PL3801526T3 - Monohydrat i postacie krystaliczne 6-[(3S,4S)-4-metylo-1-(pirymidyn-2-ylometylo)pirolidyn-3-ylo]-3-tetrahydropiran-4-ylo-7H-imidazo[1,5-a]pirazyn-8-onu - Google Patents

Monohydrat i postacie krystaliczne 6-[(3S,4S)-4-metylo-1-(pirymidyn-2-ylometylo)pirolidyn-3-ylo]-3-tetrahydropiran-4-ylo-7H-imidazo[1,5-a]pirazyn-8-onu

Info

Publication number
PL3801526T3
PL3801526T3 PL19807965.9T PL19807965T PL3801526T3 PL 3801526 T3 PL3801526 T3 PL 3801526T3 PL 19807965 T PL19807965 T PL 19807965T PL 3801526 T3 PL3801526 T3 PL 3801526T3
Authority
PL
Poland
Prior art keywords
pyrazin
tetrahydropyran
pyrrolidin
pyrimidin
ylmethyl
Prior art date
Application number
PL19807965.9T
Other languages
English (en)
Inventor
Suzanne BUTTAR
Mateusz PITAK
Adam Ross PATTERSON
Samuel Alexander STRATFORD
Ioana SOVAGO
Jun Xu
Peng Zhou
Haojuan WEI
Kuangchu DAI
Original Assignee
Cardurion Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardurion Pharmaceuticals, Inc. filed Critical Cardurion Pharmaceuticals, Inc.
Publication of PL3801526T3 publication Critical patent/PL3801526T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
PL19807965.9T 2018-05-25 2019-05-23 Monohydrat i postacie krystaliczne 6-[(3S,4S)-4-metylo-1-(pirymidyn-2-ylometylo)pirolidyn-3-ylo]-3-tetrahydropiran-4-ylo-7H-imidazo[1,5-a]pirazyn-8-onu PL3801526T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862676381P 2018-05-25 2018-05-25
US201962788323P 2019-01-04 2019-01-04
PCT/US2019/033835 WO2019226944A1 (en) 2018-05-25 2019-05-23 Monohydrate and crystalline forms of 6-[(3s,4s)-4-methyl-1- (pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl- 7h-imid azo [1,5- a] pyrazin-8-one

Publications (1)

Publication Number Publication Date
PL3801526T3 true PL3801526T3 (pl) 2024-08-05

Family

ID=68617192

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19807965.9T PL3801526T3 (pl) 2018-05-25 2019-05-23 Monohydrat i postacie krystaliczne 6-[(3S,4S)-4-metylo-1-(pirymidyn-2-ylometylo)pirolidyn-3-ylo]-3-tetrahydropiran-4-ylo-7H-imidazo[1,5-a]pirazyn-8-onu

Country Status (22)

Country Link
US (2) US12006319B2 (pl)
EP (2) EP3801526B1 (pl)
JP (2) JP7818900B2 (pl)
KR (1) KR102923255B1 (pl)
CN (2) CN117843645A (pl)
AU (1) AU2019275075B2 (pl)
BR (2) BR122023022641A2 (pl)
CA (1) CA3100988A1 (pl)
DK (1) DK3801526T3 (pl)
ES (1) ES2975792T3 (pl)
FI (1) FI3801526T3 (pl)
HR (1) HRP20240363T1 (pl)
HU (1) HUE065709T2 (pl)
IL (1) IL278875A (pl)
LT (1) LT3801526T (pl)
MA (1) MA52792A (pl)
MX (2) MX2020012636A (pl)
PL (1) PL3801526T3 (pl)
PT (1) PT3801526T (pl)
SI (1) SI3801526T1 (pl)
WO (1) WO2019226944A1 (pl)
ZA (1) ZA202401459B (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018000254A2 (pt) 2015-07-07 2018-09-04 H Lundbeck As inibidores de pde9 com cadeia principal de imidazotriazinona e cadeia principal de imidazopirazinona para o tratamento de doenças periféricas
EP3801526B1 (en) 2018-05-25 2023-12-27 Imara Inc. Monohydrate and crystalline forms of 6-[(3s,4s)-4-methyl-1- (pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl- 7h-imid azo [1,5- a] pyrazin-8-one
CN112996512B (zh) 2018-08-31 2025-01-03 卡都瑞恩医药公司 用于治疗镰状细胞病的pde9抑制剂
EP3965768A1 (en) * 2019-05-07 2022-03-16 Imara Inc. Pde9 inhibitors for treating thalassemia
US20240025904A1 (en) * 2020-10-27 2024-01-25 Cardurion Pharmaceuticals, Inc. Pde9 inhibitors for treating cardiac failure

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