PL3846783T3 - Nanocząstki zawierające takrolimus - Google Patents

Nanocząstki zawierające takrolimus

Info

Publication number
PL3846783T3
PL3846783T3 PL19816295.0T PL19816295T PL3846783T3 PL 3846783 T3 PL3846783 T3 PL 3846783T3 PL 19816295 T PL19816295 T PL 19816295T PL 3846783 T3 PL3846783 T3 PL 3846783T3
Authority
PL
Poland
Prior art keywords
tacrolimus
nanoparticles
Prior art date
Application number
PL19816295.0T
Other languages
English (en)
Inventor
Wolfgang Beier
Elke Horstkotte
Original Assignee
Nucleus Medical Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nucleus Medical Gmbh filed Critical Nucleus Medical Gmbh
Publication of PL3846783T3 publication Critical patent/PL3846783T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5161Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5138Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
PL19816295.0T 2018-12-04 2019-12-04 Nanocząstki zawierające takrolimus PL3846783T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102018130848 2018-12-04
PCT/EP2019/083691 WO2020115140A1 (en) 2018-12-04 2019-12-04 Nanoparticles comprising tacrolimus

Publications (1)

Publication Number Publication Date
PL3846783T3 true PL3846783T3 (pl) 2024-04-02

Family

ID=68766584

Family Applications (2)

Application Number Title Priority Date Filing Date
PL19213120T PL3662894T3 (pl) 2018-12-04 2019-12-03 Nanocząstki zawierające takrolimus
PL19816295.0T PL3846783T3 (pl) 2018-12-04 2019-12-04 Nanocząstki zawierające takrolimus

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL19213120T PL3662894T3 (pl) 2018-12-04 2019-12-03 Nanocząstki zawierające takrolimus

Country Status (18)

Country Link
US (2) US11311479B2 (pl)
EP (2) EP3662894B1 (pl)
JP (1) JP7641220B2 (pl)
KR (1) KR20210100142A (pl)
CN (2) CN113242732A (pl)
AU (1) AU2019392718B2 (pl)
CA (1) CA3063417C (pl)
DK (2) DK3662894T3 (pl)
ES (2) ES2894112T3 (pl)
FI (1) FI3846783T3 (pl)
HR (1) HRP20240072T1 (pl)
HU (2) HUE056067T2 (pl)
IL (1) IL283458A (pl)
PL (2) PL3662894T3 (pl)
PT (1) PT3846783T (pl)
SG (1) SG11202105778PA (pl)
SI (2) SI3662894T1 (pl)
WO (1) WO2020115140A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113425716A (zh) * 2021-05-27 2021-09-24 南京诺亚药业有限公司 一种他克莫司药物组合物及其制备方法
EP4104816A1 (en) * 2021-06-14 2022-12-21 Nucleus Medical GmbH Non-nanoparticulate applications forms of macrolides
AU2023232910A1 (en) * 2022-03-11 2024-09-12 Lts Lohmann Therapie-Systeme Ag Transmucosal therapeutic system containing a macrolide immunosuppressant
WO2024052883A1 (en) * 2022-09-10 2024-03-14 Pattanaik Smita Buccomucoadhesive patch-based drug delivery system for tacrolimus
KR20250136925A (ko) * 2023-02-06 2025-09-16 뉴클리어스 메디칼 게엠베하 면역 질환 또는 장애를 예방 또는 치료하는 방법에 사용하기 위한 마크로라이드
EP4410287A1 (en) * 2023-02-06 2024-08-07 Nucleus Medical GmbH A macrolide for use in a method of preventing or treating an immunological disease or disorder
EP4501320A1 (en) * 2023-08-02 2025-02-05 IQ medical GmbH A method of preparing an aqueous dispersion of nanoparticles

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004264974A1 (en) * 2003-08-15 2005-02-24 Arius Two, Inc. Adhesive bioerodible transmucosal drug delivery system
SG161203A1 (en) * 2004-12-15 2010-05-27 Elan Pharma Int Ltd Nanoparticulate tacrolimus formulations
BRPI0809563A2 (pt) * 2007-03-29 2014-09-16 Panacea Biotec Ltd Formas de dosagem modificadas de tacrolimus
WO2012026896A1 (en) * 2010-08-25 2012-03-01 Les Laboratoires Medis Sa Surface modified micronized tacrolimus crystalline particles and pharmaceutical compositions thereof
CN105142619A (zh) * 2013-02-21 2015-12-09 麻省理工学院 药剂的靶向颊内递送
US20180243217A1 (en) * 2015-03-17 2018-08-30 Leon-Nanodrugs Gmbh Nanoparticles comprising a stabilized boronic acid compound
DE102016101232A1 (de) 2016-01-25 2017-07-27 Instillo Gmbh Verfahren zum Herstellen von Emulsionen

Also Published As

Publication number Publication date
US20200170934A1 (en) 2020-06-04
ES2894112T3 (es) 2022-02-11
US20220079872A1 (en) 2022-03-17
WO2020115140A1 (en) 2020-06-11
SI3846783T1 (sl) 2024-03-29
FI3846783T3 (fi) 2024-01-15
ES2969096T3 (es) 2024-05-16
US11311479B2 (en) 2022-04-26
AU2019392718A1 (en) 2021-06-10
CN113242732A (zh) 2021-08-10
US11904048B2 (en) 2024-02-20
PL3662894T3 (pl) 2022-01-10
SG11202105778PA (en) 2021-06-29
PT3846783T (pt) 2024-01-19
HRP20240072T1 (hr) 2024-05-10
CA3063417A1 (en) 2020-06-04
IL283458A (en) 2021-07-29
DK3662894T3 (da) 2021-09-20
CA3063417C (en) 2023-01-03
HUE065588T2 (hu) 2024-06-28
EP3846783A1 (en) 2021-07-14
KR20210100142A (ko) 2021-08-13
EP3846783B8 (en) 2023-11-22
SI3662894T1 (sl) 2021-11-30
EP3662894A1 (en) 2020-06-10
CN120324378A (zh) 2025-07-18
EP3846783B1 (en) 2023-10-18
JP7641220B2 (ja) 2025-03-06
DK3846783T3 (da) 2024-01-15
JP2022513697A (ja) 2022-02-09
HUE056067T2 (hu) 2022-01-28
EP3662894B1 (en) 2021-07-28
AU2019392718B2 (en) 2025-07-24

Similar Documents

Publication Publication Date Title
IL270695B1 (en) catheter
AU201712948S (en) Catheter
GB201705755D0 (en) Nanostructure
SG11202105778PA (en) Nanoparticles comprising tacrolimus
EP3276442A4 (en) Moving body
HUE058967T2 (hu) Fülhallgató
SG11202001205PA (en) Anti-occlusion catheter
HUE055206T2 (hu) Multimodális jármû
EP3378695A4 (en) Moving body
EP3279100A4 (en) Can body
GB2555955B (en) Antimicrobial rubber and processes for making the same
SG11202000566RA (en) Takraw balls
EP3560984A4 (en) STRUCTURAL BODY
GB201610642D0 (en) Nanoparticles
GB201614126D0 (en) Delivery vehicle
EP3272572A4 (en) Moving body
GB201811066D0 (en) Nanoparticles
GB2551906B (en) Body component
AP01040S1 (en) Lunix balloon
GB201704303D0 (en) Catheter
AU2017903363A0 (en) Nanoparticles
GB201715933D0 (en) Vehicle
GB201714149D0 (en) Vehicle
GB201702089D0 (en) Phantom
GB201701853D0 (en) Phantom