PL3781563T3 - Inhibitory HPK1, sposób ich wytwarzania oraz ich zastosowanie - Google Patents
Inhibitory HPK1, sposób ich wytwarzania oraz ich zastosowanieInfo
- Publication number
- PL3781563T3 PL3781563T3 PL19791794.1T PL19791794T PL3781563T3 PL 3781563 T3 PL3781563 T3 PL 3781563T3 PL 19791794 T PL19791794 T PL 19791794T PL 3781563 T3 PL3781563 T3 PL 3781563T3
- Authority
- PL
- Poland
- Prior art keywords
- production
- application
- hpk1 inhibitors
- hpk1
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
- G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810381425 | 2018-04-25 | ||
| CN201810945948.2A CN110396087A (zh) | 2018-04-25 | 2018-08-20 | Hpk1激酶抑制剂、制备方法及其应用 |
| CN201810946081.2A CN110396088B (zh) | 2018-04-25 | 2018-08-20 | Hpk1激酶抑制剂、制备方法及其应用 |
| PCT/CN2019/083499 WO2019206049A1 (en) | 2018-04-25 | 2019-04-19 | Hpk1 inhibitors, preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3781563T3 true PL3781563T3 (pl) | 2022-10-03 |
Family
ID=68322176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL19791794.1T PL3781563T3 (pl) | 2018-04-25 | 2019-04-19 | Inhibitory HPK1, sposób ich wytwarzania oraz ich zastosowanie |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11999725B2 (pl) |
| EP (1) | EP3781563B1 (pl) |
| JP (1) | JP7212142B2 (pl) |
| KR (1) | KR102926807B1 (pl) |
| CN (2) | CN110396088B (pl) |
| AU (1) | AU2019260159B2 (pl) |
| BR (1) | BR112020021862A2 (pl) |
| CA (1) | CA3097949C (pl) |
| ES (1) | ES2927346T3 (pl) |
| IL (1) | IL278036B2 (pl) |
| PL (1) | PL3781563T3 (pl) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112552293A (zh) * | 2019-09-25 | 2021-03-26 | 珠海宇繁生物科技有限责任公司 | 一种protac小分子化合物及其应用 |
| CN113712966A (zh) * | 2020-05-26 | 2021-11-30 | 格格巫(珠海)生物科技有限公司 | 一种化合物在预防和治疗动物肿瘤中的应用 |
| CN113797202B (zh) * | 2020-06-16 | 2024-06-28 | 珠海宇繁生物科技有限责任公司 | Hpk1激酶抑制剂在预防和/或治疗动物的病原体感染中的应用 |
| CN117338775A (zh) * | 2020-06-16 | 2024-01-05 | 格格巫(珠海)生物科技有限公司 | 一种化合物在预防和/或治疗动物的病原体感染中的应用 |
| HRP20260277T1 (hr) * | 2020-09-30 | 2026-04-10 | Beone Medicines I Gmbh | Spojevi 3-[(1h-pirazol-4-il)oksi]pirazin-2-amina kao inhibitori hpk1 i njihova upotreba |
| CN114437058A (zh) | 2020-10-30 | 2022-05-06 | 珠海宇繁生物科技有限责任公司 | 氘代hpk1激酶抑制剂及其制备方法和应用 |
| CN114685481A (zh) * | 2020-12-31 | 2022-07-01 | 南通泰禾化工股份有限公司 | 一种氟噻唑吡乙酮的制备方法 |
| CN114685489B (zh) * | 2020-12-31 | 2025-03-07 | 南京再明医药有限公司 | 多取代含氮杂环类化合物及其应用 |
| CN114907377A (zh) * | 2021-02-10 | 2022-08-16 | 江苏恒瑞医药股份有限公司 | 稠合四环类化合物、其制备方法及其在医药上的应用 |
| CN117295746A (zh) * | 2021-04-29 | 2023-12-26 | 贝达药业股份有限公司 | Hpk1抑制剂及其在医药上的应用 |
| CN116535422B (zh) * | 2022-01-26 | 2025-04-18 | 上海交通大学 | 具有五元芳杂环并哌啶/高哌啶的hpk1抑制剂及其制备方法及用途 |
| CN114767676B (zh) * | 2022-04-22 | 2024-04-19 | 珠海宇繁生物科技有限责任公司 | Hpk1激酶抑制剂在预防和/或治疗人的病原体感染中的应用 |
| CN119707930A (zh) * | 2023-09-28 | 2025-03-28 | 甘李药业股份有限公司 | 芳香环类化合物及其制法和用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1603570T5 (da) | 2003-02-26 | 2013-12-09 | Sugen Inc | Aminoheteroarylforbindelser som proteinkinaseinhibitorer |
| DE602005020465D1 (de) | 2004-08-26 | 2010-05-20 | Pfizer | Enantiomerenreine aminoheteroaryl-verbindungen als proteinkinasehemmer |
| EP1786777A1 (en) | 2004-08-26 | 2007-05-23 | Pfizer, Inc. | Aminoheteroaryl compounds as protein tyrosine kinase inhibitors |
| GB0621607D0 (en) * | 2006-10-31 | 2006-12-06 | Chroma Therapeutics Ltd | Inhibitors of c-Met |
| US8916593B2 (en) | 2010-05-04 | 2014-12-23 | Pfizer Inc. | Alkoxy-substituted 2-aminopyridines as ALK inhibitors |
| CN103965161A (zh) * | 2013-02-02 | 2014-08-06 | 正大天晴药业集团股份有限公司 | 取代的2-氨基吡啶类蛋白激酶抑制剂 |
| RU2671212C2 (ru) | 2013-02-02 | 2018-10-30 | Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд | Замещенный 2-аминопиридин в качестве ингибитора протеинкиназы |
| CN104650049B (zh) * | 2013-08-28 | 2018-06-08 | 广东东阳光药业有限公司 | 取代的吡啶化合物及其使用方法和用途 |
| CN107206088A (zh) | 2014-12-05 | 2017-09-26 | 豪夫迈·罗氏有限公司 | 使用pd‑1轴拮抗剂和hpk1拮抗剂用于治疗癌症的方法和组合物 |
| WO2016161145A1 (en) * | 2015-03-31 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Stk4 inhibitors for treatment of hematologic malignancies |
| US20180072741A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyrimidine compounds and uses thereof |
-
2018
- 2018-08-20 CN CN201810946081.2A patent/CN110396088B/zh active Active
- 2018-08-20 CN CN201810945948.2A patent/CN110396087A/zh active Pending
-
2019
- 2019-04-19 CA CA3097949A patent/CA3097949C/en active Active
- 2019-04-19 BR BR112020021862-6A patent/BR112020021862A2/pt unknown
- 2019-04-19 EP EP19791794.1A patent/EP3781563B1/en active Active
- 2019-04-19 PL PL19791794.1T patent/PL3781563T3/pl unknown
- 2019-04-19 JP JP2021508049A patent/JP7212142B2/ja active Active
- 2019-04-19 ES ES19791794T patent/ES2927346T3/es active Active
- 2019-04-19 US US17/049,380 patent/US11999725B2/en active Active
- 2019-04-19 IL IL278036A patent/IL278036B2/en unknown
- 2019-04-19 KR KR1020207033717A patent/KR102926807B1/ko active Active
- 2019-04-19 AU AU2019260159A patent/AU2019260159B2/en active Active
-
2024
- 2024-05-03 US US18/654,114 patent/US20240300941A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210276994A1 (en) | 2021-09-09 |
| ES2927346T3 (es) | 2022-11-04 |
| BR112020021862A2 (pt) | 2021-01-26 |
| KR20210005668A (ko) | 2021-01-14 |
| AU2019260159A1 (en) | 2020-11-26 |
| IL278036B1 (en) | 2023-10-01 |
| JP7212142B2 (ja) | 2023-01-24 |
| EP3781563B1 (en) | 2022-06-29 |
| IL278036B2 (en) | 2024-02-01 |
| CN110396088A (zh) | 2019-11-01 |
| EP3781563A1 (en) | 2021-02-24 |
| EP3781563A4 (en) | 2021-02-24 |
| KR102926807B1 (ko) | 2026-02-13 |
| JP2021519827A (ja) | 2021-08-12 |
| US20240300941A1 (en) | 2024-09-12 |
| AU2019260159B2 (en) | 2024-06-06 |
| US11999725B2 (en) | 2024-06-04 |
| CN110396087A (zh) | 2019-11-01 |
| IL278036A (en) | 2020-11-30 |
| CN110396088B (zh) | 2024-03-12 |
| CA3097949C (en) | 2024-04-23 |
| CA3097949A1 (en) | 2019-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL3781563T3 (pl) | Inhibitory HPK1, sposób ich wytwarzania oraz ich zastosowanie | |
| IL287940A (en) | Fgfr inhibitors and methods of use thereof | |
| IL289612A (en) | Hpk1 inhibitors and uses thereof | |
| EP4059928A4 (en) | Rock inhibitor, preparation method therefor and use thereof | |
| IL283592A (en) | Inhibitors of apol1 and methods of using same | |
| IL280782A (en) | Inhibiting αv β6 integrin | |
| PL3788047T3 (pl) | Stałe postacie inhibitora fgfr i sposoby ich otrzymywania | |
| PL3423561T5 (pl) | Biomaty grzybów strzępkowych, sposoby ich wytwarzania i sposoby ich zastosowania | |
| PL3788044T3 (pl) | Związki hamujące rip1 oraz sposoby ich wytwarzania i wykorzystania | |
| IL257203B (en) | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors | |
| PL3509591T3 (pl) | Nowe selektywne inhibitory Jak1 i ich zastosowanie | |
| DK3710430T3 (da) | Acss2-inhibitorer og fremgangsmåder til anvendelse deraf | |
| EP3423056A4 (en) | METHODS OF REGULATING STEM CELL PROLIFERATION / GENERATION OF INNER EAR HEARING CELLS USING GSK-3-ALPHA INHIBITORS | |
| PL3577213T3 (pl) | Komórki drobnoustrojów, sposoby ich wytwarzania i ich zastosowania | |
| IL286492A (en) | Sialidase-resistant saccharide and method of making and using the same | |
| EP3947366C0 (en) | HPK1 INHIBITORS | |
| PL3752251T4 (pl) | Inhibitory arginazy i sposoby ich stosowania | |
| PL3429998T3 (pl) | Sposób wytwarzania pochodnych chinolin-2-ylo-fenyloaminy oraz jej soli | |
| PL3586071T3 (pl) | Szyba zespolona, sposób jej wytwarzania i jej zastosowanie | |
| EP3569592A4 (en) | SELECTIVE HDAC6 INHIBITORS, THEIR METHOD OF PREPARATION AND THEIR APPLICATION | |
| PT3481208T (pt) | Câmara de amadurecimento e método para o amadurecimento de frutas | |
| PL4046129T3 (pl) | Sposób wytwarzania | |
| DK3458615T3 (da) | Bioteknologisk fremgangsmåde til fremstilling af acrylamid og relativt ny bakteriestamme | |
| PL3630738T3 (pl) | Sposób wytwarzania ozanimodu | |
| IL286485A (en) | Pi4-kinase inhibitors and methods of using the same |