PL383819A1 - Enzym, esteraza lowastatyny, osadzony na nośniku nierozpuszczalnym w wodzie, sposób osadzania enzymu, zastosowanie enzymu, przepływowy reaktor biokatalityczny oraz sposób wytwarzania i/lub oczyszczania symwastatyny - Google Patents

Enzym, esteraza lowastatyny, osadzony na nośniku nierozpuszczalnym w wodzie, sposób osadzania enzymu, zastosowanie enzymu, przepływowy reaktor biokatalityczny oraz sposób wytwarzania i/lub oczyszczania symwastatyny

Info

Publication number
PL383819A1
PL383819A1 PL383819A PL38381907A PL383819A1 PL 383819 A1 PL383819 A1 PL 383819A1 PL 383819 A PL383819 A PL 383819A PL 38381907 A PL38381907 A PL 38381907A PL 383819 A1 PL383819 A1 PL 383819A1
Authority
PL
Poland
Prior art keywords
enzyme
levostatin
biocatalythic
esterase
reactor
Prior art date
Application number
PL383819A
Other languages
English (en)
Other versions
PL211815B1 (pl
Inventor
Ryszard Ostaszewski
Waldemar Kurek
Dorota Patralska
Dominik Koszelewski
Original Assignee
Instytut Chemii Organicznej Polska Akademia Nauk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Chemii Organicznej Polska Akademia Nauk filed Critical Instytut Chemii Organicznej Polska Akademia Nauk
Priority to PL383819A priority Critical patent/PL211815B1/pl
Priority to CN200880114612A priority patent/CN101848988A/zh
Priority to US12/743,040 priority patent/US20100240116A1/en
Priority to PCT/PL2008/000086 priority patent/WO2009067032A1/en
Priority to EP08851525.9A priority patent/EP2240569B1/en
Priority to RU2010122385/10A priority patent/RU2475538C2/ru
Publication of PL383819A1 publication Critical patent/PL383819A1/pl
Publication of PL211815B1 publication Critical patent/PL211815B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C12N11/12—Cellulose or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
PL383819A 2007-11-19 2007-11-19 Enzym esteraza lowastatyny osadzony na nośniku nierozpuszczalnym w wodzie, sposób osadzania enzymu, zastosowanie enzymu esterazy lowastatyny osadzonego na nosniku nierozpuszczalnym w wodzie, przepływowy reaktor biokatalityczny ze złożem oraz sposób wytwarzania i/lub oczyszczania symwastatyny PL211815B1 (pl)

Priority Applications (6)

Application Number Priority Date Filing Date Title
PL383819A PL211815B1 (pl) 2007-11-19 2007-11-19 Enzym esteraza lowastatyny osadzony na nośniku nierozpuszczalnym w wodzie, sposób osadzania enzymu, zastosowanie enzymu esterazy lowastatyny osadzonego na nosniku nierozpuszczalnym w wodzie, przepływowy reaktor biokatalityczny ze złożem oraz sposób wytwarzania i/lub oczyszczania symwastatyny
CN200880114612A CN101848988A (zh) 2007-11-19 2008-11-18 固定在固体载体上的洛伐他汀酯酶、酶固定化的方法、固定化酶的应用、生物催化流动反应器以及制备和/或纯化辛伐他汀的方法
US12/743,040 US20100240116A1 (en) 2007-11-19 2008-11-18 Lovastatin esterase enzyme immobilized on solid support, process for enzyme immobilization, use of immobilized enzyme, biocatalytic flow reactor and process for preparation and/or purification of simvastatin
PCT/PL2008/000086 WO2009067032A1 (en) 2007-11-19 2008-11-18 Lovastatin esterase enzyme immobilized on solid support, process for enzyme immobilization, use of immobilized enzyme, biocatalytic flow reactor and process for preparation and/or purification of simvastatin
EP08851525.9A EP2240569B1 (en) 2007-11-19 2008-11-18 Lovastatin esterase enzyme immobilized on solid support, process for enzyme immobilization, biocatalytic flow reactor and process for preparation and/or purification of simvastatin
RU2010122385/10A RU2475538C2 (ru) 2007-11-19 2008-11-18 Фермент ловастатин эстераза, иммобилизованный на твердом носителе, способ иммобилизации фермента, биокатализируемый проточный реактор и способ очистки симвастатина

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL383819A PL211815B1 (pl) 2007-11-19 2007-11-19 Enzym esteraza lowastatyny osadzony na nośniku nierozpuszczalnym w wodzie, sposób osadzania enzymu, zastosowanie enzymu esterazy lowastatyny osadzonego na nosniku nierozpuszczalnym w wodzie, przepływowy reaktor biokatalityczny ze złożem oraz sposób wytwarzania i/lub oczyszczania symwastatyny

Publications (2)

Publication Number Publication Date
PL383819A1 true PL383819A1 (pl) 2009-05-25
PL211815B1 PL211815B1 (pl) 2012-06-29

Family

ID=40307641

Family Applications (1)

Application Number Title Priority Date Filing Date
PL383819A PL211815B1 (pl) 2007-11-19 2007-11-19 Enzym esteraza lowastatyny osadzony na nośniku nierozpuszczalnym w wodzie, sposób osadzania enzymu, zastosowanie enzymu esterazy lowastatyny osadzonego na nosniku nierozpuszczalnym w wodzie, przepływowy reaktor biokatalityczny ze złożem oraz sposób wytwarzania i/lub oczyszczania symwastatyny

Country Status (6)

Country Link
US (1) US20100240116A1 (pl)
EP (1) EP2240569B1 (pl)
CN (1) CN101848988A (pl)
PL (1) PL211815B1 (pl)
RU (1) RU2475538C2 (pl)
WO (1) WO2009067032A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2490323C1 (ru) * 2012-06-25 2013-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный технологический институт (технический университет)" Микробиореактор и способ его эксплуатации
IT201600095611A1 (it) * 2016-09-23 2018-03-23 Archimede R&D S R L Materiale per la riduzione del contenuto di sostanze inquinanti e/o indesiderate, particolarmente in acqua e altri fluidi
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
CN109402104B (zh) * 2018-11-08 2020-07-17 山东鲁抗医药股份有限公司 一种头孢菌素酰化酶的固定化方法及固定化酶
CN112662656B (zh) * 2021-03-18 2021-07-06 凯莱英医药集团（天津）股份有限公司 酶固定化载体及其制备方法、固定化酶及其制备方法
CN115537410A (zh) * 2022-09-27 2022-12-30 凯莱英医药化学（阜新）技术有限公司 酶固定化载体及其制备方法、固定化酶及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966897A (en) * 1973-04-02 1976-06-29 Marine Colloids, Inc. Medium for use in bioassay and method of using same
HU184468B (en) 1981-07-17 1984-08-28 Reanal Finomvegyszergyar Process for preparing immobilized cholinesterase enzyme preparation
CA1188866A (en) * 1983-03-11 1985-06-18 Buckley Products Inc. Roof ridge ventilator
US4582915A (en) 1983-10-11 1986-04-15 Merck & Co., Inc. Process for C-methylation of 2-methylbutyrates
CA2053000C (en) * 1990-10-15 1995-08-29 Michael J. Conder Biosynthetic production of 6(r)-[2-(8(s)-hydroxy-2(s), 6(r)-dimethyl-1,2,6,7,8,8a(r)-hexahydronaphthyl)-ethyl]-4 (r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one triol acid by enzymatic hydrolysis of lovastatin acid using an enzyme derived from__lonostachys compactiuscula
US5223415A (en) * 1990-10-15 1993-06-29 Merck & Co., Inc. Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
SI20070A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nove soli inhibitorjev HMG-CoA reduktaze
CN102703539A (zh) * 2003-10-21 2012-10-03 维莱尼姆公司 制备新伐他汀及中间体的方法
US9303256B2 (en) * 2005-09-30 2016-04-05 Novozymes A/S Immobilization of enzymes

Also Published As

Publication number Publication date
EP2240569A1 (en) 2010-10-20
CN101848988A (zh) 2010-09-29
RU2010122385A (ru) 2011-12-27
EP2240569B1 (en) 2013-09-11
RU2475538C2 (ru) 2013-02-20
PL211815B1 (pl) 2012-06-29
US20100240116A1 (en) 2010-09-23
WO2009067032A1 (en) 2009-05-28

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