PL408417A1 - Method for producing bioresorbable polymer materials with controlled degree of reticulation, for medical applications - Google Patents
Method for producing bioresorbable polymer materials with controlled degree of reticulation, for medical applicationsInfo
- Publication number
- PL408417A1 PL408417A1 PL408417A PL40841714A PL408417A1 PL 408417 A1 PL408417 A1 PL 408417A1 PL 408417 A PL408417 A PL 408417A PL 40841714 A PL40841714 A PL 40841714A PL 408417 A1 PL408417 A1 PL 408417A1
- Authority
- PL
- Poland
- Prior art keywords
- carried out
- polymer materials
- catalyst
- oxacyclic
- dioxa
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000002861 polymer material Substances 0.000 title abstract 2
- -1 aliphatic cyclic carbonates Chemical class 0.000 abstract 3
- 239000003054 catalyst Substances 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 150000005846 sugar alcohols Polymers 0.000 abstract 3
- VLGDSNWNOFYURG-UHFFFAOYSA-N 4-propyloxetan-2-one Chemical compound CCCC1CC(=O)O1 VLGDSNWNOFYURG-UHFFFAOYSA-N 0.000 abstract 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- 238000004132 cross linking Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000178 monomer Substances 0.000 abstract 2
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 abstract 1
- LCKIEQZJEYYRIY-UHFFFAOYSA-N Titanium ion Chemical compound [Ti+4] LCKIEQZJEYYRIY-UHFFFAOYSA-N 0.000 abstract 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 abstract 1
- 125000005595 acetylacetonate group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 238000007334 copolymerization reaction Methods 0.000 abstract 1
- 150000005676 cyclic carbonates Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 239000003999 initiator Substances 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000006384 oligomerization reaction Methods 0.000 abstract 1
- 230000000399 orthopedic effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 238000007151 ring opening polymerisation reaction Methods 0.000 abstract 1
- 229910052706 scandium Inorganic materials 0.000 abstract 1
- SIXSYDAISGFNSX-UHFFFAOYSA-N scandium atom Chemical compound [Sc] SIXSYDAISGFNSX-UHFFFAOYSA-N 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000005809 transesterification reaction Methods 0.000 abstract 1
- 150000008648 triflates Chemical class 0.000 abstract 1
- 229910052726 zirconium Inorganic materials 0.000 abstract 1
Landscapes
- Polyesters Or Polycarbonates (AREA)
- Materials For Medical Uses (AREA)
Abstract
Sposób polega na tym, że syntezę bioresorbowalnych materiałów polimerowych o zwiększonej wytrzymałości mechanicznej do np. produkcji implantowalnych śrub kostnych czy płytek ortopedycznych, prowadzi się poprzez kopolimeryzację monomerów oksacyklicznych (laktyd, glikolid, ?-kaprolakton, alifatyczne węglany cykliczne) z cyklicznym alifatycznym węglanem 5-metylo-2-okso-1,3-dioksa-5-karboksylanem (2-tert-butoksy-2-oksoetylu) i/lub polialkoholami niskocząsteczkowymi lub otrzymanymi w wyniku oligomeryzacji cyklicznych węglanów i lub ?-kaprolaktonu inicjowanej polialkoholami niskocząsteczkowymi. Proces kopolimeryzacji z otwarciem pierścienia monomerów oksacyklicznych jest katalizowany w obecności inicjatora i/lub katalizatora wybranego z grupy obejmującej acetylacetoniany, alkilki, halogenki, alkoholany, triflaty; cyrkonu (IV), żelaza (III), cyny (II), tytanu (IV), skandu (III). Reakcja jest prowadzona w masie lub w roztworze nawet do konwersji powyżej 99%. Jednocześnie stosowany katalizator promuje transestryfikację międzycząsteczkową pomiędzy 5-metylo-2-okso-1,3-dioksa-5-karboksylanem (2-tert-butoksy-2-oksoetylu) i/lub polialkoholem a rosnącymi łańcuchami polimerowymi, prowadzącą do (częściowego) usieciowania produktu końcowego. Kontrola stopnia usieciowania materiału końcowego przebiega poprzez odpowiednią kompozycję substratów, jak i dobór katalizatora i parametrów reakcji.The method is based on the fact that the synthesis of bioresorbable polymer materials with increased mechanical strength for e.g. the production of implantable bone screws or orthopedic plates, is carried out by copolymerization of oxacyclic monomers (lactide, glycolide, β-caprolactone, aliphatic cyclic carbonates) with cyclic aliphatic carbonate 5- methyl-2-oxo-1,3-dioxa-5-carboxylate (2-tert-butoxy-2-oxoethyl) and / or low molecular weight polyalcohols or obtained by oligomerization of cyclic carbonates and or β-caprolactone initiated with low molecular weight polyalcohols. The ring-opening copolymerization process of oxacyclic monomers is catalyzed in the presence of an initiator and / or a catalyst selected from the group consisting of acetylacetonates, alkyls, halides, alcoholates, triflates; zirconium (IV), iron (III), tin (II), titanium (IV), scandium (III). The reaction is carried out in bulk or in solution up to a conversion of over 99%. At the same time, the catalyst used promotes inter-molecular transesterification between 5-methyl-2-oxo-1,3-dioxa-5-carboxylate (2-tert-butoxy-2-oxoethyl) and / or polyalcohol and growing polymer chains, leading to (partial) crosslinking final product. Control of the degree of crosslinking of the final material is carried out through the appropriate composition of the substrates, as well as the choice of catalyst and reaction parameters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL408417A PL235484B1 (en) | 2014-06-02 | 2014-06-02 | Method for producing bioresorbable polymer materials with controlled degree of reticulation, for medical applications |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL408417A PL235484B1 (en) | 2014-06-02 | 2014-06-02 | Method for producing bioresorbable polymer materials with controlled degree of reticulation, for medical applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL408417A1 true PL408417A1 (en) | 2015-12-07 |
| PL235484B1 PL235484B1 (en) | 2020-08-24 |
Family
ID=54776622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL408417A PL235484B1 (en) | 2014-06-02 | 2014-06-02 | Method for producing bioresorbable polymer materials with controlled degree of reticulation, for medical applications |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL235484B1 (en) |
-
2014
- 2014-06-02 PL PL408417A patent/PL235484B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL235484B1 (en) | 2020-08-24 |
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