PL4126821T3 - Sposób wytwarzania kwasu (r)-4-(1-(6-(4-(trifluoromety­lo)benzylo)-6-azaspiro[2.5]oktano-5-karboksyamido)cyklopropylo)benzoesowego lub jego soli - Google Patents

Sposób wytwarzania kwasu (r)-4-(1-(6-(4-(trifluoromety­lo)benzylo)-6-azaspiro[2.5]oktano-5-karboksyamido)cyklopropylo)benzoesowego lub jego soli

Info

Publication number
PL4126821T3
PL4126821T3 PL21720694.5T PL21720694T PL4126821T3 PL 4126821 T3 PL4126821 T3 PL 4126821T3 PL 21720694 T PL21720694 T PL 21720694T PL 4126821 T3 PL4126821 T3 PL 4126821T3
Authority
PL
Poland
Prior art keywords
azaspiro
carboxamido
octane
cyclopropyl
trifluoromethyl
Prior art date
Application number
PL21720694.5T
Other languages
English (en)
Inventor
Lucio Claudio Rovati
Roberto Artusi
Filippo Magaraci
Benedetta Buzzi
Original Assignee
Rottapharm Biotech S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rottapharm Biotech S.R.L. filed Critical Rottapharm Biotech S.R.L.
Publication of PL4126821T3 publication Critical patent/PL4126821T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL21720694.5T 2020-03-27 2021-03-19 Sposób wytwarzania kwasu (r)-4-(1-(6-(4-(trifluoromety­lo)benzylo)-6-azaspiro[2.5]oktano-5-karboksyamido)cyklopropylo)benzoesowego lub jego soli PL4126821T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20166480.2A EP3885339A1 (en) 2020-03-27 2020-03-27 Process for the preparation of (r)-4-(1-(6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)-cyclopropyl) benzoic acid or a salt thereof
PCT/EP2021/057046 WO2021191062A1 (en) 2020-03-27 2021-03-19 Process for the preparation of (r)-4-(1-(6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)-cyclopropyl) benzoic acid or a salt thereof

Publications (1)

Publication Number Publication Date
PL4126821T3 true PL4126821T3 (pl) 2024-12-02

Family

ID=70057038

Family Applications (1)

Application Number Title Priority Date Filing Date
PL21720694.5T PL4126821T3 (pl) 2020-03-27 2021-03-19 Sposób wytwarzania kwasu (r)-4-(1-(6-(4-(trifluoromety­lo)benzylo)-6-azaspiro[2.5]oktano-5-karboksyamido)cyklopropylo)benzoesowego lub jego soli

Country Status (12)

Country Link
US (1) US12404245B2 (pl)
EP (2) EP3885339A1 (pl)
JP (1) JP7837559B2 (pl)
KR (1) KR20220160031A (pl)
CN (1) CN115515936A (pl)
AR (1) AR121654A1 (pl)
AU (1) AU2021245014A1 (pl)
BR (1) BR112022019285A2 (pl)
CA (1) CA3172903A1 (pl)
ES (1) ES2986976T3 (pl)
PL (1) PL4126821T3 (pl)
WO (1) WO2021191062A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114380717A (zh) * 2022-01-28 2022-04-22 郑州猫眼农业科技有限公司 3-(叔丁氧基羰基-甲氧基羰基甲基-氨基)-丙酸甲酯及其中间体的制备方法
CN116143695B (zh) * 2023-02-17 2024-04-05 上海麦克林生化科技股份有限公司 一种1,1-二氟-5-氮杂螺[2.5]辛烷盐酸盐的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007513890A (ja) 2003-12-12 2007-05-31 メルク フロスト カナダ リミテツド カテプシンシステインプロテアーゼ阻害剤
CA2679175C (en) 2007-02-26 2015-01-13 Merck Frosst Canada Ltd. Indole and indoline cyclopropyl amide derivatives as ep4 receptor antagonists
CN102137841B (zh) * 2008-09-02 2014-05-14 日产化学工业株式会社 邻位取代卤代烷基磺酰苯胺衍生物及除草剂
EP2484674A1 (en) * 2011-02-02 2012-08-08 Rottapharm S.P.A. Spiro aminic compounds with NK1 antagonist activity
DK2729445T3 (en) 2011-07-04 2016-01-18 Rottapharm Biotech Srl CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS
ITMI20112329A1 (it) * 2011-12-21 2013-06-22 Rottapharm Spa Nuovi derivati spiro amminici
US9056860B2 (en) 2012-06-05 2015-06-16 Gilead Pharmasset Llc Synthesis of antiviral compound
ME02896B (me) * 2013-12-17 2018-04-20 Lilly Co Eli Fenoksietilni derivati prstenastog amina i njihova aktivnost kao modulatora receptora ep4
CN106928127B (zh) * 2015-12-31 2021-07-16 四川海思科制药有限公司 取代哌啶类酰胺衍生物及其制备方法和在药学上的应用
CN107954990A (zh) * 2017-11-14 2018-04-24 安徽诺全药业有限公司 一种雷迪帕维的制备方法

Also Published As

Publication number Publication date
US20230127805A1 (en) 2023-04-27
WO2021191062A1 (en) 2021-09-30
CA3172903A1 (en) 2021-09-30
EP4126821A1 (en) 2023-02-08
CN115515936A (zh) 2022-12-23
AU2021245014A1 (en) 2022-10-27
JP2023519231A (ja) 2023-05-10
AR121654A1 (es) 2022-06-29
EP3885339A1 (en) 2021-09-29
KR20220160031A (ko) 2022-12-05
EP4126821B1 (en) 2024-05-15
BR112022019285A2 (pt) 2022-11-16
US12404245B2 (en) 2025-09-02
JP7837559B2 (ja) 2026-03-31
ES2986976T3 (es) 2024-11-13
TW202140423A (zh) 2021-11-01

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