PL3917616T3 - Związki heterocykliczne i ich zastosowanie - Google Patents

Związki heterocykliczne i ich zastosowanie

Info

Publication number
PL3917616T3
PL3917616T3 PL20709748.6T PL20709748T PL3917616T3 PL 3917616 T3 PL3917616 T3 PL 3917616T3 PL 20709748 T PL20709748 T PL 20709748T PL 3917616 T3 PL3917616 T3 PL 3917616T3
Authority
PL
Poland
Prior art keywords
applications
heterocyclic compounds
heterocyclic
compounds
Prior art date
Application number
PL20709748.6T
Other languages
English (en)
Inventor
Yasushi Hattori
Yuhei Miyanohana
Yuichi Kajita
Tatsuki Koike
Yasutaka Hoashi
Norihito Tokunaga
Alexander Martin PAWLICZEK
Tsuneo Oda
Tohru Miyazaki
Yoshiteru Ito
Kohei Takeuchi
Keisuke Imamura
Takahiro Sugimoto
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=69770989&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3917616(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Publication of PL3917616T3 publication Critical patent/PL3917616T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
PL20709748.6T 2019-01-31 2020-01-30 Związki heterocykliczne i ich zastosowanie PL3917616T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019015488 2019-01-31
PCT/JP2020/004444 WO2020158958A1 (en) 2019-01-31 2020-01-30 Heterocyclic compound and use thereof

Publications (1)

Publication Number Publication Date
PL3917616T3 true PL3917616T3 (pl) 2025-09-08

Family

ID=69770989

Family Applications (1)

Application Number Title Priority Date Filing Date
PL20709748.6T PL3917616T3 (pl) 2019-01-31 2020-01-30 Związki heterocykliczne i ich zastosowanie

Country Status (32)

Country Link
US (8) US11028048B2 (pl)
EP (2) EP3917616B1 (pl)
JP (2) JP7253640B2 (pl)
KR (1) KR102882779B1 (pl)
CN (6) CN118420600A (pl)
AR (1) AR117916A1 (pl)
AU (1) AU2020215380B2 (pl)
BR (1) BR112021014180A2 (pl)
CA (1) CA3124536A1 (pl)
CL (1) CL2021001973A1 (pl)
CO (1) CO2021011188A2 (pl)
DK (1) DK3917616T3 (pl)
EA (1) EA202192138A1 (pl)
EC (1) ECSP21056325A (pl)
ES (1) ES3037650T3 (pl)
FI (1) FI3917616T3 (pl)
HR (1) HRP20250785T1 (pl)
HU (1) HUE071890T2 (pl)
IL (1) IL284073B2 (pl)
LT (1) LT3917616T (pl)
MX (1) MX2021008241A (pl)
MY (1) MY209784A (pl)
PE (1) PE20211700A1 (pl)
PH (1) PH12021551846A1 (pl)
PL (1) PL3917616T3 (pl)
PT (1) PT3917616T (pl)
RS (1) RS67170B1 (pl)
SG (1) SG11202106791XA (pl)
SI (1) SI3917616T1 (pl)
TW (1) TWI832962B (pl)
WO (1) WO2020158958A1 (pl)
ZA (1) ZA202106304B (pl)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10428023B2 (en) * 2017-08-03 2019-10-01 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
JP7253640B2 (ja) 2019-01-31 2023-04-06 武田薬品工業株式会社 複素環化合物およびその用途
EP4065585B1 (en) 2019-11-25 2025-08-20 Alkermes, Inc. Substituted macrocyclic compounds and related methods of treatment
US12448377B2 (en) 2019-11-27 2025-10-21 Takeda Pharmaceutical Company Limited Heterocyclic compound
BR112023002957A2 (pt) 2020-08-18 2023-04-04 Merck Sharp & Dohme Llc Composto, composição farmacêutica, e, métodos para tratar narcolepsia e para tratar hipersonia em um sujeito mamífero
CN116583502A (zh) * 2020-09-03 2023-08-11 欧瑞夏治疗有限公司 二环-杂环衍生物及其作为食欲素-2受体激动剂的用途
JP7811578B2 (ja) * 2020-09-03 2026-02-05 センテッサ ファーマシューティカルズ （ユーケー） リミテッド 中環状または大環状ベンジル置換複素環誘導体およびオレキシン－２受容体アゴニストとしてのそれらの使用
JP2022064180A (ja) * 2020-10-13 2022-04-25 武田薬品工業株式会社 複素環化合物
EP4236938A4 (en) * 2020-11-02 2024-10-16 Merck Sharp & Dohme LLC MACROCYCLIC UREA-OREX RECEPTOR AGONISTS
US12006330B2 (en) 2020-12-21 2024-06-11 Alkermes, Inc. Substituted macrocyclic compounds and related methods of treatment
US11760747B2 (en) 2020-12-21 2023-09-19 Alkermes, Inc. Substituted piperidino compounds and related methods of treatment
WO2022207935A1 (en) * 2021-04-02 2022-10-06 Orexia Therapeutics Limited 2-(3-ethynylbenzyl)-substituted heterocycle derivatives as orexin-2 agonists
US20240165092A1 (en) 2021-04-02 2024-05-23 Takeda Pharmaceutical Limited Company Use of an orexin 2 receptor agonist for post operation recovery
JP2025507852A (ja) 2022-03-01 2025-03-21 センテッサ ファーマシューティカルズ （ユーケー） リミテッド 中環状または大環状ベンジル置換複素環誘導体および関連の使用
WO2023199091A1 (en) 2022-04-12 2023-10-19 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2024075825A1 (ja) 2022-10-07 2024-04-11 キッセイ薬品工業株式会社 シクロペンタン化合物
EP4611745A1 (en) 2022-10-31 2025-09-10 Takeda Pharmaceutical Company Limited Dosing of orexin type 2 receptor agonists
TW202428580A (zh) 2022-10-31 2024-07-16 日商武田藥品工業股份有限公司 雜環化合物
AR131202A1 (es) 2022-11-30 2025-02-26 Takeda Pharmaceuticals Co Compuesto heterocíclico y uso del mismo
WO2024128305A1 (ja) 2022-12-16 2024-06-20 第一三共株式会社 ２－アザビシクロ［３．１．１］ヘプタン化合物
PE20252742A1 (es) 2023-03-16 2025-12-05 Takeda Pharmaceuticals Co Compuestos heterociclicos macrociclicos y sus usos
IL324946A (en) 2023-06-01 2026-01-01 H Lundbeck As Spiro-macrocyclic orexin 2 receptor agonists
EP4719397A1 (en) 2023-06-02 2026-04-08 Takeda Pharmaceutical Company Limited Use of an orexin 2 receptor agonist for improving respiratory function during sleep
WO2025124698A1 (en) 2023-12-12 2025-06-19 Idorsia Pharmaceuticals Ltd Aryl sulfone and sulfanone derivatives as orexin receptor modulators
TW202542165A (zh) 2023-12-19 2025-11-01 瑞士商愛杜西亞製藥有限公司 大環食慾素激動劑
GB202404750D0 (en) 2024-04-03 2024-05-15 Bial Portela & Ca Sa Orexin receptor agonists
TW202547460A (zh) * 2024-04-04 2025-12-16 日商橘生藥品工業股份有限公司 取代磺醯胺化合物
TW202547576A (zh) * 2024-04-04 2025-12-16 日商橘生藥品工業股份有限公司 取代磺醯胺巨環狀化合物
WO2025224168A1 (en) 2024-04-24 2025-10-30 Idorsia Pharmaceuticals Ltd Aryl sulfone and sulfanone derivatives as orexin receptor modulators
WO2025229494A1 (en) 2024-04-29 2025-11-06 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2025229493A1 (en) 2024-04-29 2025-11-06 Takeda Pharmaceutical Company Limited Dosing of orexin type 2 receptor agonists
WO2025229495A1 (en) 2024-04-29 2025-11-06 Takeda Pharmaceutical Company Limited Heterocyclic compound
US20250375417A1 (en) 2024-05-01 2025-12-11 Takeda Pharmaceutical Company Limited Orexin receptor 2 (ox2r) agonist for use in narcolepsy type 1 (nt1)
WO2026017128A1 (zh) * 2024-07-17 2026-01-22 江苏恩华药业股份有限公司 作为食欲素受体激动剂的环烯烃衍生物及其组合物和用途
WO2026019302A1 (ko) * 2024-07-18 2026-01-22 (주)셀트리온 신규한 오렉신 2 수용체 작용제 및 이의 용도

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1028305A (en) 1911-03-04 1912-06-04 Nicholas King Turnbull Machine for remaking wire-drawing dies.
US6166193A (en) 1997-07-25 2000-12-26 Board Of Regents, University Of Texas System Polynucleotides encoding MY1 receptor
EP1196609A2 (en) 1999-06-28 2002-04-17 Oklahoma Medical Research Foundation Catalytically active recombinant memapsin and methods of use thereof
AU6615300A (en) 1999-07-30 2001-02-19 Board Of Trustees Of The Leland Stanford Junior University Hypocretin and hypocretin receptors in regulation of sleep and related disorders
US7112566B1 (en) 1999-09-17 2006-09-26 The Regents Of The University Of California Systemic administration of Hypocretin-1
US6204245B1 (en) 1999-09-17 2001-03-20 The Regents Of The University Of California Treatment of narcolepsy with immunosuppressants
WO2001074162A1 (en) 2000-04-04 2001-10-11 The Regents Of The University Of California Treatment of sleep disorders with hypocretin-1
EP1581648A2 (en) 2002-09-09 2005-10-05 Nura, Inc. G protein coupled receptors and uses thereof
US20080260744A1 (en) 2002-09-09 2008-10-23 Omeros Corporation G protein coupled receptors and uses thereof
US7618786B2 (en) 2002-12-13 2009-11-17 Janssen Pharmaceutica N.V. Method for identifying modulators of human orexin-2 receptor
HUP0304101A3 (en) * 2003-12-22 2008-10-28 Sanofi Aventis Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
JP5232987B2 (ja) 2006-04-14 2013-07-10 アボット ゲーエムベーハー ウント カンパニー カーゲー ドーパミンｄ３受容体の調節に応答する障害の治療に好適なアリールオキシエチルアミン化合物
AU2012200270A1 (en) * 2007-05-23 2012-02-09 Merck Sharp & Dohme Corp. Pyridyl piperidine orexin receptor antagonists
US20110053859A1 (en) 2007-10-10 2011-03-03 The U. S. Government Respresented by the Department of Veterans Affairs Methods to reduce the effects of sleep deprivation
CA2717703A1 (en) 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Minocycline compounds and methods of use thereof
US8258163B2 (en) 2008-06-04 2012-09-04 Board Of Regents, The University Of Texas System Small-molecule agonists for type-2 orexin receptor
EP2694472B1 (en) 2011-04-05 2020-03-11 Takeda Pharmaceutical Company Limited Sulfonamide derivative and use thereof
TW201341380A (zh) * 2012-04-05 2013-10-16 Takeda Pharmaceutical 磺醯胺衍生物及其用途
BR112015007516A2 (pt) 2012-10-10 2017-07-04 Actelion Pharmaceuticals Ltd antagonistas do receptor de orexina que são derivados de [orto bi-(hetero-)aril]-[2-(meta bi-(hetero-)aril)- pirrolidin-1-il]-metanona
WO2014170343A1 (en) 2013-04-15 2014-10-23 Icm (Institut Du Cerveau Et De La Moelle Épinière) Depolarizing agents and nicotinic acetylcholine receptor modulators for treating dopaminergic-related disorders
WO2014198880A1 (en) 2013-06-14 2014-12-18 Ferrer Internacional, S.A. 2-(2-aminophenoxy)-3-chloronaphthalene-1,4-dione compounds having orexin 2 receptor agonist activity
WO2015048091A1 (en) 2013-09-24 2015-04-02 The Board Of Regents Of The University Of Texas System Orexin-control of bone formation and loss
EP3068783B1 (en) 2013-11-15 2020-09-23 The Board of Trustees of the Leland Stanford Junior University Agonists of hypocretin receptor 2 for use for treating heart failure
PE20161064A1 (es) 2013-12-12 2016-10-28 Univ Tsukuba Derivado de sulfonamida o sales de adicion de acido farmaceuticamente aceptables del mismo
WO2015147240A1 (ja) 2014-03-28 2015-10-01 国立大学法人筑波大学 敗血症の予防治療剤
JP6663909B2 (ja) 2014-08-13 2020-03-13 エオラス セラピューティクス， インコーポレイテッド オレキシンレセプターモジュレーターとしてのジフルオロピロリジン
EP3029024A1 (en) 2014-12-02 2016-06-08 Ferrer Internacional, S.A. 2-(2-aminophenoxy)-3-chloronaphthalene-1,4-dione compounds having orexin 2 receptor agonist activity
WO2016133160A1 (ja) 2015-02-19 2016-08-25 国立大学法人筑波大学 スルホンアミド誘導体またはその薬学的に許容される酸付加塩
AU2016235151A1 (en) 2015-03-24 2017-10-12 Paratek Pharmaceuticals, Inc. Minocycline compounds for biodefense
WO2016199906A1 (ja) 2015-06-12 2016-12-15 国立大学法人筑波大学 スルホンアミド誘導体またはその薬学的に許容される酸付加塩
WO2017044889A1 (en) 2015-09-10 2017-03-16 The Regents Of The University Of California Lrh-1 modulators
LT3984994T (lt) 2016-02-04 2024-10-10 Takeda Pharmaceutical Company Limited Pakeistas piperidino junginys kaip 2 tipo oreksino agonistas narkolepsijai gydyti
US11059780B2 (en) * 2017-03-08 2021-07-13 Takeda Pharmaceutical Company Limited Substituted pyrrolidine compound and use thereof
JP7012703B2 (ja) 2017-03-08 2022-02-14 武田薬品工業株式会社 置換ピロリジン化合物およびその用途
US10428023B2 (en) * 2017-08-03 2019-10-01 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
WO2019027003A1 (ja) 2017-08-03 2019-02-07 武田薬品工業株式会社 複素環化合物およびその用途
JPWO2019112007A1 (ja) 2017-12-07 2020-12-24 国立大学法人 筑波大学 鎮痛薬による眠気の予防または治療薬
JP7339250B2 (ja) 2018-06-29 2023-09-05 武田薬品工業株式会社 複素環化合物およびその用途
WO2020004537A1 (ja) 2018-06-29 2020-01-02 武田薬品工業株式会社 複素環化合物およびその用途
EP3896060B1 (en) 2018-12-12 2023-08-16 Takeda Pharmaceutical Company Limited Heterocyclic compound
US12071434B2 (en) 2018-12-12 2024-08-27 Takeda Pharmaceutical Company Limited Heterocyclic compound
BR112021010715A2 (pt) 2018-12-20 2021-11-16 Ksq Therapeutics Inc Pirazolopirimidinas substituídas e purinas substituídas e seu uso como inibidores de protease de processamento ubiquitina-específica 1 (usp1)
JP7253640B2 (ja) 2019-01-31 2023-04-06 武田薬品工業株式会社 複素環化合物およびその用途
CN113330000B (zh) 2019-01-31 2024-12-24 辉瑞公司 具有对cdk2的抑制活性的3-羰基氨基-5-环戊基-1fi-吡咯化合物
US11098029B2 (en) 2019-02-13 2021-08-24 Merck Sharp & Dohme Corp. 5-alkyl pyrrolidine orexin receptor agonists
WO2020167701A1 (en) 2019-02-13 2020-08-20 Merck Sharp & Dohme Corp. Pyrrolidine orexin receptor agonists

Also Published As

Publication number Publication date
CN113395993B (zh) 2024-02-20
CO2021011188A2 (es) 2021-10-29
RS67170B1 (sr) 2025-09-30
ES3037650T3 (en) 2025-10-03
ECSP21056325A (es) 2021-09-30
HRP20250785T1 (hr) 2025-09-12
CN118344346A (zh) 2024-07-16
MY209784A (en) 2025-08-04
KR20210121080A (ko) 2021-10-07
JP7253640B2 (ja) 2023-04-06
AR117916A1 (es) 2021-09-01
EP3917616B1 (en) 2025-06-11
KR102882779B1 (ko) 2025-11-07
IL284073A (en) 2021-08-31
IL284073B2 (en) 2025-07-01
US20200247747A1 (en) 2020-08-06
EP3917616A1 (en) 2021-12-08
IL284073B1 (en) 2025-03-01
EA202192138A1 (ru) 2022-03-10
CN118271297A (zh) 2024-07-02
US12421188B2 (en) 2025-09-23
US20250243157A1 (en) 2025-07-31
DK3917616T3 (da) 2025-07-21
WO2020158958A1 (en) 2020-08-06
ZA202106304B (en) 2023-06-28
PE20211700A1 (es) 2021-09-01
CN118271298A (zh) 2024-07-02
CN113395993A (zh) 2021-09-14
US20250243156A1 (en) 2025-07-31
US11028048B2 (en) 2021-06-08
US20250243158A1 (en) 2025-07-31
CN118420600A (zh) 2024-08-02
PH12021551846A1 (en) 2022-05-23
LT3917616T (lt) 2025-08-11
JP2023078426A (ja) 2023-06-06
CL2021001973A1 (es) 2022-04-08
US20210276949A1 (en) 2021-09-09
MX2021008241A (es) 2021-08-16
HUE071890T2 (hu) 2025-09-28
TW202043196A (zh) 2020-12-01
TWI832962B (zh) 2024-02-21
JP7502512B2 (ja) 2024-06-18
CN118290408A (zh) 2024-07-05
EP4578853A3 (en) 2025-09-03
EP4578853A2 (en) 2025-07-02
US20260092033A1 (en) 2026-04-02
SG11202106791XA (en) 2021-07-29
US12404237B2 (en) 2025-09-02
CA3124536A1 (en) 2020-08-06
BR112021014180A2 (pt) 2021-09-21
US20230040770A1 (en) 2023-02-09
AU2020215380A2 (en) 2021-08-19
US20240360080A1 (en) 2024-10-31
PT3917616T (pt) 2025-08-28
JP2022519331A (ja) 2022-03-22
FI3917616T3 (fi) 2025-07-24
AU2020215380A1 (en) 2021-08-19
AU2020215380B2 (en) 2025-09-25
US12415782B2 (en) 2025-09-16
SI3917616T1 (sl) 2025-08-29

Similar Documents

Publication Publication Date Title
PL3917616T3 (pl) Związki heterocykliczne i ich zastosowanie
EP3919483A4 (en) HETEROCYCLIC BENZOPYRIDONE COMPOUND AND USE THEREOF
IL283333A (en) New heterocyclic compounds
IL285178A (en) Compounds and uses thereof
PL3946464T3 (pl) Związki i ich koniugaty
EP3816154A4 (en) HETEROCYCLIC COMPOUND AND APPLICATION THEREOF
IL282998A (en) Pyridazinone compounds and uses thereof
EP3663281A4 (en) HETEROCYCLIC LINK AND APPLICATION OF IT
EP3594203A4 (en) SUBSTITUTED PYRROLIDINE COMPOUND AND ITS USE
IL285461A (en) Processes and compounds
EP3594202A4 (en) SUBSTITUTED PYRROLIDINE COMPOUND AND ITS USE
IL278122B1 (en) Pteridinone compounds and uses thereof
EP3872077A4 (en) HETEROCYCLIC AMIDE FOR RIP1 KINASE INHIBITION AND USES THEREOF
PL3259253T3 (pl) Pochodne sulfonylomocznika i związki pokrewne oraz ich zastosowanie
IL282588A (en) Heterocyclic kinase inhibitors and uses thereof
IL279977A (en) Anthelminthic heterocyclic compounds
DK3255042T3 (da) Heterocyklisk forbindelse og farmaceutisk sammensætning omfattende samme
EP4174069A4 (en) HETEROCYCLIC COMPOUND AND ASSOCIATED USE
IL285118A (en) Compounds and uses thereof
EP3741758A4 (en) BROMODOMAIN INHIBITOR COMPOUND AND ITS USE
EP3681877C0 (en) PYRAZOLE DERIVED COMPOUND AND ITS USE
IL284514A (en) Halo-allylamine compounds and use thereof
DK4034535T3 (da) Aza-quinolinforbindelser og anvendelser deraf
EP3952876A4 (en) HETEROCYCLIC COMPOUNDS AND THEIR USES
EP3744722A4 (en) Ss-LACTAMASE INHIBITOR AND ITS USE