PL3954689T3 - Związki pochodne pirazolopirazyny, kompozycja farmaceutyczna i ich zastosowanie - Google Patents
Związki pochodne pirazolopirazyny, kompozycja farmaceutyczna i ich zastosowanieInfo
- Publication number
- PL3954689T3 PL3954689T3 PL20788562.5T PL20788562T PL3954689T3 PL 3954689 T3 PL3954689 T3 PL 3954689T3 PL 20788562 T PL20788562 T PL 20788562T PL 3954689 T3 PL3954689 T3 PL 3954689T3
- Authority
- PL
- Poland
- Prior art keywords
- pyrazolopyrazine
- derivatives
- applications
- pharmaceutical compositions
- pharmaceutical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910294408 | 2019-04-12 | ||
| PCT/CN2020/084243 WO2020207476A1 (zh) | 2019-04-12 | 2020-04-10 | 一种吡唑并吡嗪衍生的化合物、药物组合物以及其用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3954689T3 true PL3954689T3 (pl) | 2024-08-05 |
Family
ID=72750940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL20788562.5T PL3954689T3 (pl) | 2019-04-12 | 2020-04-10 | Związki pochodne pirazolopirazyny, kompozycja farmaceutyczna i ich zastosowanie |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12404275B2 (pl) |
| EP (1) | EP3954689B1 (pl) |
| JP (1) | JP7256291B2 (pl) |
| KR (1) | KR102708872B1 (pl) |
| CN (1) | CN113924301B (pl) |
| AU (1) | AU2020256720B2 (pl) |
| BR (1) | BR112021020339A2 (pl) |
| ES (1) | ES2981909T3 (pl) |
| MX (1) | MX2021012487A (pl) |
| PL (1) | PL3954689T3 (pl) |
| WO (1) | WO2020207476A1 (pl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021241611A1 (ja) * | 2020-05-27 | 2021-12-02 | 武田薬品工業株式会社 | 複素環化合物の製造方法 |
| CN112592345B (zh) * | 2020-12-07 | 2024-09-13 | 嘉兴特科罗生物科技有限公司 | 一种三氮唑并吡嗪类化合物及其用途 |
| EP4423086A1 (en) | 2021-10-25 | 2024-09-04 | Kymera Therapeutics, Inc. | Tyk2 degraders and uses thereof |
| KR20240103022A (ko) * | 2021-11-12 | 2024-07-03 | 소테르 바이오파마 피티이. 리미티드 | 피라졸로 융합 고리 화합물 및 이의 용도 |
| EP4711367A1 (en) * | 2023-05-12 | 2026-03-18 | CMS Research & Development Pte. Ltd. | Pyrazolopyrazine compound and method for preparing crystal form thereof |
| CN119330881A (zh) * | 2024-09-06 | 2025-01-21 | 苏州汉德创宏生化科技有限公司 | 一种3-氨甲基-1-h吡唑的合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
| UY33213A (es) * | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
| KR20130094710A (ko) * | 2010-04-14 | 2013-08-26 | 어레이 바이오파마 인크. | Ｊａｋ 키나아제의 억제제로서 5,7-치환된-이미다조［1,2-ｃ］피리미딘 |
| CN103987713A (zh) * | 2011-10-12 | 2014-08-13 | 阵列生物制药公司 | 5,7-取代的咪唑并[1,2-c]嘧啶 |
| CN104804001B9 (zh) | 2014-01-24 | 2022-02-08 | 江苏柯菲平医药股份有限公司 | 4-取代吡咯并[2,3-d]嘧啶化合物及其用途 |
| CN105524067A (zh) | 2014-09-28 | 2016-04-27 | 江苏柯菲平医药股份有限公司 | 4-取代吡咯并[2,3-d]嘧啶化合物及其用途 |
| CN107278203B (zh) * | 2014-12-05 | 2020-05-19 | 阵列生物制药公司 | 作为JANUS激酶抑制剂的4,6-取代的吡唑并[1,5-a]吡嗪 |
| CN105777754B (zh) | 2014-12-16 | 2019-07-26 | 北京赛林泰医药技术有限公司 | 吡咯并嘧啶化合物 |
| CN106749338A (zh) | 2015-11-19 | 2017-05-31 | 青岛正大海尔制药有限公司 | 1,3-二取代1H-吡咯并[3,2-c]吡啶化合物及其用途 |
| ES2830446T3 (es) | 2015-12-11 | 2021-06-03 | Sichuan Kelun Biotech Biopharmaceutical Co Ltd | Derivado de azetidina, método de preparación del mismo y uso del mismo |
| CN109071546B (zh) * | 2016-02-24 | 2021-03-02 | 辉瑞大药厂 | 作为jak抑制剂的吡唑并[1,5-a]吡嗪-4-基衍生物 |
| CN107513067A (zh) | 2016-06-16 | 2017-12-26 | 北京赛林泰医药技术有限公司 | 含有取代环戊基的吡咯并嘧啶化合物 |
| WO2019034973A1 (en) * | 2017-08-14 | 2019-02-21 | Pfizer Inc. | PYRAZOLO [1,5-A] PYRAZIN-4-YL AND RELATED DERIVATIVES |
-
2020
- 2020-04-10 US US17/601,843 patent/US12404275B2/en active Active
- 2020-04-10 EP EP20788562.5A patent/EP3954689B1/en active Active
- 2020-04-10 MX MX2021012487A patent/MX2021012487A/es unknown
- 2020-04-10 ES ES20788562T patent/ES2981909T3/es active Active
- 2020-04-10 WO PCT/CN2020/084243 patent/WO2020207476A1/zh not_active Ceased
- 2020-04-10 KR KR1020217036228A patent/KR102708872B1/ko active Active
- 2020-04-10 PL PL20788562.5T patent/PL3954689T3/pl unknown
- 2020-04-10 BR BR112021020339A patent/BR112021020339A2/pt unknown
- 2020-04-10 JP JP2021559128A patent/JP7256291B2/ja active Active
- 2020-04-10 AU AU2020256720A patent/AU2020256720B2/en active Active
- 2020-04-10 CN CN202080027882.4A patent/CN113924301B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR102708872B1 (ko) | 2024-09-23 |
| US20220204513A1 (en) | 2022-06-30 |
| EP3954689A4 (en) | 2023-01-04 |
| JP7256291B2 (ja) | 2023-04-11 |
| EP3954689A1 (en) | 2022-02-16 |
| WO2020207476A1 (zh) | 2020-10-15 |
| AU2020256720A1 (en) | 2022-02-17 |
| MX2021012487A (es) | 2021-11-12 |
| KR20210149151A (ko) | 2021-12-08 |
| US12404275B2 (en) | 2025-09-02 |
| EP3954689C0 (en) | 2024-04-24 |
| AU2020256720B2 (en) | 2022-09-01 |
| CA3136468A1 (en) | 2020-10-15 |
| BR112021020339A2 (pt) | 2021-12-07 |
| CN113924301A (zh) | 2022-01-11 |
| EP3954689B1 (en) | 2024-04-24 |
| ES2981909T3 (es) | 2024-10-11 |
| JP2022526599A (ja) | 2022-05-25 |
| CN113924301B (zh) | 2024-08-16 |
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