PL3794012T3 - Kompozycje i metody chemicznego rozszczepiania i deprotekcji powierzchniowo związanych oligonukleotydów - Google Patents
Kompozycje i metody chemicznego rozszczepiania i deprotekcji powierzchniowo związanych oligonukleotydówInfo
- Publication number
- PL3794012T3 PL3794012T3 PL19727252.9T PL19727252T PL3794012T3 PL 3794012 T3 PL3794012 T3 PL 3794012T3 PL 19727252 T PL19727252 T PL 19727252T PL 3794012 T3 PL3794012 T3 PL 3794012T3
- Authority
- PL
- Poland
- Prior art keywords
- clipation
- deprotection
- compositions
- chemical
- methods
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 238000010511 deprotection reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/10—Characterised by chemical treatment
- C12Q2523/107—Chemical cleaving agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- General Chemical & Material Sciences (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862671816P | 2018-05-15 | 2018-05-15 | |
| US201962788045P | 2019-01-03 | 2019-01-03 | |
| PCT/US2019/032287 WO2019222264A1 (en) | 2018-05-15 | 2019-05-14 | Compositions and methods for chemical cleavage and deprotection of surface-bound oligonucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3794012T3 true PL3794012T3 (pl) | 2024-03-25 |
Family
ID=66669137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL19727252.9T PL3794012T3 (pl) | 2018-05-15 | 2019-05-14 | Kompozycje i metody chemicznego rozszczepiania i deprotekcji powierzchniowo związanych oligonukleotydów |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US12084474B2 (pl) |
| EP (2) | EP4306532A3 (pl) |
| JP (2) | JP7100069B2 (pl) |
| KR (3) | KR102443569B1 (pl) |
| CN (2) | CN119684383A (pl) |
| AU (3) | AU2019271121B2 (pl) |
| BR (1) | BR112019027944A2 (pl) |
| CA (2) | CA3067434C (pl) |
| DK (1) | DK3794012T3 (pl) |
| ES (1) | ES2968459T3 (pl) |
| FI (1) | FI3794012T3 (pl) |
| IL (2) | IL316537A (pl) |
| MX (2) | MX2019015174A (pl) |
| MY (1) | MY203406A (pl) |
| PL (1) | PL3794012T3 (pl) |
| PT (1) | PT3794012T (pl) |
| RU (1) | RU2766688C2 (pl) |
| SG (1) | SG11201912274UA (pl) |
| WO (1) | WO2019222264A1 (pl) |
| ZA (1) | ZA201908376B (pl) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3806996A4 (en) * | 2018-06-14 | 2022-06-08 | Corning Incorporated | Patterned flow cells for biomolecular analysis |
| US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
| WO2021231263A2 (en) * | 2020-05-12 | 2021-11-18 | Singular Genomics Systems, Inc. | Nucleic acid amplification methods |
| IL297992B2 (en) | 2020-06-22 | 2025-03-01 | Illumina Cambridge Ltd | Nucleosides and nucleotides with 3' acetal blocking group |
| EP4153606A4 (en) | 2020-07-13 | 2024-10-02 | Singular Genomics Systems, Inc. | METHODS FOR SEQUENCING COMPLEMENTARY POLYNUCLEOTIDES |
| WO2022170212A1 (en) * | 2021-02-08 | 2022-08-11 | Singular Genomics Systems, Inc. | Methods and compositions for sequencing complementary polynucleotides |
| CN113248556B (zh) * | 2021-05-18 | 2022-07-26 | 武汉科技大学 | 一种核酸枝接偶氮苯的组装体及制备方法及应用 |
| AU2022277632A1 (en) | 2021-05-20 | 2023-11-09 | Illumina Cambridge Limited | Compositions and methods for sequencing by synthesis |
| US12570831B2 (en) | 2021-06-15 | 2026-03-10 | Illumina, Inc. | Hydrogel-free surface functionalization for sequencing |
| EP4373958A1 (en) | 2021-07-23 | 2024-05-29 | Illumina, Inc. | Methods for preparing substrate surface for dna sequencing |
| WO2023069927A1 (en) | 2021-10-20 | 2023-04-27 | Illumina, Inc. | Methods for capturing library dna for sequencing |
| CA3223264A1 (en) * | 2021-11-02 | 2023-05-11 | Illumina, Inc. | Primer sets and methods and kits incorporating the primer sets |
| AU2022413575A1 (en) * | 2021-12-16 | 2024-01-18 | Illumina, Inc. | Methods for metal directed cleavage of surface-bound polynucleotides |
| EP4453256A1 (en) | 2021-12-20 | 2024-10-30 | Illumina, Inc. | Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides |
| AU2022419500A1 (en) | 2021-12-20 | 2024-01-18 | Illumina, Inc. | Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides |
| AU2022424380A1 (en) | 2021-12-29 | 2024-01-18 | Illumina, Inc. | Methods of nucleic acid sequencing using surface-bound primers |
| CN114457146B (zh) * | 2022-01-28 | 2024-11-19 | 赛纳生物科技(北京)有限公司 | 一种固相介质表面双端扩增测序的方法 |
| JP2025509651A (ja) | 2022-03-15 | 2025-04-11 | イルミナ インコーポレイテッド | 並行サンプル及びインデックス配列決定 |
| AU2023240337A1 (en) | 2022-03-22 | 2024-01-18 | Illumina, Inc. | Substrate with orthogonally functional nanodomains |
| CA3223037A1 (en) * | 2022-03-30 | 2023-10-05 | Oliver MILLER | Methods for chemical cleavage of surface-bound polynucleotides |
| EP4594480A2 (en) * | 2022-09-26 | 2025-08-06 | Ansa Biotechnologies, Inc. | Cleavable linkers for the tethering of polymerases to nucleotides |
| EP4630153A1 (en) | 2022-12-07 | 2025-10-15 | Illumina, Inc. | Etch-free photoresist patterning in multi-depth nanowells |
| AU2023409219A1 (en) | 2022-12-22 | 2024-10-03 | Illumina, Inc. | Palladium catalyst compositions and methods for sequencing by synthesis |
| WO2024137765A1 (en) | 2022-12-22 | 2024-06-27 | Illumina, Inc. | Transition-metal catalyst compositions and methods for sequencing by synthesis |
| US20240271206A1 (en) * | 2022-12-27 | 2024-08-15 | Illumina, Inc. | Methods of sequencing using 3' allyl blocked nucleotides |
| CN115820380B (zh) * | 2023-01-04 | 2024-01-30 | 深圳赛陆医疗科技有限公司 | 微流控芯片及其制备方法和应用 |
| WO2024163450A2 (en) * | 2023-01-30 | 2024-08-08 | Ansa Biotechnologies, Inc. | Methods and systems for polymer synthesis by contacting synthesis surfaces with compartmentalized liquid reagents |
| US20240401129A1 (en) | 2023-05-31 | 2024-12-05 | Illumina, Inc. | Methods for double-stranded sequencing by synthesis |
| US20250001542A1 (en) | 2023-06-09 | 2025-01-02 | Illumina, Inc. | Method for polishing a substrate |
| WO2024253995A1 (en) * | 2023-06-09 | 2024-12-12 | Illumina, Inc. | Methods of sequencing dna using flow cells containing multiple surfaces |
| WO2024256580A1 (en) | 2023-06-14 | 2024-12-19 | Illumina, Inc. | Concurrent sequencing with spatially separated rings |
| EP4735958A1 (en) | 2023-06-28 | 2026-05-06 | Illumina, Inc. | Photoresist patterning in multi-depth nanowells |
| WO2025062001A1 (en) * | 2023-09-20 | 2025-03-27 | Illumina, Inc. | Optimised nucleic acid sequencing |
| WO2025264831A1 (en) | 2024-06-18 | 2025-12-26 | Illumina, Inc. | Methods for increasing sequencing quality of gc-rich regions |
| WO2026006314A1 (en) | 2024-06-28 | 2026-01-02 | Illumina, Inc. | Tagging target regions prior to nucleotide sequencing |
| WO2026035914A1 (en) | 2024-08-09 | 2026-02-12 | Illumina, Inc. | Nucleotides having 3'-hydroxy blocking groups |
| US20260117218A1 (en) * | 2024-10-31 | 2026-04-30 | Illumina, Inc. | Controlled dna fragment length bias for amplification |
| WO2026128365A1 (en) | 2024-12-09 | 2026-06-18 | Illumina, Inc. | Methods for increasing sequencing quality |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2567523B1 (fr) * | 1984-07-12 | 1987-11-13 | Pasteur Institut | Polynucleotides lies de facon covalente a un support solide, et procede pour leur obtention |
| US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
| WO1991006678A1 (en) | 1989-10-26 | 1991-05-16 | Sri International | Dna sequencing |
| JPH08508489A (ja) | 1993-03-31 | 1996-09-10 | スターリング ウィンスロップ インコーポレイティド | 二官能価ヌクレオシド、それらのオリゴマーならびにそれらの製造方法及び使用方法 |
| JP2001517948A (ja) | 1997-04-01 | 2001-10-09 | グラクソ、グループ、リミテッド | 核酸配列決定法 |
| EP2327797B1 (en) | 1997-04-01 | 2015-11-25 | Illumina Cambridge Limited | Method of nucleic acid sequencing |
| AU9460898A (en) * | 1997-10-14 | 1999-05-03 | Sankyo Company Limited | Modified oligodeoxyribonucleotides having tggg sequence |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| PL354094A1 (pl) | 1999-08-27 | 2003-12-29 | Icn Pharmaceuticals, Inc.Icn Pharmaceuticals, Inc. | Analogi nukleozydów pirolo[2,3-d]pirymidynowychAnalogi nukleozydów pirolo[2,3-d]pirymidynowych |
| US6831069B2 (en) | 1999-08-27 | 2004-12-14 | Ribapharm Inc. | Pyrrolo[2,3-d]pyrimidine nucleoside analogs |
| UA72612C2 (en) | 2000-07-06 | 2005-03-15 | Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells | |
| EP2100971A3 (en) | 2000-07-07 | 2009-11-25 | Visigen Biotechnologies, Inc. | Real-time sequence determination |
| EP3034627B1 (en) | 2000-10-06 | 2019-01-30 | The Trustees of Columbia University in the City of New York | Massive parallel method for decoding dna and rna |
| US7211414B2 (en) | 2000-12-01 | 2007-05-01 | Visigen Biotechnologies, Inc. | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity |
| US7057026B2 (en) * | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| AU2003259350A1 (en) | 2002-08-23 | 2004-03-11 | Solexa Limited | Modified nucleotides for polynucleotide sequencing |
| EP2789383B1 (en) | 2004-01-07 | 2023-05-03 | Illumina Cambridge Limited | Molecular arrays |
| US7315019B2 (en) | 2004-09-17 | 2008-01-01 | Pacific Biosciences Of California, Inc. | Arrays of optical confinements and uses thereof |
| GB0514936D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Preparation of templates for nucleic acid sequencing |
| US7405281B2 (en) | 2005-09-29 | 2008-07-29 | Pacific Biosciences Of California, Inc. | Fluorescent nucleotide analogs and uses therefor |
| WO2007053702A2 (en) * | 2005-10-31 | 2007-05-10 | The Trustees Of Columbia University In The City Of New York | Synthesis of four color 3'-o-allyl modified photocleavable fluorescent nucleotides and related methods |
| SG170802A1 (en) | 2006-03-31 | 2011-05-30 | Solexa Inc | Systems and devices for sequence by synthesis analysis |
| CA2651453C (en) | 2006-05-11 | 2014-10-14 | Isis Pharmaceuticals, Inc. | 5'-modified bicyclic nucleic acid analogs |
| US7666854B2 (en) | 2006-05-11 | 2010-02-23 | Isis Pharmaceuticals, Inc. | Bis-modified bicyclic nucleic acid analogs |
| US7754429B2 (en) | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
| EP2089517A4 (en) | 2006-10-23 | 2010-10-20 | Pacific Biosciences California | POLYMERASEENZYME AND REAGENTS FOR ADVANCED NUCKIC ACID SEQUENCING |
| US8951781B2 (en) | 2011-01-10 | 2015-02-10 | Illumina, Inc. | Systems, methods, and apparatuses to image a sample for biological or chemical analysis |
| US20140303235A1 (en) | 2011-08-11 | 2014-10-09 | Isis Pharmaceuticals, Inc. | Linkage modified gapped oligomeric compounds and uses thereof |
| EP2850092B1 (en) | 2012-04-09 | 2017-03-01 | Ionis Pharmaceuticals, Inc. | Tricyclic nucleic acid analogs |
| US9012022B2 (en) | 2012-06-08 | 2015-04-21 | Illumina, Inc. | Polymer coatings |
| US9650406B2 (en) * | 2013-02-28 | 2017-05-16 | Centrillion Technology Holdings Corporation | Reversible terminator molecules and methods of their use |
| ES2685549T3 (es) | 2013-03-15 | 2018-10-09 | Illumina Cambridge Limited | Nucleósidos o nucleótidos modificados |
| DK3431614T3 (da) | 2013-07-01 | 2021-12-06 | Illumina Inc | Katalysator fri overfladefunktionalisering og polymerpodning |
| CN116656795A (zh) * | 2016-05-23 | 2023-08-29 | 纽约哥伦比亚大学董事会 | 核苷酸衍生物及其使用方法 |
-
2019
- 2019-05-14 IL IL316537A patent/IL316537A/en unknown
- 2019-05-14 SG SG11201912274UA patent/SG11201912274UA/en unknown
- 2019-05-14 ES ES19727252T patent/ES2968459T3/es active Active
- 2019-05-14 US US16/411,913 patent/US12084474B2/en active Active
- 2019-05-14 IL IL271446A patent/IL271446B2/en unknown
- 2019-05-14 AU AU2019271121A patent/AU2019271121B2/en active Active
- 2019-05-14 DK DK19727252.9T patent/DK3794012T3/da active
- 2019-05-14 KR KR1020197038929A patent/KR102443569B1/ko active Active
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