PL391468A1 - Nowy sposób termolabilnej ochrony funkcji hydroksylowej oraz nowe związki do realizacji tego sposobu - Google Patents

Nowy sposób termolabilnej ochrony funkcji hydroksylowej oraz nowe związki do realizacji tego sposobu

Info

Publication number
PL391468A1
PL391468A1 PL391468A PL39146810A PL391468A1 PL 391468 A1 PL391468 A1 PL 391468A1 PL 391468 A PL391468 A PL 391468A PL 39146810 A PL39146810 A PL 39146810A PL 391468 A1 PL391468 A1 PL 391468A1
Authority
PL
Poland
Prior art keywords
hydroxyl group
thermolabile
blocked
protection
new
Prior art date
Application number
PL391468A
Other languages
English (en)
Other versions
PL215851B1 (pl
Inventor
Marcin Krzysztof Chmielewski
Original Assignee
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Chemii Bioorganicznej Polskiej Akademii Nauk filed Critical Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Priority to PL391468A priority Critical patent/PL215851B1/pl
Priority to EP11728713.6A priority patent/EP2580198B1/en
Priority to US13/702,241 priority patent/US8759509B2/en
Priority to PCT/PL2011/000055 priority patent/WO2011155855A1/en
Publication of PL391468A1 publication Critical patent/PL391468A1/pl
Publication of PL215851B1 publication Critical patent/PL215851B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Przedmiotem wynalazku jest nowy sposób termolabilnej ochrony funkcji hydroksylowej zwłaszcza w nukleozydach, nukleotydach oligomerach, kwasach nukleinowych w reakcjach syntezy organicznej oraz nowe związki do realizacji tego sposobu, o wzorze 1 oraz o wzorze ogólnym 3. Sposób termolabilnej ochrony funkcji hydroksylowej charakteryzuje się tym, że 1, 2 i 3- rzędowa grupa hydroksylowa przekształca się w grupę o wzorze ogólnym 3, w którym R oznacza resztę ochranianej cząsteczki, w reakcji pomiędzy związkiem o ogólnym wzorze 1 a związkiem, którego grupa hydroksylowa ma być zablokowana, reakcję blokowania prowadzi się za pomocą ogólnie znanych metod odpowiednich do tego celu w obecności katalizatora zasadowego, otrzymując produkt, w którym grupa hydroksylowa jest zablokowana, a następnie związek z zablokowaną grupą hydroksylową można użyć do różnych procesów chemicznych, a po ich zakończeniu odblokowuje się rozpuszczoną w rozpuszczalniku zablokowaną grupę hydroksylową w temperaturze 50-95°C.
PL391468A 2010-06-10 2010-06-10 Nowy sposób termolabilnej ochrony funkcji hydroksylowej oraz nowe zwiazki do realizacji tego sposobu PL215851B1 (pl)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PL391468A PL215851B1 (pl) 2010-06-10 2010-06-10 Nowy sposób termolabilnej ochrony funkcji hydroksylowej oraz nowe zwiazki do realizacji tego sposobu
EP11728713.6A EP2580198B1 (en) 2010-06-10 2011-06-01 Thermolabile 2-(n-2-pyridiyl-n-benzyl)-aminoethyloxycarbonyl derivatives as hydroxyl function protecting agents
US13/702,241 US8759509B2 (en) 2010-06-10 2011-06-01 Way of using thermolabile groups to protect hydroxyl functions and compounds for implementing the procedure
PCT/PL2011/000055 WO2011155855A1 (en) 2010-06-10 2011-06-01 Thermolabile 2 - (n- 2 - pyridiyl - n- benzyl) - aminoethyloxycarbonyl derivatives as hydroxyl function protecting agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL391468A PL215851B1 (pl) 2010-06-10 2010-06-10 Nowy sposób termolabilnej ochrony funkcji hydroksylowej oraz nowe zwiazki do realizacji tego sposobu

Publications (2)

Publication Number Publication Date
PL391468A1 true PL391468A1 (pl) 2011-12-19
PL215851B1 PL215851B1 (pl) 2014-02-28

Family

ID=44627685

Family Applications (1)

Application Number Title Priority Date Filing Date
PL391468A PL215851B1 (pl) 2010-06-10 2010-06-10 Nowy sposób termolabilnej ochrony funkcji hydroksylowej oraz nowe zwiazki do realizacji tego sposobu

Country Status (4)

Country Link
US (1) US8759509B2 (pl)
EP (1) EP2580198B1 (pl)
PL (1) PL215851B1 (pl)
WO (1) WO2011155855A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201705925D0 (en) 2017-04-12 2017-05-24 Evonetix Ltd Cleavable protecting and linker groups

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7612197B2 (en) 2003-05-09 2009-11-03 The United States of America as repesented by the Secretary of the Department of Health and Human Services Thermolabile hydroxyl protecting groups and methods of use

Also Published As

Publication number Publication date
US20130085272A1 (en) 2013-04-04
PL215851B1 (pl) 2014-02-28
US8759509B2 (en) 2014-06-24
EP2580198A1 (en) 2013-04-17
EP2580198B1 (en) 2016-08-10
WO2011155855A1 (en) 2011-12-15

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