PL390493A1 - Cykliczne tetrapeptydy i ich zastosowanie - Google Patents

Cykliczne tetrapeptydy i ich zastosowanie

Info

Publication number
PL390493A1
PL390493A1 PL390493A PL39049310A PL390493A1 PL 390493 A1 PL390493 A1 PL 390493A1 PL 390493 A PL390493 A PL 390493A PL 39049310 A PL39049310 A PL 39049310A PL 390493 A1 PL390493 A1 PL 390493A1
Authority
PL
Poland
Prior art keywords
application
cyclic tetrapeptides
tetrapeptides
cyclic
immunosuppressive
Prior art date
Application number
PL390493A
Other languages
English (en)
Other versions
PL219569B1 (pl
Inventor
Janusz Zabrocki
Michał Zimecki
Andrzej Kaszuba
Krzysztof Kaczmarek
Original Assignee
Politechnika Łódzka
Peptaderm Spółka Z Ograniczoną Odpowiedzialnością
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politechnika Łódzka, Peptaderm Spółka Z Ograniczoną Odpowiedzialnością filed Critical Politechnika Łódzka
Priority to PL390493A priority Critical patent/PL219569B1/pl
Priority to CN201180019907.7A priority patent/CN102858779B/zh
Priority to EP11745399.3A priority patent/EP2536732B1/en
Priority to CA2827694A priority patent/CA2827694C/en
Priority to KR1020127024471A priority patent/KR101704665B1/ko
Priority to ES11745399.3T priority patent/ES2611663T3/es
Priority to RU2012139668/04A priority patent/RU2568436C2/ru
Priority to AU2011217882A priority patent/AU2011217882B2/en
Priority to JP2012554079A priority patent/JP5901543B2/ja
Priority to BR112012020833A priority patent/BR112012020833A2/pt
Priority to PCT/US2011/025571 priority patent/WO2011103524A2/en
Priority to US13/579,933 priority patent/US20130224232A1/en
Publication of PL390493A1 publication Critical patent/PL390493A1/pl
Priority to IL221535A priority patent/IL221535A/en
Priority to US13/593,716 priority patent/US9382292B2/en
Priority to IL224410A priority patent/IL224410A/en
Publication of PL219569B1 publication Critical patent/PL219569B1/pl
Priority to US15/201,565 priority patent/US10238713B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Przedmiotem zgłoszenia są nowe cykliczne tetrapeptydy i ich zastosowanie do wytwarzania leków immunosupresyjnych lub przeciwzapalnych.
PL390493A 2010-02-19 2010-02-19 Cykliczne tetrapeptydy i ich zastosowanie PL219569B1 (pl)

Priority Applications (16)

Application Number Priority Date Filing Date Title
PL390493A PL219569B1 (pl) 2010-02-19 2010-02-19 Cykliczne tetrapeptydy i ich zastosowanie
AU2011217882A AU2011217882B2 (en) 2010-02-19 2011-02-19 Cyclic tetrapeptides and therapeutic applications thereof
PCT/US2011/025571 WO2011103524A2 (en) 2010-02-19 2011-02-19 Cyclic tetrapeptides and therapeutic applications thereof
CA2827694A CA2827694C (en) 2010-02-19 2011-02-19 Cyclic tetrapeptides and therapeutic applications thereof
KR1020127024471A KR101704665B1 (ko) 2010-02-19 2011-02-19 환형 테트라펩티드류 및 이들의 치료적 적용
ES11745399.3T ES2611663T3 (es) 2010-02-19 2011-02-19 Tetrapéptidos cíclicos y aplicaciones terapéuticas de los mismos
RU2012139668/04A RU2568436C2 (ru) 2010-02-19 2011-02-19 Циклические тетрапептиды и их терапевтическое применение
CN201180019907.7A CN102858779B (zh) 2010-02-19 2011-02-19 环状四肽及其治疗性应用
JP2012554079A JP5901543B2 (ja) 2010-02-19 2011-02-19 環式テトラペプチド及びその治療応用
BR112012020833A BR112012020833A2 (pt) 2010-02-19 2011-02-19 tetrapeptídeos cíclicos e aplicações terapêuticas destes
EP11745399.3A EP2536732B1 (en) 2010-02-19 2011-02-19 Cyclic tetrapeptides and therapeutic applications thereof
US13/579,933 US20130224232A1 (en) 2010-02-19 2011-02-19 Cyclic tetrapeptides and therapeutic applications thereof
IL221535A IL221535A (en) 2010-02-19 2012-08-19 Cyclic tetrapeptides and their therapeutic applications
US13/593,716 US9382292B2 (en) 2010-02-19 2012-08-24 Cyclic tetrapeptides and therapeutic applications thereof
IL224410A IL224410A (en) 2010-02-19 2013-01-27 Cyclic tetrapeptides and pharmaceuticals containing them
US15/201,565 US10238713B2 (en) 2010-02-19 2016-07-04 Cyclic tetrapeptides and therapeutic applications thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL390493A PL219569B1 (pl) 2010-02-19 2010-02-19 Cykliczne tetrapeptydy i ich zastosowanie

Publications (2)

Publication Number Publication Date
PL390493A1 true PL390493A1 (pl) 2011-08-29
PL219569B1 PL219569B1 (pl) 2015-05-29

Family

ID=44483608

Family Applications (1)

Application Number Title Priority Date Filing Date
PL390493A PL219569B1 (pl) 2010-02-19 2010-02-19 Cykliczne tetrapeptydy i ich zastosowanie

Country Status (13)

Country Link
US (3) US20130224232A1 (pl)
EP (1) EP2536732B1 (pl)
JP (1) JP5901543B2 (pl)
KR (1) KR101704665B1 (pl)
CN (1) CN102858779B (pl)
AU (1) AU2011217882B2 (pl)
BR (1) BR112012020833A2 (pl)
CA (1) CA2827694C (pl)
ES (1) ES2611663T3 (pl)
IL (2) IL221535A (pl)
PL (1) PL219569B1 (pl)
RU (1) RU2568436C2 (pl)
WO (1) WO2011103524A2 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL219569B1 (pl) 2010-02-19 2015-05-29 Peptaderm Spółka Z Ograniczoną Odpowiedzialnością Cykliczne tetrapeptydy i ich zastosowanie
WO2016179398A1 (en) 2015-05-05 2016-11-10 Washington University Isoform-selective lysine deacetylase inhibitors
US10154997B2 (en) 2015-08-04 2018-12-18 Washington University Treatment of parasitic diseases using KDAC inhibitor compounds
WO2018232285A1 (en) * 2017-06-16 2018-12-20 University Of Florida Research Foundation, Incorporated Macrocyclic peptides and derivatives thereof with opioid activity

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862925A (en) * 1973-07-05 1975-01-28 American Home Prod Preparation of somatotropin release inhibiting factor and intermediates therefor
US3842067A (en) 1973-07-27 1974-10-15 American Home Prod Synthesis of(des-asn5)-srif and intermediates
JPS5726506B2 (pl) * 1974-03-08 1982-06-04
IT1077010B (it) * 1976-09-01 1985-04-27 Snam Progetti Processo per la preparazione di copolimeri dell isobutilene contenenti insaturazioni ed atomi di alogeno reattivi
US4105603A (en) 1977-03-28 1978-08-08 The Salk Institute For Biological Studies Peptides which effect release of hormones
JPH0334991A (ja) * 1989-06-30 1991-02-14 Shionogi & Co Ltd 環状テトラペプチドおよびその製造法
US5216124A (en) * 1989-12-15 1993-06-01 G. D. Searle & Co. Substituted cyclic tetrapeptides
US5541287A (en) 1992-06-09 1996-07-30 Neorx Corporation Pretargeting methods and compounds
US6777217B1 (en) * 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US6013763A (en) 1996-06-04 2000-01-11 Genentech, Inc. Peptide variants of protein A
US6281331B1 (en) 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
CA2324348C (en) * 1998-03-23 2006-03-14 Trimeris, Inc. Methods and compositions for peptide synthesis
DE19816922A1 (de) 1998-04-16 1999-10-21 Wolfgang Beck Einfache Synthese von cyclischen Tetrapeptiden aus nichtaktivierten Peptidestern an Metallzentren
AUPP505798A0 (en) * 1998-08-04 1998-08-27 Fujisawa Pharmaceutical Co., Ltd. Novel compound fr225497 substance
BR9914779A (pt) 1998-10-13 2001-07-03 Fujisawa Pharmaceutical Co Composto wf27082, processo para sua produção, composição farmacêutica contendo o mesmo, cepa de fundos pertencente ao gênero acremonium, composto tendo atividade inibidora de desacetilase de histona, processo para sua produção, seu método e uso
GB9903087D0 (en) * 1999-02-12 1999-03-31 Glaxo Group Ltd Process
ES2295961T3 (es) * 2003-12-31 2008-04-16 F. Hoffmann-La Roche Ag Proceso para la sintesis peptidica utilizacndo una cantidad reducida de agente de desproteccion.
WO2006049597A1 (en) 2004-10-27 2006-05-11 Avanir Pharmaceuticals Amino acid-derived compounds as modulators of the reverse cholesterol transport
KR100848073B1 (ko) * 2004-12-14 2008-07-24 주식회사바이오러넥스 Ｒｕｎｘ2를 아세틸화하여 Ｒｕｎｘ2 활성을증가시킴으로써 ＢＭＰ에 의한 골형성 경로를 활성화시키는방법
PT2061512T (pt) 2006-08-23 2020-01-14 Yeda Res & Dev Conjugados de péptidos com rgd e fotossensibilizantes de (bacterio)clorofila e as suas utilizações
AU2009219682B2 (en) 2008-02-27 2015-06-18 Yeda Research & Development Co. Ltd RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors
US8809278B2 (en) * 2008-07-11 2014-08-19 University Of Kansas Cyclic tetrapeptides
GB0918579D0 (en) 2009-10-22 2009-12-09 Imp Innovations Ltd Gadd45beta targeting agents
PL219569B1 (pl) 2010-02-19 2015-05-29 Peptaderm Spółka Z Ograniczoną Odpowiedzialnością Cykliczne tetrapeptydy i ich zastosowanie

Also Published As

Publication number Publication date
EP2536732A2 (en) 2012-12-26
IL221535A (en) 2016-08-31
PL219569B1 (pl) 2015-05-29
RU2568436C2 (ru) 2015-11-20
ES2611663T3 (es) 2017-05-09
EP2536732B1 (en) 2016-10-19
CA2827694C (en) 2018-09-18
WO2011103524A3 (en) 2011-12-29
IL224410A (en) 2017-07-31
JP5901543B2 (ja) 2016-04-13
KR101704665B1 (ko) 2017-02-08
US9382292B2 (en) 2016-07-05
JP2013520440A (ja) 2013-06-06
WO2011103524A8 (en) 2012-09-13
BR112012020833A2 (pt) 2017-12-19
US20170157204A1 (en) 2017-06-08
CN102858779A (zh) 2013-01-02
AU2011217882B2 (en) 2015-02-05
KR20130088004A (ko) 2013-08-07
AU2011217882A1 (en) 2012-10-11
EP2536732A4 (en) 2014-04-30
CA2827694A1 (en) 2011-08-25
CN102858779B (zh) 2016-08-03
US20130108655A1 (en) 2013-05-02
US20130224232A1 (en) 2013-08-29
US10238713B2 (en) 2019-03-26
RU2012139668A (ru) 2014-03-27
WO2011103524A2 (en) 2011-08-25

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