PL401114A1 - Sulforaphane derivatives, their precursors and a method for their preparation - Google Patents
Sulforaphane derivatives, their precursors and a method for their preparationInfo
- Publication number
- PL401114A1 PL401114A1 PL401114A PL40111412A PL401114A1 PL 401114 A1 PL401114 A1 PL 401114A1 PL 401114 A PL401114 A PL 401114A PL 40111412 A PL40111412 A PL 40111412A PL 401114 A1 PL401114 A1 PL 401114A1
- Authority
- PL
- Poland
- Prior art keywords
- formula
- precursors
- preparation
- sulforaphane
- subject
- Prior art date
Links
- SUVMJBTUFCVSAD-UHFFFAOYSA-N sulforaphane Chemical class CS(=O)CCCCN=C=S SUVMJBTUFCVSAD-UHFFFAOYSA-N 0.000 title abstract 4
- 239000002243 precursor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- QSLPNSWXUQHVLP-UHFFFAOYSA-N $l^{1}-sulfanylmethane Chemical compound [S]C QSLPNSWXUQHVLP-UHFFFAOYSA-N 0.000 abstract 1
- SUVMJBTUFCVSAD-JTQLQIEISA-N 4-Methylsulfinylbutyl isothiocyanate Natural products C[S@](=O)CCCCN=C=S SUVMJBTUFCVSAD-JTQLQIEISA-N 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000003178 anti-diabetic effect Effects 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 229930014626 natural product Natural products 0.000 abstract 1
- 150000004763 sulfides Chemical class 0.000 abstract 1
- 150000003457 sulfones Chemical class 0.000 abstract 1
- 229960005559 sulforaphane Drugs 0.000 abstract 1
- 235000015487 sulforaphane Nutrition 0.000 abstract 1
- 150000003462 sulfoxides Chemical class 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Przedmiotem wynalazku są nowe związki – analogi naturalnego produktu, sulforafanu o wzorze CH3S(O)(CH2)4N=C=S, wykazujące właściwości biologiczne, w tym działanie przeciwnowotworowe, przeciwcukrzycowe o przeciwbakteryjne. Nowe związki przedstawione są wzorem ogólnym 1, w którym RF oznacza grupę o wzorze CnF2n+1, gdzie n oznacza liczbę naturalną od 1 do 7, x oznacza liczbę 0, 1 lub 2, z oznacza liczbę 0, 1 lub 2, m oznacza liczbę 0, 1 lub 2, a y oznacza liczbę naturalną od 3 do 6, inaczej mówiąc: sulfidów o wzorze 1 gdy m=0, sulfotlenków o wzorze 1, ich racematów, gdy m=1, oraz sulfonów o wzorze 1 ω-izotiocyjanianoalkilowo-polifluoroalkilowych, gdy m=2. Przedmiotem wynalazku są również prekursory tych związków oraz sposób wytwarzania pochodnych sulforafanu o wzorze ogólnym 1.The subject of the invention are new compounds - analogues of the natural product, sulforaphane of the formula CH3S(O)(CH2)4N=C=S, exhibiting biological properties, including anticancer, antidiabetic and antibacterial activity. The new compounds are presented by the general formula 1, where RF is a group of the formula CnF2n+1, where n is a natural number from 1 to 7, x is a number 0, 1 or 2, z is a number 0, 1 or 2, m is a number 0, 1 or 2, and y is a natural number from 3 to 6, in other words: sulfides of the formula 1 when m=0, sulfoxides of the formula 1, their racemates when m=1, and sulfones of the formula 1 ω-isothiocyanatoalkyl-polyfluoroalkyl when m=2. The subject of the invention are also precursors of these compounds and a method for the preparation of sulforaphane derivatives of the general formula 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL401114A PL220620B1 (en) | 2012-10-09 | 2012-10-09 | Sulforaphane derivatives, their precursors and a method for their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL401114A PL220620B1 (en) | 2012-10-09 | 2012-10-09 | Sulforaphane derivatives, their precursors and a method for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL401114A1 true PL401114A1 (en) | 2014-04-14 |
| PL220620B1 PL220620B1 (en) | 2015-11-30 |
Family
ID=50442155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL401114A PL220620B1 (en) | 2012-10-09 | 2012-10-09 | Sulforaphane derivatives, their precursors and a method for their preparation |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL220620B1 (en) |
-
2012
- 2012-10-09 PL PL401114A patent/PL220620B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL220620B1 (en) | 2015-11-30 |
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