PL381824A1 - Sekwencja siRNA, wektor, cel molekularny dla reagentów siRNA i wektorów wprowadzanych do komórek i tkanek, sposób oceny specyficzności wyciszania zmutowanego transkryptu, sposób badania oddziaływań enzymów szlaku interferencji RNA z transkryptami oraz zastosowanie sekwencji siRNA i wektora - Google Patents

Sekwencja siRNA, wektor, cel molekularny dla reagentów siRNA i wektorów wprowadzanych do komórek i tkanek, sposób oceny specyficzności wyciszania zmutowanego transkryptu, sposób badania oddziaływań enzymów szlaku interferencji RNA z transkryptami oraz zastosowanie sekwencji siRNA i wektora

Info

Publication number
PL381824A1
PL381824A1 PL381824A PL38182407A PL381824A1 PL 381824 A1 PL381824 A1 PL 381824A1 PL 381824 A PL381824 A PL 381824A PL 38182407 A PL38182407 A PL 38182407A PL 381824 A1 PL381824 A1 PL 381824A1
Authority
PL
Poland
Prior art keywords
manner
sirna
specifity
enz
silencing
Prior art date
Application number
PL381824A
Other languages
English (en)
Inventor
Włodzimierz Krzyżosiak
Jacek Król
Agnieszka Fiszer
Original Assignee
Instytut Chemii Bioorganicznej Pan W Poznaniu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Chemii Bioorganicznej Pan W Poznaniu filed Critical Instytut Chemii Bioorganicznej Pan W Poznaniu
Priority to PL381824A priority Critical patent/PL381824A1/pl
Priority to PCT/PL2008/000017 priority patent/WO2008103060A1/en
Publication of PL381824A1 publication Critical patent/PL381824A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL381824A 2007-02-22 2007-02-22 Sekwencja siRNA, wektor, cel molekularny dla reagentów siRNA i wektorów wprowadzanych do komórek i tkanek, sposób oceny specyficzności wyciszania zmutowanego transkryptu, sposób badania oddziaływań enzymów szlaku interferencji RNA z transkryptami oraz zastosowanie sekwencji siRNA i wektora PL381824A1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL381824A PL381824A1 (pl) 2007-02-22 2007-02-22 Sekwencja siRNA, wektor, cel molekularny dla reagentów siRNA i wektorów wprowadzanych do komórek i tkanek, sposób oceny specyficzności wyciszania zmutowanego transkryptu, sposób badania oddziaływań enzymów szlaku interferencji RNA z transkryptami oraz zastosowanie sekwencji siRNA i wektora
PCT/PL2008/000017 WO2008103060A1 (en) 2007-02-22 2008-02-15 A sirna sequence, vector, a molecular target for sirna reagents and vectors introduced into cells and tissues, a method of evaluating the specificity of the silencing of the mutated transcript, a method of examining the interactions of enzymes on the rnai pathway with transcripts as well as the application of the sirna sequ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL381824A PL381824A1 (pl) 2007-02-22 2007-02-22 Sekwencja siRNA, wektor, cel molekularny dla reagentów siRNA i wektorów wprowadzanych do komórek i tkanek, sposób oceny specyficzności wyciszania zmutowanego transkryptu, sposób badania oddziaływań enzymów szlaku interferencji RNA z transkryptami oraz zastosowanie sekwencji siRNA i wektora

Publications (1)

Publication Number Publication Date
PL381824A1 true PL381824A1 (pl) 2008-09-01

Family

ID=39472552

Family Applications (1)

Application Number Title Priority Date Filing Date
PL381824A PL381824A1 (pl) 2007-02-22 2007-02-22 Sekwencja siRNA, wektor, cel molekularny dla reagentów siRNA i wektorów wprowadzanych do komórek i tkanek, sposób oceny specyficzności wyciszania zmutowanego transkryptu, sposób badania oddziaływań enzymów szlaku interferencji RNA z transkryptami oraz zastosowanie sekwencji siRNA i wektora

Country Status (2)

Country Link
PL (1) PL381824A1 (pl)
WO (1) WO2008103060A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2639852T3 (es) 2007-10-26 2017-10-30 Academisch Ziekenhuis Leiden Medios y métodos para contrarrestar los trastornos musculares
EP2119783A1 (en) 2008-05-14 2009-11-18 Prosensa Technologies B.V. Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
EP2421971B1 (en) 2009-04-24 2016-07-06 BioMarin Technologies B.V. Oligonucleotide comprising an inosine for treating dmd
NZ627896A (en) 2012-01-27 2016-11-25 Biomarin Technologies B V Rna modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy
JP2021534755A (ja) * 2018-08-22 2021-12-16 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル 筋強直性ジストロフィープロテインキナーゼの発現を抑制および／またはｄｍｐｋ遺伝子の３’非翻訳領域におけるトリヌクレオチドリピート伸長に干渉するための組換えウイルス産物および方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7589189B2 (en) * 2003-05-14 2009-09-15 Japan Science And Technology Agency Inhibition of the expression of huntingtin gene
DK2821085T3 (da) * 2003-09-12 2020-08-03 Univ Massachusetts Rna-interferens til behandling af "gain-of-function"-forstyrrelser

Also Published As

Publication number Publication date
WO2008103060A1 (en) 2008-08-28

Similar Documents

Publication Publication Date Title
BRPI0906241A2 (pt) Molécula de ácido nucléico isolada, gene quimérico, vetor e método de transformação de uma célula bacteriana.
MX2010008099A (es) Anticuerpos y angiopoyetina-2 estabilizados y sus usos.
WO2008061213A3 (en) Genetic variations associated with tumors
WO2009100188A3 (en) Methods for detection of corn event das-59132
EA201691664A1 (ru) МУТИРОВАННЫЕ ГЕНЫ СИНТАЗЫ АЦЕТОГИДРОКСИКИСЛОТ В Brassica
WO2014182528A3 (en) Multiplex labeling of molecules by sequential hybridization barcoding
WO2010062913A3 (en) Methods and systems for analysis of sequencing data
WO2009129505A3 (en) Compositions, methods, and kits using synthetic probes for determining the presence of a target nucleic acid
WO2010117817A3 (en) Methods for generating target specific probes for solution based capture
PL381824A1 (pl) Sekwencja siRNA, wektor, cel molekularny dla reagentów siRNA i wektorów wprowadzanych do komórek i tkanek, sposób oceny specyficzności wyciszania zmutowanego transkryptu, sposób badania oddziaływań enzymów szlaku interferencji RNA z transkryptami oraz zastosowanie sekwencji siRNA i wektora
EP2100970A3 (en) Ig genes specific oligonucleotides and uses thereof
WO2009102983A3 (en) Efficient induction of pluripotent stem cells using small molecule compounds
NZ588658A (en) Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor
MX2010002965A (es) Deteccion mejorada de la expresion de mage-a.
MX2010002113A (es) Metodos para detectar oligonucleotidos.
MX338063B (es) Molecula de union especifica al rsv.
MX2014002854A (es) Metodos para etiquetar bibliotecas codificadas por adn.
WO2007128982A3 (en) Compositions and methods for epigenetic modification of nucleic acid sequences in vivo
WO2008147430A3 (en) Microrna-formatted multitarget interfering rna vector constructs and methods of using the same
EP2473631A4 (en) BINDING-INDUCED HAIR NEEDLE DETECTION SYSTEM
MX2011009597A (es) Deteccion mejorada de la expresion del gen.
MX2010001380A (es) Hibridación in-situ para detectar marcadores de arn y adn.
BRPI0922957A2 (pt) modificação de vetores de ácido nucleico
PH12012500908A1 (en) Methods of propagating monkey adenoviral vectors
EP2504348A4 (en) METHODS, REAGENTS AND KITS FOR DETECTING NUCLEIC ACID MOLECULES

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)