PL407399A1 - 2-[2-(4-phenylpiperazin-1-yl)-2-oxoethyl]-3-(4-fluorobenzoyl)-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide with anti-inflammatory and analgesic activity and method for producing it - Google Patents
2-[2-(4-phenylpiperazin-1-yl)-2-oxoethyl]-3-(4-fluorobenzoyl)-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide with anti-inflammatory and analgesic activity and method for producing itInfo
- Publication number
- PL407399A1 PL407399A1 PL407399A PL40739914A PL407399A1 PL 407399 A1 PL407399 A1 PL 407399A1 PL 407399 A PL407399 A PL 407399A PL 40739914 A PL40739914 A PL 40739914A PL 407399 A1 PL407399 A1 PL 407399A1
- Authority
- PL
- Poland
- Prior art keywords
- benzothiazine
- hydroxy
- phenylpiperazin
- oxoethyl
- inflammatory
- Prior art date
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- LJYWVPFHSSKPPG-UHFFFAOYSA-N C1(=CC=CC=C1)N1CCN(CC1)C(CN1S(C2=C(C(=C1C(C1=CC=C(C=C1)F)=O)O)C=CC=C2)(=O)=O)=O Chemical compound C1(=CC=CC=C1)N1CCN(CC1)C(CN1S(C2=C(C(=C1C(C1=CC=C(C=C1)F)=O)O)C=CC=C2)(=O)=O)=O LJYWVPFHSSKPPG-UHFFFAOYSA-N 0.000 title 1
- 230000001760 anti-analgesic effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- VHIWWIFXKVGUMK-UHFFFAOYSA-N 2-chloro-1-(4-phenylpiperazin-1-yl)ethanone Chemical compound C1CN(C(=O)CCl)CCN1C1=CC=CC=C1 VHIWWIFXKVGUMK-UHFFFAOYSA-N 0.000 abstract 1
- ZVUREGCACRYUQF-UHFFFAOYSA-N CC(C=C1)=CC=C1C(C(N(CC(N(CC1)CCN1C1=CC=CC=C1)=O)SC1=C2C=CC=C1)=C2O)=O Chemical compound CC(C=C1)=CC=C1C(C(N(CC(N(CC1)CCN1C1=CC=CC=C1)=O)SC1=C2C=CC=C1)=C2O)=O ZVUREGCACRYUQF-UHFFFAOYSA-N 0.000 abstract 1
- FTMIWKQGXLRTCM-UHFFFAOYSA-N CC(C=C1)=CC=C1C(C(NS(C1=C2C=CC=C1)(=O)=O)=C2O)=O Chemical compound CC(C=C1)=CC=C1C(C(NS(C1=C2C=CC=C1)(=O)=O)=C2O)=O FTMIWKQGXLRTCM-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000007126 N-alkylation reaction Methods 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem wynalazku jest nowa pochodna o nazwie chemicznej 1,1-ditlenek 2-[2-(4-fenylopiperazyn-1-ylo)-2-oksoetylo]-4-hydroksy-3-(4-metylobenzoilo)-2H-1,2-benzotiazyny o aktywności przeciwbólowej i przeciwzapalnej oraz sposób otrzymywania nowej pochodnej przez N-alkilację 1,1-diokso-4-hydroksy-3-(4-metylobenzoilo)-2H-1,2-benzotiazyny za pomocą 1-(2-chloroacetylo)-4-fenylopiperazyny w obecności etanolanu sodowego w środowisku wrzącego, bezwodnego etanolu.The present invention relates to a new derivative with the chemical name 2- [2- (4-phenylpiperazin-1-yl) -2-oxoethyl] -4-hydroxy-3- (4-methylbenzoyl) -2H-1,2 -benzothiazine with analgesic and anti-inflammatory activity and the method of obtaining a new derivative by N-alkylation of 1,1-dioxo-4-hydroxy-3- (4-methylbenzoyl) -2H-1,2-benzothiazine with 1- (2-chloroacetyl) -4-phenylpiperazine in the presence of sodium ethoxide in boiling anhydrous ethanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL407399A PL407399A1 (en) | 2014-03-04 | 2014-03-04 | 2-[2-(4-phenylpiperazin-1-yl)-2-oxoethyl]-3-(4-fluorobenzoyl)-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide with anti-inflammatory and analgesic activity and method for producing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL407399A PL407399A1 (en) | 2014-03-04 | 2014-03-04 | 2-[2-(4-phenylpiperazin-1-yl)-2-oxoethyl]-3-(4-fluorobenzoyl)-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide with anti-inflammatory and analgesic activity and method for producing it |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL407399A1 true PL407399A1 (en) | 2015-09-14 |
Family
ID=54064919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL407399A PL407399A1 (en) | 2014-03-04 | 2014-03-04 | 2-[2-(4-phenylpiperazin-1-yl)-2-oxoethyl]-3-(4-fluorobenzoyl)-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide with anti-inflammatory and analgesic activity and method for producing it |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL407399A1 (en) |
-
2014
- 2014-03-04 PL PL407399A patent/PL407399A1/en unknown
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