PL3870594T3 - Proces oczyszczania oligonukleotydów - Google Patents

Proces oczyszczania oligonukleotydów

Info

Publication number
PL3870594T3
PL3870594T3 PL19789691.3T PL19789691T PL3870594T3 PL 3870594 T3 PL3870594 T3 PL 3870594T3 PL 19789691 T PL19789691 T PL 19789691T PL 3870594 T3 PL3870594 T3 PL 3870594T3
Authority
PL
Poland
Prior art keywords
purification process
oligonucleotide purification
oligonucleotide
purification
Prior art date
Application number
PL19789691.3T
Other languages
English (en)
Inventor
Joerg Lill
Filippo Sladojevich
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=63965524&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3870594(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of PL3870594T3 publication Critical patent/PL3870594T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/20—Specific permeability or cut-off range
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
PL19789691.3T 2018-10-24 2019-10-22 Proces oczyszczania oligonukleotydów PL3870594T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18202335 2018-10-24
PCT/EP2019/078704 WO2020083898A1 (en) 2018-10-24 2019-10-22 Process for the purification of oligonucleotides

Publications (1)

Publication Number Publication Date
PL3870594T3 true PL3870594T3 (pl) 2023-12-11

Family

ID=63965524

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19789691.3T PL3870594T3 (pl) 2018-10-24 2019-10-22 Proces oczyszczania oligonukleotydów

Country Status (14)

Country Link
US (1) US12043642B2 (pl)
EP (1) EP3870594B1 (pl)
JP (1) JP7419354B2 (pl)
KR (1) KR102842855B1 (pl)
CN (1) CN112771062B (pl)
AU (1) AU2019365382B2 (pl)
BR (1) BR112021003998A2 (pl)
CA (1) CA3105153A1 (pl)
ES (1) ES2957683T3 (pl)
IL (1) IL282368B2 (pl)
MX (1) MX2021002891A (pl)
PL (1) PL3870594T3 (pl)
TW (1) TWI853845B (pl)
WO (1) WO2020083898A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023067038A1 (en) 2021-10-22 2023-04-27 Roche Innovation Center Copenhagen A/S Process for oligonucleotide purification
CN115057901A (zh) * 2022-07-12 2022-09-16 赛普特环保技术(厦门)有限公司 一种核苷提纯系统及提纯工艺
EP4622985A1 (en) * 2022-11-22 2025-10-01 Ionis Pharmaceuticals, Inc. Methods for deprotecting and purifying oligonucleotide compounds
CN117143165B (zh) * 2023-08-30 2026-02-03 上海奥锐特生物科技有限公司 一种寡核苷酸的纯化方法
WO2025231081A1 (en) * 2024-05-01 2025-11-06 Alnylam Pharmaceuticals, Inc. Method for separating oligonucleotides
WO2026062247A1 (en) 2024-09-20 2026-03-26 Astrazeneca Ab Liquid-phase oligonucleotide synthesis using 2-(2-nitrophenyl)propyloxycarbonyl (nppoc) as a protecting group

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1155887A (zh) * 1994-07-05 1997-07-30 海布里顿公司 用deae-5pw阴离子-离子交换色谱和疏水作用色谱纯化硫代磷酸寡脱氧核苷酸
US6632938B2 (en) * 2001-06-07 2003-10-14 Isis Pharmaceuticals, Inc. Processes of purifying oligonucleotides
US20030153741A1 (en) * 2002-02-08 2003-08-14 Marek Kwiatkowski Methods for separating oligonucleotides
US7655790B2 (en) * 2002-07-12 2010-02-02 Sirna Therapeutics, Inc. Deprotection and purification of oligonucleotides and their derivatives
US7345163B2 (en) * 2002-08-28 2008-03-18 Quiatech Ab Process for separating and deprotecting oligonucleotides
UY29460A1 (es) * 2005-04-08 2006-11-30 Noxxon Pharma Ag Acidos nucleicos de union a ghrelin
CA2690611C (en) * 2007-06-12 2015-12-08 Novo Nordisk A/S Improved process for the production of nucleotide sugars
CA2696460A1 (en) * 2007-08-13 2009-02-19 Pfizer Inc. Combination motif immune stimulatory oligonucleotides with improved activity
CA2721969C (en) * 2008-04-24 2016-06-07 Girindus America, Inc. Process for the manufacture of oligonucleotides
CN102574912B (zh) * 2009-09-29 2014-12-24 弗·哈夫曼-拉罗切有限公司 缓冲溶质的过滤前调节
GB201012418D0 (en) * 2010-07-23 2010-09-08 Santaris Pharma As Process
DK2970948T3 (en) * 2013-03-15 2019-04-08 Glaxosmithkline Biologicals Sa METHODS OF RNA PURIFICATION
WO2015061246A1 (en) 2013-10-21 2015-04-30 Isis Pharmaceuticals, Inc. Method for solution phase detritylation of oligomeric compounds
US9850269B2 (en) * 2014-04-25 2017-12-26 Translate Bio, Inc. Methods for purification of messenger RNA
US10577388B2 (en) * 2015-10-02 2020-03-03 Roche Innovation Center Copenhagen A/S Oligonucleotide conjugation process
CN116063365A (zh) * 2015-12-16 2023-05-05 味之素株式会社 寡核苷酸的制备方法以及核苷、核苷酸或寡核苷酸
WO2018215049A1 (en) * 2017-05-23 2018-11-29 F. Hoffmann-La Roche Ag Process for galnac oligonucleotide conjugates

Also Published As

Publication number Publication date
TWI853845B (zh) 2024-09-01
IL282368A (en) 2021-06-30
IL282368B1 (en) 2024-05-01
WO2020083898A1 (en) 2020-04-30
JP2022512550A (ja) 2022-02-07
KR102842855B1 (ko) 2025-08-05
IL282368B2 (en) 2024-09-01
CA3105153A1 (en) 2020-04-30
US20210347800A1 (en) 2021-11-11
EP3870594C0 (en) 2023-08-02
CN112771062B (zh) 2024-01-16
MX2021002891A (es) 2021-06-04
AU2019365382B2 (en) 2024-02-08
KR20210086603A (ko) 2021-07-08
ES2957683T3 (es) 2024-01-24
EP3870594B1 (en) 2023-08-02
US12043642B2 (en) 2024-07-23
TW202033535A (zh) 2020-09-16
JP7419354B2 (ja) 2024-01-22
EP3870594A1 (en) 2021-09-01
BR112021003998A2 (pt) 2021-05-25
CN112771062A (zh) 2021-05-07
AU2019365382A1 (en) 2021-02-18

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