PL3880818T3 - Kwasy nukleinowe do hamowania ekspresji LPA w komórce - Google Patents

Kwasy nukleinowe do hamowania ekspresji LPA w komórce

Info

Publication number: PL3880818T3
Authority: PL; Poland
Prior art keywords: cell; nucleic acids; lpa expression; inhibiting lpa; inhibiting
Prior art date: 2018-11-13

Application number

PL19801033.2T

Other languages

English (en)

Inventor

David Anthony RIDER

Lucas Bethge

Christian Frauendorf

Adrien WEINGAERTNER

Judith HAUPTMANN

Sibylle DAMES

Steffen Schubert

Stephan TENBAUM

Original Assignee

Silence Therapeutics Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-11-13

Filing date

2019-11-13

Publication date

2023-01-23

2018-11-13 Priority claimed from PCT/EP2018/081106 external-priority patent/WO2019092283A1/en

2019-11-13 Application filed by Silence Therapeutics Gmbh filed Critical Silence Therapeutics Gmbh

2023-01-23 Publication of PL3880818T3 publication Critical patent/PL3880818T3/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
- C12N2310/3533—Halogen
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/532—Closed or circular
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL19801033.2T 2018-11-13 2019-11-13 Kwasy nukleinowe do hamowania ekspresji LPA w komórce PL3880818T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
PCT/EP2018/081106 WO2019092283A1 (en)	2017-11-13	2018-11-13	Nucleic acids for inhibiting expression of lpa in a cell
EP19174466		2019-05-14
PCT/EP2019/081158 WO2020099476A1 (en)	2018-11-13	2019-11-13	Nucleic acids for inhibiting expression of lpa in a cell

Publications (1)

Publication Number	Publication Date
PL3880818T3 true PL3880818T3 (pl)	2023-01-23

Family

ID=66554180

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL19801033.2T PL3880818T3 (pl)	2018-11-13	2019-11-13	Kwasy nukleinowe do hamowania ekspresji LPA w komórce

Country Status (31)

Country	Link
US (3)	US20220002722A1 (pl)
EP (2)	EP3880818B1 (pl)
JP (1)	JP7245328B2 (pl)
KR (1)	KR102553386B1 (pl)
CN (2)	CN119842706A (pl)
AU (1)	AU2019380628B2 (pl)
BR (1)	BR112021009213A2 (pl)
CA (1)	CA3119239C (pl)
CL (1)	CL2021001225A1 (pl)
CO (1)	CO2021007372A2 (pl)
CR (1)	CR20210301A (pl)
DK (1)	DK3880818T3 (pl)
EA (1)	EA202190895A1 (pl)
ES (1)	ES2932295T3 (pl)
FI (1)	FI3880818T3 (pl)
HR (1)	HRP20221358T1 (pl)
HU (1)	HUE060703T2 (pl)
IL (1)	IL283159B1 (pl)
LT (1)	LT3880818T (pl)
MA (1)	MA58208B1 (pl)
MX (1)	MX2021005590A (pl)
PE (1)	PE20211282A1 (pl)
PH (1)	PH12021550801B1 (pl)
PL (1)	PL3880818T3 (pl)
PT (1)	PT3880818T (pl)
RS (1)	RS63778B1 (pl)
SA (1)	SA521421963B1 (pl)
SG (1)	SG11202103882QA (pl)
SI (1)	SI3880818T1 (pl)
SM (1)	SMT202300050T1 (pl)
WO (1)	WO2020099476A1 (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK3607069T3 (da) *	2017-04-05	2022-11-21	Silence Therapeutics Gmbh	Produkter og sammensætninger
HRP20230127T1 (hr)	2017-11-13	2023-03-31	Silence Therapeutics Gmbh	Nukleinske kiseline za inhibiranje ekspresije lpa u stanici
PH12021550801B1 (en)	2018-11-13	2024-04-26	Silence Therapeutics Gmbh	Nucleic acids for inhibiting expression of lpa in a cell
WO2022079221A1 (en)	2020-10-16	2022-04-21	Sanofi	Rna compositions and methods for inhibiting lipoprotein(a)
WO2023041508A2 (en) *	2021-09-14	2023-03-23	Argonaute RNA Limited	Treatment of cardiovascular disease
IL312811A (en)	2021-11-16	2024-07-01	Shanghai Argo Biopharmaceutical Co Ltd	Composition and method for inhibiting angiotensinogen (agt) protein expression
TW202345865A (zh) *	2022-01-24	2023-12-01	大陸商上海舶望製藥有限公司	抑制LPA(Apo(a))蛋白表達的組合物和方法
KR20240147992A (ko)	2022-02-09	2024-10-10	사일런스 테라퓨틱스 게엠베하	Lpa 발현의 치료적 억제
CN114703184B (zh) *	2022-03-11	2024-06-18	厦门甘宝利生物医药有限公司	Lpa抑制剂及其用途
WO2024013334A1 (en) *	2022-07-15	2024-01-18	Silence Therapeutics Gmbh	Nucleic acids for inhibiting expression of agt in a cell
CN115851723B (zh) *	2022-10-24	2023-10-03	厦门甘宝利生物医药有限公司	一种抑制lpa基因表达的rna抑制剂及其应用
WO2024151937A1 (en) *	2023-01-13	2024-07-18	Eli Lilly And Company	Therapeutic oligonucleotide-containing pharmaceutical compositions and dosing regimens using the same
CN119585432B (zh) *	2023-08-22	2025-08-12	成都先衍生物技术有限公司	一种靶向AGT基因表达的siRNA及其缀合物和用途
WO2025064821A2 (en)	2023-09-21	2025-03-27	Ionis Pharmaceuticals, Inc.	Compounds and methods for inhibiting lpa
WO2026046153A1 (zh) *	2024-08-26	2026-03-05	倍臻生物技术（苏州）有限公司	修饰的双链核糖核酸及其应用

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NL9201440A (nl)	1992-08-11	1994-03-01	Univ Leiden	Triantennaire clusterglycosiden, hun bereiding en toepassing.
US7259150B2 (en) *	2001-08-07	2007-08-21	Isis Pharmaceuticals, Inc.	Modulation of apolipoprotein (a) expression
US7227014B2 (en)	2001-08-07	2007-06-05	Isis Pharmaceuticals, Inc.	Antisense modulation of apolipoprotein (a) expression
US20060160759A1 (en)	2002-09-28	2006-07-20	Jianzhu Chen	Influenza therapeutic
CN101278059A (zh) *	2005-07-28	2008-10-01	肿瘤疗法科学股份有限公司	诊断和治疗肾细胞癌的方法
WO2009151644A2 (en)	2008-06-13	2009-12-17	Yale University	Small molecule inhibitors of autotaxin methods of use
EP2490699A1 (en) *	2009-10-20	2012-08-29	Santaris Pharma A/S	Oral delivery of therapeutically effective lna oligonucleotides
EP3564374A1 (en) *	2013-06-21	2019-11-06	Ionis Pharmaceuticals, Inc.	Compositions and methods for modulation of target nucleic acids
WO2016149020A1 (en) *	2015-03-17	2016-09-22	Arrowhead Research Corporation	Rna interference agents
JOP20160211B1 (ar) *	2015-10-01	2021-08-17	Arrowhead Pharmaceuticals Inc	تراكيب وأساليب لتثبيط تعبير جيني للـ lpa
EP3228326A1 (en)	2016-04-05	2017-10-11	Silence Therapeutics GmbH	Nucleic acid linked to a trivalent glycoconjugate
DK3607069T3 (da)	2017-04-05	2022-11-21	Silence Therapeutics Gmbh	Produkter og sammensætninger
HRP20230127T1 (hr) *	2017-11-13	2023-03-31	Silence Therapeutics Gmbh	Nukleinske kiseline za inhibiranje ekspresije lpa u stanici
EP3735461A1 (en) *	2017-11-13	2020-11-11	Silence Therapeutics GmbH	Nucleic acids for inhibiting expression of aldh2 in a cell
PH12021550801B1 (en)	2018-11-13	2024-04-26	Silence Therapeutics Gmbh	Nucleic acids for inhibiting expression of lpa in a cell

2019
- 2019-11-13 PH PH1/2021/550801A patent/PH12021550801B1/en unknown
- 2019-11-13 BR BR112021009213-7A patent/BR112021009213A2/pt active IP Right Grant
- 2019-11-13 PL PL19801033.2T patent/PL3880818T3/pl unknown
- 2019-11-13 SG SG11202103882QA patent/SG11202103882QA/en unknown
- 2019-11-13 HU HUE19801033A patent/HUE060703T2/hu unknown
- 2019-11-13 EP EP19801033.2A patent/EP3880818B1/en active Active
- 2019-11-13 CA CA3119239A patent/CA3119239C/en active Active
- 2019-11-13 AU AU2019380628A patent/AU2019380628B2/en active Active
- 2019-11-13 ES ES19801033T patent/ES2932295T3/es active Active
- 2019-11-13 HR HRP20221358TT patent/HRP20221358T1/hr unknown
- 2019-11-13 EA EA202190895A patent/EA202190895A1/ru unknown
- 2019-11-13 SM SM20230050T patent/SMT202300050T1/it unknown
- 2019-11-13 EP EP22197500.6A patent/EP4219712A3/en not_active Withdrawn
- 2019-11-13 KR KR1020217017471A patent/KR102553386B1/ko active Active
- 2019-11-13 CN CN202510076171.0A patent/CN119842706A/zh active Pending
- 2019-11-13 FI FIEP19801033.2T patent/FI3880818T3/fi active
- 2019-11-13 DK DK19801033.2T patent/DK3880818T3/da active
- 2019-11-13 CR CR20210301A patent/CR20210301A/es unknown
- 2019-11-13 WO PCT/EP2019/081158 patent/WO2020099476A1/en not_active Ceased
- 2019-11-13 MA MA58208A patent/MA58208B1/fr unknown
- 2019-11-13 US US17/293,303 patent/US20220002722A1/en not_active Abandoned
- 2019-11-13 PE PE2021000650A patent/PE20211282A1/es unknown
- 2019-11-13 MX MX2021005590A patent/MX2021005590A/es unknown
- 2019-11-13 PT PT198010332T patent/PT3880818T/pt unknown
- 2019-11-13 LT LTEPPCT/EP2019/081158T patent/LT3880818T/lt unknown
- 2019-11-13 RS RS20221119A patent/RS63778B1/sr unknown
- 2019-11-13 SI SI201930387T patent/SI3880818T1/sl unknown
- 2019-11-13 CN CN201980074785.8A patent/CN113227372A/zh active Pending
- 2019-11-13 JP JP2021525771A patent/JP7245328B2/ja active Active
2021
- 2021-05-06 SA SA521421963A patent/SA521421963B1/ar unknown
- 2021-05-10 CL CL2021001225A patent/CL2021001225A1/es unknown
- 2021-05-12 IL IL283159A patent/IL283159B1/en unknown
- 2021-06-04 CO CONC2021/0007372A patent/CO2021007372A2/es unknown
- 2021-12-22 US US17/559,479 patent/US11499153B2/en active Active
2025
- 2025-07-08 US US19/263,110 patent/US20260078372A1/en active Pending

Also Published As

Publication number	Publication date
CN113227372A (zh)	2021-08-06
AU2019380628A1 (en)	2021-05-20
EP4219712A3 (en)	2023-11-22
PH12021550801A1 (en)	2021-10-04
RS63778B1 (sr)	2022-12-30
HRP20221358T1 (hr)	2022-12-23
IL283159A (en)	2021-06-30
IL283159B1 (en)	2026-01-01
US20260078372A1 (en)	2026-03-19
BR112021009213A2 (pt)	2021-08-10
FI3880818T3 (fi)	2022-12-15
SI3880818T1 (sl)	2023-01-31
US20220002722A1 (en)	2022-01-06
MX2021005590A (es)	2023-01-24
SA521421963B1 (ar)	2024-03-25
SG11202103882QA (en)	2021-05-28
EP4219712A2 (en)	2023-08-02
SMT202300050T1 (it)	2023-03-17
WO2020099476A1 (en)	2020-05-22
US11499153B2 (en)	2022-11-15
HUE060703T2 (hu)	2023-04-28
EA202190895A1 (ru)	2021-08-10
JP2022507282A (ja)	2022-01-18
MA58208B1 (fr)	2022-12-30
KR102553386B1 (ko)	2023-07-07
CL2021001225A1 (es)	2021-12-24
CA3119239A1 (en)	2020-05-22
DK3880818T3 (da)	2022-12-05
AU2019380628B2 (en)	2024-10-31
US20220170016A1 (en)	2022-06-02
PT3880818T (pt)	2022-12-06
JP7245328B2 (ja)	2023-03-23
LT3880818T (lt)	2022-12-27
ES2932295T3 (es)	2023-01-17
CO2021007372A2 (es)	2021-07-09
PE20211282A1 (es)	2021-07-19
CA3119239C (en)	2024-06-04
PH12021550801B1 (en)	2024-04-26
KR20210095878A (ko)	2021-08-03
EP3880818A1 (en)	2021-09-22
CN119842706A (zh)	2025-04-18
CR20210301A (es)	2021-09-16
EP3880818B1 (en)	2022-09-28

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