PL3894407T3 - Sposób wytwarzania apiksabanu - Google Patents

Sposób wytwarzania apiksabanu

Info

Publication number
PL3894407T3
PL3894407T3 PL19829432.4T PL19829432T PL3894407T3 PL 3894407 T3 PL3894407 T3 PL 3894407T3 PL 19829432 T PL19829432 T PL 19829432T PL 3894407 T3 PL3894407 T3 PL 3894407T3
Authority
PL
Poland
Prior art keywords
preparing apixaban
apixaban
preparing
Prior art date
Application number
PL19829432.4T
Other languages
English (en)
Inventor
Andreja Radman KASTELIC
David KRALJ
Katja JUG
Primoz Benkic
Jerneja BÖHM
Ivanka Kolenc
Original Assignee
Krka, D.D., Novo Mesto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka, D.D., Novo Mesto filed Critical Krka, D.D., Novo Mesto
Publication of PL3894407T3 publication Critical patent/PL3894407T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PL19829432.4T 2018-12-11 2019-12-10 Sposób wytwarzania apiksabanu PL3894407T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18211726.7A EP3666773A1 (en) 2018-12-11 2018-12-11 Process for preparing apixaban
PCT/EP2019/084451 WO2020120485A1 (en) 2018-12-11 2019-12-10 Process for preparing apixaban

Publications (1)

Publication Number Publication Date
PL3894407T3 true PL3894407T3 (pl) 2025-09-29

Family

ID=64664916

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19829432.4T PL3894407T3 (pl) 2018-12-11 2019-12-10 Sposób wytwarzania apiksabanu

Country Status (5)

Country Link
EP (2) EP3666773A1 (pl)
EA (1) EA202191502A1 (pl)
PL (1) PL3894407T3 (pl)
SI (1) SI3894407T1 (pl)
WO (1) WO2020120485A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022022550A (ja) * 2020-06-26 2022-02-07 ダイト株式会社 アピキサバンの新規製造方法
WO2022150030A2 (en) * 2021-01-08 2022-07-14 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi A film coated tablet of apixaban
KR20240046550A (ko) * 2021-08-11 2024-04-09 란도스 바이오파마, 인크. Nlrx1의 테트라히드로피라졸로피리딘-유사체 리간드 및 그의 용도
WO2023218470A1 (en) * 2022-05-12 2023-11-16 Iol Chemicals And Pharmaceuticals Limited Efficient process for preparation of apixaban having crystalline particles with d90 greater than 89 micron
CN115417807B (zh) * 2022-10-17 2024-07-16 扬子江药业集团上海海尼药业有限公司 阿哌沙班中间体的制备方法及其应用
CN115385910B (zh) * 2022-10-26 2022-12-30 山东信谊制药有限公司 一种阿哌沙班中间体的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI320039B (en) 2001-09-21 2010-02-01 Lactam-containing compounds and derivatives thereof as factor xa inhibitors
US7396932B2 (en) 2004-09-28 2008-07-08 Bristol-Myers Squibb Company Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
SMT201900212T1 (it) 2010-02-25 2019-05-10 Pfizer Formulazione di apixaban
JP2014516072A (ja) 2011-06-10 2014-07-07 ディフアルマ フランチス ソシエタ ア レスポンサビリタ リミタータ アピキサバン製造方法
WO2013119328A1 (en) * 2012-02-07 2013-08-15 Assia Chemical Industries Ltd. Solid state forms of apixaban
WO2014108919A2 (en) 2013-01-09 2014-07-17 Msn Laboratories Limited NOVEL INTERMEDIATE AND POLYMORPHS OF 1-(4-METHOXYPHENYL)-7-OXO-6-[4-(2-OXOPIPERIDIN-1-YL)PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-c] PYRIDINE-3-CARBOXAMIDE AND PROCESS THEREOF
WO2014203275A2 (en) 2013-06-18 2014-12-24 Cadila Healthcare Limited An improved process for the preparation of apixaban and intermediates thereof
ES2881373T3 (es) 2014-09-05 2021-11-29 Unichem Lab Ltd Un procedimiento mejorado para la preparación de apixabán e intermedios del mismo
EP3212620B1 (en) 2014-10-28 2020-11-25 Jubilant Generics Limited (Formerly Jubilant Life Sciences Division) Process for the preparation of apixaban and intermediates thereof

Also Published As

Publication number Publication date
WO2020120485A1 (en) 2020-06-18
EA202191502A1 (ru) 2021-10-12
EP3894407B1 (en) 2025-07-02
SI3894407T1 (sl) 2025-10-30
EP3666773A1 (en) 2020-06-17
EP3894407A1 (en) 2021-10-20

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