PL402323A1 - Sposób wytwarzania pochodnych taksanu - Google Patents

Sposób wytwarzania pochodnych taksanu

Info

Publication number
PL402323A1
PL402323A1 PL402323A PL40232303A PL402323A1 PL 402323 A1 PL402323 A1 PL 402323A1 PL 402323 A PL402323 A PL 402323A PL 40232303 A PL40232303 A PL 40232303A PL 402323 A1 PL402323 A1 PL 402323A1
Authority
PL
Poland
Prior art keywords
group
hydrogen
alcohol
compounds
forms
Prior art date
Application number
PL402323A
Other languages
English (en)
Inventor
Arturo Battaglia
Andrea Guerrini
Giacomo Carenzi
Eleonora Baldelli
Ezio Bombardelli
Gabriele Fontana
Maria Gelmi
Donato Pocar
Original Assignee
Indena S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena S.P.A. filed Critical Indena S.P.A.
Publication of PL402323A1 publication Critical patent/PL402323A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

Przedmiotem wynalazku jest sposób wytwarzania zwiazków o wzorze XIV wychodzac ze zwiazków o wzorze XIII, w którym R2 oznacza acyl lub grupe zabezpieczajaca alkohol; R3 oznacza wodór, acyl, alkil lub wziety razem z R4 tworzy grupy C=O, C=S, SO, SO2; R4 oznacza wodór lub wziety razem z R3 tworzy grupy C=O, C=S, SO, SO2; R6 oznacza aryl, podstawiony aryl, heteroaryl; który obejmuje a) selektywna redukcje grupy azydowej do grupy aminowej; b) ewentualne traktowanie srodkami alkilujacymi lub acylujacymi; c) odszczepienie grupy zabezpieczajacej C7; d) otwarcie oksazolidyny.
PL402323A 2002-09-10 2003-09-05 Sposób wytwarzania pochodnych taksanu PL402323A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001921A ITMI20021921A1 (it) 2002-09-10 2002-09-10 Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.

Publications (1)

Publication Number Publication Date
PL402323A1 true PL402323A1 (pl) 2013-04-02

Family

ID=31986024

Family Applications (4)

Application Number Title Priority Date Filing Date
PL402333A PL402333A1 (pl) 2002-09-10 2003-09-05 Zwiazki pochodne taksanu
PL402332A PL402332A1 (pl) 2002-09-10 2003-09-05 Sposób wytwarzania pochodnych taksanu
PL402323A PL402323A1 (pl) 2002-09-10 2003-09-05 Sposób wytwarzania pochodnych taksanu
PL03375625A PL375625A1 (pl) 2002-09-10 2003-09-05 Pochodne taksanu funkcjonalizowane w pozycji 14 oraz sposób ich wytwarzania

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PL402333A PL402333A1 (pl) 2002-09-10 2003-09-05 Zwiazki pochodne taksanu
PL402332A PL402332A1 (pl) 2002-09-10 2003-09-05 Sposób wytwarzania pochodnych taksanu

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL03375625A PL375625A1 (pl) 2002-09-10 2003-09-05 Pochodne taksanu funkcjonalizowane w pozycji 14 oraz sposób ich wytwarzania

Country Status (20)

Country Link
US (1) US7498452B2 (pl)
EP (6) EP2298754B9 (pl)
JP (2) JP4690039B2 (pl)
KR (1) KR101096918B1 (pl)
CN (1) CN1681799A (pl)
AT (1) ATE398113T1 (pl)
AU (1) AU2003267049B8 (pl)
CA (1) CA2498277C (pl)
DE (1) DE60321577D1 (pl)
DK (4) DK2077264T3 (pl)
ES (4) ES2432024T3 (pl)
IL (5) IL167336A (pl)
IT (1) ITMI20021921A1 (pl)
NO (3) NO332250B1 (pl)
PL (4) PL402333A1 (pl)
PT (4) PT2264019E (pl)
RU (1) RU2320652C2 (pl)
SG (1) SG164282A1 (pl)
SI (4) SI1537093T1 (pl)
WO (1) WO2004024706A2 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20012185A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
CN107056767B (zh) * 2015-12-04 2022-07-15 江苏恩华络康药物研发有限公司 用于制备水溶性紫杉烷类衍生物的方法及中间体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504222A (en) 1993-08-20 1996-04-02 The Scripps Research Institute Transformations of taxol
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
IL108444A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C2 taxane derivatives and pharmaceutical compositions containing them
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IL127598A (en) * 1994-01-28 2003-04-10 Upjohn Co Process for preparing isotaxol analogs
US5719177A (en) 1994-11-04 1998-02-17 Pharmacia S.P.A. Taxane derivatives
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
ITMI991483A1 (it) * 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
KR100922146B1 (ko) * 2000-08-04 2009-10-19 센서즈 포 메드슨 앤드 사이언스 인코포레이티드 수성 환경에서의 분석물 검출
IT1318678B1 (it) * 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
ITMI20012186A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato

Also Published As

Publication number Publication date
CN1681799A (zh) 2005-10-12
EP1980557A3 (en) 2008-12-31
IL214430A0 (en) 2011-09-27
IL167336A (en) 2009-11-18
EP2077264A3 (en) 2009-09-16
PT2264019E (pt) 2013-10-28
EP2264019A1 (en) 2010-12-22
ITMI20021921A1 (it) 2004-03-11
DK2264019T3 (da) 2013-10-28
ES2433580T3 (es) 2013-12-11
RU2005106361A (ru) 2005-10-10
IL214432A (en) 2014-05-28
PT2298754E (pt) 2013-11-07
SG164282A1 (en) 2010-09-29
ES2307965T3 (es) 2008-12-01
EP2298754B1 (en) 2013-08-07
KR101096918B1 (ko) 2011-12-22
NO20110782L (no) 2005-05-10
EP1537093A2 (en) 2005-06-08
ES2432024T3 (es) 2013-11-29
DK1537093T3 (da) 2008-10-27
AU2003267049B8 (en) 2010-03-04
NO332366B1 (no) 2012-09-03
PL402333A1 (pl) 2013-04-02
JP2010270145A (ja) 2010-12-02
WO2004024706A2 (en) 2004-03-25
ATE398113T1 (de) 2008-07-15
SI2298754T1 (sl) 2013-11-29
EP2281820A3 (en) 2011-05-04
IL197815A (en) 2013-02-28
ES2398324T3 (es) 2013-03-15
EP2264019B1 (en) 2013-07-24
CA2498277C (en) 2011-07-05
US7498452B2 (en) 2009-03-03
SI2264019T1 (sl) 2013-10-30
WO2004024706A3 (en) 2004-07-08
RU2320652C2 (ru) 2008-03-27
NO20110781L (no) 2005-05-10
EP2281820A2 (en) 2011-02-09
NO332367B1 (no) 2012-09-03
PL375625A1 (pl) 2005-12-12
EP1537093B1 (en) 2008-06-11
JP4690039B2 (ja) 2011-06-01
AU2003267049A1 (en) 2004-04-30
DK2077264T3 (da) 2013-03-04
DE60321577D1 (de) 2008-07-24
IL214432A0 (en) 2011-09-27
AU2003267049B2 (en) 2010-02-11
IL214431A (en) 2014-05-28
PL402332A1 (pl) 2013-04-02
DK2298754T3 (da) 2013-11-04
US20060122258A1 (en) 2006-06-08
IL214431A0 (en) 2011-09-27
EP2077264B1 (en) 2012-11-14
SI1537093T1 (sl) 2008-10-31
EP1980557A2 (en) 2008-10-15
EP2298754B9 (en) 2013-12-18
EP2077264A2 (en) 2009-07-08
EP2298754A1 (en) 2011-03-23
PT2077264E (pt) 2013-01-29
SI2077264T1 (sl) 2013-03-29
NO20051774L (no) 2005-05-10
NO332250B1 (no) 2012-08-06
CA2498277A1 (en) 2004-03-25
JP2006503030A (ja) 2006-01-26
PT1537093E (pt) 2008-09-02
KR20050035540A (ko) 2005-04-18

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