PL405648A1 - Sposób diagnozowania raka watrobowokomórkowego, zastosowanie markera mikroRNA do diagnozowania zmiany chorobowej w obrębie wątroby, oceny stopnia zaawansowania choroby oraz oceny podatności pacjenta i/lub choroby na zaproponowane leczenie oraz zawierający takie markery zestaw diagnostyczny - Google Patents

Sposób diagnozowania raka watrobowokomórkowego, zastosowanie markera mikroRNA do diagnozowania zmiany chorobowej w obrębie wątroby, oceny stopnia zaawansowania choroby oraz oceny podatności pacjenta i/lub choroby na zaproponowane leczenie oraz zawierający takie markery zestaw diagnostyczny

Info

Publication number
PL405648A1
PL405648A1 PL40564813A PL40564813A PL405648A1 PL 405648 A1 PL405648 A1 PL 405648A1 PL 40564813 A PL40564813 A PL 40564813A PL 40564813 A PL40564813 A PL 40564813A PL 405648 A1 PL405648 A1 PL 405648A1
Authority
PL
Poland
Prior art keywords
disease
diagnosing
patient
mir
vulnerability
Prior art date
Application number
PL40564813A
Other languages
English (en)
Inventor
Krystian Jażdżewski
Kinga Dymecka
Anna Wójcicka
Anna Kubiak
Wojciech Gierlikowski
Monika Maciąg
Monika Kolanowska
Agnieszka Czajka
Marta Kotlarek
Michał Śierniak
Original Assignee
Warszawski Uniwersytet Medyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warszawski Uniwersytet Medyczny filed Critical Warszawski Uniwersytet Medyczny
Priority to PL40564813A priority Critical patent/PL405648A1/pl
Priority to PCT/IB2014/065342 priority patent/WO2015056195A1/en
Publication of PL405648A1 publication Critical patent/PL405648A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Przedmiotem wynalazku jest sposób diagnozowania raka wątroby i różnicowania raka wątrobowokomórkowego od przerzutów raka z jelita grubego do wątroby u pacjenta. Sposób obejmuje: - dostarczanie pochodzącej od pacjenta próbki biologicznej, - określenie ilości jednego lub więcej miRNA wybranego z grupy obejmującej miR-146a-5p, miR-125b-5p, miR-141-3p, miR-1269a w próbce biologicznej, - porównanie ekspresji miRNA z poziomem ekspresji miRNA otrzymywanym w grupie kontrolnej, w którym to sposobie u pacjenta diagnozuje się wystąpienie nowotworu i różnicuje jego podłoże, jeśli poziom ekspresji miRNA w próbce biologicznej jest zmieniony względem poziomu ekspresji obserwowanej w próbkach płynów biologicznych pochodzących od zdrowych pacjentów. Wynalazek dotyczy również zastosowania markera mikroRNA oraz zestawu zawierającego markery.
PL40564813A 2013-10-15 2013-10-15 Sposób diagnozowania raka watrobowokomórkowego, zastosowanie markera mikroRNA do diagnozowania zmiany chorobowej w obrębie wątroby, oceny stopnia zaawansowania choroby oraz oceny podatności pacjenta i/lub choroby na zaproponowane leczenie oraz zawierający takie markery zestaw diagnostyczny PL405648A1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL40564813A PL405648A1 (pl) 2013-10-15 2013-10-15 Sposób diagnozowania raka watrobowokomórkowego, zastosowanie markera mikroRNA do diagnozowania zmiany chorobowej w obrębie wątroby, oceny stopnia zaawansowania choroby oraz oceny podatności pacjenta i/lub choroby na zaproponowane leczenie oraz zawierający takie markery zestaw diagnostyczny
PCT/IB2014/065342 WO2015056195A1 (en) 2013-10-15 2014-10-15 Use of microrna markers for diagnosis of liver lesions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL40564813A PL405648A1 (pl) 2013-10-15 2013-10-15 Sposób diagnozowania raka watrobowokomórkowego, zastosowanie markera mikroRNA do diagnozowania zmiany chorobowej w obrębie wątroby, oceny stopnia zaawansowania choroby oraz oceny podatności pacjenta i/lub choroby na zaproponowane leczenie oraz zawierający takie markery zestaw diagnostyczny

Publications (1)

Publication Number Publication Date
PL405648A1 true PL405648A1 (pl) 2015-04-27

Family

ID=52827737

Family Applications (1)

Application Number Title Priority Date Filing Date
PL40564813A PL405648A1 (pl) 2013-10-15 2013-10-15 Sposób diagnozowania raka watrobowokomórkowego, zastosowanie markera mikroRNA do diagnozowania zmiany chorobowej w obrębie wątroby, oceny stopnia zaawansowania choroby oraz oceny podatności pacjenta i/lub choroby na zaproponowane leczenie oraz zawierający takie markery zestaw diagnostyczny

Country Status (2)

Country Link
PL (1) PL405648A1 (pl)
WO (1) WO2015056195A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019081610A1 (en) * 2017-10-24 2019-05-02 Universite Paris Descartes DIAGNOSIS AND / OR PROGNOSIS OF HER2-DEPENDENT CANCER USING AT LEAST ONE MIRIK USED AS A BIOMARKER
WO2019204576A1 (en) * 2018-04-19 2019-10-24 The University Of Chicago Methods and kits for diagnosis and triage of patients with colorectal liver metastases
CA3110668C (en) * 2018-09-20 2022-01-11 Tamirna Gmbh Micro-rna signatures for the prediction of liver dysfunction
CN109182530A (zh) * 2018-11-05 2019-01-11 中国科学技术大学 肝细胞癌rna生物标志物
KR102275465B1 (ko) * 2019-01-18 2021-07-09 사회복지법인 삼성생명공익재단 전이성 대장암 치료물질 스크리닝 방법
CN110229899B (zh) * 2019-06-19 2024-04-09 广州医科大学附属第三医院 用于结直肠癌早期诊断或预后预测的血浆标记物组合
CN113755597B (zh) * 2021-10-14 2022-12-06 杭州师范大学 外周血外泌体miRNA联合标志物在制备检测HBV阳性肝硬化早期肝癌试剂盒中的应用
CN114990216B (zh) * 2022-05-31 2023-04-21 山东大学齐鲁医院 微小rna分子作为生物标记物在胆管癌预后中的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052184A2 (en) 2002-12-12 2004-06-24 Oncotech, Inc. Genes related to sensitivity and resistance to chemotherapeutic drug treatment
US20090186353A1 (en) * 2004-10-04 2009-07-23 Rosetta Genomics Ltd. Cancer-related nucleic acids
WO2006060742A2 (en) 2004-12-02 2006-06-08 Oncotech, Inc. Reagents and methods for predicting drug resistance
EP2502630B1 (en) 2006-01-05 2015-03-11 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer
US20080076674A1 (en) 2006-07-06 2008-03-27 Thomas Litman Novel oligonucleotide compositions and probe sequences useful for detection and analysis of non coding RNAs associated with cancer
WO2008046911A2 (en) 2006-10-20 2008-04-24 Exiqon A/S Novel human micrornas associated with cancer
US9096906B2 (en) * 2007-03-27 2015-08-04 Rosetta Genomics Ltd. Gene expression signature for classification of tissue of origin of tumor samples
US20100273172A1 (en) * 2007-03-27 2010-10-28 Rosetta Genomics Ltd. Micrornas expression signature for determination of tumors origin
US20090099034A1 (en) 2007-06-07 2009-04-16 Wisconsin Alumni Research Foundation Reagents and Methods for miRNA Expression Analysis and Identification of Cancer Biomarkers
EP2613149B1 (en) 2007-07-25 2014-09-17 University Of Louisville Research Foundation, Inc. Exosome-associated microRNA as a diagnostic marker
WO2009080437A1 (en) 2007-12-21 2009-07-02 Exiqon A/S Micro-rna based drug resistance analysis method
WO2009143379A2 (en) 2008-05-21 2009-11-26 Fred Hutchinson Cancer Research Center Use of extracellular rna to measure disease
RU2011102818A (ru) 2008-06-27 2012-08-10 Новартис Форшунгсстифтунг Цвайгнидерлассунг Фридрих Мишер Инститьют Фор Байомедикал Рисерч (Ch) Прогнозирование ответа на противовирусную терапию
EP3211098B1 (en) * 2008-11-10 2023-03-15 Battelle Memorial Institute Method utilizing microrna to determine physiological conditions
WO2010145035A1 (en) 2009-06-19 2010-12-23 Siu K W Michael Renal cell carcinoma biomarkers
EP2341145A1 (en) 2009-12-30 2011-07-06 febit holding GmbH miRNA fingerprint in the diagnosis of diseases
WO2011135459A2 (en) * 2010-04-29 2011-11-03 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy
WO2012128902A1 (en) * 2011-03-18 2012-09-27 Baylor Research Institute Changes in the expression of mir-200c/141 cluster of micrornas as biomarkers for epithelial-to-mesenchymal transition in human colorectal cancer metastasis

Also Published As

Publication number Publication date
WO2015056195A1 (en) 2015-04-23

Similar Documents

Publication Publication Date Title
PL406033A1 (pl) Sposób diagnozowania raka brodawkowatego tarczycy, zastosowanie markera mikroRNA do diagnozowania nowotworu tarczycy, oceny stopnia zaawansowania choroby oraz oceny podatności pacjenta i/lub choroby na zaproponowane leczenie oraz zawierający takie markery zestaw diagnostyczny
MX2023001945A (es) Composiciones y metodos para el cribado de tumores solidos.
PH12018550037A1 (en) Quencher containing water-soluble polymer-conjugated nanomaterial and use thereof
BR112014030750A2 (pt) Método para diagnóstico, prognóstico e tratamento da metástase do câncer pulmonar
BR112015011359A2 (pt) método para indicar uma presença ou não presença de câncer de próstata agressivo
BR112012017084A2 (pt) métodos para previsão de resposta de câncer de mama triplo-negativo à terapia
WO2016138105A3 (en) Assays to determine dna methylation and dna methylation markers of cancer
BR112014018331A8 (pt) Biomarcadores e terapias combinadas usando vírus oncolítico e imunomodulação
BR112015008255A2 (pt) método para o diagnóstico, prognóstico e tratamento de metástase de câncer de próstata
BR112015026159A2 (pt) dispositivo de transferência de coleta de sangue
WO2011015602A3 (en) Lung cancer biomarkers
EP2971132A4 (en) FABRIC AND BLOOD-BASED MIRNA BIOMARKERS FOR THE DIAGNOSIS, FORECASTING AND PREDICTING THE METASTAS POTENTIAL IN COLOR LECTAL CANCER
EP4219760A3 (en) Methods, compositions, and devices utilizing microrna to determine physiological conditions
MX360236B (es) Uso de marcadores en el diagnostico y tratamiento de cancer de prostata.
BR112014003877A2 (pt) biomarcadores de micro-rna e métodos de uso dos mesmos
BR112016013976A2 (pt) método para determinar se um indivíduo é afetado por um câncer, método para discriminar entre câncer colorretal e pancreático dentre indivíduos que resultam ser positivos para o método, método para determinar o estágio de um câncer colorretal em um indivíduo afetado e uso de um kit de rt-pcr quantitativo para performar o método
EP3444362A3 (en) Circulating mirnas as early detection marker and prognostic marker
EP4270007A3 (en) Use of dna-transcription factor complexes for cancer detection
WO2014020444A3 (en) Methods and compositions for diagnosis and prognosis in breast cancer
MX2016001948A (es) Método para diagnosticar un tumor pulmonar maligno.
BR112015027249A2 (pt) método de diagnóstico de câncer
BR102015015096A2 (pt) método de detecção in vitro de câncer de tireoide em um paciente, método in vitro de diferenciação entre câncer de tireoide e tecido de tireoide normal ou de lesões benignas de tireoide, uso de um conjunto de genes, método de obtenção de dados para direcionamento do tratamento do cancer de tireoide, kit laboratorial e dispositivo para classificar uma amostra biológica de glândula tireoide como maligna ou benigna
ES2523903B1 (es) Método de obtención de datos útiles para el diagnóstico diferencial de la fibrosis hepática
EP3832309A4 (en) COMPOSITION FOR DIAGNOSIS OF BONE METASTASIS OF CANCER AND KIT WITH THIS COMPOSITION
WO2019103421A3 (ko) 유전자의 cpg 메틸화 변화를 이용한 간암의 예후 또는 위험도를 평가하는 방법