PL407937A1 - Genistein-caffeine cocrystal, and a method for obtaining genistein-caffeine cocrystal - Google Patents
Genistein-caffeine cocrystal, and a method for obtaining genistein-caffeine cocrystalInfo
- Publication number
- PL407937A1 PL407937A1 PL407937A PL40793714A PL407937A1 PL 407937 A1 PL407937 A1 PL 407937A1 PL 407937 A PL407937 A PL 407937A PL 40793714 A PL40793714 A PL 40793714A PL 407937 A1 PL407937 A1 PL 407937A1
- Authority
- PL
- Poland
- Prior art keywords
- genistein
- caffeine
- obtaining
- amount
- crystal
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem wynalazku jest kokryształ genisteina-kofeina o wzorze 3. Wynalazek dotyczy również sposobu otrzymania kokryształu genisteina-kofeina o wzorze 3, który polega na tym, że genisteinę w ilości 25.0 mg do 50.0 mg oraz kofeinę w ilości od 18.1 mg do 36.2 mg w stosunku stechiometrycznym 1:1 rozpuszcza się w od 5 do 10 ml metanolu, etanolu, izopropanolu, 2-metoksy etanolu lub 1-metoksy-2-propanolu, po czym całość miesza się, przesącza, a następnie pozostawia do powolnego odparowania w temperaturze pokojowej. Natomiast po 4 do 24 dniach zbiera się kryształy. W odmianie sposobu otrzymywania kokryształu genisteina-kofeina o wzorze 3, genisteinę i kofeinę w ilości stechiometrycznej 1:1 zawiesza się w octanie etylu lub acetonitrylu w ilości 2 ml na każde 50 mg genisteiny, całość miesza przez 24 h w temperaturze pokojowej, po czym otrzymany materiał mikrokrystaliczny przesącza się i suszy w temperaturze pokojowej przez okres 12 do 24 godzin. Następnie poddaje analizie na dyfraktometrze proszkowym lub spektrometrze FT-Raman.The invention relates to a genistein-caffeine co-crystal of formula 3. The invention also relates to a method for obtaining a genistein-caffeine co-crystal of formula 3, which consists in the fact that genistein in the amount of 25.0 mg to 50.0 mg and caffeine in the amount from 18.1 mg to 36.2 mg in the ratio stoichiometric 1: 1 is dissolved in 5 to 10 ml of methanol, ethanol, isopropanol, 2-methoxy ethanol or 1-methoxy-2-propanol, after which it is stirred, filtered and then allowed to slowly evaporate at room temperature. However, after 4 to 24 days, crystals are collected. In a variation of the method of obtaining the co-crystal genistein-caffeine of formula 3, genistein and caffeine in a stoichiometric amount of 1: 1 are suspended in ethyl acetate or acetonitrile in an amount of 2 ml for every 50 mg of genistein, the whole is stirred for 24 h at room temperature, then the obtained material microcrystalline is filtered and dried at room temperature for 12 to 24 hours. Then analyzed on a powder diffractometer or FT-Raman spectrometer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL407937A PL223376B1 (en) | 2014-04-17 | 2014-04-17 | Genistein-caffeine cocrystal, and a method for obtaining genistein-caffeine cocrystal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL407937A PL223376B1 (en) | 2014-04-17 | 2014-04-17 | Genistein-caffeine cocrystal, and a method for obtaining genistein-caffeine cocrystal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL407937A1 true PL407937A1 (en) | 2014-12-22 |
| PL223376B1 PL223376B1 (en) | 2016-10-31 |
Family
ID=52106938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL407937A PL223376B1 (en) | 2014-04-17 | 2014-04-17 | Genistein-caffeine cocrystal, and a method for obtaining genistein-caffeine cocrystal |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL223376B1 (en) |
-
2014
- 2014-04-17 PL PL407937A patent/PL223376B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL223376B1 (en) | 2016-10-31 |
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