PL3790873T3 - Związki 1h-indazolo-3-karboksyamidowe jako inhibitory kinazy syntazy glikogenu 3 beta - Google Patents

Związki 1h-indazolo-3-karboksyamidowe jako inhibitory kinazy syntazy glikogenu 3 beta

Info

Publication number
PL3790873T3
PL3790873T3 PL19721295T PL19721295T PL3790873T3 PL 3790873 T3 PL3790873 T3 PL 3790873T3 PL 19721295 T PL19721295 T PL 19721295T PL 19721295 T PL19721295 T PL 19721295T PL 3790873 T3 PL3790873 T3 PL 3790873T3
Authority
PL
Poland
Prior art keywords
indazole
glycogen synthase
synthase kinase
carboxamide compounds
beta inhibitors
Prior art date
Application number
PL19721295T
Other languages
English (en)
Inventor
Guido Furlotti
Claudia CAVARISCHIA
Rosa BUONFIGLIO
Rosella Ombrato
Tommaso Iacoangeli
Original Assignee
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. filed Critical Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
Publication of PL3790873T3 publication Critical patent/PL3790873T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL19721295T 2018-05-07 2019-05-06 Związki 1h-indazolo-3-karboksyamidowe jako inhibitory kinazy syntazy glikogenu 3 beta PL3790873T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18171084 2018-05-07
EP19721295.4A EP3790873B1 (en) 2018-05-07 2019-05-06 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
PCT/EP2019/061532 WO2019215075A1 (en) 2018-05-07 2019-05-06 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors

Publications (1)

Publication Number Publication Date
PL3790873T3 true PL3790873T3 (pl) 2022-06-27

Family

ID=62134122

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19721295T PL3790873T3 (pl) 2018-05-07 2019-05-06 Związki 1h-indazolo-3-karboksyamidowe jako inhibitory kinazy syntazy glikogenu 3 beta

Country Status (28)

Country Link
US (1) US11472795B2 (pl)
EP (1) EP3790873B1 (pl)
JP (1) JP7411574B2 (pl)
KR (1) KR102778690B1 (pl)
CN (1) CN112135821B (pl)
AU (1) AU2019265606B2 (pl)
BR (1) BR112020021922A2 (pl)
CA (1) CA3094896A1 (pl)
CY (1) CY1125293T1 (pl)
DK (1) DK3790873T3 (pl)
EA (1) EA202092422A1 (pl)
ES (1) ES2913975T3 (pl)
GE (2) GEAP202215506A (pl)
HR (1) HRP20220664T1 (pl)
HU (1) HUE058894T2 (pl)
IL (1) IL278330B2 (pl)
LT (1) LT3790873T (pl)
MA (1) MA52557A (pl)
MD (1) MD3790873T2 (pl)
MX (1) MX2020011882A (pl)
PL (1) PL3790873T3 (pl)
PT (1) PT3790873T (pl)
RS (1) RS63255B1 (pl)
SG (1) SG11202009230WA (pl)
SI (1) SI3790873T1 (pl)
SM (1) SMT202200227T1 (pl)
UA (1) UA128089C2 (pl)
WO (1) WO2019215075A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250243181A2 (en) * 2019-12-16 2025-07-31 Korea Research Institute Of Chemical Technology Novel indazole derivative and use thereof
CN114230565B (zh) * 2020-09-09 2023-10-27 成都奥睿药业有限公司 5-取代吲哚3-酰胺衍生物及其制备方法和用途
EP4259619A1 (en) * 2020-12-08 2023-10-18 Disarm Therapeutics, Inc. Benzopyrazole inhibitors of sarm1

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR950704328A (ko) 1992-11-05 1995-11-17 데이비드 로버츠 5-HT₄ 수용체 길항제로서의 피페리딘 유도체(Piperidine Derivatives as 5-HT₄ Receptor Antagonists)
GB0218625D0 (en) 2002-08-10 2002-09-18 Astex Technology Ltd Pharmaceutical compounds
ITMI20030287A1 (it) 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20030972A1 (it) 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
KR101061599B1 (ko) * 2008-12-05 2011-09-02 한국과학기술연구원 비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물
TW201040191A (en) 2009-03-27 2010-11-16 Abbott Gmbh & Co Kg Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
HUE041576T2 (hu) * 2011-09-14 2019-05-28 Samumed Llc Indazol-3-karboxamid-származékok és alkalmazásuk Wnt/b-katenin szignalizáló útvonal inhibitorokként
RS54567B1 (sr) 2012-02-21 2016-06-30 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1h-indazol-3-karboksamidna jedinjenja kao inhibitori 3-beta kinaze glikogen sintetaze
HRP20160124T1 (hr) * 2012-02-21 2016-03-11 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. - S.P.A. Uporaba spojeva 1h-indazol-3-karboksamida kao inhibitora glikogen sinteze kinaze-3 beta
MX2016012208A (es) * 2014-03-20 2017-01-26 Samumed Llc Indazol-3-carboxamidas 5-substituidas y preparacion y uso de las mismas.
SG11202008029UA (en) * 2018-02-23 2020-09-29 Samumed Llc 5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof

Also Published As

Publication number Publication date
CA3094896A1 (en) 2019-11-14
US11472795B2 (en) 2022-10-18
DK3790873T3 (da) 2022-05-23
MD3790873T2 (ro) 2022-07-31
AU2019265606A1 (en) 2020-10-15
JP2021523134A (ja) 2021-09-02
HRP20220664T1 (hr) 2022-06-24
SI3790873T1 (sl) 2022-07-29
EP3790873B1 (en) 2022-04-27
MA52557A (fr) 2021-03-17
CN112135821A (zh) 2020-12-25
UA128089C2 (uk) 2024-04-03
ES2913975T3 (es) 2022-06-07
KR102778690B1 (ko) 2025-03-12
RS63255B1 (sr) 2022-06-30
MX2020011882A (es) 2021-01-20
KR20210005863A (ko) 2021-01-15
BR112020021922A2 (pt) 2021-01-26
JP7411574B2 (ja) 2024-01-11
GEP20227437B (en) 2022-11-10
EA202092422A1 (ru) 2021-02-12
HUE058894T2 (hu) 2022-09-28
CY1125293T1 (el) 2025-03-28
US20210053956A1 (en) 2021-02-25
LT3790873T (lt) 2022-06-10
GEAP202215506A (en) 2022-07-11
WO2019215075A1 (en) 2019-11-14
AU2019265606B2 (en) 2023-10-12
IL278330A (pl) 2020-12-31
CN112135821B (zh) 2024-05-31
IL278330B2 (en) 2024-06-01
IL278330B1 (en) 2024-02-01
SG11202009230WA (en) 2020-11-27
EP3790873A1 (en) 2021-03-17
PT3790873T (pt) 2022-05-11
SMT202200227T1 (it) 2022-07-21

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