunomodulator and anti-inflammatory compounds
US20140031383A1 (en) 2011-02-08 2014-01-30 Dana-Farber Cancer Institute, Inc. Methods for treatment of melanoma
RU2485112C1 (ru) * 2012-04-26 2013-06-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" 4-(4-бромфенил)-4-оксо-2-{[3-(этоксикарбонил)-4,5-диметилтиен-2-ил]амино}-2-бутеновая кислота, обладающая противовоспалительной и анальгетической активностью
MX2016013341A (es) 2014-04-11 2017-09-01 Panoptes Pharma Gmbh Agentes antiinflamatorios como compuestos virostaticos.
HK1231417A1 (zh) * 2014-05-08 2017-12-22 帕诺泰斯制药有限公司 用於治疗眼科疾病和障碍的化合物
KR20190093205A (ko) 2016-12-21 2019-08-08 바이오테릭스, 인코포레이티드 단백질 표적화에 사용하기 위한 티에노피롤 유도체, 조성물, 방법 및 이의 용도
IL276918B2 (en) 2018-03-09 2024-10-01 Panoptes Pharma Ges M B H Ophthalmic formulation comprising albumin and an active compound
JP7358373B2 (ja) 2018-03-16 2023-10-10 イミュニック アクチェンゲゼルシャフト 抗炎症薬、免疫調節薬及び抗増殖薬としての新規カルシウム塩多形
WO2022167402A1 (en) 2021-02-02 2022-08-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of therapy comprising administering a therapeutically effective combination comprising a dhodh inhibitor and an idh inhibitor
CA3215002A1 (en) 2021-04-09 2022-10-13 Christian Gege Deuterated dhodh inhibitors
UY40087A (es) * 2021-12-23 2023-06-30 Immunic Ag Inhibidores de DHODH que contienen un bioisóstero de ácido carboxílico.
IL315335A (en) * 2022-03-01 2024-10-01 Kiora Pharmaceuticals Gmbh salts of dehydrogenase inhibitor (DHOD)
WO2023172818A1 (en) * 2022-03-09 2023-09-14 Kiora Pharmaceuticals Gmbh Polymorphs of a dihydroorotate dehydrogenase (dhod) inhibitor
TW202444688A (zh) 2023-03-29 2024-11-16 德商埃慕尼克股份公司 作為nurr1激動劑之維多氟地莫(vidofludimus)及相關結構
PY2454653A (es) 2023-06-28 2025-04-21 Immunic Ag Inhibidores de dhodh heteroaromáticos
WO2025215126A1 (en) 2024-04-12 2025-10-16 Immunic Ag Synthesis of vidofludimus and its calcium salt

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL186239B (nl) 1975-06-05 Hoechst Ag Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
AU1526483A (en) * 1982-06-14 1983-12-22 Nippon Kayaku Kabushiki Kaisha N-substituted-3,4,5,6-tetrahydrophthalamic acids
ZA839187B (en) * 1982-12-10 1984-07-25 Ciba Geigy Ag Amide compounds
JPS59118750A (ja) * 1982-12-27 1984-07-09 Eisai Co Ltd カルボン酸アミド化合物およびその誘導体
GB8311519D0 (en) * 1983-04-27 1983-06-02 Fisons Plc Nitrogen heterocycles
GB8323293D0 (en) * 1983-08-31 1983-10-05 Zyma Sa Substituted flavene and thioflavene derivatives
DE3402026A1 (de) 1984-01-21 1985-07-25 Basf Ag, 6700 Ludwigshafen Neue 2-aminothiophenderivate
DE3534440A1 (de) 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
DE3812225A1 (de) * 1988-04-13 1989-10-26 Basf Ag Isoxazol(isothiazol)-5-carbonsaeureamide
DE59009528D1 (de) * 1989-09-22 1995-09-21 Basf Ag Carbonsäureamide.
DE3932052A1 (de) * 1989-09-26 1991-04-04 Basf Ag Oxazol- bzw. thiazolcarbonsaeureamide
DE3933573A1 (de) * 1989-10-07 1991-04-18 Basf Ag Carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
DE59106349D1 (de) 1990-06-23 1995-10-05 Basf Ag Dicarbonsäureimide als Herbizide.
DE4023048A1 (de) * 1990-07-20 1992-01-23 Basf Ag Dicarbonsaeureimide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
DE4108181A1 (de) * 1991-03-14 1992-09-17 Basf Ag Isoxazol- und isothiazol-5-carbonsaeureamide
EP0633771A4 (en) * 1992-04-02 1995-02-22 Smithkline Beecham Corporation Compounds.
JP3055365B2 (ja) * 1993-06-30 2000-06-26 東洋インキ製造株式会社 ２，５−ジ（アリールアミノ）−３，６−ジヒドロテレフタル酸ジアルキルエステル類の製造法およびこれを中間体とするキナクリドン類の製造法
GB9320299D0 (en) 1993-10-01 1993-11-17 Roussel Lab Ltd Isoxazole derivatives
DE19547648A1 (de) 1995-12-20 1997-06-26 Hoechst Ag Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate
DE19610955A1 (de) 1996-03-20 1997-09-25 Hoechst Ag Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid
CN1234029A (zh) * 1996-08-27 1999-11-03 盐野义制药株式会社 色烯－3－羚酸衍生物
US6187797B1 (en) * 1996-12-23 2001-02-13 Dupont Pharmaceuticals Company Phenyl-isoxazoles as factor XA Inhibitors
AU730224B2 (en) * 1996-12-23 2001-03-01 Du Pont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
CA2276034A1 (en) * 1996-12-23 1998-07-02 Mimi Lifen Quan Oxygen or sulfur containing 5-membered heteroaromatics as factor xa inhibitors
US6020357A (en) * 1996-12-23 2000-02-01 Dupont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
IL133526A0 (en) * 1997-06-19 2001-04-30 Du Pont Pharm Co Inhibitors of factor xa with a neutral p1 specificity group
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
WO1999038846A1 (en) 1998-01-30 1999-08-05 Procept, Inc. Immunosuppressive agents
GB9804343D0 (en) 1998-02-27 1998-04-22 Univ Cardiff Chemical compounds
EP1127054A4 (en) * 1998-10-29 2006-11-02 Bristol Myers Squibb Co INHIBITORS OF IMPDH ENZYME
CZ20014679A3 (cs) * 1999-06-24 2002-04-17 Nihon Nohyaku Co., Ltd. Diamidové deriváty heterocyklické dikarboxylové kyseliny, zemědělské a zahradnické insekticidy a způsob jejich pouľití
JP4706810B2 (ja) * 1999-06-24 2011-06-22 日本農薬株式会社 ピリジン環ジカルボン酸ジアミド誘導体及び農園芸用殺虫剤並びにその使用方法
WO2001021160A2 (en) * 1999-09-23 2001-03-29 Axxima Pharmaceuticals Aktiengesellschaft Carboxymide and aniline derivatives as selective inhibitors of pathogens
AU7622000A (en) 1999-10-01 2001-05-10 Institute Of Molecular And Cell Biology Compounds for the treatment of viral-mediated diseases
EP1652839A3 (en) * 1999-10-28 2006-07-05 Daiichi Pharmaceutical Co., Ltd. Drug efflux pump inhibitor
WO2001032628A1 (en) * 1999-11-03 2001-05-10 Bristol-Myers Squibb Pharma Company Cyano compounds as factor xa inhibitors
AU2001268711A1 (en) * 2000-06-23 2002-01-08 Bristol-Myers Squibb Pharma Company Heteroaryl-phenyl substituted factor xa inhibitors
RU2181270C1 (ru) 2000-07-21 2002-04-20 Общество с ограниченной ответственностью "Медицинское предприятие "ХИТ плюс" Способ повреждения термонетолерантных патологических биоструктур организма теплокровных
JP2002128768A (ja) * 2000-10-26 2002-05-09 Dai Ichi Seiyaku Co Ltd 薬剤排出ポンプ阻害作用を有する化合物
JP2002322054A (ja) * 2001-04-26 2002-11-08 Dai Ichi Seiyaku Co Ltd 薬剤排出ポンプ阻害薬
CN101624391A (zh) * 2001-06-11 2010-01-13 病毒化学医药公司 用作黄病毒感染抗病毒剂的噻吩衍生物
MXPA04000224A (es) * 2001-07-10 2005-07-25 4Sc Ag Novedosos compuestos como agentes antiinflamatorios, inmunomoduladores y antiproliferativos.
DE10133665A1 (de) * 2001-07-11 2003-01-30 Boehringer Ingelheim Pharma Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung
GB0219896D0 (en) * 2002-08-27 2002-10-02 Bayer Ag Dihydropyridine derivatives
JP4093023B2 (ja) * 2002-11-15 2008-05-28 コニカミノルタビジネステクノロジーズ株式会社 非磁性一成分現像用トナーおよび画像形成方法

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BR0317687A (pt) 2005-11-22
CN1939896A (zh) 2007-04-04
EP1578741A1 (en) 2005-09-28
CA2509138A1 (en) 2004-07-08
IL169184A0 (en) 2009-02-11
EP1581477B1 (en) 2009-12-02
CA2509139C (en) 2012-03-20
JP2010215655A (ja) 2010-09-30
AU2003293914A1 (en) 2004-07-14
JP2006511564A (ja) 2006-04-06
CY1111851T1 (el) 2015-11-04
RU2005123402A (ru) 2006-01-20
RU2005123401A (ru) 2006-01-20
WO2004056797A1 (en) 2004-07-08
NO20052907D0 (no) 2005-06-15
ZA200504387B (en) 2006-02-22
ATE516284T1 (de) 2011-07-15
CN1732147A (zh) 2006-02-08
SI1578741T1 (sl) 2011-11-30
KR20050089843A (ko) 2005-09-08
AU2003299316A1 (en) 2004-07-14
IL169257A0 (en) 2007-07-04
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CN1732163B (zh) 2012-07-18
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