PL408981A1 - Pochodne 2,3'-anhydro-2'-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie - Google Patents

Pochodne 2,3'-anhydro-2'-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie

Info

Publication number
PL408981A1
PL408981A1 PL408981A PL40898114A PL408981A1 PL 408981 A1 PL408981 A1 PL 408981A1 PL 408981 A PL408981 A PL 408981A PL 40898114 A PL40898114 A PL 40898114A PL 408981 A1 PL408981 A1 PL 408981A1
Authority
PL
Poland
Prior art keywords
anhydro
deoxy
derivatives
fluorouridine
producing
Prior art date
Application number
PL408981A
Other languages
English (en)
Other versions
PL225283B1 (pl
Inventor
Lech Celewicz
Karol Kacprzak
Marta Lewandowska
Piotr Ruszkowski
Original Assignee
Uniwersytet Im. Adama Mickiewicza W Poznaniu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Im. Adama Mickiewicza W Poznaniu filed Critical Uniwersytet Im. Adama Mickiewicza W Poznaniu
Priority to PL408981A priority Critical patent/PL225283B1/pl
Priority to EP14772458.7A priority patent/EP3172216B1/en
Priority to CA2887025A priority patent/CA2887025C/en
Priority to US14/420,487 priority patent/US9260468B1/en
Priority to PL14772458T priority patent/PL3172216T3/pl
Priority to PCT/PL2014/050050 priority patent/WO2015050468A1/en
Priority to CN201480002600.XA priority patent/CN105722845A/zh
Priority to JP2015544030A priority patent/JP5894351B2/ja
Publication of PL408981A1 publication Critical patent/PL408981A1/pl
Publication of PL225283B1 publication Critical patent/PL225283B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Przedmiotem wynalazku są nowe pochodne 2,3'-anhydro-2'-deoksy-5-fluorourydyny, o ogólnym wzorze 1 gdzie R oznacza grupę trifluorometylową, 2,2,2-trifluoroetylową difluorometylową, perfluoroetylową, 1-fluoroetylową, 2-fluoroetylową, 1,1-difluoroetylową, 1,2-difluoroetylową, 2,2-difluoroetylową, 1,1,2-trifluoroetylową, 1,2,2-trifluoroetylową, 1,1,2,2-tetrafluoroetylową, 1,2,2,2-tetrafluoroetylową. W drugim aspekcie przedmiotem wynalazku jest sposób wytwarzania pochodnych 2,3'-anhydro-2'-deoksy-5-fluorourydyny o ogólnym wzorze 1. W trzecim aspekcie przedmiotem wynalazku jest zastosowanie pochodnych 2,3'-anhydro-2'-deoksy-5-fluorourydyny o ogólnym wzorze 1, w terapii przeciwnowotworowej raka piersi, raka szyjki macicy, raka płuca oraz raka nosogardzieli.
PL408981A 2014-07-24 2014-07-24 Pochodne 2,3’-anhydro-2’-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie PL225283B1 (pl)

Priority Applications (8)

Application Number Priority Date Filing Date Title
PL408981A PL225283B1 (pl) 2014-07-24 2014-07-24 Pochodne 2,3’-anhydro-2’-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie
EP14772458.7A EP3172216B1 (en) 2014-07-24 2014-08-22 2,3'-anhydro-2'-déoxy-5-fluorouridine derivatives with cytotoxic activity, a manufacturing process and use thereof
CA2887025A CA2887025C (en) 2014-07-24 2014-08-22 2,3'-anhydro-2'-deoxy-5-fluorouridine derivatives with cytotoxic activity, a manufacturing process and application
US14/420,487 US9260468B1 (en) 2014-07-24 2014-08-22 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives with cytotoxic activity, a manufacturing process and application
PL14772458T PL3172216T3 (pl) 2014-07-24 2014-08-22 Pochodne 2,3’-anhydro-2’-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie
PCT/PL2014/050050 WO2015050468A1 (en) 2014-07-24 2014-08-22 2,3'-Anhydro-2'-deoxy-5-fluorouridine derivatives with cytotoxic activity, a manufacturing process and application
CN201480002600.XA CN105722845A (zh) 2014-07-24 2014-08-22 2,3′-脱水-2′-脱氧-5-氟尿苷衍生物与细胞毒活性、制备方法及应用
JP2015544030A JP5894351B2 (ja) 2014-07-24 2014-08-22 細胞毒性活性を有する２，３’−アンヒドロ−２’−デオキシ−５−フルオロウリジン誘導体、その製造プロセスおよび使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL408981A PL225283B1 (pl) 2014-07-24 2014-07-24 Pochodne 2,3’-anhydro-2’-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie

Publications (2)

Publication Number Publication Date
PL408981A1 true PL408981A1 (pl) 2015-06-22
PL225283B1 PL225283B1 (pl) 2017-03-31

Family

ID=52778964

Family Applications (2)

Application Number Title Priority Date Filing Date
PL408981A PL225283B1 (pl) 2014-07-24 2014-07-24 Pochodne 2,3’-anhydro-2’-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie
PL14772458T PL3172216T3 (pl) 2014-07-24 2014-08-22 Pochodne 2,3’-anhydro-2’-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL14772458T PL3172216T3 (pl) 2014-07-24 2014-08-22 Pochodne 2,3’-anhydro-2’-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie

Country Status (7)

Country Link
US (1) US9260468B1 (pl)
EP (1) EP3172216B1 (pl)
JP (1) JP5894351B2 (pl)
CN (1) CN105722845A (pl)
CA (1) CA2887025C (pl)
PL (2) PL225283B1 (pl)
WO (1) WO2015050468A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114644651A (zh) * 2022-04-13 2022-06-21 中国人民解放军军事科学院军事医学研究院 芳氧基磷酰化氨基酸酯化合物的制备方法
WO2025236011A1 (en) * 2024-05-10 2025-11-13 Board Of Regents, The University Of Texas System Compositions for phosphorous-azole exchange chemistry and use thereof to target functional protein sites

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102464688A (zh) * 2010-11-19 2012-05-23 医影生物医药科技(上海)有限公司 胸苷环磷酸酯化合物及其抗肿瘤用途
US9095599B2 (en) * 2011-01-03 2015-08-04 Nanjing Molecular Research, Inc. O-(substituted benzyl) phosphoramidate compounds and therapeutic use
DK3031812T3 (en) * 2011-03-01 2018-09-17 NuCana plc CHEMICAL COMPOUNDS

Also Published As

Publication number Publication date
JP2015537040A (ja) 2015-12-24
JP5894351B2 (ja) 2016-03-30
US20160024133A1 (en) 2016-01-28
CA2887025C (en) 2016-01-05
EP3172216A1 (en) 2017-05-31
WO2015050468A1 (en) 2015-04-09
CN105722845A (zh) 2016-06-29
US9260468B1 (en) 2016-02-16
PL3172216T3 (pl) 2019-04-30
EP3172216B1 (en) 2018-10-10
PL225283B1 (pl) 2017-03-31
CA2887025A1 (en) 2015-04-09

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