PL379625A1 - Nowy sposób syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli - Google Patents

Nowy sposób syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli

Info

Publication number: PL379625A1
Authority: PL; Poland
Prior art keywords: perindopril; synthesis; pharmaceutically acceptable; acceptable salts; novel method
Prior art date: 2003-07-31

Application number

PL379625A

Other languages

English (en)

Other versions

PL211802B1 (pl

Inventor

Claude Fugier

Thierry Dubuffet

Pascal Langlois

Original Assignee

Les Laboratoires Servier

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-31

Filing date

2004-07-29

Publication date

2006-10-30

2004-07-29 Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier

2006-10-30 Publication of PL379625A1 publication Critical patent/PL379625A1/pl

2012-06-29 Publication of PL211802B1 publication Critical patent/PL211802B1/pl

Links

230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title 1
229960002582 perindopril Drugs 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hospice & Palliative Care (AREA)
Indole Compounds (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PL379625A 2003-07-31 2004-07-29 Sposób otrzymywania perindoprilu i jego farmaceutycznie dopuszczalnych soli oraz związek przejściowy PL211802B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03291930A EP1367062B1 (fr)	2003-07-31	2003-07-31	Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables

Publications (2)

Publication Number	Publication Date
PL379625A1 true PL379625A1 (pl)	2006-10-30
PL211802B1 PL211802B1 (pl)	2012-06-29

Family

ID=29414889

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL379625A PL211802B1 (pl)	2003-07-31	2004-07-29	Sposób otrzymywania perindoprilu i jego farmaceutycznie dopuszczalnych soli oraz związek przejściowy

Country Status (19)

Country	Link
US (1)	US7368580B2 (pl)
EP (1)	EP1367062B1 (pl)
JP (1)	JP4263744B2 (pl)
CN (1)	CN100439392C (pl)
AR (1)	AR045150A1 (pl)
AT (1)	ATE338058T1 (pl)
AU (1)	AU2004261440B2 (pl)
CY (1)	CY1105789T1 (pl)
DE (1)	DE60307925T2 (pl)
DK (1)	DK1367062T3 (pl)
EA (1)	EA008644B1 (pl)
ES (1)	ES2271497T3 (pl)
MY (1)	MY139098A (pl)
NZ (1)	NZ544880A (pl)
PL (1)	PL211802B1 (pl)
PT (1)	PT1367062E (pl)
SI (1)	SI1367062T1 (pl)
WO (1)	WO2005012328A2 (pl)
ZA (1)	ZA200600480B (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI21800A (sl) *	2004-05-14	2005-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nov postopek sinteze perindoprila
WO2016178591A2 (en)	2015-05-05	2016-11-10	Gene Predit, Sa	Genetic markers and treatment of male obesity
PH12018502155B1 (en)	2016-04-20	2024-03-27	Servier Lab	Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES8604144A1 (es) *	1984-11-21	1986-01-16	Farmhispania	Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico
FR2807431B1 (fr) *	2000-04-06	2002-07-19	Adir	Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
ES2240919T3 (es) *	2003-03-12	2005-10-16	Les Laboratoires Servier	Nuevo procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables.
PT1319668E (pt) *	2003-03-12	2005-02-28	Servier Lab	Novo processo de sintese de derivados do acido (2s,3as,7as)-1-[(s)-alanil]-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese de perindopril

2003
- 2003-07-31 DE DE60307925T patent/DE60307925T2/de not_active Expired - Lifetime
- 2003-07-31 PT PT03291930T patent/PT1367062E/pt unknown
- 2003-07-31 EP EP03291930A patent/EP1367062B1/fr not_active Expired - Lifetime
- 2003-07-31 DK DK03291930T patent/DK1367062T3/da active
- 2003-07-31 AT AT03291930T patent/ATE338058T1/de active
- 2003-07-31 ES ES03291930T patent/ES2271497T3/es not_active Expired - Lifetime
- 2003-07-31 SI SI200330449T patent/SI1367062T1/sl unknown
2004
- 2004-07-29 PL PL379625A patent/PL211802B1/pl unknown
- 2004-07-29 AR ARP040102692A patent/AR045150A1/es not_active Application Discontinuation
- 2004-07-29 JP JP2006521622A patent/JP4263744B2/ja not_active Expired - Fee Related
- 2004-07-29 MY MYPI20043052A patent/MY139098A/en unknown
- 2004-07-29 WO PCT/FR2004/002036 patent/WO2005012328A2/fr not_active Ceased
- 2004-07-29 CN CNB2004800212086A patent/CN100439392C/zh not_active Expired - Fee Related
- 2004-07-29 NZ NZ544880A patent/NZ544880A/en not_active IP Right Cessation
- 2004-07-29 AU AU2004261440A patent/AU2004261440B2/en not_active Ceased
- 2004-07-29 US US10/566,558 patent/US7368580B2/en not_active Expired - Fee Related
- 2004-07-29 ZA ZA200600480A patent/ZA200600480B/en unknown
- 2004-07-29 EA EA200600249A patent/EA008644B1/ru not_active IP Right Cessation
2006
- 2006-11-16 CY CY20061101671T patent/CY1105789T1/el unknown

Also Published As

Publication number	Publication date
HK1096407A1 (zh)	2007-06-01
ZA200600480B (en)	2007-05-30
PT1367062E (pt)	2006-12-29
JP4263744B2 (ja)	2009-05-13
EP1367062B1 (fr)	2006-08-30
EA200600249A1 (ru)	2006-06-30
AU2004261440B2 (en)	2008-07-31
CY1105789T1 (el)	2011-02-02
DE60307925D1 (de)	2006-10-12
PL211802B1 (pl)	2012-06-29
WO2005012328A3 (fr)	2005-03-24
DE60307925T2 (de)	2007-05-24
ES2271497T3 (es)	2007-04-16
US7368580B2 (en)	2008-05-06
DK1367062T3 (da)	2007-01-02
CN1826351A (zh)	2006-08-30
NZ544880A (en)	2009-03-31
WO2005012328A2 (fr)	2005-02-10
US20060189813A1 (en)	2006-08-24
SI1367062T1 (sl)	2006-12-31
MY139098A (en)	2009-08-28
JP2006528653A (ja)	2006-12-21
EA008644B1 (ru)	2007-06-29
ATE338058T1 (de)	2006-09-15
CN100439392C (zh)	2008-12-03
AU2004261440A1 (en)	2005-02-10
EP1367062A1 (fr)	2003-12-03
AR045150A1 (es)	2005-10-19

Publication	Publication Date	Title
AU4847001A (en)	2001-08-20	Method for synthesis of perindopril and its pharmaceutically acceptable salts
AU2001248470A1 (en)	2001-11-01	Method for synthesis of perindopril and its pharmaceutically acceptable salts
ZA200510324B (en)	2007-03-28	Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
SI1420028T1 (sl)	2007-06-30	Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
SI1367061T1 (sl)	2006-04-30	Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
EG24152A (en)	2008-08-19	Novel method for the synthesis of s-indoline-2-carboxylic acid and application thereof in synthesis of perindopril
SI1380590T1 (sl)	2006-12-31	Postopek za sintezo perindoprila in njenih farmacevtsko sprejemljivih soli
SI1371659T1 (sl)	2006-02-28	Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
SI1420029T1 (sl)	2008-08-31	Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
SI1380591T1 (sl)	2006-02-28	Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
SI1403275T1 (sl)	2006-02-28	Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
PL379631A1 (pl)	2006-10-30	Nowy sposób syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli
PL379625A1 (pl)	2006-10-30	Nowy sposób syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli
IL165802A0 (en)	2006-01-15	Process for the preparation of phenylalanine enamide derivatives
SI1422236T1 (sl)	2007-06-30	Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
PL1753720T3 (pl)	2014-09-30	Proces wytwarzania peryndoprylu i jego soli
AU2003210296A8 (en)	2003-09-04	Process for the preparation of 4-hetero-substituted phenylalanine derivatives
SI1268424T1 (sl)	2007-12-31	Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli