PL378710A1 - Polimorficzny lek zatrzymujący agregację płytek krwi - Google Patents

Polimorficzny lek zatrzymujący agregację płytek krwi

Info

Publication number: PL378710A1
Authority: PL; Poland
Prior art keywords: mixture; type solvent; preparation; sulfuric acid; polymorph form
Prior art date: 2003-07-02

Application number

PL378710A

Other languages

English (en)

Inventor

Nagy Peter Kotay

Gyula Simig

Jozsef Barkoczy

Tamas Gregor

Bela Farkas

Donath Györgyi Vereczkeyne

Kalman Nagy

Gyulane Körtvelyessy

Zsuzsanna Szent-Kirallyi

Original Assignee

Egis Gyogyszergyar Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-02

Filing date

2004-06-30

Publication date

2006-05-15

2003-07-02 Priority claimed from HU0302028A external-priority patent/HU0302028D0/hu

2004-06-23 Priority claimed from HU0401272A external-priority patent/HU226773B1/hu

2004-06-30 Application filed by Egis Gyogyszergyar Rt. filed Critical Egis Gyogyszergyar Rt.

2006-05-15 Publication of PL378710A1 publication Critical patent/PL378710A1/pl

Links

238000002360 preparation method Methods 0.000 title abstract 3
101000783577 Dendroaspis angusticeps Thrombostatin Proteins 0.000 title 1
101000783578 Dendroaspis jamesoni kaimosae Dendroaspin Proteins 0.000 title 1
229940127218 antiplatelet drug Drugs 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000106 platelet aggregation inhibitor Substances 0.000 title 1
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 10
239000000203 mixture Substances 0.000 abstract 9
239000002904 solvent Substances 0.000 abstract 8
229950010477 clopidogrel hydrogen sulphate Drugs 0.000 abstract 6
FDEODCTUSIWGLK-UHFFFAOYSA-N hydrogen sulfate;hydron;methyl 2-(2-chlorophenyl)-2-(6,7-dihydro-4h-thieno[3,2-c]pyridin-5-yl)acetate Chemical compound OS(O)(=O)=O.C1CC=2SC=CC=2CN1C(C(=O)OC)C1=CC=CC=C1Cl FDEODCTUSIWGLK-UHFFFAOYSA-N 0.000 abstract 6
239000005552 B01AC04 - Clopidogrel Substances 0.000 abstract 3
229960003009 clopidogrel Drugs 0.000 abstract 3
GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 abstract 3
238000001035 drying Methods 0.000 abstract 2
238000001914 filtration Methods 0.000 abstract 2
239000002244 precipitate Substances 0.000 abstract 2
239000000725 suspension Substances 0.000 abstract 2
238000005406 washing Methods 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

PL378710A 2003-07-02 2004-06-30 Polimorficzny lek zatrzymujący agregację płytek krwi PL378710A1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU0302028A HU0302028D0 (en)	2003-07-02	2003-07-02	Process for the production of crystalline polymorphous form of an anticoagulant agent
HU0401272A HU226773B1 (en)	2004-06-23	2004-06-23	Process for the production of clopidogrel hydrogensulfate polymorph 1

Publications (1)

Publication Number	Publication Date
PL378710A1 true PL378710A1 (pl)	2006-05-15

Family

ID=89985327

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL378710A PL378710A1 (pl)	2003-07-02	2004-06-30	Polimorficzny lek zatrzymujący agregację płytek krwi
PL04743729T PL1644381T3 (pl)	2003-07-02	2004-06-30	Proces wytwarzania krystalicznego polimorfu jako leku do hamowania agregacji płytek krwi

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL04743729T PL1644381T3 (pl)	2003-07-02	2004-06-30	Proces wytwarzania krystalicznego polimorfu jako leku do hamowania agregacji płytek krwi

Country Status (14)

Country	Link
US (1)	US20070142637A1 (pl)
EP (1)	EP1644381B1 (pl)
JP (1)	JP4681545B2 (pl)
KR (1)	KR101155679B1 (pl)
CN (1)	CN1812993B (pl)
AT (1)	ATE461201T1 (pl)
BG (1)	BG109429A (pl)
CA (1)	CA2530449C (pl)
CZ (1)	CZ200641A3 (pl)
DE (1)	DE602004026059D1 (pl)
EA (1)	EA010684B1 (pl)
PL (2)	PL378710A1 (pl)
SK (1)	SK50102006A3 (pl)
WO (1)	WO2005003139A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1740593B1 (en) *	2004-04-19	2016-04-06	KRKA, tovarna zdravil, d.d., Novo mesto	Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form i
WO2007032023A2 (en) *	2005-07-12	2007-03-22	Rpg Life Sciences Limited	A process for preparation of methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h)-acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
CA2655844A1 (en) *	2006-08-03	2008-02-14	Teva Pharmaceutical Industries Ltd.	Process for preparing clopidogrel bisulphate
WO2011010318A1 (en) *	2009-07-23	2011-01-27	Praveen Laboratories Private Limited	Process for the preparation of clopidogrel polymorphous form 1 using seed chrystals
CN102070648A (zh) *	2010-12-07	2011-05-25	天津红日药业股份有限公司	I型硫酸氢氯吡格雷的制备方法
CN102702224A (zh) *	2012-06-25	2012-10-03	山东齐都药业有限公司	I型硫酸氢氯吡格雷的制备方法
CN107337683B (zh) *	2017-08-16	2019-08-16	中荣凯特（北京）生物科技有限公司	一种噻吩并吡啶类衍生物硫酸氢盐的晶型ⅱ及其制备方法和应用
CN113121559B (zh) *	2019-12-31	2023-08-29	惠州信立泰药业有限公司	一种高堆密度的ii型硫酸氢氯吡格雷球形结晶及制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2623810B2 (fr) *	1987-02-17	1992-01-24	Sanofi Sa	Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2779726B1 (fr) *	1998-06-15	2001-05-18	Sanofi Sa	Forme polymorphe de l'hydrogenosulfate de clopidogrel
MXPA03006133A (es) *	2001-01-24	2004-05-04	Cadila Healthcare Ltd	Proceso para preparar clopidogrel.
GB0125708D0 (en) *	2001-10-26	2001-12-19	Generics Uk Ltd	Novel compounds and processes
AU2002366383B2 (en) *	2001-12-18	2007-06-14	Teva Pharmaceutical Industries Ltd.	Polymorphs of clopidogrel hydrogensulfate

2004
- 2004-06-30 CA CA2530449A patent/CA2530449C/en not_active Expired - Fee Related
- 2004-06-30 PL PL378710A patent/PL378710A1/pl not_active Application Discontinuation
- 2004-06-30 PL PL04743729T patent/PL1644381T3/pl unknown
- 2004-06-30 DE DE602004026059T patent/DE602004026059D1/de not_active Expired - Fee Related
- 2004-06-30 KR KR1020067000012A patent/KR101155679B1/ko not_active Expired - Fee Related
- 2004-06-30 CZ CZ20060041A patent/CZ200641A3/cs unknown
- 2004-06-30 WO PCT/HU2004/000070 patent/WO2005003139A1/en not_active Ceased
- 2004-06-30 AT AT04743729T patent/ATE461201T1/de not_active IP Right Cessation
- 2004-06-30 EP EP04743729A patent/EP1644381B1/en not_active Expired - Lifetime
- 2004-06-30 JP JP2006516497A patent/JP4681545B2/ja not_active Expired - Fee Related
- 2004-06-30 EA EA200600138A patent/EA010684B1/ru not_active IP Right Cessation
- 2004-06-30 SK SK5010-2006A patent/SK50102006A3/sk unknown
- 2004-06-30 US US10/563,133 patent/US20070142637A1/en not_active Abandoned
- 2004-06-30 CN CN2004800181228A patent/CN1812993B/zh not_active Expired - Fee Related
2006
- 2006-02-02 BG BG109429A patent/BG109429A/en unknown

Also Published As

Publication number	Publication date
EA200600138A1 (ru)	2006-08-25
JP2007516167A (ja)	2007-06-21
KR20060026119A (ko)	2006-03-22
CN1812993A (zh)	2006-08-02
EP1644381A1 (en)	2006-04-12
CZ200641A3 (cs)	2006-05-17
WO2005003139A1 (en)	2005-01-13
EA010684B1 (ru)	2008-10-30
ATE461201T1 (de)	2010-04-15
KR101155679B1 (ko)	2012-06-13
SK50102006A3 (sk)	2006-05-04
CN1812993B (zh)	2011-06-29
DE602004026059D1 (de)	2010-04-29
CA2530449C (en)	2010-03-23
US20070142637A1 (en)	2007-06-21
PL1644381T3 (pl)	2010-08-31
BG109429A (en)	2006-10-31
CA2530449A1 (en)	2005-01-13
EP1644381B1 (en)	2010-03-17
JP4681545B2 (ja)	2011-05-11

Similar Documents

Publication	Publication Date	Title
US20080051581A1 (en)	2008-02-28	Novel process for the manufacture of (+)-(S)-clopidogrel bisulfate form-1
PL1644381T3 (pl)	2010-08-31	Proces wytwarzania krystalicznego polimorfu jako leku do hamowania agregacji płytek krwi
DE60324301D1 (de)	2008-12-04	Verfahren zur herstellung der kristallform i von clopidogrel-hydrogensulphat
BG108868A (en)	2005-09-30	Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds
ES2528198T3 (es)	2015-02-05	Nuevos polimorfos cristalinos de clopidogrel
DE602008005461D1 (de)	2011-04-21	Verfahren zur herstellung von essigsäure-5-ä2-cyclopropyl-1-(2-fluorphenyl)-2-oxoethylü-4,5,6,7-tetrahydrothienoä3,2-cüpyridin-2-yl-ester (prasugrel)
KR101050105B1 (ko)	2011-07-19	(ｓ)-(+)-클로피도그렐 비설페이트의 상이한 형태의 제조방법
EA200702073A1 (ru)	2008-12-30	Способ получения пиридо[2,3-d]пиримидин-7-оновых и 3,4-дигидропиримидо[4,5-d]пиримидин-2(1н)-оновых производных
HRP20150056T1 (hr)	2015-04-24	Soli clopidogrela i postupak pripreme
SI9420016B (sl)	2002-12-31	Enantioselektivna sinteza 5,6 -dihidro-(S)-4-(etilamino)-(S)-6-metil-4H-tieno /2,3-b/ tiopiran-2- sulfonamid 7,7- dioksida in sorodnih spojin
DE4107521A1 (de)	1992-09-10	Neue acylaminosubstituierte hetrazepine
CN110590805A (zh)	2019-12-20	高纯度ii晶型硫酸氢氯吡格雷的制备方法
WO2004048385A3 (en)	2004-08-05	A process for the preparation of crystalline form 1 or clopidogrel hydrogen sulfate
DK1620439T3 (da)	2008-11-17	Hidtil ukendte polymorfer af olanzapinhydrochlorid
HUP0401272A2 (hu)	2005-02-28	Eljárás clopidogrel-hidrogénszulfát kristályos polimorf módosulatának előállítására
EA200801963A1 (ru)	2009-02-27	СПОСОБ ПОЛУЧЕНИЯ ПОЛИМОРФНОЙ ФОРМЫ I ГИДРОСУЛЬФАТА (S)-(+)-МЕТИЛ-α-(2-ХЛОРФЕНИЛ)-6,7-ДИГИДРОТИЕНО-[3,2-C] ПИРИДИН-5(4H)-АЦЕТАТА
EP2491044A1 (en)	2012-08-29	Improved process for preparation of clopiodogrel bisulfate crystalline form-1
WO2020223551A1 (en)	2020-11-05	Inhibiting otub1
US20060100231A1 (en)	2006-05-11	Amorphous clopidogrel hydrogen sulfate
EP2264016A3 (en)	2011-03-23	A process for producing pure form form of 2-Methyl-4-(4-Methyl-1-Piperazinyl)-10h-thieno[2,3-B][1,5] benzodiazepine
EP2089396B1 (en)	2011-06-22	A process for preparing (s)-(+)-clopidogrel base and its salts
TNSN06311A1 (en)	2007-12-03	Clopidogrel salt and polymorphic forms thereof
WO2006087729B1 (en)	2006-11-09	Rapid resolution process for clopidogrel base and a process for preparation of clopidogrel bisulfate polymorph - form i
EA200701770A1 (ru)	2008-02-28	СПОСОБ РАЦЕМИЗАЦИИ R(-) ИЗОМЕРА МЕТИЛОВОГО ЭФИРА (2-ХЛОРФЕНИЛ)-6,7-ДИГИДРОТИЕНО[3,2-c]ПИРИДИН-5(4Н)-УКСУСНОЙ КИСЛОТЫ
Battersby et al.	1992	Synthetic studies relevant to biosynthetic research on vitamin B12. Part 11. Modification of the east and west building blocks and study of different assembly methods for synthesis of isobacteriochlorins

Legal Events

Date	Code	Title	Description
2013-11-29	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)