PL409663A1 - Zastosowanie peptydowych pochodnych estrów kwasów 1-aminoalkilofosfonowych jako inhibitorów proteazy NS3/4A ekspresjonowanej przez ludzki wirus zapalenia wątroby typu C (HCV) - Google Patents
Zastosowanie peptydowych pochodnych estrów kwasów 1-aminoalkilofosfonowych jako inhibitorów proteazy NS3/4A ekspresjonowanej przez ludzki wirus zapalenia wątroby typu C (HCV)Info
- Publication number
- PL409663A1 PL409663A1 PL409663A PL40966314A PL409663A1 PL 409663 A1 PL409663 A1 PL 409663A1 PL 409663 A PL409663 A PL 409663A PL 40966314 A PL40966314 A PL 40966314A PL 409663 A1 PL409663 A1 PL 409663A1
- Authority
- PL
- Poland
- Prior art keywords
- hcv
- acid esters
- peptide derivatives
- aminalkyl
- inhibitors
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 206010019799 Hepatitis viral Diseases 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 title 1
- 239000004365 Protease Substances 0.000 title 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title 1
- 241000700605 Viruses Species 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000003008 phosphonic acid esters Chemical class 0.000 title 1
- 201000001862 viral hepatitis Diseases 0.000 title 1
- 241000711549 Hepacivirus C Species 0.000 abstract 2
- VUYWLCHFKCFCNH-QWRGUYRKSA-N (2s)-1-[(2s)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]pyrrolidine-2-carboxylic acid Chemical compound CC(C)(C)OC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(O)=O VUYWLCHFKCFCNH-QWRGUYRKSA-N 0.000 abstract 1
- XWUSALIIUZARQE-UHFFFAOYSA-N 1,1,2,2-tetrafluoropropane Chemical group CC(F)(F)C(F)F XWUSALIIUZARQE-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Wynalazek dotyczy zastosowania peptydowych pochodnych estrów kwasów 1-aminoalkilofosfonowych o wzorze ogólnym I w którym (W) oznacza podstawnik Boc-Val-Pro lub Cbz-Val-Pro, (R) oznacza pierścień fenylowy podstawiony w pozycji para grupą X, która oznacza: wodór, grupę S-metylową, grupę O-metylową, chlor lub podstawnik 2,2,3,3-tetrafluoropropanowy jako inhibitorów proteazy NS3/4A ekspresjonowanej przez ludzki wirus zapalenia wątroby typu C (HCV).
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL409663A PL227285B1 (pl) | 2014-10-02 | 2014-10-02 | Zastosowanie peptydowych pochodnych estrów kwasów 1-aminoalkilofosfonowych jako inhibitorów proteazy NS3/4A ekspresjonowanej przez ludzki wirus zapalenia watroby typu C (HCV) |
| PCT/IB2015/054670 WO2016051289A1 (en) | 2014-10-02 | 2015-06-22 | Antiviral pharmaceutical preparation for use in treatment of hepatitis c |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL409663A PL227285B1 (pl) | 2014-10-02 | 2014-10-02 | Zastosowanie peptydowych pochodnych estrów kwasów 1-aminoalkilofosfonowych jako inhibitorów proteazy NS3/4A ekspresjonowanej przez ludzki wirus zapalenia watroby typu C (HCV) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL409663A1 true PL409663A1 (pl) | 2015-06-22 |
| PL227285B1 PL227285B1 (pl) | 2017-11-30 |
Family
ID=53396838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL409663A PL227285B1 (pl) | 2014-10-02 | 2014-10-02 | Zastosowanie peptydowych pochodnych estrów kwasów 1-aminoalkilofosfonowych jako inhibitorów proteazy NS3/4A ekspresjonowanej przez ludzki wirus zapalenia watroby typu C (HCV) |
Country Status (2)
| Country | Link |
|---|---|
| PL (1) | PL227285B1 (pl) |
| WO (1) | WO2016051289A1 (pl) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS66213B1 (sr) * | 2021-04-16 | 2024-12-31 | Fujian Akeylink Biotechnology Co Ltd | Jedinjenje kratkog peptida prolina modifikovanog prstenom i upotreba istog |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070232527A1 (en) | 2005-06-02 | 2007-10-04 | Anima Ghosal | Medicaments and methods combining a HCV protease inhibitor and an AKR competitor |
| US20120158515A1 (en) | 2010-12-21 | 2012-06-21 | Yahoo! Inc. | Dynamic advertisement serving based on an avatar |
-
2014
- 2014-10-02 PL PL409663A patent/PL227285B1/pl unknown
-
2015
- 2015-06-22 WO PCT/IB2015/054670 patent/WO2016051289A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| PL227285B1 (pl) | 2017-11-30 |
| WO2016051289A1 (en) | 2016-04-07 |
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