PL378082A1 - Sposób wytwarzania soli tolperyzonu - Google Patents

Sposób wytwarzania soli tolperyzonu

Info

Publication number: PL378082A1
Authority: PL; Poland
Prior art keywords: tolperisone; acid; addition salt; producing salts; producing
Prior art date: 2002-12-05

Application number

PL378082A

Other languages

English (en)

Inventor

Laszlo Czollner

Beate Kälz

Jan Rothenburger

Stefan Welzig

Original Assignee

Sanochemia Pharmazeutika Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-05

Filing date

2003-03-31

Publication date

2006-02-20

2003-03-31 Application filed by Sanochemia Pharmazeutika Ag filed Critical Sanochemia Pharmazeutika Ag

2006-02-20 Publication of PL378082A1 publication Critical patent/PL378082A1/pl

Links

FSKFPVLPFLJRQB-UHFFFAOYSA-N 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone Chemical class C=1C=C(C)C=CC=1C(=O)C(C)CN1CCCCC1 FSKFPVLPFLJRQB-UHFFFAOYSA-N 0.000 title abstract 4
150000003839 salts Chemical class 0.000 title abstract 3
229960005334 tolperisone Drugs 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
239000002253 acid Substances 0.000 abstract 4
ROLMZTIHUMKEAI-UHFFFAOYSA-N 4,5-difluoro-2-hydroxybenzonitrile Chemical compound OC1=CC(F)=C(F)C=C1C#N ROLMZTIHUMKEAI-UHFFFAOYSA-N 0.000 abstract 1
PATYHUUYADUHQS-UHFFFAOYSA-N 4-methylpropiophenone Chemical compound CCC(=O)C1=CC=C(C)C=C1 PATYHUUYADUHQS-UHFFFAOYSA-N 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
SNQXJPARXFUULZ-UHFFFAOYSA-N dioxolane Chemical compound C1COOC1 SNQXJPARXFUULZ-UHFFFAOYSA-N 0.000 abstract 1
238000001914 filtration Methods 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Steroid Compounds (AREA)
Cephalosporin Compounds (AREA)

PL378082A 2002-12-05 2003-03-31 Sposób wytwarzania soli tolperyzonu PL378082A1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AT0182302A AT413539B (de)	2002-12-05	2002-12-05	Verfahren zum herstellen von salzen des tolperison

Publications (1)

Publication Number	Publication Date
PL378082A1 true PL378082A1 (pl)	2006-02-20

Family

ID=32398619

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL378082A PL378082A1 (pl)	2002-12-05	2003-03-31	Sposób wytwarzania soli tolperyzonu

Country Status (14)

Country	Link
US (2)	US7385060B2 (pl)
EP (1)	EP1567510B1 (pl)
AT (2)	AT413539B (pl)
AU (1)	AU2003227075A1 (pl)
CA (1)	CA2507691C (pl)
DE (1)	DE50306068D1 (pl)
DK (1)	DK1567510T3 (pl)
ES (1)	ES2275140T3 (pl)
HR (1)	HRP20050501A2 (pl)
MX (1)	MXPA05005571A (pl)
NO (1)	NO20053176L (pl)
PL (1)	PL378082A1 (pl)
PT (1)	PT1567510E (pl)
WO (1)	WO2004050648A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT413539B (de) *	2002-12-05	2006-03-15	Sanochemia Pharmazeutika Ag	Verfahren zum herstellen von salzen des tolperison
DE102005014080B4 (de) *	2005-03-21	2007-11-22	Birds Pharma Gmbh Berolina Innovative Research & Development Services	Additionssalze des Tolperison, Verfahren zu deren Herstellung, Verwendung derselben und diese enthaltende Arzneimittel
AT505225A1 (de) *	2007-04-26	2008-11-15	Sanochemia Pharmazeutika Ag	0erfahren zur herstellung von hoch reinem 2,4'-dimethyl-3-piperidino-propiophenon (tolperison), dieses enthaltende pharmazeutische zusammensetzungen, sowie tolperison enthaltende wirkstoffformulierungen
US20100249423A1 (en) *	2009-03-09	2010-09-30	Sanochemia Pharmazeutika Ag	Tolperisone controlled release tablet
CN107868065B (zh) *	2017-10-19	2021-05-18	湖北美林药业有限公司	一种盐酸托哌酮化合物及其制备方法
CN116253699A (zh) *	2021-12-09	2023-06-13	广州白云山汉方现代药业有限公司	一种盐酸托哌酮新晶型及其制备方法
CN115932082A (zh) *	2022-11-24	2023-04-07	嘉实（湖南）医药科技有限公司	一种盐酸托哌酮有关物质的测定方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5295674A (en)	1976-02-09	1977-08-11	Nippon Carbide Ind Co Ltd	Preparation of 4#-substituted-2-methyl-2-piperidinopropiophenone and i ts salts
AT413539B (de) *	2002-12-05	2006-03-15	Sanochemia Pharmazeutika Ag	Verfahren zum herstellen von salzen des tolperison

2002
- 2002-12-05 AT AT0182302A patent/AT413539B/de not_active IP Right Cessation
2003
- 2003-03-31 MX MXPA05005571A patent/MXPA05005571A/es active IP Right Grant
- 2003-03-31 PL PL378082A patent/PL378082A1/pl not_active Application Discontinuation
- 2003-03-31 ES ES03812092T patent/ES2275140T3/es not_active Expired - Lifetime
- 2003-03-31 PT PT03812092T patent/PT1567510E/pt unknown
- 2003-03-31 AT AT03812092T patent/ATE348821T1/de not_active IP Right Cessation
- 2003-03-31 EP EP03812092A patent/EP1567510B1/de not_active Expired - Lifetime
- 2003-03-31 US US10/537,434 patent/US7385060B2/en not_active Expired - Lifetime
- 2003-03-31 HR HR20050501A patent/HRP20050501A2/xx not_active Application Discontinuation
- 2003-03-31 DE DE50306068T patent/DE50306068D1/de not_active Expired - Fee Related
- 2003-03-31 AU AU2003227075A patent/AU2003227075A1/en not_active Abandoned
- 2003-03-31 WO PCT/AT2003/000092 patent/WO2004050648A1/de not_active Ceased
- 2003-03-31 CA CA2507691A patent/CA2507691C/en not_active Expired - Fee Related
- 2003-03-31 DK DK03812092T patent/DK1567510T3/da active
2005
- 2005-06-28 NO NO20053176A patent/NO20053176L/no not_active Application Discontinuation
2008
- 2008-04-04 US US12/080,605 patent/US20080188522A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2003227075A1 (en)	2004-06-23
EP1567510A1 (de)	2005-08-31
NO20053176D0 (no)	2005-06-28
HRP20050501A2 (en)	2005-08-31
US7385060B2 (en)	2008-06-10
CA2507691A1 (en)	2004-06-17
EP1567510B1 (de)	2006-12-20
NO20053176L (no)	2005-09-05
DK1567510T3 (da)	2007-04-02
US20080188522A1 (en)	2008-08-07
CA2507691C (en)	2010-10-12
HK1085199A1 (en)	2006-08-18
AT413539B (de)	2006-03-15
MXPA05005571A (es)	2005-10-18
US20060041141A1 (en)	2006-02-23
ATE348821T1 (de)	2007-01-15
DE50306068D1 (de)	2007-02-01
PT1567510E (pt)	2007-02-28
ATA18232002A (de)	2005-08-15
ES2275140T3 (es)	2007-06-01
WO2004050648A1 (de)	2004-06-17

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Legal Events

Date	Code	Title	Description
2012-05-31	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)