PL411432A1 - Water-soluble intelligent gold complexes (III), method for producing water-soluble intelligent gold complexes (III) and their application - Google Patents
Water-soluble intelligent gold complexes (III), method for producing water-soluble intelligent gold complexes (III) and their applicationInfo
- Publication number
- PL411432A1 PL411432A1 PL411432A PL41143215A PL411432A1 PL 411432 A1 PL411432 A1 PL 411432A1 PL 411432 A PL411432 A PL 411432A PL 41143215 A PL41143215 A PL 41143215A PL 411432 A1 PL411432 A1 PL 411432A1
- Authority
- PL
- Poland
- Prior art keywords
- iii
- soluble
- water
- gold
- intelligent
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- OSVXSBDYLRYLIG-UHFFFAOYSA-N chlorine dioxide Inorganic materials O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 abstract 4
- CBMIPXHVOVTTTL-UHFFFAOYSA-N gold(3+) Chemical class [Au+3] CBMIPXHVOVTTTL-UHFFFAOYSA-N 0.000 abstract 4
- 235000019398 chlorine dioxide Nutrition 0.000 abstract 2
- BZSXEZOLBIJVQK-UHFFFAOYSA-N 2-methylsulfonylbenzoic acid Chemical compound CS(=O)(=O)C1=CC=CC=C1C(O)=O BZSXEZOLBIJVQK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004155 Chlorine dioxide Substances 0.000 abstract 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001805 chlorine compounds Chemical class 0.000 abstract 1
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002343 gold Chemical class 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hcl hcl Chemical compound Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Ujawniono wodorozpuszczalne, inteligentne kompleksy złota (III) o ogólnym wzorze 1: [AU(CN)m]n(m-p)n • (ClO2)rn, gdzie m ma wartość od 3 do 6, n ma wartość od 1 do 10, p ma wartość od 1 do 3, a r ma wartość od 0,1 do 2. Przedmiotem rozwiązania jest również sposób otrzymywania wodorozpuszczalnych, inteligentnych kompleksów złota (III), który polega na tym, że klastry złota wielokrotnie roztwarza się chemicznie, w kwasie solnym (HCl) w obecności przynajmniej 10 molowego nadmiaru chlorków jedno wartościowych metali alkalicznych i każdorazowo odparowuje do sucha, aż do uzyskania wielkości klastrów poniżej 1 nanometra, korzystnie mono-dijonów złota (III), a następnie w roztworze wodnym lub wodno-alkoholowym reaguje z cyjankiem jednowartościowego metalu alkalicznego w stosunku molowym od 1:3 do 1:6 w obecności łagodnego utleniacza, którym jest ditlenek chloru (IV) lub jego prekursor chloran (III) sodu, użyty w stosunku molowym 0,1 do 2 w stosunku do złota (III). Rozwiązanie dotyczy także zastosowania wodorozpuszczalnych, inteligentnych kompleksów złota (III) o wzorze 1, jako pojedynczego leku lub jako składnika środka farmaceutycznego złożonej kompozycji farmaceutycznej w uzasadnionej ilości i dowolnym sposobie podawania w chorobach nowotworowych.Water-soluble intelligent gold (III) complexes with general formula 1 are disclosed: [AU (CN) m] n (mp) n • (ClO2) rn, where m is from 3 to 6, n is from 1 to 10, p has a value from 1 to 3, and a value from 0.1 to 2. The subject of the solution is also the method of obtaining water-soluble, intelligent gold (III) complexes, which consists in the fact that gold clusters are repeatedly chemically dissolved in hydrochloric acid (HCl) ) in the presence of at least 10 molar excess of chlorides of monovalent alkali metals and each time evaporates to dryness until the cluster size is less than 1 nanometer, preferably gold (III) mononionion, and then reacts with a monovalent metal cyanide in aqueous or aqueous-alcoholic solution alkaline in a molar ratio of 1: 3 to 1: 6 in the presence of a mild oxidant, which is chlorine dioxide (IV) or its precursor sodium chlorate (III), used in a molar ratio of 0.1 to 2 relative to evil ta (III). The solution also relates to the use of water-soluble, intelligent gold (III) complexes of formula 1 as a single drug or as a pharmaceutical ingredient in a complex pharmaceutical composition in a reasonable amount and in any method of administration in cancer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL411432A PL235135B1 (en) | 2015-03-01 | 2015-03-01 | Water-soluble intelligent gold complexes (III), method for producing water-soluble intelligent gold complexes (III) and their application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL411432A PL235135B1 (en) | 2015-03-01 | 2015-03-01 | Water-soluble intelligent gold complexes (III), method for producing water-soluble intelligent gold complexes (III) and their application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL411432A1 true PL411432A1 (en) | 2016-09-12 |
| PL235135B1 PL235135B1 (en) | 2020-06-01 |
Family
ID=56855115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL411432A PL235135B1 (en) | 2015-03-01 | 2015-03-01 | Water-soluble intelligent gold complexes (III), method for producing water-soluble intelligent gold complexes (III) and their application |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL235135B1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019008013A1 (en) | 2017-07-04 | 2019-01-10 | Szczepaniak Stanislaw | Water-soluble gold (iii) complexes, methods of producing water-soluble gold (iii) complexes and their use |
-
2015
- 2015-03-01 PL PL411432A patent/PL235135B1/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019008013A1 (en) | 2017-07-04 | 2019-01-10 | Szczepaniak Stanislaw | Water-soluble gold (iii) complexes, methods of producing water-soluble gold (iii) complexes and their use |
| PL422125A1 (en) * | 2017-07-04 | 2019-01-14 | Stanisław Szczepaniak | Water-soluble intelligent gold complexes (III), method for producing water-soluble intelligent gold complexes (III) and their application |
| US11548792B2 (en) | 2017-07-04 | 2023-01-10 | Stanislaw SZCZEPANIAK | Water-soluble gold (III) complexes, methods of producing water-soluble gold (III) complexes and their use |
Also Published As
| Publication number | Publication date |
|---|---|
| PL235135B1 (en) | 2020-06-01 |
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