PL3805220T3 - Policykliczne pochodne karbamoilopirydonu w leczeniu hiv - Google Patents

Policykliczne pochodne karbamoilopirydonu w leczeniu hiv

Info

Publication number
PL3805220T3
PL3805220T3 PL19810498.6T PL19810498T PL3805220T3 PL 3805220 T3 PL3805220 T3 PL 3805220T3 PL 19810498 T PL19810498 T PL 19810498T PL 3805220 T3 PL3805220 T3 PL 3805220T3
Authority
PL
Poland
Prior art keywords
hiv
treatment
polycyclic carbamoylpyridone
carbamoylpyridone derivatives
derivatives
Prior art date
Application number
PL19810498.6T
Other languages
English (en)
Inventor
Yoshiyuki Taoda
Yuto Unoh
Original Assignee
Shionogi & Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co., Ltd filed Critical Shionogi & Co., Ltd
Publication of PL3805220T3 publication Critical patent/PL3805220T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PL19810498.6T 2018-05-31 2019-05-30 Policykliczne pochodne karbamoilopirydonu w leczeniu hiv PL3805220T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018104156 2018-05-31
PCT/JP2019/021446 WO2019230858A1 (ja) 2018-05-31 2019-05-30 多環性カルバモイルピリドン誘導体

Publications (1)

Publication Number Publication Date
PL3805220T3 true PL3805220T3 (pl) 2024-11-04

Family

ID=68698918

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19810498.6T PL3805220T3 (pl) 2018-05-31 2019-05-30 Policykliczne pochodne karbamoilopirydonu w leczeniu hiv

Country Status (37)

Country Link
US (3) US11649236B2 (pl)
EP (2) EP3805220B1 (pl)
JP (2) JP7328962B2 (pl)
KR (2) KR20250002769A (pl)
CN (2) CN117327072A (pl)
AR (1) AR115455A1 (pl)
AU (2) AU2019277548B2 (pl)
BR (1) BR112020024077A2 (pl)
CA (1) CA3102063A1 (pl)
CL (1) CL2020003002A1 (pl)
CO (1) CO2020014294A2 (pl)
CR (2) CR20230571A (pl)
DK (1) DK3805220T3 (pl)
DO (1) DOP2020000221A (pl)
EA (1) EA202092921A1 (pl)
ES (1) ES2984245T3 (pl)
FI (1) FI3805220T3 (pl)
HR (1) HRP20241221T1 (pl)
HU (1) HUE068170T2 (pl)
IL (2) IL313474A (pl)
LT (1) LT3805220T (pl)
MA (1) MA52795B1 (pl)
MD (1) MD3805220T2 (pl)
MX (2) MX2020012176A (pl)
MY (1) MY198568A (pl)
NZ (1) NZ771017A (pl)
PE (2) PE20251594A1 (pl)
PH (1) PH12020552000A1 (pl)
PL (1) PL3805220T3 (pl)
PT (1) PT3805220T (pl)
RS (1) RS65891B1 (pl)
SG (1) SG11202011382PA (pl)
SI (1) SI3805220T1 (pl)
SM (1) SMT202400330T1 (pl)
UA (1) UA129229C2 (pl)
WO (1) WO2019230858A1 (pl)
ZA (1) ZA202007567B (pl)

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CN119462659A (zh) 2019-03-22 2025-02-18 吉利德科学公司 桥连三环氨基甲酰基吡啶酮化合物及其药学用途
US12577241B2 (en) 2019-11-28 2026-03-17 Shionogi & Co., Ltd. Polycyclic pyridopyrazine derivative
JPWO2021107066A1 (pl) * 2019-11-28 2021-06-03
PE20221569A1 (es) 2020-02-24 2022-10-06 Gilead Sciences Inc Compuestos tetraciclicos para el tratamiento de infecciones por vih
WO2021233302A1 (zh) * 2020-05-21 2021-11-25 南京明德新药研发有限公司 稠环衍生物及其在药学上的应用
EP4188379B1 (en) * 2020-07-27 2026-02-25 Merck Sharp & Dohme LLC Polycyclic cap-dependent endonuclease inhibitors for treating or preventing influenza
WO2022072520A1 (en) 2020-09-30 2022-04-07 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and uses thereof
LT4196479T (lt) * 2021-01-19 2023-12-11 Gilead Sciences, Inc. Pakeistieji piridotriazino junginiai ir jų panaudojimo būdai
CN117751118A (zh) * 2021-07-30 2024-03-22 吉斯凯(苏州)制药有限公司 大环吡啶酮类化合物及其应用
TW202446773A (zh) 2022-04-06 2024-12-01 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途
WO2024061257A1 (zh) * 2022-09-20 2024-03-28 吉斯凯(苏州)制药有限公司 多环氮杂环酮类化合物及其应用

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EP3548031B1 (en) 2016-12-02 2023-07-19 Merck Sharp & Dohme LLC Tricyclic heterocycle compounds useful as hiv integrase inhibitors
EP3752144B1 (en) 2018-02-15 2022-12-28 Merck Sharp & Dohme LLC Tricyclic heterocycle compounds useful as hiv integrase inhibitors
JP2021522254A (ja) 2018-04-27 2021-08-30 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｈｉｖインテグラーゼ阻害剤として有用な三環式複素環化合物
CN110526930B (zh) 2018-05-23 2022-06-03 莫云芬 抗hiv病毒的含硫多环-羟基吡啶酮甲酰胺类似物及其应用
AU2019277547B2 (en) 2018-05-31 2024-10-10 Shionogi & Co., Ltd. Polycyclic pyridone derivative
US11884683B2 (en) 2018-06-05 2024-01-30 Merck Sharp & Dohme Llc Tricyclic heterocycle compounds useful as HIV integrase inhibitors
CN108957755B (zh) 2018-07-27 2021-04-30 京东方科技集团股份有限公司 一种显示组件及其控制方法、平视显示器及汽车
CN119462659A (zh) 2019-03-22 2025-02-18 吉利德科学公司 桥连三环氨基甲酰基吡啶酮化合物及其药学用途

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ES2984245T3 (es) 2024-10-29
IL279051B1 (en) 2024-09-01
EP3805220B1 (en) 2024-07-31
EP4257137A2 (en) 2023-10-11
PH12020552000A1 (en) 2021-09-27
SMT202400330T1 (it) 2024-09-16
JP7679427B2 (ja) 2025-05-19
BR112020024077A2 (pt) 2021-02-09
US11649236B2 (en) 2023-05-16
EP4257137A3 (en) 2023-11-01
AU2019277548A1 (en) 2021-01-14
MD3805220T2 (ro) 2024-10-31
SI3805220T1 (sl) 2024-10-30
KR20210015922A (ko) 2021-02-10
CR20230571A (es) 2024-01-22
NZ771017A (en) 2026-01-30
MX2023010377A (es) 2023-09-12
HRP20241221T1 (hr) 2024-12-06
CN112513042A (zh) 2021-03-16
PE20251594A1 (es) 2025-06-16
ZA202007567B (en) 2022-04-28
MX2020012176A (es) 2021-01-29
CN117327072A (zh) 2024-01-02
JPWO2019230858A1 (ja) 2021-06-24
CA3102063A1 (en) 2019-12-05
HUE068170T2 (hu) 2024-12-28
CR20200644A (es) 2021-02-05
CO2020014294A2 (es) 2020-12-21
AU2024200783B2 (en) 2026-03-26
EP3805220A4 (en) 2022-01-05
WO2019230858A1 (ja) 2019-12-05
DOP2020000221A (es) 2021-03-15
RS65891B1 (sr) 2024-09-30
JP2023145723A (ja) 2023-10-11
IL313474A (en) 2024-08-01
KR102741390B1 (ko) 2024-12-10
AU2024200783A1 (en) 2024-02-29
US20230227454A1 (en) 2023-07-20
MA52795B1 (fr) 2024-09-30
CN112513042B (zh) 2023-09-29
KR20250002769A (ko) 2025-01-07
JP7328962B2 (ja) 2023-08-17
IL279051A (en) 2021-01-31
MA52795A (fr) 2021-04-14
EP3805220A1 (en) 2021-04-14
SG11202011382PA (en) 2020-12-30
PE20210477A1 (es) 2021-03-11
EA202092921A1 (ru) 2021-04-07
LT3805220T (lt) 2024-08-26
US12139489B2 (en) 2024-11-12
MY198568A (en) 2023-09-05
DK3805220T3 (da) 2024-08-26
AR115455A1 (es) 2021-01-20
IL279051B2 (en) 2025-01-01
AU2019277548B2 (en) 2023-12-14
US20240352015A1 (en) 2024-10-24
PT3805220T (pt) 2024-08-16
FI3805220T3 (fi) 2024-08-30
US20210122751A1 (en) 2021-04-29
CL2020003002A1 (es) 2021-04-16
UA129229C2 (uk) 2025-02-19

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