PL394569A1 - Asymetrycznie podstawione pochodne antrapirydazonu jako cytostatyki modulujace opornosc wielolekowa komórek nowotworowych - Google Patents
Asymetrycznie podstawione pochodne antrapirydazonu jako cytostatyki modulujace opornosc wielolekowa komórek nowotworowychInfo
- Publication number
- PL394569A1 PL394569A1 PL394569A PL39456911A PL394569A1 PL 394569 A1 PL394569 A1 PL 394569A1 PL 394569 A PL394569 A PL 394569A PL 39456911 A PL39456911 A PL 39456911A PL 394569 A1 PL394569 A1 PL 394569A1
- Authority
- PL
- Poland
- Prior art keywords
- cytostatics
- tumor cells
- multidrug resistance
- antrapyridazone
- asymmetrically substituted
- Prior art date
Links
- 230000036457 multidrug resistance Effects 0.000 title abstract 3
- 239000000824 cytostatic agent Substances 0.000 title abstract 2
- 230000001085 cytostatic effect Effects 0.000 title abstract 2
- 210000004881 tumor cell Anatomy 0.000 title abstract 2
- GNRKYCMWPJCWIR-UHFFFAOYSA-N 15,16-diazatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2,4,6,9,11,13(17)-heptaene-8,14-dione Chemical class C1=CC(C(=O)C=2C3=CC=CC=2)=C2C3=NNC(=O)C2=C1 GNRKYCMWPJCWIR-UHFFFAOYSA-N 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/36—Benzo-cinnolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL394569A PL394569A1 (pl) | 2011-04-14 | 2011-04-14 | Asymetrycznie podstawione pochodne antrapirydazonu jako cytostatyki modulujace opornosc wielolekowa komórek nowotworowych |
| CA2831388A CA2831388A1 (en) | 2011-04-14 | 2012-04-13 | Asymmetrically substituted anthrapyridazone derivatives as cytostatics |
| JP2014505102A JP6013451B2 (ja) | 2011-04-14 | 2012-04-13 | 細胞増殖抑制剤としての非対称に置換されたアントラピリダゾン誘導体 |
| US14/111,022 US9096536B2 (en) | 2011-04-14 | 2012-04-13 | Asymmetrically substituted anthrapyridazone derivatives as cytostatics |
| PCT/PL2012/000025 WO2012141604A1 (en) | 2011-04-14 | 2012-04-13 | Asymmetrically substituted anthrapyridazone derivatives as cytostatics |
| KR1020137030144A KR20140027995A (ko) | 2011-04-14 | 2012-04-13 | 세포증식억제제로서의 비대칭 치환된 안트라피리다존 유도체 |
| BR112013026190A BR112013026190A2 (pt) | 2011-04-14 | 2012-04-13 | derivados de antrapiridazona assimetricamente substituídos como citostáticos |
| AU2012243487A AU2012243487A1 (en) | 2011-04-14 | 2012-04-13 | Asymmetrically substituted anthrapyridazone derivatives as cytostatics |
| EP12722932.6A EP2697205A1 (en) | 2011-04-14 | 2012-04-13 | Asymmetrically substituted anthrapyridazone derivatives as cytostatics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL394569A PL394569A1 (pl) | 2011-04-14 | 2011-04-14 | Asymetrycznie podstawione pochodne antrapirydazonu jako cytostatyki modulujace opornosc wielolekowa komórek nowotworowych |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL394569A1 true PL394569A1 (pl) | 2012-10-22 |
Family
ID=46147661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL394569A PL394569A1 (pl) | 2011-04-14 | 2011-04-14 | Asymetrycznie podstawione pochodne antrapirydazonu jako cytostatyki modulujace opornosc wielolekowa komórek nowotworowych |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9096536B2 (pl) |
| EP (1) | EP2697205A1 (pl) |
| JP (1) | JP6013451B2 (pl) |
| KR (1) | KR20140027995A (pl) |
| AU (1) | AU2012243487A1 (pl) |
| BR (1) | BR112013026190A2 (pl) |
| CA (1) | CA2831388A1 (pl) |
| PL (1) | PL394569A1 (pl) |
| WO (1) | WO2012141604A1 (pl) |
-
2011
- 2011-04-14 PL PL394569A patent/PL394569A1/pl unknown
-
2012
- 2012-04-13 WO PCT/PL2012/000025 patent/WO2012141604A1/en not_active Ceased
- 2012-04-13 CA CA2831388A patent/CA2831388A1/en not_active Abandoned
- 2012-04-13 EP EP12722932.6A patent/EP2697205A1/en not_active Withdrawn
- 2012-04-13 KR KR1020137030144A patent/KR20140027995A/ko not_active Withdrawn
- 2012-04-13 US US14/111,022 patent/US9096536B2/en not_active Expired - Fee Related
- 2012-04-13 BR BR112013026190A patent/BR112013026190A2/pt not_active IP Right Cessation
- 2012-04-13 AU AU2012243487A patent/AU2012243487A1/en not_active Abandoned
- 2012-04-13 JP JP2014505102A patent/JP6013451B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2697205A1 (en) | 2014-02-19 |
| US9096536B2 (en) | 2015-08-04 |
| KR20140027995A (ko) | 2014-03-07 |
| JP2014515022A (ja) | 2014-06-26 |
| AU2012243487A1 (en) | 2013-10-17 |
| JP6013451B2 (ja) | 2016-10-26 |
| BR112013026190A2 (pt) | 2019-09-24 |
| US20140031357A1 (en) | 2014-01-30 |
| WO2012141604A1 (en) | 2012-10-18 |
| CA2831388A1 (en) | 2012-10-18 |
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