PL396476A1 - Method for producing a thermosensitive coating substrate, the substrate with a thermosensitive coating and its use - Google Patents

Method for producing a thermosensitive coating substrate, the substrate with a thermosensitive coating and its use

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Publication number
PL396476A1
PL396476A1 PL396476A PL39647611A PL396476A1 PL 396476 A1 PL396476 A1 PL 396476A1 PL 396476 A PL396476 A PL 396476A PL 39647611 A PL39647611 A PL 39647611A PL 396476 A1 PL396476 A1 PL 396476A1
Authority
PL
Poland
Prior art keywords
substrate
coating
substituted
polymer
thermosensitive
Prior art date
Application number
PL396476A
Other languages
Polish (pl)
Other versions
PL222090B1 (en
Inventor
Alicja Utrata-Wesolek
Wojciech Wałach
Natalia Oleszko
Andrzej Dworak
Barbara Trzebicka
Agnieszka Kowalczuk
Jacek Anioł
Marta Lesiak
Anna Sitkowska
Aleksander L. Sieroń
Marek Kawecki
Justyna Glik
Agnieszka Klama-Baryła
Mariusz Nowak
Original Assignee
Centrum Materialów Polimerowych I Weglowych Polskiej Akademii Nauk
Centrum Leczenia Oparzeń
Śląski Uniwersytet Medyczny W Katowicach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centrum Materialów Polimerowych I Weglowych Polskiej Akademii Nauk, Centrum Leczenia Oparzeń, Śląski Uniwersytet Medyczny W Katowicach filed Critical Centrum Materialów Polimerowych I Weglowych Polskiej Akademii Nauk
Priority to PL396476A priority Critical patent/PL222090B1/en
Publication of PL396476A1 publication Critical patent/PL396476A1/en
Publication of PL222090B1 publication Critical patent/PL222090B1/en

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Abstract

Przedmiotem wynalazku jest podloze z powloka z termoczulego polimeru o zmiennym powinowactwie do wody (LCST) w zakresie 0-80°C oraz sposób jego wytwarzania przez immobilizacje na zmodyfikowanej powierzchni podloza bazowego nieorganicznego, korzystnie szklanego lub krzemowego, polimeru termoczulego z grupy homo i (ko)polimerów 2-podstawionych-2-oksazolin, przez szczepienie lancuchów monomeru 2-podstawionych -2-oksazolin z wytworzeniem powloki zwiazanej kowalencyjnie z funkcyjna grupa lacznika sililowego podloza bazowego. Immobilizacje polimeru prowadzi sie przez szczepienie inicjujace kationowa polimeryzacje od podloza lub terminujac polimeryzacje przez grupy funkcyjne na podloze, do wytworzenia na podlozu bazowym powloki o konformacji szczotki polimerowej i gestosci lancuchów 0,1-1,8 lancucha/nm2. Podloze z powloka termoczula utworzona z polimerów z grupy homo i (ko)polimerów 2-podstawionych -2-oksazolin jest przeznaczone dla hodowli komórkowych, zwlaszcza komórek skóry.The subject of the invention is a substrate made of a thermosensitive polymer coating with variable water affinity (LCST) in the range of 0-80 ° C and a method for its production by immobilization on a modified surface of an inorganic base substrate, preferably glass or silicon, a homo-sensitive thermosensitive polymer (co ) 2-substituted-2-oxazoline polymers, by grafting the 2-substituted -2-oxazoline monomer chains to form a coating covalently bonded to the silyl linker functional group of the base substrate. Immobilization of the polymer is carried out by grafting initiating cationic polymerization from the substrate or terminating polymerization by functional groups on the substrate to form a coating on the base substrate with a polymer brush conformation and a chain density of 0.1-1.8 chain / nm2. The thermosensitive coating made of homo polymers and 2-substituted -2-oxazolines (co) polymers is intended for cell cultures, especially skin cells.

PL396476A 2011-09-30 2011-09-30 Method for producing a thermosensitive coating substrate, the substrate with a thermosensitive coating and its use PL222090B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL396476A PL222090B1 (en) 2011-09-30 2011-09-30 Method for producing a thermosensitive coating substrate, the substrate with a thermosensitive coating and its use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL396476A PL222090B1 (en) 2011-09-30 2011-09-30 Method for producing a thermosensitive coating substrate, the substrate with a thermosensitive coating and its use

Publications (2)

Publication Number Publication Date
PL396476A1 true PL396476A1 (en) 2013-04-02
PL222090B1 PL222090B1 (en) 2016-06-30

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ID=48040862

Family Applications (1)

Application Number Title Priority Date Filing Date
PL396476A PL222090B1 (en) 2011-09-30 2011-09-30 Method for producing a thermosensitive coating substrate, the substrate with a thermosensitive coating and its use

Country Status (1)

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PL (1) PL222090B1 (en)

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Publication number Publication date
PL222090B1 (en) 2016-06-30

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