PL4036095T3 - Pochodne 4-fluoro-1H-pyrazolo[3,4-c]pirydyny jako selektywne inhibitory kinazy tyrozynowej Brutona (BTK) w leczeniu chłoniaka z komórek B i chorób autoimmunologicznych - Google Patents

Pochodne 4-fluoro-1H-pyrazolo[3,4-c]pirydyny jako selektywne inhibitory kinazy tyrozynowej Brutona (BTK) w leczeniu chłoniaka z komórek B i chorób autoimmunologicznych

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Publication number
PL4036095T3
PL4036095T3 PL20867917.5T PL20867917T PL4036095T3 PL 4036095 T3 PL4036095 T3 PL 4036095T3 PL 20867917 T PL20867917 T PL 20867917T PL 4036095 T3 PL4036095 T3 PL 4036095T3
Authority
PL
Poland
Prior art keywords
btk
pyrazolo
fluoro
inhibitors
treatment
Prior art date
Application number
PL20867917.5T
Other languages
English (en)
Inventor
Chunli SHEN
Xiawei WEI
Chengde Wu
Guoping Hu
Ning Jiang
Wei Zheng
Jian Li
Shuhui Chen
Original Assignee
Jumbo Drug Bank Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jumbo Drug Bank Co., Ltd. filed Critical Jumbo Drug Bank Co., Ltd.
Publication of PL4036095T3 publication Critical patent/PL4036095T3/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL20867917.5T 2019-09-26 2020-09-25 Pochodne 4-fluoro-1H-pyrazolo[3,4-c]pirydyny jako selektywne inhibitory kinazy tyrozynowej Brutona (BTK) w leczeniu chłoniaka z komórek B i chorób autoimmunologicznych PL4036095T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910919180 2019-09-26
CN202010330226 2020-04-24
PCT/CN2020/117690 WO2021057893A1 (zh) 2019-09-26 2020-09-25 作为选择性btk激酶抑制剂的吡唑并吡啶类化合物

Publications (1)

Publication Number Publication Date
PL4036095T3 true PL4036095T3 (pl) 2024-04-15

Family

ID=75164834

Family Applications (1)

Application Number Title Priority Date Filing Date
PL20867917.5T PL4036095T3 (pl) 2019-09-26 2020-09-25 Pochodne 4-fluoro-1H-pyrazolo[3,4-c]pirydyny jako selektywne inhibitory kinazy tyrozynowej Brutona (BTK) w leczeniu chłoniaka z komórek B i chorób autoimmunologicznych

Country Status (20)

Country Link
US (1) US11739090B2 (pl)
EP (1) EP4036095B1 (pl)
JP (1) JP7213604B2 (pl)
KR (1) KR102500569B1 (pl)
CN (1) CN114450289B (pl)
AU (1) AU2020355845B2 (pl)
BR (1) BR112022005729A2 (pl)
CA (1) CA3152587C (pl)
DK (1) DK4036095T3 (pl)
ES (1) ES2972813T3 (pl)
FI (1) FI4036095T3 (pl)
HR (1) HRP20240283T1 (pl)
HU (1) HUE065965T2 (pl)
LT (1) LT4036095T (pl)
MX (1) MX2022003707A (pl)
PL (1) PL4036095T3 (pl)
PT (1) PT4036095T (pl)
RS (1) RS65239B1 (pl)
SI (1) SI4036095T1 (pl)
WO (1) WO2021057893A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112023019299A2 (pt) * 2021-03-23 2023-12-05 Jumbo Drug Bank Co Ltd Forma cristalina a de um composto piridopirazol substituído com flúor, seu método de preparação e uso
CN119365194A (zh) * 2022-07-28 2025-01-24 成都嘉葆药银医药科技有限公司 吡唑并吡啶类化合物在制备治疗包括中枢神经系统疾病的btk相关疾病的药物中的用途

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* Cited by examiner, † Cited by third party
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SG10201508035TA (en) * 2007-03-28 2015-10-29 Pharmacyclics Inc Inhibitors of bruton's tyrosine kinase
US20150152115A1 (en) * 2007-12-27 2015-06-04 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
JP2013503124A (ja) 2009-08-27 2013-01-31 ポリマーズ シーアールシー リミテッド ナノ銀−酸化亜鉛組成物
EP2548877A1 (en) * 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
CN103848810A (zh) * 2012-11-30 2014-06-11 北京赛林泰医药技术有限公司 鲁顿酪氨酸激酶抑制剂
WO2014113942A1 (en) * 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Btk inhibitors
US20160113893A1 (en) * 2013-06-12 2016-04-28 Proximagen Limited New therapeutic uses of enzyme inhibitors
EP3082809B1 (en) 2013-12-20 2021-01-20 Merck Sharp & Dohme Corp. Btk inhibitors
EP3082811B1 (en) * 2013-12-20 2020-01-15 Merck Sharp & Dohme Corp. Btk inhibitors
CN105017256A (zh) * 2014-04-29 2015-11-04 浙江导明医药科技有限公司 多氟化合物作为布鲁顿酪氨酸激酶抑制剂
CN105085474B (zh) * 2014-05-07 2018-05-18 北京赛林泰医药技术有限公司 鲁顿酪氨酸激酶抑制剂
CN105399756B (zh) * 2014-09-05 2019-06-25 广东东阳光药业有限公司 Btk抑制剂及其用途
WO2016106627A1 (en) * 2014-12-31 2016-07-07 Merck Sharp & Dohme Corp. Btk inhibitors
WO2016106652A1 (en) * 2014-12-31 2016-07-07 Merck Sharp & Dohme Corp. Biarylether imidazopyrazine btk inhibitors
TW201718572A (zh) * 2015-06-24 2017-06-01 普林斯匹亞生物製藥公司 酪胺酸激酶抑制劑
CN105753863B (zh) * 2015-09-11 2018-07-31 东莞市真兴贝特医药技术有限公司 氧代二氢咪唑并吡啶类化合物及其应用
CA3009669C (en) * 2016-01-21 2023-08-08 Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. Bruton's tyrosine kinase inhibitors
PL3426637T3 (pl) 2016-03-11 2022-05-30 Angel Pharmaceutical Co., Ltd. Związki i sposoby modulowania kinazy tyrozynowej brutona
EP3492471B1 (en) * 2016-08-17 2020-12-02 Shenzhen TargetRx, Inc. Fused bicyclic compound for inhibiting activity of tyrosine kinase
JOP20190113A1 (ar) * 2016-11-18 2019-05-15 Biocad Joint Stock Co مثبطات بروتون تيروزين كيناز
CN106588937B (zh) * 2017-01-16 2018-09-21 东莞市真兴贝特医药技术有限公司 咪唑并吡嗪类化合物及其制备方法和应用
CN110272416A (zh) * 2018-03-14 2019-09-24 武汉宇科源医药生物科技有限公司 吡唑并[3,4-c]吡啶-7-胺衍生物及其制备方法和应用

Also Published As

Publication number Publication date
AU2020355845B2 (en) 2023-04-06
CA3152587A1 (en) 2021-04-01
AU2020355845A1 (en) 2022-05-19
KR20220061262A (ko) 2022-05-12
MX2022003707A (es) 2022-06-23
KR102500569B1 (ko) 2023-02-16
DK4036095T3 (da) 2024-03-04
US20220324864A1 (en) 2022-10-13
EP4036095B1 (en) 2024-01-31
RS65239B1 (sr) 2024-03-29
EP4036095A4 (en) 2022-12-07
PT4036095T (pt) 2024-02-19
SI4036095T1 (sl) 2024-04-30
LT4036095T (lt) 2024-03-25
US11739090B2 (en) 2023-08-29
BR112022005729A2 (pt) 2022-06-21
JP7213604B2 (ja) 2023-01-27
ES2972813T3 (es) 2024-06-17
CA3152587C (en) 2023-05-23
HUE065965T2 (hu) 2024-06-28
CN114450289B (zh) 2024-01-02
CN114450289A (zh) 2022-05-06
EP4036095A1 (en) 2022-08-03
WO2021057893A1 (zh) 2021-04-01
JP2022542196A (ja) 2022-09-29
HRP20240283T1 (hr) 2024-05-10
FI4036095T3 (fi) 2024-02-14

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