PL408526A1 - Derivatives of 4-benzoyl-1-(2,3-dichloro-benzoyl)-thiosemicarbazide - Google Patents
Derivatives of 4-benzoyl-1-(2,3-dichloro-benzoyl)-thiosemicarbazideInfo
- Publication number
- PL408526A1 PL408526A1 PL408526A PL40852614A PL408526A1 PL 408526 A1 PL408526 A1 PL 408526A1 PL 408526 A PL408526 A PL 408526A PL 40852614 A PL40852614 A PL 40852614A PL 408526 A1 PL408526 A1 PL 408526A1
- Authority
- PL
- Poland
- Prior art keywords
- benzoyl
- chloro
- methyl
- thiosemicarbazide
- derivatives
- Prior art date
Links
- UUTDGIBOCRXYOD-UHFFFAOYSA-N N-[[(2,3-dichlorobenzoyl)amino]carbamothioyl]benzamide Chemical class C(C1=CC=CC=C1)(=O)NC(NNC(C1=C(C(=CC=C1)Cl)Cl)=O)=S UUTDGIBOCRXYOD-UHFFFAOYSA-N 0.000 title 1
- -1 1-(2,3-dichlorobenzoyl)-thiosemicarbazide derivatives Chemical class 0.000 abstract 1
- 241000192125 Firmicutes Species 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem wynalazku są nowe pochodne 1-(2,3-dichlorobenzoilo)-tiosemikarbazydu o wzorze ogólnym 1, w którym R oznacza podstawnik: o-metylowy, m-metylowy, p-nitrowy, o-chlorowy, m-chlorowy, p-chlorowy, sposób ich wytwarzania oraz ich zastosowanie medyczne. Związki według wynalazku wykazują silną aktywność inhibicyjną wobec bakterii Gram-dodatnich i mogą stanowić związki wyjściowe w otrzymywaniu leków o dobrej aktywności profilaktycznej lub terapeutycznej, skutecznych podczas infekcji wywoływanych zarówno przez drobnoustroje oportunistyczne jak i ścisłe patogeny oporne na większość znanych obecnie substancji przeciwdrobnoustrojowych.The subject of the invention are new 1-(2,3-dichlorobenzoyl)-thiosemicarbazide derivatives of the general formula 1, in which R is the substituent: o-methyl, m-methyl, p-nitro, o-chloro, m-chloro, p-chloro , the method of their production and their medical use. The compounds of the invention have a strong inhibitory activity against Gram-positive bacteria and can be used as starting compounds in the preparation of drugs with good prophylactic or therapeutic activity, effective against infections caused by both opportunistic microorganisms and strict pathogens resistant to most of the currently known antimicrobial substances.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL408526A PL226146B1 (en) | 2014-06-11 | 2014-06-11 | Derivatives of 4-benzoyl-1-(2,3-dichloro-benzoyl)-thiosemicarbazide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL408526A PL226146B1 (en) | 2014-06-11 | 2014-06-11 | Derivatives of 4-benzoyl-1-(2,3-dichloro-benzoyl)-thiosemicarbazide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL408526A1 true PL408526A1 (en) | 2015-12-21 |
| PL226146B1 PL226146B1 (en) | 2017-06-30 |
Family
ID=54887914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL408526A PL226146B1 (en) | 2014-06-11 | 2014-06-11 | Derivatives of 4-benzoyl-1-(2,3-dichloro-benzoyl)-thiosemicarbazide |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL226146B1 (en) |
-
2014
- 2014-06-11 PL PL408526A patent/PL226146B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL226146B1 (en) | 2017-06-30 |
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