PL403432A1 - Kwas (E)-3-arylo-3-oksoprop-1-enylo-2-fosfonowy i jego pochodne - sposób ich wytwarzania oraz ich zastosowanie - Google Patents
Kwas (E)-3-arylo-3-oksoprop-1-enylo-2-fosfonowy i jego pochodne - sposób ich wytwarzania oraz ich zastosowanieInfo
- Publication number
- PL403432A1 PL403432A1 PL403432A PL40343213A PL403432A1 PL 403432 A1 PL403432 A1 PL 403432A1 PL 403432 A PL403432 A PL 403432A PL 40343213 A PL40343213 A PL 40343213A PL 403432 A1 PL403432 A1 PL 403432A1
- Authority
- PL
- Poland
- Prior art keywords
- aryl
- oxoprop
- enyl
- derivatives
- phosphonic acid
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 abstract 1
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 abstract 1
- -1 3,5-dimethoxyphenyl Chemical group 0.000 abstract 1
- 125000002015 acyclic group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 238000009830 intercalation Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem wynalazku jest kwas (E)-3-arylo-3-oksoprop-1-enylo-2-fosfonowy oraz jego pochodne w postaci estrów lub soli, sposób ich wytwarzania i zastosowanie jako związków mających zdolność oddziaływania z kwasami nukleinowymi, w tym o właściwościach interkalujących DNA i działaniu przeciwnowotworowym. Związki te przedstawione są wzorem 1, w którym Ar- oznacza grupę arylową wybraną z grupy obejmującej grupę fenylową, benzo[d][1,3]dioksolanową, 3,5-dimetoksyfenylową, 3,4,5-trimetoksyfenylową, niepodstawioną lub podstawioną grupą alkoksylową cykliczną, zwłaszcza grupą 1,3-dioksametylenową -OCH2O-, albo acykliczną zwłaszcza metoksylową MeO, etoksylową EtO, propoksylową PrO lub butoksylową BuO, a także grupę heteroarylową, wybraną z grupy obejmującej grupę tienylową, pirolową, furylową lub pirydynową, R1, R2- są takie same lub różne i oznaczają grupę -OH, -OMetal, gdzie Metal oznacza Li, Na, K, Zn, Mg, lub grupę -OAlkil gdzie Alkil zawiera od 1 do 5 atomów węgla.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL403432A PL230602B1 (pl) | 2013-04-04 | 2013-04-04 | Kwas (E)-3-arylo-3-oksoprop-1-enylo-2-fosfonowy i jego pochodne, sposob ich wytwarzania oraz ich zastosowanie |
| EP20140150857 EP2787001A1 (en) | 2013-04-04 | 2014-01-12 | (E)-3-Aryl-3-oxoprop-1-enyl-2-phosphonic acid and its derivatives, methods for their preparation and their use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL403432A PL230602B1 (pl) | 2013-04-04 | 2013-04-04 | Kwas (E)-3-arylo-3-oksoprop-1-enylo-2-fosfonowy i jego pochodne, sposob ich wytwarzania oraz ich zastosowanie |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL403432A1 true PL403432A1 (pl) | 2014-10-13 |
| PL230602B1 PL230602B1 (pl) | 2018-11-30 |
Family
ID=49918584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL403432A PL230602B1 (pl) | 2013-04-04 | 2013-04-04 | Kwas (E)-3-arylo-3-oksoprop-1-enylo-2-fosfonowy i jego pochodne, sposob ich wytwarzania oraz ich zastosowanie |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP2787001A1 (pl) |
| PL (1) | PL230602B1 (pl) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3337337A (en) | 1965-12-16 | 1967-08-22 | John W Weeton | Method for producing fiber reinforced metallic composites |
| KR940003548U (ko) | 1992-08-14 | 1994-02-21 | 김형술 | 세탁물 건조기 |
| US6447724B1 (en) | 1998-08-11 | 2002-09-10 | Caliper Technologies Corp. | DNA sequencing using multiple fluorescent labels being distinguishable by their decay times |
| WO2002045707A2 (en) | 2000-12-06 | 2002-06-13 | Lyles Mark B | Polynucleotide intercalator interceptors and inhibitors |
| US7306809B2 (en) | 2002-09-13 | 2007-12-11 | Lipo Chemicals, Inc. | Optically activated particles for use in cosmetic compositions |
| US8969027B2 (en) | 2008-03-03 | 2015-03-03 | Kansas State University Research Foundation | Protease assay |
| CA2658520C (en) | 2008-03-19 | 2016-11-08 | F. Hoffmann-La Roche Ag | Nucleic acid amplification in the presence of modified randomers |
| CN102014967A (zh) | 2008-03-21 | 2011-04-13 | 阿德利夫股份有限公司 | 芘携带肽穿过血脑屏障的用途 |
| EP2342340A1 (en) | 2008-09-22 | 2011-07-13 | Rxi Pharmaceuticals Corporation | Rna interference in skin indications |
| US8268977B2 (en) | 2008-11-20 | 2012-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Strongly quenching oligomeric excimer/quencher pairs for detection schemes |
| WO2012055409A1 (en) | 2010-10-27 | 2012-05-03 | Quantibact A/S | Capture of methylated rna and/or dna sequences by specific probes |
| KR20130113476A (ko) | 2010-10-27 | 2013-10-15 | ?티백트 에이/에스 | 인터칼레이터 （ｉｎｔｅｒｃａｌａｔｏｒ） 분자를 포함하는 프로브에 의한 표적 ＤＮＡ 및 ＲＮＡ의 캡쳐 |
-
2013
- 2013-04-04 PL PL403432A patent/PL230602B1/pl unknown
-
2014
- 2014-01-12 EP EP20140150857 patent/EP2787001A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP2787001A1 (en) | 2014-10-08 |
| PL230602B1 (pl) | 2018-11-30 |
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