PL383287A1 - Kompozycja lipidowa do wytwarzania lipidowego nośnika dla leków genetycznych i jej zastosowanie - Google Patents

Kompozycja lipidowa do wytwarzania lipidowego nośnika dla leków genetycznych i jej zastosowanie

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Publication number
PL383287A1
PL383287A1 PL383287A PL38328707A PL383287A1 PL 383287 A1 PL383287 A1 PL 383287A1 PL 383287 A PL383287 A PL 383287A PL 38328707 A PL38328707 A PL 38328707A PL 383287 A1 PL383287 A1 PL 383287A1
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PL
Poland
Prior art keywords
weight
production
composition
lipides
application
Prior art date
Application number
PL383287A
Other languages
English (en)
Other versions
PL208054B1 (pl
Inventor
Aleksander F. Sikorski
Paulina Wyrozumska
Marta Walasek
Kazimierz Kuliczkowski
Original Assignee
Uniwersytet Wrocławski
Akademia Medyczna im. Piastów Śląskich we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Uniwersytet Wrocławski, Akademia Medyczna im. Piastów Śląskich we Wrocławiu filed Critical Uniwersytet Wrocławski
Priority to PL383287A priority Critical patent/PL208054B1/pl
Priority to PCT/PL2008/000062 priority patent/WO2009031911A1/en
Publication of PL383287A1 publication Critical patent/PL383287A1/pl
Publication of PL208054B1 publication Critical patent/PL208054B1/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Kompozycja lipidowa do wytwarzania lipidowego nośnika dla leków genetycznych charakteryzuje się tym, że zawiera 38,7% wagowych fosfatydylocholiny (PC), 15,4% wagowych distearoilofosfatydyloetanoloaminowej pochodnej glikolu polietylenowego 2000 (sól amonowa) (DSPE-PEG), od 10,9 do 16,8% wagowych dioleiolofosfatydyloetanolaminy (DOPE), od 4,05 do 6,75% wagowych 3ß-N-dimetyloetanokarbamoilo cholesterolu (DC-CHOL) i od 23,4 do 30,6% wagowych soli trimetyloamoniowej 1,2 -dioleilopropanu (DOTAP), przy czym PC, DOPE i DC-CHOL stanowią zewnętrzna błonę nośnika, a DOTAP wchodzi skład rdzenia nośnika zamkniętego w jego wnętrzu.
PL383287A 2007-09-06 2007-09-06 Kompozycja lipidowa do wytwarzania lipidowego nośnika dla leków genetycznych i jej zastosowanie PL208054B1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL383287A PL208054B1 (pl) 2007-09-06 2007-09-06 Kompozycja lipidowa do wytwarzania lipidowego nośnika dla leków genetycznych i jej zastosowanie
PCT/PL2008/000062 WO2009031911A1 (en) 2007-09-06 2008-09-02 Cationic liposome carrier for genetic drugs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL383287A PL208054B1 (pl) 2007-09-06 2007-09-06 Kompozycja lipidowa do wytwarzania lipidowego nośnika dla leków genetycznych i jej zastosowanie

Publications (2)

Publication Number Publication Date
PL383287A1 true PL383287A1 (pl) 2009-03-16
PL208054B1 PL208054B1 (pl) 2011-03-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL383287A PL208054B1 (pl) 2007-09-06 2007-09-06 Kompozycja lipidowa do wytwarzania lipidowego nośnika dla leków genetycznych i jej zastosowanie

Country Status (2)

Country Link
PL (1) PL208054B1 (pl)
WO (1) WO2009031911A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105163721B (zh) * 2012-05-23 2018-05-22 俄亥俄州立大学 脂质纳米颗粒组合物以及制备和使用其的方法
US10253315B2 (en) * 2012-08-30 2019-04-09 Commissariat A L'energie Atomique Et Aux Energies Alternatives Method for transfection of nucleic acids into eukaryotic cells in 3D scaffold
PL407947A1 (pl) * 2014-04-18 2015-10-26 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Ukierunkowana, liposomowa postać kompleksu oligonukleotyd-polietylenoimina, jej zastosowanie oraz sposób otrzymywania
PL233741B1 (pl) 2014-04-18 2019-11-29 Wroclawskie Centrum Badan Eit Spolka Z Ograniczona Odpowiedzialnoscia Kompozycja lipidowa sluzaca do wytworzenia kierowanego za pomoca przeciwcial liposomowego nosnika lekow genetycznych oraz jej zastosowanie
WO2017220099A1 (en) 2016-06-24 2017-12-28 Statens Serum Institut Adjuvants with modified drainage properties
CN110101664A (zh) * 2019-05-06 2019-08-09 西安交通大学医学院第一附属医院 用于递送具有特异性剪切hpv16型基因功能的核酸类药物的系统及其制备方法
CN111603571A (zh) * 2020-05-28 2020-09-01 中国药科大学 线粒体靶向类脂质载体Mito-Aliposome、其复合物，制备方法和用途
CN114699420A (zh) * 2022-03-08 2022-07-05 南方科技大学 一种用于治疗前列腺癌组合物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69820465T2 (de) * 1997-06-23 2004-09-16 Alza Corp., Mountain View Liposomen-umschlossene polynukleotidzusammensetzung sowie verfahren
US20030203865A1 (en) * 2001-04-30 2003-10-30 Pierrot Harvie Lipid-comprising drug delivery complexes and methods for their production
EP1691780A2 (en) * 2003-11-21 2006-08-23 Alza Corporation Gene delivery mediated by liposome-dna complex with cleavable peg surface modification

Also Published As

Publication number Publication date
PL208054B1 (pl) 2011-03-31
WO2009031911A1 (en) 2009-03-12

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