PL379702A1 - Pochodne benzamidu jako agoniści oksytocyny i antagoniści wazopresyny - Google Patents

Pochodne benzamidu jako agoniści oksytocyny i antagoniści wazopresyny

Info

Publication number: PL379702A1
Authority: PL; Poland
Prior art keywords: benzamide derivatives; vasopressin antagonists; oxytocin agonists; oxytocin; agonists
Prior art date: 2003-02-14

Application number

PL379702A

Other languages

English (en)

Inventor

Peter Hudson

Andrzej Roman Batt

Celine Marguerite Simone Heeney

Andrew John Baxter

Michael Bryan Roe

Peter Andrew Robson

Original Assignee

Vantia Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-02-14

Filing date

2004-02-12

Publication date

2006-11-13

2004-02-12 Application filed by Vantia Limited filed Critical Vantia Limited

2006-11-13 Publication of PL379702A1 publication Critical patent/PL379702A1/pl

Links

101800000989 Oxytocin Proteins 0.000 title 1
XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 title 1
102100031951 Oxytocin-neurophysin 1 Human genes 0.000 title 1
229940116211 Vasopressin antagonist Drugs 0.000 title 1
239000000556 agonist Substances 0.000 title 1
150000003936 benzamides Chemical class 0.000 title 1
XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 title 1
229960001723 oxytocin Drugs 0.000 title 1
239000003038 vasopressin antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Gynecology & Obstetrics (AREA)
Diabetes (AREA)
Pregnancy & Childbirth (AREA)
Cardiology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Gastroenterology & Hepatology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PL379702A 2003-02-14 2004-02-12 Pochodne benzamidu jako agoniści oksytocyny i antagoniści wazopresyny PL379702A1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03003394A EP1449844A1 (en)	2003-02-14	2003-02-14	benzamide derivatives as oxytocin agonists and vasopressin antagonists

Publications (1)

Publication Number	Publication Date
PL379702A1 true PL379702A1 (pl)	2006-11-13

Family

ID=32731527

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL379702A PL379702A1 (pl)	2003-02-14	2004-02-12	Pochodne benzamidu jako agoniści oksytocyny i antagoniści wazopresyny

Country Status (13)

Country	Link
US (2)	US7407949B2 (pl)
EP (2)	EP1449844A1 (pl)
JP (1)	JP2006517530A (pl)
KR (1)	KR100725560B1 (pl)
CN (1)	CN100349896C (pl)
AU (1)	AU2004212140B2 (pl)
CA (1)	CA2513220A1 (pl)
MX (1)	MXPA05008601A (pl)
NO (1)	NO20054225L (pl)
NZ (1)	NZ540768A (pl)
PL (1)	PL379702A1 (pl)
RU (1)	RU2340617C2 (pl)
WO (1)	WO2004072083A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0000079D0 (en)	2000-01-05	2000-02-23	Ferring Bv	Novel antidiuretic agents
EP1632494A1 (en)	2004-08-24	2006-03-08	Ferring B.V.	Vasopressin v1a antagonists
AU2006306547A1 (en) *	2005-10-24	2007-05-03	Wyeth	Tricyclic compounds useful as oxytocin receptor agonists
GB0903493D0 (en)	2009-02-27	2009-04-08	Vantia Ltd	New compounds
US8263633B2 (en) *	2009-09-28	2012-09-11	F. Hoffman-La Roche Ag	Benzoxepin PI3K inhibitor compounds and methods of use
GB201004677D0 (en)	2010-03-19	2010-05-05	Vantia Ltd	New salt
CN102905720A (zh)	2010-05-18	2013-01-30	日内瓦大学	催产素样分子的新用途及相关的方法
EP2575853B1 (en)	2010-05-25	2016-08-24	INSERM - Institut National de la Santé et de la Recherche Médicale	Methods and pharmaceutical composition for the treatment of a feeding disorder with early-onset in a patient
CA3046809A1 (en) *	2016-12-12	2018-06-21	The University Of Sydney	Non-peptide oxytocin receptor agonists
US11033601B2 (en)	2017-09-14	2021-06-15	The Regents Of The University Of Colorado, A Body Corporate	Selective inhibition of V1b for treating fatty liver

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5760031A (en) *	1993-07-29	1998-06-02	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists
AR011913A1 (es) *	1997-03-06	2000-09-13	Yamano Masaki	Derivados de 4,4-difluoro-2,3,4,5-tetrahidro-1h-1-benzoazepina y composiciones farmaceuticas de los mismos.
GB2326639A (en) *	1997-06-18	1998-12-30	Merck & Co Inc	Piperazine Oxytocin Receptor Antagonists
US7326700B2 (en) *	2001-04-12	2008-02-05	Wyeth	Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
GB0115515D0 (en) *	2001-06-25	2001-08-15	Ferring Bv	Oxytocin agonisys
GB0120051D0 (en) *	2001-08-16	2001-10-10	Ferring Bv	Oxytocin agonists

2003
- 2003-02-14 EP EP03003394A patent/EP1449844A1/en not_active Withdrawn
2004
- 2004-02-12 NZ NZ540768A patent/NZ540768A/en unknown
- 2004-02-12 CN CNB2004800042329A patent/CN100349896C/zh not_active Expired - Fee Related
- 2004-02-12 JP JP2006500029A patent/JP2006517530A/ja not_active Withdrawn
- 2004-02-12 PL PL379702A patent/PL379702A1/pl not_active Application Discontinuation
- 2004-02-12 KR KR1020057014970A patent/KR100725560B1/ko not_active Expired - Fee Related
- 2004-02-12 AU AU2004212140A patent/AU2004212140B2/en not_active Ceased
- 2004-02-12 RU RU2005122323/04A patent/RU2340617C2/ru not_active IP Right Cessation
- 2004-02-12 CA CA002513220A patent/CA2513220A1/en not_active Abandoned
- 2004-02-12 MX MXPA05008601A patent/MXPA05008601A/es active IP Right Grant
- 2004-02-12 US US10/541,460 patent/US7407949B2/en not_active Expired - Fee Related
- 2004-02-12 EP EP04710384A patent/EP1592693A1/en not_active Withdrawn
- 2004-02-12 WO PCT/EP2004/001304 patent/WO2004072083A1/en not_active Ceased
2005
- 2005-09-12 NO NO20054225A patent/NO20054225L/no not_active Application Discontinuation
2008
- 2008-06-20 US US12/213,576 patent/US20080275026A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2004072083A1 (en)	2004-08-26
NO20054225D0 (no)	2005-09-12
KR100725560B1 (ko)	2007-06-08
CA2513220A1 (en)	2004-08-26
US7407949B2 (en)	2008-08-05
JP2006517530A (ja)	2006-07-27
CN1751050A (zh)	2006-03-22
KR20050098931A (ko)	2005-10-12
AU2004212140A1 (en)	2004-08-26
EP1592693A1 (en)	2005-11-09
NO20054225L (no)	2005-11-14
MXPA05008601A (es)	2005-11-04
RU2005122323A (ru)	2006-02-27
NZ540768A (en)	2008-05-30
AU2004212140B2 (en)	2006-12-21
EP1449844A1 (en)	2004-08-25
US20080275026A1 (en)	2008-11-06
RU2340617C2 (ru)	2008-12-10
CN100349896C (zh)	2007-11-21
US20060166971A1 (en)	2006-07-27

Legal Events

Date	Code	Title	Description
2011-12-30	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
TWI319387B (en)	2010-01-11	Benzamide derivatives
AU2003238597A8 (en)	2004-01-06	Benzimidazole compounds and their use as estrogen agonists/antagonists
IL165841A0 (en)	2006-01-15	Mchir antagonists
IL185343A0 (en)	2008-02-09	2-(4-oxo-4h-quinazolin-3-yl)acetamides and their use as vasopressin v3 antagonists
IL172467A0 (en)	2006-04-10	Quinolyl amide derivatives as ccr-5 antagonists
EP1550657A4 (en)	2009-12-30	AMINO COMPOUNDS AND THEIR USE
HRP20040883A2 (en)	2004-12-31	Pyridinoylpiperidines as 5-ht1f agonists
EP1675830A4 (en)	2008-08-20	HETEROCYCLIC AMIDES AND SULFONAMIDES
PL372295A1 (pl)	2005-07-11	Pochodne chinoliny jako antagoniści NPY
EP1572103A4 (en)	2008-02-13	ANTI-ANGIOGENIC USES OF IL-6 ANTAGONISTS
PL1619180T3 (pl)	2010-05-31	ANTAGONISTA CaSR
IL169336A0 (en)	2007-07-04	Substituted 1-piperidin-4-yl-4-pyrrolidin-3-yl-piperazine derivatives and their use as neurokinin antagonists
GB0219961D0 (en)	2002-10-02	Oxytocin inhibitors
TWI340740B (en)	2011-04-21	Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists
PL379702A1 (pl)	2006-11-13	Pochodne benzamidu jako agoniści oksytocyny i antagoniści wazopresyny
IL178461A0 (en)	2007-02-11	Substituted 4-alkyl -and 4-alkanoyl-piperidine derivatives and their use as neurokinin antagonists
EG24929A (en)	2011-01-05	Substituted diketopiperazines and their use as oxytocin antagonists
IL159821A0 (en)	2004-06-20	Diazacycloalkanes as oxytocin agonists
IL179912A0 (en)	2007-05-15	Substituted diketopiperazines as oxytocin antagonists
DE60303424D1 (de)	2006-04-13	D-Ring Halterung
ZA200707090B (en)	2008-10-29	2-(4-oxo-4H-quinazolin-3-yl) acetamides and their use as vasopressin V3 antagonists
IL169337A0 (en)	2007-07-04	Substituted 1-piperidin-3-yl-4-piperidin-4-yl-piperazine derivatives and their use as neurokinin antagonists
HK1081534A (en)	2006-05-19	Benzamide derivatives as oxytocin agonists and vasopressin antagonists
AU2003223329A8 (en)	2003-10-20	Antagonists of rf-amide neuropeptides
PL1902047T3 (pl)	2010-09-30	Związek karboksyamidowy i jego zastosowanie