PL401500A1 - Nowe alkanoloamidowe pochodne kwasu cynamonowego oraz zastosowanie alkanoloamidowych pochodnych kwasu cynamonowego do wytwarzania leków - Google Patents

Nowe alkanoloamidowe pochodne kwasu cynamonowego oraz zastosowanie alkanoloamidowych pochodnych kwasu cynamonowego do wytwarzania leków

Info

Publication number
PL401500A1
PL401500A1 PL401500A PL40150012A PL401500A1 PL 401500 A1 PL401500 A1 PL 401500A1 PL 401500 A PL401500 A PL 401500A PL 40150012 A PL40150012 A PL 40150012A PL 401500 A1 PL401500 A1 PL 401500A1
Authority
PL
Poland
Prior art keywords
cinnamic acid
aminopropan
alkanolamides
acid derivatives
aminobutan
Prior art date
Application number
PL401500A
Other languages
English (en)
Other versions
PL220733B1 (pl
Inventor
Agnieszka Gunia
Anna Maria Waszkielewicz
Henryk Marona
Original Assignee
Uniwersytet Jagielloński
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Jagielloński filed Critical Uniwersytet Jagielloński
Priority to PL401500A priority Critical patent/PL220733B1/pl
Priority to PCT/PL2013/000139 priority patent/WO2014073994A2/en
Publication of PL401500A1 publication Critical patent/PL401500A1/pl
Publication of PL220733B1 publication Critical patent/PL220733B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Przedmiotem wynalazku są nowe alkanoloamidowe pochodne kwasu cynamonowego o ogólnym wzorze1 i konfiguracji korzystnie trans, w którym R1 oznacza (R)-2-aminopropan-1-ol, (S)-2-aminopropan-1-ol, (S)-1-aminopropan-2-ol, (R,S)-1-aminobutan-2-ol, (R,S)-2-amino-3-metylobutan-1-ol, a R2 oznacza wodór lub grupę metylową w odpowiedniej pozycji pierścienia fenylowego, korzystnie w pozycji 2. Wynalazek obejmuje również zastosowanie alkanoloamidowych pochodnych kwasu cynamonowego o ogólnym wzorze 1, w którym R1 oznacza (R)-2-aminopropan-1-ol, (S)-2-aminopropan-1-ol, (S)-1-aminopropan-2-ol, (R,S)-1-aminobutan-2-ol, (R,S)-2-amino-3-metylobutan-1-ol, (R,S)-2-aminopropan-1-ol, (R,S)-1-aminopropan-2-ol, (R,S)-2-aminobutan-1-ol, (R)-2-aminobutan-1-ol, (trans)-4-aminocykloheksanol, 3-hydroksypiperydyna, a R2 oznacza wodór, chlor lub grupę metylową w odpowiedniej pozycji pierścienia fenylowego, korzystnie 4 dla chloru, 2 dla grupy metylowej, do wytwarzania leków stosowanych w leczeniu i profilaktyce schorzeń lub symptomów o podłożu neurologicznym, zwłaszcza padaczki i/lub bólu.
PL401500A 2012-11-07 2012-11-07 Nowe alkanoloamidowe pochodne kwasu cynamonowego oraz zastosowanie alkanoloamidowych pochodnych kwasu cynamonowego do wytwarzania leków PL220733B1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL401500A PL220733B1 (pl) 2012-11-07 2012-11-07 Nowe alkanoloamidowe pochodne kwasu cynamonowego oraz zastosowanie alkanoloamidowych pochodnych kwasu cynamonowego do wytwarzania leków
PCT/PL2013/000139 WO2014073994A2 (en) 2012-11-07 2013-10-31 New alkanolamide derivatives of cinnamic acid and use of alkanolamide derivatives of cinnamic acid for preparation of drugs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL401500A PL220733B1 (pl) 2012-11-07 2012-11-07 Nowe alkanoloamidowe pochodne kwasu cynamonowego oraz zastosowanie alkanoloamidowych pochodnych kwasu cynamonowego do wytwarzania leków

Publications (2)

Publication Number Publication Date
PL401500A1 true PL401500A1 (pl) 2014-05-12
PL220733B1 PL220733B1 (pl) 2015-12-31

Family

ID=49880910

Family Applications (1)

Application Number Title Priority Date Filing Date
PL401500A PL220733B1 (pl) 2012-11-07 2012-11-07 Nowe alkanoloamidowe pochodne kwasu cynamonowego oraz zastosowanie alkanoloamidowych pochodnych kwasu cynamonowego do wytwarzania leków

Country Status (2)

Country Link
PL (1) PL220733B1 (pl)
WO (1) WO2014073994A2 (pl)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015020545A2 (en) 2013-08-09 2015-02-12 Uniwersytet Jagielloński New derivatives of n-[(phenoxy)ethoxy]alkylaminoalkanols and their use for preparation of drugs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2040181A1 (pl) * 1969-04-02 1971-01-22 Lipha
US4309444A (en) 1976-02-03 1982-01-05 Burroughs Wellcome Co. Biologically active amides
US4190674A (en) 1976-02-03 1980-02-26 Burroughs Wellcome Co. 3-Fluoro-N-cyclopropylcinnamide
US4107320A (en) 1976-08-06 1978-08-15 Burroughs Wellcome Co. Biologically active amides
US4175924A (en) 1977-02-10 1979-11-27 Hazen Research, Inc. Treatment of coal with metal containing compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015020545A2 (en) 2013-08-09 2015-02-12 Uniwersytet Jagielloński New derivatives of n-[(phenoxy)ethoxy]alkylaminoalkanols and their use for preparation of drugs

Also Published As

Publication number Publication date
WO2014073994A3 (en) 2014-07-17
WO2014073994A2 (en) 2014-05-15
PL220733B1 (pl) 2015-12-31

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