PL379627A1 - Nowy sposób syntezy perindoprylu oraz jego farmaceutycznie dopuszczalnych soli - Google Patents

Nowy sposób syntezy perindoprylu oraz jego farmaceutycznie dopuszczalnych soli

Info

Publication number: PL379627A1
Authority: PL; Poland
Prior art keywords: perindopril; formula; ester; hexahydroindole; synthesis
Prior art date: 2003-08-29

Application number

PL379627A

Other languages

English (en)

Other versions

PL211507B1 (pl

Inventor

Thierry Dubuffet

Jean-Pierre Lecouve

Original Assignee

Les Laboratoires Servier

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-08-29

Filing date

2004-08-27

Publication date

2006-10-30

2004-08-27 Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier

2006-10-30 Publication of PL379627A1 publication Critical patent/PL379627A1/pl

2012-05-31 Publication of PL211507B1 publication Critical patent/PL211507B1/pl

Links

229960002582 perindopril Drugs 0.000 title abstract 5
230000015572 biosynthetic process Effects 0.000 title abstract 3
IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title abstract 3
150000003839 salts Chemical class 0.000 title abstract 3
238000003786 synthesis reaction Methods 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
-1 amino acid halide Chemical class 0.000 abstract 8
YSNIDNCLWUNTOC-UHFFFAOYSA-N 2,3,3a,4,5,6-hexahydro-1h-indole-2-carboxylic acid Chemical compound C1CCC=C2NC(C(=O)O)CC21 YSNIDNCLWUNTOC-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
239000003054 catalyst Substances 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 2
125000004185 ester group Chemical group 0.000 abstract 2
YERWBBMSDMSDKT-UHFFFAOYSA-N ethyl 2-oxopentanoate Chemical compound CCCC(=O)C(=O)OCC YERWBBMSDMSDKT-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Peptides Or Proteins (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Catalysts (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL379627A 2003-08-29 2004-08-27 Sposób wytwarzania perindoprilu oraz jego farmaceutycznie dopuszczalnych soli PL211507B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03292133A EP1371659B1 (fr)	2003-08-29	2003-08-29	Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables

Publications (2)

Publication Number	Publication Date
PL379627A1 true PL379627A1 (pl)	2006-10-30
PL211507B1 PL211507B1 (pl)	2012-05-31

Family

ID=29558494

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL379627A PL211507B1 (pl)	2003-08-29	2004-08-27	Sposób wytwarzania perindoprilu oraz jego farmaceutycznie dopuszczalnych soli

Country Status (17)

Country	Link
US (1)	US7223872B2 (pl)
EP (1)	EP1371659B1 (pl)
JP (1)	JP4331207B2 (pl)
CN (1)	CN100374459C (pl)
AR (1)	AR045517A1 (pl)
AT (1)	ATE306496T1 (pl)
AU (1)	AU2004270429B2 (pl)
DE (1)	DE60301820T2 (pl)
DK (1)	DK1371659T3 (pl)
EA (1)	EA008626B1 (pl)
ES (1)	ES2250853T3 (pl)
MY (1)	MY136288A (pl)
NZ (1)	NZ545338A (pl)
PL (1)	PL211507B1 (pl)
SI (1)	SI1371659T1 (pl)
WO (1)	WO2005023843A1 (pl)
ZA (1)	ZA200601426B (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1380590T1 (sl) *	2003-08-29	2006-12-31	Servier Lab	Postopek za sintezo perindoprila in njenih farmacevtsko sprejemljivih soli
ATE310012T1 (de) *	2003-08-29	2005-12-15	Servier Lab	Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen
US7456296B2 (en) *	2003-10-21	2008-11-25	Lupin Ltd	Method for preparation of crystalline perindopril erbumine
SI21704A (en) *	2004-01-14	2005-08-31	Lek Farmacevtska Druzba Dd	New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
EP1987828A1 (en)	2005-01-06	2008-11-05	IPCA Laboratories Limited	salts of perindopril and their use in the therapy of hypertension
WO2016178591A2 (en)	2015-05-05	2016-11-10	Gene Predit, Sa	Genetic markers and treatment of male obesity
PH12018502155B1 (en)	2016-04-20	2024-03-27	Servier Lab	Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN113980096A (zh) *	2021-11-29	2022-01-28	绍兴市上虞区武汉理工大学高等研究院	一种吨级培哚普利叔丁胺的合成工艺方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1319668E (pt) *	2003-03-12	2005-02-28	Servier Lab	Novo processo de sintese de derivados do acido (2s,3as,7as)-1-[(s)-alanil]-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese de perindopril
ATE310012T1 (de) *	2003-08-29	2005-12-15	Servier Lab	Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen

2003
- 2003-08-29 EP EP03292133A patent/EP1371659B1/fr not_active Expired - Lifetime
- 2003-08-29 DE DE60301820T patent/DE60301820T2/de not_active Expired - Lifetime
- 2003-08-29 DK DK03292133T patent/DK1371659T3/da active
- 2003-08-29 AT AT03292133T patent/ATE306496T1/de active
- 2003-08-29 ES ES03292133T patent/ES2250853T3/es not_active Expired - Lifetime
- 2003-08-29 SI SI200330103T patent/SI1371659T1/sl unknown
2004
- 2004-08-26 MY MYPI20043494A patent/MY136288A/en unknown
- 2004-08-27 CN CNB2004800235321A patent/CN100374459C/zh not_active Expired - Fee Related
- 2004-08-27 ZA ZA200601426A patent/ZA200601426B/xx unknown
- 2004-08-27 PL PL379627A patent/PL211507B1/pl unknown
- 2004-08-27 US US10/570,565 patent/US7223872B2/en not_active Expired - Fee Related
- 2004-08-27 NZ NZ545338A patent/NZ545338A/en not_active IP Right Cessation
- 2004-08-27 WO PCT/FR2004/002198 patent/WO2005023843A1/fr not_active Ceased
- 2004-08-27 JP JP2006524396A patent/JP4331207B2/ja not_active Expired - Fee Related
- 2004-08-27 EA EA200600455A patent/EA008626B1/ru not_active IP Right Cessation
- 2004-08-27 AU AU2004270429A patent/AU2004270429B2/en not_active Ceased
- 2004-08-27 AR ARP040103080A patent/AR045517A1/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU2004270429A1 (en)	2005-03-17
CN100374459C (zh)	2008-03-12
NZ545338A (en)	2009-03-31
DK1371659T3 (da)	2005-11-21
ZA200601426B (en)	2007-05-30
EA200600455A1 (ru)	2006-08-25
US7223872B2 (en)	2007-05-29
DE60301820D1 (de)	2006-02-23
HK1097852A1 (en)	2007-07-06
DE60301820T2 (de)	2006-07-13
ATE306496T1 (de)	2005-10-15
AU2004270429B2 (en)	2007-05-24
EP1371659B1 (fr)	2005-10-12
EP1371659A1 (fr)	2003-12-17
CN1835965A (zh)	2006-09-20
MY136288A (en)	2008-09-30
US20070088168A1 (en)	2007-04-19
PL211507B1 (pl)	2012-05-31
WO2005023843A1 (fr)	2005-03-17
AR045517A1 (es)	2005-11-02
JP2007536202A (ja)	2007-12-13
EA008626B1 (ru)	2007-06-29
SI1371659T1 (sl)	2006-02-28
JP4331207B2 (ja)	2009-09-16
ES2250853T3 (es)	2006-04-16

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PL379627A1 (pl)	2006-10-30	Nowy sposób syntezy perindoprylu oraz jego farmaceutycznie dopuszczalnych soli
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