PL413494A1 - New N-alkyl derivatives of 2,2'-bibenzimidazole and method for obtaining them - Google Patents
New N-alkyl derivatives of 2,2'-bibenzimidazole and method for obtaining themInfo
- Publication number
- PL413494A1 PL413494A1 PL413494A PL41349415A PL413494A1 PL 413494 A1 PL413494 A1 PL 413494A1 PL 413494 A PL413494 A PL 413494A PL 41349415 A PL41349415 A PL 41349415A PL 413494 A1 PL413494 A1 PL 413494A1
- Authority
- PL
- Poland
- Prior art keywords
- bibenzimidazole
- new
- alkyl
- obtaining
- alkyl derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001350 alkyl halides Chemical class 0.000 abstract 2
- VEZJRJGLFIXQHG-UHFFFAOYSA-N 2-(1h-benzimidazol-2-yl)-1h-benzimidazole Chemical compound C1=CC=C2NC(C=3NC4=CC=CC=C4N=3)=NC2=C1 VEZJRJGLFIXQHG-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 159000000000 sodium salts Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem zgłoszenia są nowe N-alkilo-2,2'-bibenzimidazole o wzorze 1, w którym R oznacza podstawnik alkilowy o długości łańcucha węglowego od jednego do dwudziestu atomów węgla, prosty lub rozgałęziony, wraz ze sposobem ich otrzymywania, który charakteryzuje się tym, że reakcję prowadzi się z soli sodowej 2,2'-bibenzimidazolu i odpowiedniego halogenku alkilowego w aprotycznym polarnym rozpuszczalniku, ogrzewając stopniowo mieszaninę reakcyjną do temperatury wrzenia w czasie koniecznym do uzyskania stanu równowagi, przy nadmiarze halogenku alkilowego w stosunku do soli sodowej, a uzyskany surowy produkt oczyszcza się metodą chromatografii kolumnowej.The subject of the application are new N-alkyl-2,2'-bibenzimidazoles of formula 1, in which R is an alkyl substituent with a carbon chain length of one to twenty carbon atoms, straight or branched, together with the method of their preparation, which is characterized by that the reaction is carried out from 2,2'-bibenzimidazole sodium and the corresponding alkyl halide in an aprotic polar solvent, gradually heating the reaction mixture to the boiling point for the time necessary to achieve equilibrium, with an excess of alkyl halide relative to the sodium salt, and the resulting crude the product is purified by column chromatography.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL413494A PL413494A1 (en) | 2015-08-10 | 2015-08-10 | New N-alkyl derivatives of 2,2'-bibenzimidazole and method for obtaining them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL413494A PL413494A1 (en) | 2015-08-10 | 2015-08-10 | New N-alkyl derivatives of 2,2'-bibenzimidazole and method for obtaining them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL413494A1 true PL413494A1 (en) | 2017-02-13 |
Family
ID=57965378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL413494A PL413494A1 (en) | 2015-08-10 | 2015-08-10 | New N-alkyl derivatives of 2,2'-bibenzimidazole and method for obtaining them |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL413494A1 (en) |
-
2015
- 2015-08-10 PL PL413494A patent/PL413494A1/en unknown
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